Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Phosphatidylcholine289 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A16897 | 28106137 | Sci Rep | Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats. | 2017 | Details |
| A17066 | 28012135 | Lipids | Eicosapentaenoic Acid-Enriched Phosphatidylcholine Attenuated Hepatic Steatosis Through Regulation of Cholesterol Metabolism in Rats with Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A17575 | 27739180 | Mol Nutr Food Res | Alterations in the plasma metabolite profile associated with improved hepatic function and glycemia in mice fed lingonberry supplemented high-fat diets. | 2016 | Details |
| A17852 | 27527746 | Am J Gastroenterol | Clinical and Metabolic Characterization of Lean Caucasian Subjects With Non-alcoholic Fatty Liver. | 2016 | Details |
| A18106 | 27348904 | Zhongguo Zhen Jiu | [Non-alcoholic fatty liver disease of liver stagnation and spleen deficiency pattern treated with acupoint embedding therapy: a randomized controlled trial]. | 2016 | Details |
| A18153 | 27317851 | Clin Gastroenterol Hepatol | Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites. | 2016 | Details |
| A18227 | 27273168 | Nat Rev Gastroenterol Hepatol | The role of the gut microbiota in NAFLD. | 2016 | Details |
| A18423 | 27145114 | Mol Nutr Food Res | Biochanin A improves hepatic steatosis and insulin resistance by regulating the hepatic lipid and glucose metabolic pathways in diet-induced obese mice. | 2016 | Details |
| A18498 | 27090939 | Biochim Biophys Acta | Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis. | 2016 | Details |
| A18512 | 27081834 | Mol Med Rep | Artemisia capillaris formula inhibits hepatic steatosis via an miR‑122‑induced decrease in fatty acid synthase expression in vivo and in vitro. | 2016 | Details |
| A18580 | 27049024 | J Lipid Res | Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis. | 2016 | Details |
| A18758 | 26968211 | Am J Physiol Gastrointest Liver Physiol | Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis. | 2016 | Details |
| A18910 | 26873633 | Biochim Biophys Acta | iPLA2β deficiency attenuates obesity and hepatic steatosis in ob/ob mice through hepatic fatty-acyl phospholipid remodeling. | 2016 | Details |
| A19017 | 26817937 | Nutr Metab Cardiovasc Dis | Serum palmitoleate acts as a lipokine in subjects at high cardiometabolic risk. | 2015 | Details |
| A19031 | 26811286 | Int Rev Cell Mol Biol | Phosphatidylethanolamine Metabolism in Health and Disease. | 2015 | Details |
| A19055 | 26797396 | Am J Physiol Gastrointest Liver Physiol | Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice. | 2016 | Details |
| A19089 | 26773011 | Adv Nutr | Choline, Its Potential Role in Nonalcoholic Fatty Liver Disease, and the Case for Human and Bacterial Genes. | 2016 | Details |
| A19103 | 26764184 | Gastroenterology | Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes. | 2016 | Details |
| A19322 | 26629827 | PLoS One | Hyperreactivity of Blood Leukocytes in Patients with NAFLD to Ex Vivo Lipopolysaccharide Treatment Is Modulated by Metformin and Phosphatidylcholine but Not by Alpha Ketoglutarate. | 2015 | Details |
| A19695 | 26406121 | Hepatology | Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes. | 2015 | Details |
| A19814 | 26330688 | Trans Am Clin Climatol Assoc | A Lipidomic Readout of Disease Progression in A Diet-Induced Mouse Model of Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A19827 | 26322888 | PLoS One | Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A19877 | 26289793 | Sci Rep | Characterization of hepatic lipid profiles in a mouse model with nonalcoholic steatohepatitis and subsequent fibrosis. | 2015 | Details |
| A20136 | 26133820 | Zhonghua Gan Zang Bing Za Zhi | [Effects of telmisartan on resistin expression in a rat model of nonalcoholic steatohepatitis and insulin resistance]. | 2015 | Details |
| A20175 | 26108973 | Eur J Clin Invest | Ursodeoxycholyl Lysophosphatidylethanolamide modifies aberrant lipid profiles in NAFLD. | 2015 | Details |
| A20584 | 25873078 | Exp Biol Med (Maywood) | Nonalcoholic fatty liver disease: update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine. | 2015 | Details |
| A20788 | 25733650 | Am J Clin Nutr | High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice. | 2015 | Details |
| A20963 | 25617046 | Expert Rev Gastroenterol Hepatol | Effects of Mediterranean diet supplemented with silybin-vitamin E-phospholipid complex in overweight patients with non-alcoholic fatty liver disease. | 2015 | Details |
| A20982 | 25603556 | Biochim Biophys Acta | Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis. | 2015 | Details |
| A21268 | 25445436 | Life Sci | Beneficial effects of phosphatidylcholine on high-fat diet-induced obesity, hyperlipidemia and fatty liver in mice. | 2014 | Details |
| A21489 | 25281863 | J Hepatol | Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways. | 2014 | Details |
| A21763 | 25063232 | Int J Biochem Cell Biol | Exercise alters liver mitochondria phospholipidomic profile and mitochondrial activity in non-alcoholic steatohepatitis. | 2014 | Details |
| A21765 | 25061561 | Mol Metab | Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels. | 2014 | Details |
| A21875 | 24987492 | Oxid Med Cell Longev | Serum oxidative stress markers and lipidomic profile to detect NASH patients responsive to an antioxidant treatment: a pilot study. | 2014 | Details |
| A22082 | 24830603 | Exp Mol Pathol | Lipidomic analysis of the liver from high-fat diet induced obese mice identifies changes in multiple lipid classes. | 2014 | Details |
| A22250 | 24719358 | FASEB J | Plasma membrane phospholipase A2 controls hepatocellular fatty acid uptake and is responsive to pharmacological modulation: implications for nonalcoholic steatohepatitis. | 2014 | Details |
| A22392 | 24622832 | J Physiol Pharmacol | Effects of treatment with melatonin and tryptophan on liver enzymes, parameters of fat metabolism and plasma levels of cytokines in patients with non-alcoholic fatty liver disease--14 months follow up. | 2014 | Details |
| A22487 | 24520780 | Zhongguo Zhong Xi Yi Jie He Za Zhi | [Treatment of nonalcoholic steatohepatitis by Jianpi Shugan Recipe: a multi-center, randomized, controlled clinical trial]. | 2014 | Details |
| A22519 | 24495527 | Proc Nutr Soc | 'The way to a man's heart is through his gut microbiota'--dietary pro- and prebiotics for the management of cardiovascular risk. | 2014 | Details |
| A22705 | 24368431 | J Nutr | Choline supplementation protects against liver damage by normalizing cholesterol metabolism in Pemt/Ldlr knockout mice fed a high-fat diet. | 2013 | Details |
| A22728 | 24353111 | Biofactors | Novel insights on interactions between folate and lipid metabolism. | 2013 | Details |
| A22799 | 24295779 | Biochim Biophys Acta | Omega-3 phospholipids from fish suppress hepatic steatosis by integrated inhibition of biosynthetic pathways in dietary obese mice. | 2014 | Details |
| A22953 | 24179615 | World J Hepatol | Rapid chromatographic method to decipher distinct alterations in lipid classes in NAFLD/NASH. | 2013 | Details |
| A23085 | 24053454 | BMC Gastroenterol | The role of ursodeoxycholic acid in non-alcoholic steatohepatitis: a systematic review. | 2013 | Details |
| A23088 | 24048683 | Dig Dis Sci | Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease. | 2013 | Details |
| A23390 | 23824212 | Diabetologia | Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids. | 2013 | Details |
| A23683 | 23567080 | J Hepatol | Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression. | 2013 | Details |
| A23722 | 23537027 | Appl Physiol Nutr Metab | Nonalcoholic fatty liver disease is associated with lower hepatic and erythrocyte ratios of phosphatidylcholine to phosphatidylethanolamine. | 2012 | Details |
| A23745 | 23514731 | Diabetes Care | Circulating lysophosphatidylcholines are markers of a metabolically benign nonalcoholic fatty liver. | 2013 | Details |
| A23799 | 23472083 | PLoS One | Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism. | 2013 | Details |
| A23817 | 23451176 | PLoS One | Differential intrahepatic phospholipid zonation in simple steatosis and nonalcoholic steatohepatitis. | 2013 | Details |
| A23853 | 23426790 | Int J Mol Med | Anti-inflammatory effects of total alkaloids from Rubus alceifolius Poir [corrected]. on non-alcoholic fatty liver disease through regulation of the NF-κB pathway. | 2013 | Details |
| A24007 | 23305008 | Klin Lab Diagn | [The unity of pathogenesis of insulin resistance syndrome and non-alcoholic fatty disease of liver. The metabolic disorder of fatty acids and triglycerides]. | 2012 | Details |
| A24278 | 23044079 | Dig Liver Dis | The pro-inflammatory action of tumour necrosis factor-α in non-alcoholic steatohepatitis is independent of the NSMAF gene product. | 2012 | Details |
| A24541 | 22780848 | Hepatol Res | Plasma free choline is a novel non-invasive biomarker for early-stage non-alcoholic steatohepatitis: A multi-center validation study. | 2012 | Details |
| A24665 | 22641094 | J Hepatol | A hedgehog survival pathway in 'undead' lipotoxic hepatocytes. | 2012 | Details |
| A24916 | 22364002 | Eksp Klin Gastroenterol | [Study of clinical efficiency of essential phospholipids and silymarin combination in nonalcoholic and alcoholic steatohepatitis]. | 2011 | Details |
| A24933 | 22343419 | Free Radic Biol Med | Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. | 2012 | Details |
| A24975 | 22290395 | Hepatology | Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. | 2012 | Details |
| A25083 | 22183915 | Hepatology | Ursodeoxycholyl lysophosphatidylethanolamide improves steatosis and inflammation in murine models of nonalcoholic fatty liver disease. | 2012 | Details |
| A25204 | 22095799 | Hepatology | Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice. | 2012 | Details |
| A25275 | 22015962 | J Hepatol | A lipid to treat non-alcoholic fatty liver disease - the dawn of 'lipo-rehabilitation'? | 2011 | Details |
| A25429 | 21857953 | PLoS One | Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model. | 2011 | Details |
| A25441 | 21837751 | Hepatology | Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice. | 2011 | Details |
| A25488 | 21773586 | Food Funct | The impact of choline availability on muscle lipid metabolism. | 2010 | Details |
| A25522 | 21745592 | Biochim Biophys Acta | Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis. | 2011 | Details |
| A25800 | 21446920 | Clin Sci (Lond) | Methionine and protein metabolism in non-alcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine. | 2011 | Details |
| A25822 | 21426695 | Zhonghua Er Ke Za Zhi | [Metformin prevents non-alcoholic fatty liver disease in rats: role of phospholipase A2/lysophosphatidylcholine lipoapoptosis pathway in hepatocytes]. | 2011 | Details |
| A26355 | 20602678 | Liver Int | Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes. | 2010 | Details |
| A26426 | 20473736 | Chin J Integr Med | Effect of Xuezhikang Capsule on serum tumor necrosis factor-alpha and interleukin-6 in patients with nonalcoholic fatty liver disease and hyperlipidemia. | 2010 | Details |
| A26596 | 20131032 | Chin J Integr Med | Treatment of non-alcoholic fatty liver disease by Qianggan Capsule. | 2010 | Details |
| A26660 | 20032580 | J Atheroscler Thromb | Expression of perilipin and adipophilin in nonalcoholic fatty liver disease; relevance to oxidative injury and hepatocyte ballooning. | 2009 | Details |
| A26698 | 19937697 | Hepatology | The plasma lipidomic signature of nonalcoholic steatohepatitis. | 2009 | Details |
| A26699 | 19936233 | PLoS One | IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. | 2009 | Details |
| A26824 | 19710104 | Innate Immun | Interleukin-6 is associated with liver lipid homeostasis but not with cell death in experimental hepatic steatosis. | 2009 | Details |
| A27472 | 18324772 | J Agric Food Chem | Dietary phosphatidylinositol prevents the development of nonalcoholic fatty liver disease in Zucker (fa/fa) rats. | 2008 | Details |
| A27694 | 17654743 | Hepatology | A lipidomic analysis of nonalcoholic fatty liver disease. | 2007 | Details |
| A27960 | 16895997 | Proc Natl Acad Sci U S A | Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. | 2006 | Details |
| A28082 | 16496325 | Hepatology | Localization of oxidized phosphatidylcholine in nonalcoholic fatty liver disease: impact on disease progression. | 2006 | Details |
| A28225 | 16051693 | FASEB J | Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD). | 2005 | Details |
| A28348 | 15554233 | Drug Metab Rev | The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role. | 2004 | Details |
| A28578 | 9407327 | J Gastroenterol Hepatol | Abnormality in fatty acid composition of gastric mucosal phospholipids in patients with liver cirrhosis and its correction with a polyunsaturated fatty acid-enriched soft oil capsule. | 1997 | Details |
| A29027 | 34679736 | Antioxidants (Basel) | Oxidative Stress Linked Organ Lipid Hydroperoxidation and Dysregulation in Mouse Model of Nonalcoholic Steatohepatitis: Revealed by Lipidomic Profiling of Liver and Kidney. | 2021 | Details |
| A29029 | 34676758 | J Proteome Res | Nontargeted Serum Lipid Profiling of Nonalcoholic Steatohepatitis by Multisegment Injection-Nonaqueous Capillary Electrophoresis-Mass Spectrometry: A Multiplexed Separation Platform for Resolving Ionic Lipids. | 2021 | Details |
| A29316 | 34262459 | Front Pharmacol | Kaempferol Alleviates Steatosis and Inflammation During Early Non-Alcoholic Steatohepatitis Associated With Liver X Receptor α-Lysophosphatidylcholine Acyltransferase 3 Signaling Pathway. | 2021 | Details |
| A29742 | 33590776 | Gut Microbes | The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases. | 2022 | Details |
| A30666 | 32025163 | J Clin Exp Hepatol | Characterisation of the Serum Metabolic Signature of Cholangiocarcinoma in a United Kingdom Cohort. | 2019 | Details |
| A31417 | 30615497 | FASEB J | A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling. | 2019 | Details |
| A31996 | 29369831 | Curr Opin Lipidol | Novel metabolic phenotypes in lecithin cholesterol acyltyransferase-deficient mice. | 2018 | Details |
| A32096 | 29197066 | Br J Pharmacol | Characterization of the properties of a selective, orally bioavailable autotaxin inhibitor in preclinical models of advanced stages of liver fibrosis. | 2018 | Details |
| A32463 | 28385694 | Am J Physiol Gastrointest Liver Physiol | Phosphatidylcholine transfer protein/StarD2 promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis. | 2017 | Details |
| A32695 | 27754931 | J Pharmacol Exp Ther | Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis. | 2016 | Details |
| A33443 | 25977701 | Evid Based Complement Alternat Med | Metabolomics profiling to investigate the pharmacologic mechanisms of berberine for the treatment of high-fat diet-induced nonalcoholic steatohepatitis. | 2015 | Details |
| A34247 | 23974795 | Mol Pharmacol | Ursodeoxycholyl lysophosphatidylethanolamide inhibits lipoapoptosis by shifting fatty acid pools toward monosaturated and polyunsaturated fatty acids in mouse hepatocytes. | 2013 | Details |
| A35325 | 21081801 | J Physiol Pharmacol | The effects of L-tryptophan and melatonin on selected biochemical parameters in patients with steatohepatitis. | 2010 | Details |
| A35544 | 20395294 | J Biol Chem | Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. | 2010 | Details |
| A35699 | 19884114 | Evid Based Complement Alternat Med | Antioxidant and hepatoprotective effects of silibinin in a rat model of nonalcoholic steatohepatitis. | 2011 | Details |
| A35887 | 19496180 | Hepatology | Bile salt-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent. | 2009 | Details |
| A36192 | 18769506 | Nutr Res | The Combination of S-adenosylmethionine and Dilinoleoylphosphatidylcholine Attenuates Non-alcoholic Steatohepatitis Produced in Rats by a High-Fat Diet. | 2007 | Details |
| A36514 | 17951222 | J Lipid Res | Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes. | 2007 | Details |