Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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lipogenesis1889 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A31606 | 31696159 | ACS Pharmacol Transl Sci | Inhibition of Hepatotoxicity by a LXR Inverse Agonist in a Model of Alcoholic Liver Disease. | 2018 | Details |
| A31832 | 29740221 | Hepat Med | Effect of sitagliptin on hepatic histological activity and fibrosis of nonalcoholic steatohepatitis patients: a 1-year randomized control trial. | 2018 | Details |
| A31982 | 29404462 | Hepatol Commun | Intermittent hypoxia is a proinflammatory stimulus resulting in IL-6 expression and M1 macrophage polarization. | 2017 | Details |
| A32145 | 29116096 | Sci Rep | AQP3 is regulated by PPARγ and JNK in hepatic stellate cells carrying PNPLA3 I148M. | 2017 | Details |
| A32164 | 29068700 | Nutr Cancer | Silibinin Reduces the Impact of Obesity on Invasive Liver Cancer. | 2017 | Details |
| A32722 | 27685150 | PLoS One | Macrophage Stimulating Protein Enhances Hepatic Inflammation in a NASH Model. | 2016 | Details |
| A32876 | 27185461 | J Mol Biol | The Nutrient-Dependent O-GlcNAc Modification Controls the Expression of Liver Fatty Acid Synthase. | 2016 | Details |
| A32934 | 27062266 | Hepatol Res | L-carnitine prevents metabolic steatohepatitis in obese diabetic KK-Ay mice. | 2016 | Details |
| A33515 | 25830098 | Mol Metab | The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis. | 2015 | Details |
| A33799 | 25132496 | Cancer Cell | ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. | 2014 | Details |
| A34237 | 23996730 | Hepatology | Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice. | 2013 | Details |
| A34335 | 26201785 | Hepatol Int | B cell-activating factor is associated with the histological severity of nonalcoholic fatty liver disease. | 2012 | Details |
| A34453 | 23409132 | PLoS One | Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. | 2013 | Details |
| A34583 | 23147115 | Int J Obes (Lond) | Increased insulin receptor substrate 2 expression is associated with steatohepatitis and altered lipid metabolism in obese subjects. | 2012 | Details |
| A35022 | 21933146 | Curr Pharm Des | Metabolic therapy: lessons from liver diseases. | 2011 | Details |
| A35316 | 21119028 | Am J Physiol Endocrinol Metab | Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis. | 2010 | Details |
| A35434 | 20683968 | Hepatology | Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. | 2010 | Details |
| A35490 | 20548288 | Lab Invest | Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. | 2010 | Details |
| A35531 | 20425484 | Curr Gastroenterol Rep | Nontriglyceride hepatic lipotoxicity: the new paradigm for the pathogenesis of NASH. | 2010 | Details |
| A35556 | 20371730 | Dis Model Mech | Medaka as a model for human nonalcoholic steatohepatitis. | 2010 | Details |
| A35753 | 19764881 | Antioxid Redox Signal | Thioredoxin-binding protein-2 deficiency enhances methionine-choline deficient diet-induced hepatic steatosis but inhibits steatohepatitis in mice. | 2009 | Details |
| A35907 | 19444873 | Hepatology | Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice. | 2009 | Details |
| A36019 | 19195626 | Diabetes Metab | Insulin resistance and steatosis in humans. | 2008 | Details |
| A36688 | 17459514 | J Hepatol | Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model. | 2007 | Details |
| A36801 | 17241878 | Gastroenterology | Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. | 2006 | Details |
| A36997 | 16768111 | Nihon Rinsho | [Insulin resistance]. | 2006 | Details |
| A37142 | 19858584 | Saudi J Gastroenterol | Endocannabinoids and non-alcoholic steatohepatitis. | 2009 | Details |
| A37309 | 15985534 | FASEB J | Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis. | 2005 | Details |
| A42238 | 35121169 | Mol Metab | Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction. | 2022 | Details |
| A42274 | 35022960 | Mol Cell Biochem | Autophagy: a molecular switch to regulate adipogenesis and lipolysis. | 2022 | Details |
| A42422 | 34572325 | Biomedicines | Glycomacropeptide for Management of Insulin Resistance and Liver Metabolic Perturbations. | 2021 | Details |
| A42430 | 34542351 | Crit Rev Food Sci Nutr | Branched chain amino acids-friend or foe in the control of energy substrate turnover and insulin sensitivity? | 2021 | Details |
| A42469 | 34455076 | Pharmacol Res | The pivotal role of Nrf2 activators in adipocyte biology. | 2021 | Details |
| A42673 | 33826778 | Hepatology | Therapeutic Potential of G Protein-Coupled Receptors Against Nonalcoholic Steatohepatitis. | 2021 | Details |
| A42706 | 33693864 | J Nutr | Milk Fat Globule Membrane Supplementation During Suckling Ameliorates Maternal High Fat Diet-Induced Hepatic Steatosis in Adult Male Offspring of Mice. | 2021 | Details |
| A42713 | 33666565 | J Mol Endocrinol | Oleanolic acid derivative HA-20 inhibits adipogenesis in a manner involving PPARγ-FABP4/aP2 pathway. | 2021 | Details |
| A42865 | 33257823 | Nat Rev Endocrinol | Metabolic liver disease - what's in a name? | 2021 | Details |
| A42874 | 33247737 | Toxicol Sci | Inhibition of Acetyl-CoA Carboxylase Causes Malformations in Rats and Rabbits: Comparison of Mammalian Findings and Alternative Assays. | 2021 | Details |
| A42933 | 33045592 | Environ Pollut | 4-Hexylphenol influences adipogenic differentiation and hepatic lipid accumulation in vitro. | 2020 | Details |
| A42971 | 32923835 | Hepatol Commun | Self-Organizing Human Induced Pluripotent Stem Cell Hepatocyte 3D Organoids Inform the Biology of the Pleiotropic TRIB1 Gene. | 2020 | Details |
| A42986 | 32887949 | Nat Rev Endocrinol | Role of fructose in NASH defined. | 2020 | Details |
| A43081 | 32614087 | Hepatology | Acyl Coenzyme A Thioesterase 9: A Novel Target for Nonalcoholic Fatty Liver Disease by Shuttling Mitochondrial Short-Chain Fatty Acids? | 2020 | Details |
| A43141 | 32443199 | Environ Pollut | Lipidomics insight into chronic exposure to ambient air pollution in mice. | 2020 | Details |
| A43153 | 32419825 | Evid Based Complement Alternat Med | Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation. | 2020 | Details |
| A43246 | 32184272 | Diabetes | Branched-Chain Amino Acids Exacerbate Obesity-Related Hepatic Glucose and Lipid Metabolic Disorders via Attenuating Akt2 Signaling. | 2020 | Details |
| A43307 | 32012270 | J Cell Physiol | Effects of different fatty acids on BRL3A rat liver cell damage. | 2020 | Details |
| A43344 | 31945627 | Nutr Res | A maple syrup extract alleviates liver injury in type 2 diabetic model mice. | 2019 | Details |
| A43468 | 31649547 | Front Pharmacol | Mitophagy in Hepatic Insulin Resistance: Therapeutic Potential and Concerns. | 2019 | Details |
| A43500 | 31576746 | Chem Res Toxicol | Dose-Dependent Effects of Triclocarban Exposure on Lipid Homeostasis in Rats. | 2019 | Details |
| A43504 | 31570275 | J Hepatol | Endoscopic bariatric and metabolic therapies for non-alcoholic fatty liver disease. | 2019 | Details |
| A43576 | 31369090 | J Clin Endocrinol Metab | Overeating Saturated Fat Promotes Fatty Liver and Ceramides Compared With Polyunsaturated Fat: A Randomized Trial. | 2019 | Details |
| A43587 | 31345023 | J Agric Food Chem | Processed Meat Protein Promoted Inflammation and Hepatic Lipogenesis by Upregulating Nrf2/Keap1 Signaling Pathway in Glrx-Deficient Mice. | 2019 | Details |
| A43663 | 31160717 | Cell Death Differ | SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity. | 2019 | Details |
| A43671 | 31142011 | Int J Mol Sci | Involvement of G-Protein-Coupled Receptor 40 in the Inhibitory Effects of Docosahexaenoic Acid on SREBP1-Mediated Lipogenic Enzyme Expression in Primary Hepatocytes. | 2019 | Details |
| A43673 | 31137678 | Int J Mol Sci | Adipokinome Signatures in Obese Mouse Models Reflect Adipose Tissue Health and Are Associated with Serum Lipid Composition. | 2019 | Details |
| A43716 | 31048404 | J Lipid Res | Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption. | 2019 | Details |
| A43844 | 30721927 | Am J Clin Nutr | Measure for measure? | 2019 | Details |
| A43866 | 30654277 | J Nutr Biochem | A mix of dietary fermentable fibers improves lipids handling by the liver of overfed minipigs. | 2018 | Details |
| A43874 | 30625338 | Toxicol Appl Pharmacol | Metformin delays AKT/c-Met-driven hepatocarcinogenesis by regulating signaling pathways for de novo lipogenesis and ATP generation. | 2019 | Details |
| A43945 | 30379616 | Annu Rev Physiol | Phospholipid Remodeling in Physiology and Disease. | 2018 | Details |
| A44044 | 30054343 | J Lipid Res | Fatty liver disrupts glycerol metabolism in gluconeogenic and lipogenic pathways in humans. | 2018 | Details |
| A44155 | 29558206 | Am J Physiol Endocrinol Metab | Dose-dependent quantitative effects of acute fructose administration on hepatic de novo lipogenesis in healthy humans. | 2018 | Details |
| A44161 | 29546310 | J Nutr | Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation. | 2018 | Details |
| A44170 | 29523556 | Circ Cardiovasc Imaging | Prevalent Cardiovascular Disease Events and T1 Mapping Defined Hepatic Fibrosis. | 2018 | Details |
| A44186 | 29474539 | Endocrinology | miR-1224-5p Enhances Hepatic Lipogenesis by Targeting Adenosine Monophosphate-Activated Protein Kinase α1 in Male Mice. | 2018 | Details |
| A44245 | 29254285 | Clin Mol Hepatol | Picroside II attenuates fatty acid accumulation in HepG2 cells via modulation of fatty acid uptake and synthesis. | 2017 | Details |
| A44353 | 28866102 | Life Sci | Liver steatosis in hypothalamic obese rats improves after duodeno-jejunal bypass by reduction in de novo lipogenesis pathway. | 2017 | Details |
| A44388 | 28739056 | Nutr Res | Supplementation with Vitis vinifera L. skin extract improves insulin resistance and prevents hepatic lipid accumulation and steatosis in high-fat diet-fed mice. | 2017 | Details |
| A44438 | 28628040 | J Clin Invest | Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity. | 2017 | Details |
| A44462 | 28548281 | J Intern Med | Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity. | 2017 | Details |
| A44531 | 28331449 | Ochsner J | Cyclin D1 in the Liver: Role of Noncanonical Signaling in Liver Steatosis and Hormone Regulation. | 2017 | Details |
| A44576 | 28133767 | Hepatology | The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism. | 2017 | Details |
| A44582 | 28096127 | Adv Nutr | Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases. | 2017 | Details |
| A44623 | 27918207 | Can J Physiol Pharmacol | Gemigliptin ameliorates Western-diet-induced metabolic syndrome in mice. | 2016 | Details |
| A44625 | 27914812 | Biochem Biophys Res Commun | Protective effects of gomisin N against hepatic steatosis through AMPK activation. | 2016 | Details |
| A44646 | 27822554 | mSystems | Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism. | 2016 | Details |
| A44655 | 27664470 | Am J Pathol | REV-ERBα Activates C/EBP Homologous Protein to Control Small Heterodimer Partner-Mediated Oscillation of Alcoholic Fatty Liver. | 2016 | Details |
| A44673 | 27699898 | J Intern Med | Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids. | 2016 | Details |
| A44690 | 27732084 | Endocrinology | RABL2 Is Required for Hepatic Fatty Acid Homeostasis and Its Dysfunction Leads to Steatosis and a Diabetes-Like State. | 2016 | Details |
| A44764 | 27385159 | Diabetes | Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis. | 2016 | Details |
| A44776 | 27347126 | Oncol Lett | Elovl6 is a poor prognostic predictor in breast cancer. | 2016 | Details |
| A44784 | 27318725 | Cells Tissues Organs | Short Exposure to a High-Sucrose Diet and the First 'Hit' of Nonalcoholic Fatty Liver Disease in Mice. | 2016 | Details |
| A44843 | 27099587 | Gastroenterol Hepatol (N Y) | Pathogenesis and Prevention of Hepatic Steatosis. | 2015 | Details |
| A44854 | 27056371 | Diabetologia | The liver in focus. | 2016 | Details |
| A44872 | 27013659 | J Biol Chem | Liver MicroRNA-291b-3p Promotes Hepatic Lipogenesis through Negative Regulation of Adenosine 5'-Monophosphate (AMP)-activated Protein Kinase α1. | 2016 | Details |
| A44920 | 26790190 | Pharmazie | Nectandrin B, a lignan isolated from nutmeg, inhibits liver X receptor-α-induced hepatic lipogenesis through AMP-activated protein kinase activation. | 2015 | Details |
| A44977 | 26564715 | Am J Physiol Gastrointest Liver Physiol | Glial cell line-derived neurotrophic factor protects against high-fat diet-induced hepatic steatosis by suppressing hepatic PPAR-γ expression. | 2015 | Details |
| A44995 | 26504484 | Evid Based Complement Alternat Med | Deepure Tea Improves High Fat Diet-Induced Insulin Resistance and Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A45004 | 26455261 | J Agric Food Chem | Gomisin J Inhibits Oleic Acid-Induced Hepatic Lipogenesis by Activation of the AMPK-Dependent Pathway and Inhibition of the Hepatokine Fetuin-A in HepG2 Cells. | 2015 | Details |
| A45033 | 26376348 | Gastroenterology | Physiological Mechanisms of Weight Gain-Induced Steatosis in People With Obesity. | 2015 | Details |
| A45095 | 26092479 | Life Sci | Improvement in the expression of hepatic genes involved in fatty acid metabolism in obese rats supplemented with taurine. | 2015 | Details |
| A45099 | 26085100 | J Biol Chem | Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance. | 2015 | Details |
| A45240 | 25564660 | Proc Natl Acad Sci U S A | Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids. | 2015 | Details |
| A45256 | 25514904 | J Lipid Res | KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression. | 2014 | Details |
| A45293 | 25357150 | J Med Food | Vigna nakashimae extract prevents hepatic steatosis in obese mice fed high-fat diets. | 2014 | Details |
| A45383 | 24895043 | Endocrine | Basis of aggravated hepatic lipid metabolism by chronic stress in high-fat diet-fed rat. | 2014 | Details |
| A45387 | 24875102 | Am J Physiol Gastrointest Liver Physiol | Human FABP1 T94A variant impacts fatty acid metabolism and PPAR-α activation in cultured human female hepatocytes. | 2014 | Details |
| A45406 | 24768697 | Toxicol Lett | Mitochondrial dysfunction in early life resulted from perinatal bisphenol A exposure contributes to hepatic steatosis in rat offspring. | 2014 | Details |
| A45509 | 24223615 | Evid Based Complement Alternat Med | Zerumbone, a Natural Cyclic Sesquiterpene of Zingiber zerumbet Smith, Attenuates Nonalcoholic Fatty Liver Disease in Hamsters Fed on High-Fat Diet. | 2013 | Details |
| A45539 | 24062606 | J Clin Biochem Nutr | S-Allyl cysteine improves nonalcoholic fatty liver disease in type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats via regulation of hepatic lipogenesis and glucose metabolism. | 2013 | Details |