Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Toll-like receptor 4290 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A15376 | 28939830 | Sci Rep | Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD. | 2017 | Details |
| A15396 | 28931589 | J Nutr | Oral Supplementation of Glutamine Attenuates the Progression of Nonalcoholic Steatohepatitis in C57BL/6J Mice. | 2017 | Details |
| A15439 | 28906444 | Nutrients | Short-Term Intake of a Fructose-, Fat- and Cholesterol-Rich Diet Causes Hepatic Steatosis in Mice: Effect of Antibiotic Treatment. | 2017 | Details |
| A15956 | 28637520 | Br J Nutr | Citrulline decreases hepatic endotoxin-induced injury in fructose-induced non-alcoholic liver disease: an ex vivo study in the isolated perfused rat liver. | 2017 | Details |
| A15991 | 28623125 | Biochem Biophys Res Commun | Chronic intermittent hypoxia induces liver fibrosis in mice with diet-induced obesity via TLR4/MyD88/MAPK/NF-kB signaling pathways. | 2017 | Details |
| A16025 | 28604704 | Nat Med | Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling. | 2017 | Details |
| A16123 | 28551086 | Redox Biol | HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease. | 2017 | Details |
| A16148 | 28538192 | Biomed Pharmacother | Hepatic anti-inflammatory effect of hexane extracts of Dioscorea batatas Decne: Possible suppression of toll-like receptor 4-mediated signaling. | 2017 | Details |
| A16259 | 28481357 | Nat Med | Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4. | 2017 | Details |
| A16317 | 28462384 | Cell Mol Gastroenterol Hepatol | TRIF Differentially Regulates Hepatic Steatosis and Inflammation/Fibrosis in Mice. | 2017 | Details |
| A16332 | 28454924 | Toxicol Appl Pharmacol | Dual effect of silymarin on experimental non-alcoholic steatohepatitis induced by irinotecan. | 2017 | Details |
| A16369 | 28434046 | Amino Acids | Oral arginine supplementation protects female mice from the onset of non-alcoholic steatohepatitis. | 2017 | Details |
| A16502 | 28349964 | Sci Rep | Probiotics may delay the progression of nonalcoholic fatty liver disease by restoring the gut microbiota structure and improving intestinal endotoxemia. | 2017 | Details |
| A16503 | 28349245 | J Gastroenterol | Effect of miglitol on the suppression of nonalcoholic steatohepatitis development and improvement of the gut environment in a rodent model. | 2017 | Details |
| A16540 | 28325574 | J Chin Med Assoc | Decoy receptor 3 analogous supplement protects steatotic rat liver from ischemia-reperfusion injury. | 2017 | Details |
| A16843 | 28132721 | Immunobiology | Hepatic interleukin-6 production is maintained during endotoxin tolerance and facilitates lipid accumulation. | 2017 | Details |
| A17037 | 28038359 | J Nutr Biochem | Green tea extract treatment reduces NFκB activation in mice with diet-induced nonalcoholic steatohepatitis by lowering TNFR1 and TLR4 expression and ligand availability. | 2016 | Details |
| A17236 | 27895422 | World J Gastroenterol | Genetic polymorphism in CD14 gene, a co-receptor of TLR4 associated with non-alcoholic fatty liver disease. | 2016 | Details |
| A17246 | 27890642 | Free Radic Biol Med | Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation. | 2016 | Details |
| A17268 | 27876107 | Br J Nutr | Sodium butyrate protects mice from the development of the early signs of non-alcoholic fatty liver disease: role of melatonin and lipid peroxidation. | 2016 | Details |
| A17478 | 27619543 | J Nutr Biochem | Cranberry extract attenuates hepatic inflammation in high-fat-fed obese mice. | 2016 | Details |
| A17543 | 27752155 | Beijing Da Xue Xue Bao Yi Xue Ban | [Nicotine alleviates the liver inflammation of non-alcoholic steatohepatitis induced by high-fat and high-fructose in mice]. | 2016 | Details |
| A17887 | 27496089 | Eur J Nutr | Oral citrulline supplementation protects female mice from the development of non-alcoholic fatty liver disease (NAFLD). | 2016 | Details |
| A18141 | 27323620 | Zhongguo Zhong Xi Yi Jie He Za Zhi | [Effect of Compound Zhajin Granule on Toll-like Receptor 4 Signaling Pathway in Nonalcoholic Steatohepatitis Mice]. | 2016 | Details |
| A18336 | 27197843 | Br J Nutr | Preventive effects of citrulline on Western diet-induced non-alcoholic fatty liver disease in rats. | 2016 | Details |
| A18348 | 27188904 | Nutr Res | Alternate-day fasting protects the livers of mice against high-fat diet-induced inflammation associated with the suppression of Toll-like receptor 4/nuclear factor κB signaling. | 2016 | Details |
| A18521 | 27074921 | Dig Dis Sci | Treatment with Oxidized Phospholipids Directly Inhibits Nonalcoholic Steatohepatitis and Liver Fibrosis Without Affecting Steatosis. | 2016 | Details |
| A18680 | 27001282 | Nutr Res | Opuntia ficus-indica seed attenuates hepatic steatosis and promotes M2 macrophage polarization in high-fat diet-fed mice. | 2015 | Details |
| A18805 | 26930651 | PLoS One | Metformin Changes the Relationship between Blood Monocyte Toll-Like Receptor 4 Levels and Nonalcoholic Fatty Liver Disease-Ex Vivo Studies. | 2016 | Details |
| A18820 | 26921863 | J Affect Disord | Insulin receptor sensitizer, dicholine succinate, prevents both Toll-like receptor 4 (TLR4) upregulation and affective changes induced by a high-cholesterol diet in mice. | 2016 | Details |
| A18881 | 26889220 | Exp Ther Med | Hepcidin in non-alcoholic fatty liver disease regulated by the TLR4/NF-κB signaling pathway. | 2015 | Details |
| A19014 | 26818807 | Sci Rep | Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice. | 2016 | Details |
| A19088 | 26773297 | Hepatology | Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. | 2016 | Details |
| A19163 | 26718771 | Am J Physiol Gastrointest Liver Physiol | Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation. | 2015 | Details |
| A19322 | 26629827 | PLoS One | Hyperreactivity of Blood Leukocytes in Patients with NAFLD to Ex Vivo Lipopolysaccharide Treatment Is Modulated by Metformin and Phosphatidylcholine but Not by Alpha Ketoglutarate. | 2015 | Details |
| A19364 | 26603137 | Am J Pathol | Diet-Induced Obesity Enhances Progression of Hepatocellular Carcinoma through Tenascin-C/Toll-Like Receptor 4 Signaling. | 2015 | Details |
| A19372 | 26600967 | World J Gastrointest Pathophysiol | Starring role of toll-like receptor-4 activation in the gut-liver axis. | 2015 | Details |
| A19374 | 26600310 | J Cell Biochem | Dietary Saturated Fat Promotes Development of Hepatic Inflammation Through Toll-Like Receptor 4 in Mice. | 2015 | Details |
| A19413 | 26582088 | Gastroenterology | TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice. | 2015 | Details |
| A19622 | 26450277 | Br J Nutr | Supplementation of sodium butyrate protects mice from the development of non-alcoholic steatohepatitis (NASH). | 2015 | Details |
| A19632 | 26447219 | Am J Physiol Renal Physiol | NKT cell modulates NAFLD potentiation of metabolic oxidative stress-induced mesangial cell activation and proximal tubular toxicity. | 2015 | Details |
| A19932 | 26256903 | Ann Hepatol | Development of steatohepatitis in Ob/Ob mice is dependent on Toll-like receptor 4. | 2016 | Details |
| A20006 | 26212089 | J Gastroenterol Hepatol | Small intestinal bacterial overgrowth and toll-like receptor signaling in patients with non-alcoholic fatty liver disease. | 2016 | Details |
| A20051 | 26190501 | J Gastroenterol | Beneficial effects of combined ursodeoxycholic acid and angiotensin-II type 1 receptor blocker on hepatic fibrogenesis in a rat model of nonalcoholic steatohepatitis. | 2015 | Details |
| A20077 | 26172853 | Biochim Biophys Acta | Novel role of TLR4 in NAFLD development: Modulation of metabolic enzymes expression. | 2015 | Details |
| A20083 | 26168700 | J Nutr Biochem | Diets rich in fructose, fat or fructose and fat alter intestinal barrier function and lead to the development of nonalcoholic fatty liver disease over time. | 2015 | Details |
| A20171 | 26113297 | Am J Physiol Gastrointest Liver Physiol | Hepatic TLR4 signaling in obese NAFLD. | 2015 | Details |
| A20284 | 26045709 | Hepat Mon | Saturated Fatty Acid inhibits viral replication in chronic hepatitis B virus infection with nonalcoholic Fatty liver disease by toll-like receptor 4-mediated innate immune response. | 2015 | Details |
| A20291 | 26043290 | Eur J Gastroenterol Hepatol | Efficacy of rifaximin on circulating endotoxins and cytokines in patients with nonalcoholic fatty liver disease. | 2015 | Details |
| A20402 | 25989356 | Am J Pathol | NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment. | 2015 | Details |
| A20412 | 25984739 | Nutrients | MiRNA-194 Regulates Palmitic Acid-Induced Toll-Like Receptor 4 Inflammatory Responses in THP-1 Cells. | 2015 | Details |
| A20531 | 25906757 | J Endocrinol Invest | 1,25(OH)2D3 downregulates the Toll-like receptor 4-mediated inflammatory pathway and ameliorates liver injury in diabetic rats. | 2015 | Details |
| A20712 | 25786512 | Liver Int | Acute atorvastatin is hepatoprotective against ischaemia-reperfusion injury in mice by modulating eNOS and microparticle formation. | 2015 | Details |
| A20759 | 25751957 | Zhongguo Zhong Yao Za Zhi | [Effects of soothing liver and invigorating spleen recipes on LPS-induced hepatocytes injury of rats and TLR4/p38MAPK signal pathway]. | 2014 | Details |
| A20787 | 25736031 | Clin Nutr | Effect of specific amino acids on hepatic lipid metabolism in fructose-induced non-alcoholic fatty liver disease. | 2015 | Details |
| A20823 | 25712260 | Brain Behav Immun | Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol diet. | 2015 | Details |
| A20855 | 25684563 | J Gastroenterol Hepatol | Role of serum toll-like receptors 2 and 4 in non-alcoholic steatohepatitis and liver fibrosis. | 2015 | Details |
| A20880 | 25668433 | PLoS Negl Trop Dis | Trypanosoma cruzi infection is a potent risk factor for non-alcoholic steatohepatitis enhancing local and systemic inflammation associated with strong oxidative stress and metabolic disorders. | 2015 | Details |
| A20903 | 25654290 | Zhonghua Gan Zang Bing Za Zhi | [Association of intestinal epithelial tight junctions, E.coli, intestinal mucosa Toll-like receptor-4 and tumor necrosis factor-alpha in rabbit with non-alcoholic fatty liver disease]. | 2014 | Details |
| A21062 | 27682116 | Microorganisms | Gut Microbiota and Host Reaction in Liver Diseases. | 2015 | Details |
| A21208 | 25479137 | Gastroenterology | Blockade of PD1 and TIM3 restores innate and adaptive immunity in patients with acute alcoholic hepatitis. | 2014 | Details |
| A21230 | 25468829 | Int J Obes (Lond) | Fetuin-A: a novel link between obesity and related complications. | 2014 | Details |
| A21303 | 25421042 | Mol Med Rep | Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic stellate cell activation and remission of intestinal permeability in a rat non-alcoholic steatohepatitis model. | 2014 | Details |
| A21314 | 25413054 | Nan Fang Yi Ke Da Xue Xue Bao | [Effect of electro-acupuncture on hepatic Toll-like receptor 4 and nuclear factor κB expressions in rats with non-alcoholic fatty liver disease]. | 2014 | Details |
| A21488 | 25281898 | Int Immunopharmacol | 3, 3'-Diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance. | 2014 | Details |
| A21650 | 25152980 | Ann Hepatol | Kupffer cells: increasingly significant role in nonalcoholic fatty liver disease. | 2015 | Details |
| A21726 | 25089018 | J Gastroenterol Hepatol | Sophocarpine attenuates toll-like receptor 4 in steatotic hepatocytes to suppress pro-inflammatory cytokines synthesis. | 2015 | Details |
| A21761 | 25064435 | J Hepatol | Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent. | 2014 | Details |
| A21847 | 25003671 | Turk J Gastroenterol | Role of gut microbiota: obesity and NAFLD. | 2014 | Details |
| A21853 | 24998970 | Toxicol Appl Pharmacol | Evaluation of Aroclor 1260 exposure in a mouse model of diet-induced obesity and non-alcoholic fatty liver disease. | 2014 | Details |
| A21856 | 24997224 | Exp Mol Pathol | TLR3/4 signaling is mediated via the NFκB-CXCR4/7 pathway in human alcoholic hepatitis and non-alcoholic steatohepatitis which formed Mallory-Denk bodies. | 2014 | Details |
| A21998 | 24901254 | PLoS One | Cholesterol-induced non-alcoholic fatty liver disease and atherosclerosis aggravated by systemic inflammation. | 2014 | Details |
| A22107 | 24816278 | PLoS One | Lactoferrin dampens high-fructose corn syrup-induced hepatic manifestations of the metabolic syndrome in a murine model. | 2014 | Details |
| A22227 | 24739055 | Clin Exp Pharmacol Physiol | Toll-like receptor-4 signalling in the progression of non-alcoholic fatty liver disease induced by high-fat and high-fructose diet in mice. | 2014 | Details |
| A22334 | 24653580 | Afr J Tradit Complement Altern Med | p38 MAPK signal pathway involved in anti-inflammatory effect of Chaihu-Shugan-San and Shen-ling-bai-zhu-San on hepatocyte in non-alcoholic steatohepatitis rats. | 2013 | Details |
| A22343 | 24650018 | Liver Int | Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis. | 2014 | Details |
| A22346 | 24649857 | Liver Int | Hepatic toll-like receptor 4 expression is associated with portal inflammation and fibrosis in patients with NAFLD. | 2014 | Details |
| A22424 | 24587658 | World J Gastroenterol | Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver. | 2014 | Details |
| A22586 | 24443993 | Metab Syndr Relat Disord | TLR4 gene polymorphism in patients with nonalcoholic fatty liver disease in comparison to healthy controls. | 2014 | Details |
| A22627 | 24400795 | Immunology | Probiotic antigens stimulate hepatic natural killer T cells. | 2014 | Details |
| A22778 | 24314869 | J Nutr Biochem | Effects of a Lactobacillus paracasei B21060 based synbiotic on steatosis, insulin signaling and toll-like receptor expression in rats fed a high-fat diet. | 2013 | Details |
| A22781 | 24312613 | PLoS One | Pro-inflammatory activated Kupffer cells by lipids induce hepatic NKT cells deficiency through activation-induced cell death. | 2013 | Details |
| A23289 | 23896376 | Biochimie | Ectopic lipid accumulation: A potential cause for metabolic disturbances and a contributor to the alteration of kidney function. | 2013 | Details |
| A23312 | 23855302 | J Gastroenterol Hepatol | Differences in innate immune signaling between alcoholic and non-alcoholic steatohepatitis. | 2013 | Details |
| A23315 | 23855294 | J Gastroenterol Hepatol | Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis. | 2013 | Details |
| A23338 | 23861108 | Dig Dis Sci | Betaine protects against high-fat-diet-induced liver injury by inhibition of high-mobility group box 1 and Toll-like receptor 4 expression in rats. | 2013 | Details |
| A23471 | 23750414 | Zhong Yao Cai | [Effects of soothing liver and invigorating spleen recipes on the mRNA and protein expression of TLR4 in hepatic tissues of rats with NASH]. | 2013 | Details |
| A24014 | 23301938 | J Gastroenterol Hepatol | Cross talk between toll-like receptor-4 signaling and angiotensin-II in liver fibrosis development in the rat model of non-alcoholic steatohepatitis. | 2013 | Details |
| A24049 | 23280158 | Dig Liver Dis | Gut-liver axis and fibrosis in nonalcoholic fatty liver disease: an input for novel therapies. | 2012 | Details |
| A24254 | 23071295 | J Lipid Res | CCN1 expression in hepatocytes contributes to macrophage infiltration in nonalcoholic fatty liver disease in mice. | 2012 | Details |
| A24383 | 22952059 | Mol Med | Female mice are more susceptible to nonalcoholic fatty liver disease: sex-specific regulation of the hepatic AMP-activated protein kinase-plasminogen activator inhibitor 1 cascade, but not the hepatic endotoxin response. | 2012 | Details |
| A24420 | 22915297 | J Nutr | Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. | 2012 | Details |
| A24431 | 22902548 | J Hepatol | Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model. | 2012 | Details |
| A24472 | 22863080 | Liver Int | α-lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats. | 2012 | Details |
| A24481 | 22851489 | J Clin Endocrinol Metab | Increased tenascin C and Toll-like receptor 4 levels in visceral adipose tissue as a link between inflammation and extracellular matrix remodeling in obesity. | 2012 | Details |
| A24545 | 22768838 | Cell Metab | Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling. | 2012 | Details |
| A24556 | 22751700 | Diabetes | Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages. | 2012 | Details |
| A24561 | 22749137 | J Nutr Biochem | Lactobacillus casei Shirota protects from fructose-induced liver steatosis: a mouse model. | 2012 | Details |
| A24764 | 22525431 | Lab Invest | Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function. | 2012 | Details |
| A24852 | 22432744 | J Gastroenterol Hepatol | Atorvastatin protects obese mice against hepatic ischemia-reperfusion injury by Toll-like receptor-4 suppression and endothelial nitric oxide synthase activation. | 2012 | Details |