Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Choline1715 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A02784 | 34242656 | Am J Pathol | Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Is Associated with Increased Intestinal Inflammation. | 2021 | Details |
| A02799 | 34235481 | Curr Res Struct Biol | A two-stage computational approach to predict novel ligands for a chemosensory receptor. | 2020 | Details |
| A02909 | 34200685 | Metabolites | Metabolomic Study of High-Fat Diet-Induced Obese (DIO) and DIO Plus CCl4-Induced NASH Mice and the Effect of Obeticholic Acid. | 2021 | Details |
| A02910 | 34200615 | Nutrients | Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet. | 2021 | Details |
| A02932 | 34192596 | Life Sci | Demethylenetetrahydroberberine alleviates nonalcoholic fatty liver disease by inhibiting the NLRP3 inflammasome and oxidative stress in mice. | 2021 | Details |
| A02965 | 34182909 | Curr Vasc Pharmacol | Association of PAF and its Metabolic Enzymes with GGT and the Fatty Liver Index in Healthy Volunteers. | 2021 | Details |
| A02966 | 34182070 | Free Radic Biol Med | Ethnicity-specific alterations of plasma and hepatic lipidomic profiles are related to high NAFLD rate and severity in Hispanic Americans, a pilot study. | 2021 | Details |
| A03012 | 34164507 | Ann Transl Med | Butyrate ameliorates alcoholic fatty liver disease via reducing endotoxemia and inhibiting liver gasdermin D-mediated pyroptosis. | 2021 | Details |
| A03032 | 34156680 | Eur Rev Med Pharmacol Sci | The PKM2 activator TEPP-46 attenuates MCD feeding-induced nonalcoholic steatohepatitis by inhibiting the activation of Kupffer cells. | 2021 | Details |
| A03058 | 34151243 | JHEP Rep | Aramchol downregulates stearoyl CoA-desaturase 1 in hepatic stellate cells to attenuate cellular fibrogenesis. | 2021 | Details |
| A03082 | 34137937 | Metabolomics | Plasma and stool metabolomics to identify microbiota derived-biomarkers of metabolic dysfunction-associated fatty liver disease: effect of PNPLA3 genotype. | 2021 | Details |
| A03128 | 34119474 | Am J Pathol | Decreased Portal Circulation Augments Fibrosis and Ductular Reaction in Nonalcoholic Fatty Liver Disease in Mice. | 2021 | Details |
| A03180 | 34098145 | Mol Metab | Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression. | 2021 | Details |
| A03188 | 34095305 | Biomed Res Int | A Combination of Geniposide and Chlorogenic Acid Combination Ameliorates Nonalcoholic Steatohepatitis in Mice by Inhibiting Kupffer Cell Activation. | 2021 | Details |
| A03200 | 34092291 | Chin J Nat Med | Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptor α. | 2021 | Details |
| A03220 | 34082879 | J Biomed Nanotechnol | Study on the Inhibitory Effects of Naringenin-Loaded Nanostructured Lipid Carriers Against Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03243 | 34074098 | Vnitr Lek | Serum butyrylcholinesterase/HDL-cholesterol ratio and atherogenic index of plasma in patients with fatty liver disease. | 2021 | Details |
| A03248 | 34072586 | Int J Mol Sci | One Week of CDAHFD Induces Steatohepatitis and Mitochondrial Dysfunction with Oxidative Stress in Liver. | 2021 | Details |
| A03317 | 34047448 | Mol Nutr Food Res | Soyasaponin A2 Alleviates Steatohepatitis Possibly through Regulating Bile Acids and Gut Microbiota in the Methionine and Choline-Deficient (MCD) Diet-induced Nonalcoholic Steatohepatitis (NASH) Mice. | 2021 | Details |
| A03338 | 34036256 | JHEP Rep | A human liver chimeric mouse model for non-alcoholic fatty liver disease. | 2021 | Details |
| A03403 | 34014450 | Hepatol Int | Hepatic stellate cells-specific LOXL1 deficiency abrogates hepatic inflammation, fibrosis, and corrects lipid metabolic abnormalities in non-obese NASH mice. | 2021 | Details |
| A03440 | 33999818 | IEEE Trans Med Imaging | Non-Invasive Photothermal Strain Imaging of Non-Alcoholic Fatty Liver Disease in Live Animals. | 2021 | Details |
| A03485 | 33987359 | Ann Transl Med | ENO3 promoted the progression of NASH by negatively regulating ferroptosis via elevation of GPX4 expression and lipid accumulation. | 2021 | Details |
| A03493 | 33984334 | Metabolism | A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage. | 2021 | Details |
| A03508 | 33977946 | Food Funct | DHA-enriched phosphatidylserine ameliorates non-alcoholic fatty liver disease and intestinal dysbacteriosis in mice induced by a high-fat diet. | 2021 | Details |
| A03532 | 33966599 | Autophagy | Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death. | 2021 | Details |
| A03543 | 33962045 | Ann Hepatol | Assessment of hepatic fatty acids during non-alcoholic steatohepatitis progression using magnetic resonance spectroscopy. | 2021 | Details |
| A03561 | 33953700 | Front Endocrinol (Lausanne) | Exenatide Attenuates Non-Alcoholic Steatohepatitis by Inhibiting the Pyroptosis Signaling Pathway. | 2021 | Details |
| A03564 | 33952843 | Nihon Yakurigaku Zasshi | [The roles of gap junctional intercellular communication in non-alcoholic steatohepatitis (NASH) and liver fibrosis]. | 2021 | Details |
| A03588 | 33940220 | Ann Hepatol | Mineralocorticoid receptor modulation by dietary sodium influences NAFLD development in mice. | 2021 | Details |
| A03612 | 33931568 | Sci Immunol | Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases. | 2021 | Details |
| A03683 | 33903148 | Gut | Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target. | 2021 | Details |
| A03685 | 33902194 | Zhonghua Gan Zang Bing Za Zhi | [Study of liver fat and iron deposition quantification based on magnetic resonance imaging in rats with nonalcoholic fatty liver disease]. | 2021 | Details |
| A03686 | 33902193 | Zhonghua Gan Zang Bing Za Zhi | [Phosphonate inhibits steatosis and lobular inflammation of non-alcoholic steatohepatitis through depleting macrophages]. | 2021 | Details |
| A03714 | 33894425 | Cell Mol Gastroenterol Hepatol | Caspase-11-Mediated Hepatocytic Pyroptosis Promotes the Progression of Nonalcoholic Steatohepatitis. | 2021 | Details |
| A03782 | 33865898 | Metabolism | Collagen β(1-O) galactosyltransferase 2 deficiency contributes to lipodystrophy and aggravates NAFLD related to HMW adiponectin in mice. | 2021 | Details |
| A03784 | 33865013 | Biomed Pharmacother | Salvia-Nelumbinis naturalis extract protects mice against MCD diet-induced steatohepatitis via activation of colonic FXR-FGF15 pathway. | 2021 | Details |
| A03818 | 33857628 | Free Radic Biol Med | Hepatocyte-specific deletion of Nlrp6 in mice exacerbates the development of non-alcoholic steatohepatitis. | 2021 | Details |
| A03860 | 33841814 | Food Sci Nutr | Functional beverages improve insulin resistance and hepatic steatosis modulating lysophospholipids in diet-induced obese rats. | 2021 | Details |
| A03930 | 33813878 | Am J Physiol Endocrinol Metab | Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis. | 2021 | Details |
| A03937 | 33812253 | Int Immunopharmacol | BMP9 promotes methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in non-obese mice by enhancing NF-κB dependent macrophage polarization. | 2021 | Details |
| A03950 | 33809964 | Metabolites | Stable Isotopic Tracer Phospholipidomics Reveals Contributions of Key Phospholipid Biosynthetic Pathways to Low Hepatocyte Phosphatidylcholine to Phosphatidylethanolamine Ratio Induced by Free Fatty Acids. | 2021 | Details |
| A04000 | 33794741 | Autophagy | The ménage à trois of autophagy, lipid droplets and liver disease. | 2021 | Details |
| A04019 | 33787507 | Dis Model Mech | Modulation of serotonin in the gut-liver neural axis ameliorates the fatty and fibrotic changes in non-alcoholic fatty liver. | 2021 | Details |
| A04029 | 33784797 | Phytother Res | Isotschimgine alleviates nonalcoholic steatohepatitis and fibrosis via FXR agonism in mice. | 2021 | Details |
| A04059 | 33773468 | Biomed Pharmacother | 4-Acetylantroquinonol B ameliorates nonalcoholic steatohepatitis by suppression of ER stress and NLRP3 inflammasome activation. | 2021 | Details |
| A04098 | 33761609 | Biomed Pharmacother | Ethyl pyruvate supplemented in drinking water ameliorates experimental nonalcoholic steatohepatitis. | 2021 | Details |
| A04109 | 33754067 | Theranostics | NAD+-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin. | 2021 | Details |
| A04120 | 33750416 | J Transl Med | LncRNA-Gm9795 promotes inflammation in non-alcoholic steatohepatitis via NF-[Formula: see text]B/JNK pathway by endoplasmic reticulum stress. | 2021 | Details |
| A04164 | 33731798 | Sci Rep | Quantitative, noninvasive MRI characterization of disease progression in a mouse model of non-alcoholic steatohepatitis. | 2021 | Details |
| A04178 | 33726979 | Dig Liver Dis | Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine. | 2021 | Details |
| A04179 | 33726778 | Chin Med | Hepatoprotective effect of Qushihuayu formula on non-alcoholic steatohepatitis induced by MCD diet in rat. | 2021 | Details |
| A04255 | 33687678 | Methods Mol Biol | Co-Culture of Human Mesenchymal Stromal Cells and Primary Mouse Hepatocytes. | 2021 | Details |
| A04260 | 33685086 | Zhonghua Gan Zang Bing Za Zhi | [Role of 1, 25-dihydroxyvitamin D3 in liver lipid metabolism induced by methionine-choline-deficient diet in rats]. | 2021 | Details |
| A04289 | 33675775 | Biochem Pharmacol | Activation of FXR modulates SOCS3/Jak2/STAT3 signaling axis in a NASH-dependent hepatocellular carcinoma animal model. | 2021 | Details |
| A04326 | 33665176 | Front Pediatr | Liver Enzymes Correlate With Metabolic Syndrome, Inflammation, and Endothelial Dysfunction in Prepubertal Children With Obesity. | 2021 | Details |
| A04330 | 33664289 | Sci Rep | Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury. | 2021 | Details |
| A04366 | 33647280 | Gastroenterology | Squalene Epoxidase Induces Nonalcoholic Steatohepatitis Via Binding to Carbonic Anhydrase III and is a Therapeutic Target. | 2021 | Details |
| A04376 | 33642551 | Biol Pharm Bull | Deletion of TRPC3 or TRPC6 Fails to Attenuate the Formation of Inflammation and Fibrosis in Non-alcoholic Steatohepatitis. | 2021 | Details |
| A04410 | 33629536 | Mol Nutr Food Res | Effect of Mastiha supplementation on NAFLD: The MAST4HEALTH Randomised, Controlled Trial. | 2021 | Details |
| A04419 | 33626003 | Turk J Gastroenterol | Berberine inhibits liver damage in rats with non-alcoholic fatty liver disease by regulating TLR4/MyD88/NF-κB pathway. | 2020 | Details |
| A04470 | 33603909 | Maedica (Bucur) | Red Blood Cell Dysfunction in Non-Alcoholic Fatty Liver Disease: Marker and Mediator of Molecular Mechanisms. | 2020 | Details |
| A04480 | 33601157 | J Pharm Biomed Anal | Therapeutic potential of puerarin against methionine-choline-deficient diet-induced non-alcoholic steatohepatitis determined by combination of 1H NMR spectroscopy-based metabonomics and 16S rRNA gene sequencing. | 2021 | Details |
| A04482 | 33600604 | J Gastroenterol Hepatol | Visfatin exacerbates hepatic inflammation and fibrosis in a methionine-choline-deficient diet mouse model. | 2021 | Details |
| A04590 | 33571553 | J Hepatol | Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH. | 2021 | Details |
| A04600 | 33567710 | Int J Environ Res Public Health | Nutritional Approach Targeting Gut Microbiota in NAFLD-To Date. | 2021 | Details |
| A04745 | 33516698 | Life Sci | Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis. | 2021 | Details |
| A04747 | 33515803 | Ann Hepatol | Effects of chronic HBV infection on lipid metabolism in non-alcoholic fatty liver disease: A lipidomic analysis. | 2021 | Details |
| A04755 | 33514796 | Sci Rep | Multiparametric ultrasound imaging for the assessment of normal versus steatotic livers. | 2021 | Details |
| A04803 | 33500717 | Theranostics | Intravital imaging of interactions between iNKT and kupffer cells to clear free lipids during steatohepatitis. | 2021 | Details |
| A04817 | 33495844 | Mol Med Rep | Effects of renalase deficiency on liver fibrosis markers in a nonalcoholic steatohepatitis mouse model. | 2021 | Details |
| A04818 | 33494735 | BMC Complement Med Ther | Yellow loosestrife (Lysimachia vulgaris var. davurica) ameliorates liver fibrosis in db/db mice with methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis. | 2021 | Details |
| A04844 | 33486695 | Arch Pharm Res | Inhibition of hyaluronan synthesis by 4-methylumbelliferone ameliorates non-alcoholic steatohepatitis in choline-deficient L-amino acid-defined diet-induced murine model. | 2021 | Details |
| A04886 | 33466889 | Metabolites | Two Metabolomics Phenotypes of Human Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease According to Fibrosis Severity. | 2021 | Details |
| A04904 | 33457424 | J Diabetes Res | Effects of Sodium-Glucose Cotransporter 2 Inhibition on Glucose Metabolism, Liver Function, Ascites, and Hemodynamics in a Mouse Model of Nonalcoholic Steatohepatitis and Type 2 Diabetes. | 2020 | Details |
| A04951 | 33439102 | Am J Physiol Gastrointest Liver Physiol | Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling. | 2021 | Details |
| A04968 | 33435509 | Biomedicines | The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model. | 2021 | Details |
| A05004 | 33417276 | Mol Syst Biol | Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis. | 2021 | Details |
| A05009 | 33411984 | J Appl Microbiol | The interplay between host cellular and gut microbial metabolism in NAFLD development and prevention. | 2021 | Details |
| A05012 | 33410857 | Food Funct | Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling. | 2021 | Details |
| A05034 | 33400402 | J Cell Mol Med | Val-Val-Tyr-Pro protects against non-alcoholic steatohepatitis in mice by modulating the gut microbiota and gut-liver axis activation. | 2021 | Details |
| A05037 | 33398776 | Hepatol Int | Elobixibat, an ileal bile acid transporter inhibitor, ameliorates non-alcoholic steatohepatitis in mice. | 2021 | Details |
| A05058 | 33391254 | Front Immunol | A Mineralocorticoid Receptor Deficiency in Myeloid Cells Reduces Liver Steatosis by Impairing Activation of CD8+ T Cells in a Nonalcoholic Steatohepatitis Mouse Model. | 2020 | Details |
| A05070 | 33388433 | Free Radic Biol Med | Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress. | 2021 | Details |
| A05095 | 33378413 | PLoS One | A CD209 ligand and a sialidase inhibitor differentially modulate adipose tissue and liver macrophage populations and steatosis in mice on the Methionine and Choline-Deficient (MCD) diet. | 2020 | Details |
| A05131 | 33362385 | World J Gastroenterol | Untargeted metabolomics characteristics of nonobese nonalcoholic fatty liver disease induced by high-temperature-processed feed in Sprague-Dawley rats. | 2020 | Details |
| A05133 | 33361348 | Gut | RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease. | 2020 | Details |
| A05136 | 33359683 | Free Radic Biol Med | ER stress-induced adipocytes secrete-aldo-keto reductase 1B7-containing exosomes that cause nonalcoholic steatohepatitis in mice. | 2020 | Details |
| A05150 | 33353230 | Nutrients | Effects of Caffeine and Chlorogenic Acid on Nonalcoholic Steatohepatitis in Mice Induced by Choline-Deficient, L-Amino Acid-Defined, High-Fat Diet. | 2020 | Details |
| A05155 | 33352229 | Pharmacol Res | Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome-mediated diseases. | 2020 | Details |
| A05224 | 33333172 | Biochimie | Beneficial and deleterious effects of sitagliptin on a methionine/choline-deficient diet-induced steatohepatitis in rats. | 2020 | Details |
| A05245 | 33326461 | PLoS One | The pharmacodynamic and differential gene expression analysis of PPAR α/δ agonist GFT505 in CDAHFD-induced NASH model. | 2020 | Details |
| A05272 | 33317575 | Lipids Health Dis | A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet. | 2020 | Details |
| A05293 | 33310185 | Biochem Biophys Res Commun | Impaired CCR9/CCL25 signalling induced by inefficient dendritic cells contributes to intestinal immune imbalance in nonalcoholic steatohepatitis. | 2020 | Details |
| A05304 | 33308101 | Am J Chin Med | Antrodia Cinnamomea Attenuates Non-Alcoholic Steatohepatitis by Suppressing NLRP3 Inflammasome Activation In Vitro and In Vivo. | 2020 | Details |
| A05308 | 33306695 | PLoS One | Associations between serum trace elements and inflammation in two animal models of nonalcoholic fatty liver disease. | 2020 | Details |
| A05311 | 33306506 | Am J Gastroenterol | Impact of the Association Between PNPLA3 Genetic Variation and Dietary Intake on the Risk of Significant Fibrosis in Patients With NAFLD. | 2021 | Details |
| A05318 | 33303970 | Lab Invest | Stress can attenuate hepatic lipid accumulation via elevation of hepatic β-muricholic acid levels in mice with nonalcoholic steatohepatitis. | 2020 | Details |
| A05337 | 33298075 | Lipids Health Dis | Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease. | 2020 | Details |
| A05355 | 33284502 | Hepatology | Metabolic Landscape of the Mouse Liver by Quantitative 31 P Nuclear Magnetic Resonance Analysis of the Phosphorome. | 2021 | Details |