Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Peroxisome proliferator-activated receptor gamma207 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A19139 | 26732252 | Sci Rep | Aliskiren Reduces Hepatic steatosis and Epididymal Fat Mass and Increases Skeletal Muscle Insulin Sensitivity in High-Fat Diet-Fed Mice. | 2016 | Details |
| A19776 | 26356709 | Medicine (Baltimore) | Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease: The Role of DNA Hydroxymethylation and TET Proteins. | 2015 | Details |
| A19823 | 26325536 | J Hepatol | Gestational exercise protects adult male offspring from high-fat diet-induced hepatic steatosis. | 2015 | Details |
| A20309 | 26035752 | Int J Mol Sci | Effect of Chronic Pioglitazone Treatment on Hepatic Gene Expression Profile in Obese C57BL/6J Mice. | 2015 | Details |
| A20596 | 25865685 | Hepatobiliary Pancreat Dis Int | Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease. | 2015 | Details |
| A20784 | 25736301 | Biochim Biophys Acta | Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet. | 2015 | Details |
| A20816 | 25714891 | Braz J Med Biol Res | Sorafenib prevents liver fibrosis in a non-alcoholic steatohepatitis (NASH) rodent model. | 2015 | Details |
| A21512 | 25265201 | Nanotoxicology | Intratracheal exposure to multi-walled carbon nanotubes induces a nonalcoholic steatohepatitis-like phenotype in C57BL/6J mice. | 2014 | Details |
| A21846 | 25003952 | J Hepatol | Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo. | 2014 | Details |
| A22074 | 24837835 | Int J Mol Sci | Role of mitochondria in nonalcoholic fatty liver disease. | 2014 | Details |
| A22195 | 24754177 | Zhongguo Zhong Yao Za Zhi | [Effect of pure total flavonoids from citrus on hepatic SIRT1/PGC-1alpha pathway in mice with NASH]. | 2014 | Details |
| A22222 | 24742471 | J Nutr Biochem | Insight into the impact of dietary saturated fat on tissue-specific cellular processes underlying obesity-related diseases. | 2014 | Details |
| A22571 | 24456353 | J Med Food | Cooked rice inhibits hepatic fat accumulation by regulating lipid metabolism-related gene expression in mice fed a high-fat diet. | 2014 | Details |
| A22664 | 24376752 | PLoS One | COH-SR4 reduces body weight, improves glycemic control and prevents hepatic steatosis in high fat diet-induced obese mice. | 2013 | Details |
| A22714 | 24362075 | J Hepatol | Cardiotrophin-1 eliminates hepatic steatosis in obese mice by mechanisms involving AMPK activation. | 2013 | Details |
| A22757 | 24327268 | Hepatology | Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPARγ. | 2014 | Details |
| A22833 | 24275089 | Food Chem Toxicol | Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice. | 2013 | Details |
| A22868 | 24265809 | PLoS One | Antidiabetic effects of chamomile flowers extract in obese mice through transcriptional stimulation of nutrient sensors of the peroxisome proliferator-activated receptor (PPAR) family. | 2013 | Details |
| A23106 | 24038081 | Hepatology | All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade. | 2014 | Details |
| A23356 | 23845075 | Curr Diabetes Rev | The influence of diabetes in the pathogenesis and the clinical course of hepatocellular carcinoma: recent findings and new perspectives. | 2013 | Details |
| A23584 | 23656726 | Br J Nutr | Effects of long-term administration of saturated and n-3 fatty acid-rich diets on lipid utilisation and oxidative stress in rat liver and muscle tissues. | 2013 | Details |
| A23875 | 23410526 | Biochim Biophys Acta | Prevention and reversal of hepatic steatosis with a high-protein diet in mice. | 2013 | Details |
| A24068 | 23269818 | Am J Clin Nutr | A common variant in the peroxisome proliferator-activated receptor-γ coactivator-1α gene is associated with nonalcoholic fatty liver disease in obese children. | 2012 | Details |
| A24154 | 23174781 | Hepatology | Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway. | 2013 | Details |
| A24295 | 23031808 | Gene | Association of peroxisome proliferator activated receptor-γ gene with non-alcoholic fatty liver disease in Asian Indians residing in north India. | 2012 | Details |
| A24676 | 22617561 | Curr Opin Clin Nutr Metab Care | DNA methylation and hepatic insulin resistance and steatosis. | 2012 | Details |
| A25133 | 22152320 | Zhonghua Gan Zang Bing Za Zhi | [Effects of telmisartan on nonalcoholic steatohepatitis rat model by activating peroxisome proliferator-activated receptor r]. | 2011 | Details |
| A25349 | 21939732 | Mol Cell Endocrinol | PPARG gene Pro12Ala variant contributes to the development of non-alcoholic fatty liver in middle-aged and older Chinese population. | 2011 | Details |
| A25508 | 21742296 | Clin Res Hepatol Gastroenterol | Liver fibrogenesis and metabolic factors. | 2011 | Details |
| A25779 | 21464822 | Lab Invest | Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice. | 2011 | Details |
| A25905 | 21339203 | Gut | The role of apolipoprotein A5 in non-alcoholic fatty liver disease. | 2011 | Details |
| A25922 | 21325336 | Acta Biochim Biophys Sin (Shanghai) | PGC-1 coactivators in the control of energy metabolism. | 2011 | Details |
| A26202 | 20890895 | Hepatology | Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter. | 2010 | Details |
| A26273 | 20803499 | Hepatology | A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents. | 2010 | Details |
| A26336 | 20629985 | J Cell Mol Med | High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxia. | 2010 | Details |
| A26417 | 20492333 | J Gastroenterol Hepatol | Influence of polygenetic polymorphisms on the susceptibility to non-alcoholic fatty liver disease of Chinese people. | 2010 | Details |
| A27054 | 19254570 | Cell Metab | The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. | 2009 | Details |
| A27199 | 19001666 | J Lipid Res | Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease. | 2008 | Details |
| A27352 | 18588668 | BMC Gastroenterol | Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD). | 2008 | Details |
| A27417 | 18422468 | Expert Opin Pharmacother | Pleiotropic effects of thiazolidinediones. | 2008 | Details |
| A27583 | 17999673 | Liver Int | Effect of peroxisome proliferator-activated receptors-gamma and co-activator-1alpha genetic polymorphisms on plasma adiponectin levels and susceptibility of non-alcoholic fatty liver disease in Chinese people. | 2007 | Details |
| A27603 | 17928738 | J Pharmacol Sci | Life style-related diseases of the digestive system: gene expression in nonalcoholic steatohepatitis patients and treatment strategies. | 2007 | Details |
| A27662 | 17567459 | J Gastroenterol Hepatol | Role of mitochondria in non-alcoholic fatty liver disease. | 2007 | Details |
| A27695 | 17654601 | Hepatology | Effects of rosiglitazone on the liver histology and mitochondrial function in ob/ob mice. | 2007 | Details |
| A27917 | 17029217 | J Pathol | Disrupted galectin-3 causes non-alcoholic fatty liver disease in male mice. | 2006 | Details |
| A28276 | 15828235 | Nihon Rinsho | [The roles of PPARs in digestive diseases]. | 2005 | Details |
| A29196 | 34430785 | Hepatol Commun | Deuterium-Stabilized (R)-Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPARγ Activity. | 2021 | Details |
| A30134 | 32923834 | Hepatol Commun | The Selective Peroxisome Proliferator-Activated Receptor Gamma Modulator CHS-131 Improves Liver Histopathology and Metabolism in a Mouse Model of Obesity and Nonalcoholic Steatohepatitis. | 2020 | Details |
| A30204 | 32821335 | World J Hepatol | Anti-inflammatory and anti-oxidant effects of aloe vera in rats with non-alcoholic steatohepatitis. | 2020 | Details |
| A32173 | 29057935 | Sci Rep | Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice. | 2017 | Details |
| A32923 | 27083546 | Poult Sci | Expression and methylation of microsomal triglyceride transfer protein and acetyl-CoA carboxylase are associated with fatty liver syndrome in chicken. | 2016 | Details |
| A33639 | 25536170 | J Agric Food Chem | Purified anthocyanins from bilberry and black currant attenuate hepatic mitochondrial dysfunction and steatohepatitis in mice with methionine and choline deficiency. | 2015 | Details |
| A34685 | 22882855 | Chin Med J (Engl) | Pioglitazone ameliorates nonalcoholic steatohepatitis by down-regulating hepatic nuclear factor-kappa B and cyclooxygenases-2 expression in rats. | 2012 | Details |
| A34881 | 22318941 | Hepatology | Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. | 2012 | Details |
| A36511 | 17963695 | Biochem Biophys Res Commun | Telmisartan prevents hepatic fibrosis and enzyme-altered lesions in liver cirrhosis rat induced by a choline-deficient L-amino acid-defined diet. | 2007 | Details |
| A36597 | 17661371 | Hepatology | The effects of 48 weeks of rosiglitazone on hepatocyte mitochondria in human nonalcoholic steatohepatitis. | 2007 | Details |
| A38442 | 11232700 | Am J Gastroenterol | A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis. | 2001 | Details |
| A42698 | 33728291 | Can J Gastroenterol Hepatol | Liver Cancer: Therapeutic Challenges and the Importance of Experimental Models. | 2021 | Details |
| A42806 | 33425000 | Evid Based Complement Alternat Med | Ulmus parvifolia Jacq. Exhibits Antiobesity Properties and Potentially Induces Browning of White Adipose Tissue. | 2020 | Details |
| A43201 | 32316687 | Nutrients | Shikonin Attenuates Hepatic Steatosis by Enhancing Beta Oxidation and Energy Expenditure via AMPK Activation. | 2020 | Details |
| A43573 | 31378113 | J Int Med Res | Tanshinone IIA ameliorates non-alcoholic fatty liver disease through targeting peroxisome proliferator-activated receptor gamma and toll-like receptor 4. | 2019 | Details |
| A43657 | 31168510 | Hepatol Commun | Protective Function of Mitogen-Activated Protein Kinase Phosphatase 5 in Aging- and Diet-Induced Hepatic Steatosis and Steatohepatitis. | 2019 | Details |
| A43827 | 30770439 | Proc Natl Acad Sci U S A | PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin. | 2019 | Details |
| A44286 | 29154162 | J Nutr Biochem | Epigenetic reprogramming in metabolic disorders: nutritional factors and beyond. | 2017 | Details |
| A44418 | 28685102 | Neural Plast | Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice. | 2017 | Details |
| A44517 | 28386270 | PPAR Res | Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPARδ Regulation in Hyperlipidemic and Hypertensive Conditions. | 2017 | Details |
| A44531 | 28331449 | Ochsner J | Cyclin D1 in the Liver: Role of Noncanonical Signaling in Liver Steatosis and Hormone Regulation. | 2017 | Details |
| A45301 | 25287814 | J Nutr Biochem | High-protein diets prevent steatosis and induce hepatic accumulation of monomethyl branched-chain fatty acids. | 2014 | Details |
| A45436 | 24597776 | J Nat Prod | Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma. | 2014 | Details |
| A45486 | 24361124 | Gastroenterology | Gluconeogenic signals regulate iron homeostasis via hepcidin in mice. | 2013 | Details |
| A45622 | 23602251 | Nutr Res | Gly482Ser mutation impairs the effects of peroxisome proliferator-activated receptor γ coactivator-1α on decreasing fat deposition and stimulating phosphoenolpyruvate carboxykinase expression in hepatocytes. | 2013 | Details |
| A46221 | 20211973 | Endocrinology | Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet. | 2010 | Details |
| A46276 | 19838201 | Nat Med | Foxo1 integrates insulin signaling with mitochondrial function in the liver. | 2009 | Details |
| A46581 | 17482764 | Med Hypotheses | Peroxisome proliferator-activated receptor gamma: a common link for non-alcoholic fatty liver disease and colorectal cancer? | 2007 | Details |
| A47001 | 30721374 | Cell Biol Toxicol | Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes. | 2019 | Details |
| A47118 | 25622859 | J Nutr Biochem | Enhanced AMPK phosphorylation contributes to the beneficial effects of Lactobacillus rhamnosus GG supernatant on chronic-alcohol-induced fatty liver disease. | 2014 | Details |
| A47134 | 25362106 | J Pharmacol Exp Ther | Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model. | 2014 | Details |
| A47154 | 24797033 | Alcohol Clin Exp Res | Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury. | 2014 | Details |
| A47918 | 29404444 | Hepatol Commun | Hairy and enhancer of split 6 prevents hepatic lipid accumulation through inhibition of Pparg2 expression. | 2017 | Details |
| A47949 | 28540526 | Eur J Nutr | High-fat diet inhibits PGC-1α suppressive effect on NFκB signaling in hepatocytes. | 2017 | Details |
| A48212 | 19549744 | J Clin Endocrinol Metab | Thyroid hormone-related regulation of gene expression in human fatty liver. | 2009 | Details |
| A48539 | 34483915 | Front Pharmacol | Anti-Adipogenic Effect of Alchemilla monticola is Mediated Via PI3K/AKT Signaling Inhibition in Human Adipocytes. | 2021 | Details |
| A48908 | 24814604 | Am J Pathol | Adverse signaling of scavenger receptor class B1 and PGC1s in alcoholic hepatosteatosis and steatohepatitis and protection by betaine in rat. | 2014 | Details |
| A49739 | 35654114 | Metabolism | GW9662, a peroxisome proliferator-activated receptor gamma antagonist, attenuates the development of non-alcoholic fatty liver disease. | 2022 | Details |
| A50212 | 35472433 | J Nutr Biochem | Chlorogenic acid alleviated liver fibrosis in methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice and its mechanism. | 2022 | Details |
| A50252 | 35455445 | Pharmaceuticals (Basel) | Discovery of 5,7-Dimethoxy-2-(3,4,5-trimethoxyphenoxy)-chromen-4-one with Lipid Lowering Effects in Hepatocytes. | 2022 | Details |
| A50332 | 35430208 | Eur J Pharmacol | The lactate receptor GPR81 mediates hepatic lipid metabolism and the therapeutic effect of metformin on experimental NAFLDs. | 2022 | Details |
| A50410 | 35401831 | Theranostics | Hepatic PRMT1 ameliorates diet-induced hepatic steatosis via induction of PGC1α. | 2022 | Details |
| A50964 | 30284737 | J Physiol | Sex differences in the regulation of hepatic mitochondrial turnover following physical activity: do males need more quality control than females? | 2018 | Details |
| A51359 | 35308208 | Front Pharmacol | Therapeutic Effects of Berberine on Liver Fibrosis are associated With Lipid Metabolism and Intestinal Flora. | 2022 | Details |
| A51462 | 33989565 | Cell Chem Biol | Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions. | 2021 | Details |
| A51869 | 33556473 | Mol Cell Endocrinol | Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome. | 2021 | Details |
| A51996 | 32512788 | Antioxidants (Basel) | Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Conversion of White to Beige Fat in Mice. | 2020 | Details |
| A52002 | 32477454 | World J Diabetes | Maternal low protein diet induces persistent expression changes in metabolic genes in male rats. | 2020 | Details |
| A52171 | 30463291 | Nutrients | Ishige okamurae Extract Suppresses Obesity and Hepatic Steatosis in High Fat Diet-Induced Obese Mice. | 2018 | Details |
| A52225 | 29931052 | Cardiovasc Res | Heart specific PGC-1α deletion identifies metabolome of cardiac restricted metabolic heart failure. | 2019 | Details |
| A52238 | 29852870 | Curr Alzheimer Res | Acetylcholinesterase Inhibitor Donepezil Effects on Plasma β-Hydroxybutyrate Levels in the Treatment of Alzheimer's Disease. | 2018 | Details |
| A52257 | 29641977 | Toxicol Appl Pharmacol | Chronic low-dose exposure of nonylphenol alters energy homeostasis in the reproductive system of female rats. | 2018 | Details |
| A52349 | 28269997 | Antioxid Redox Signal | PGC-1α Downregulation in Steatotic Liver Enhances Ischemia-Reperfusion Injury and Impairs Ischemic Preconditioning. | 2017 | Details |
| A52352 | 28256090 | Aging Cell | Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction. | 2017 | Details |