Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A52564 | 25582085 | Nutr Res | Early hepatic insult in the offspring of obese maternal mice. | 2014 | Details |
| A52570 | 25487878 | Sci Rep | Protopanaxatriol, a novel PPARγ antagonist from Panax ginseng, alleviates steatosis in mice. | 2014 | Details |
| A52577 | 25437555 | Cell Rep | Changes in nucleosome occupancy associated with metabolic alterations in aged mammalian liver. | 2014 | Details |
| A52588 | 25295789 | Cell Metab | CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. | 2014 | Details |
| A52618 | 24773203 | Alcohol Clin Exp Res | Modulation of fatty acid and bile acid metabolism by peroxisome proliferator-activated receptor α protects against alcoholic liver disease. | 2014 | Details |
| A52631 | 24486395 | Eur J Pharmacol | Silymarin ameliorates fructose induced insulin resistance syndrome by reducing de novo hepatic lipogenesis in the rat. | 2014 | Details |
| A52650 | 24184811 | Gastroenterology | Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. | 2013 | Details |
| A52657 | 24069029 | Front Genet | Temporal clustering of gene expression links the metabolic transcription factor HNF4α to the ER stress-dependent gene regulatory network. | 2013 | Details |
| A52674 | 23769925 | Gene | The C57BL/6J Niemann-Pick C1 mouse model with decreased gene dosage has impaired glucose tolerance independent of body weight. | 2013 | Details |
| A52701 | 23317789 | Prog Mol Biol Transl Sci | Adiponectin receptors in energy homeostasis and obesity pathogenesis. | 2013 | Details |
| A52715 | 23033902 | Biosci Rep | Trans-Golgi proteins participate in the control of lipid droplet and chylomicron formation. | 2013 | Details |
| A52751 | 22471957 | Cardiovasc Hematol Agents Med Chem | PPAR- γ agonist in treatment of diabetes: cardiovascular safety considerations. | 2012 | Details |
| A52756 | 22414273 | J Gastroenterol Hepatol | Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposity. | 2012 | Details |
| A52766 | 22297608 | Antivir Ther | Ritonavir-induced lipoatrophy and dyslipidaemia is reversed by the anti-inflammatory drug leflunomide in a PPAR-γ-dependent manner. | 2012 | Details |
| A52794 | 21849896 | Curr Opin Clin Nutr Metab Care | Origins of metabolic complications in obesity: adipose tissue and free fatty acid trafficking. | 2011 | Details |
| A52800 | 21725989 | Hepatology | Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. | 2011 | Details |
| A52811 | 21459324 | Cell Metab | Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia. | 2011 | Details |
| A52829 | 21205225 | Basic Clin Pharmacol Toxicol | Monosodium glutamate neonatal intoxication associated with obesity in adult stage is characterized by chronic inflammation and increased mRNA expression of peroxisome proliferator-activated receptors in mice. | 2011 | Details |
| A52831 | 21178610 | Curr Opin Clin Nutr Metab Care | Fatty acid regulation of hepatic lipid metabolism. | 2011 | Details |
| A52846 | 20832799 | Atherosclerosis | High-fat diet without excess calories induces metabolic disorders and enhances atherosclerosis in rabbits. | 2010 | Details |
| A52850 | 20699090 | Clin Chim Acta | Triglycerides and gallstone formation. | 2010 | Details |
| A52853 | 20670429 | Lipids Health Dis | Glycyrrhizic acid improved lipoprotein lipase expression, insulin sensitivity, serum lipid and lipid deposition in high-fat diet-induced obese rats. | 2010 | Details |
| A52854 | 20649581 | Br J Pharmacol | Irbesartan treatment up-regulates hepatic expression of PPARalpha and its target genes in obese Koletsky (fa(k)/fa(k)) rats: a link to amelioration of hypertriglyceridaemia. | 2010 | Details |
| A52866 | 20487553 | BMC Gastroenterol | Nutrigenomics therapy of hepatisis C virus induced-hepatosteatosis. | 2010 | Details |
| A52891 | 19920214 | Am J Physiol Endocrinol Metab | Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice. | 2009 | Details |
| A52893 | 19859993 | World J Gastroenterol | Steatosis and insulin resistance in hepatitis C: a way out for the virus? | 2009 | Details |
| A52903 | 19796705 | Biochim Biophys Acta | Lipotoxicity in macrophages: evidence from diseases associated with the metabolic syndrome. | 2009 | Details |
| A52929 | 19398469 | Cardiovasc Res | Cardiac peroxisome proliferator-activated receptor-alpha activation causes increased fatty acid oxidation, reducing efficiency and post-ischaemic functional loss. | 2009 | Details |
| A52934 | 19349323 | Circulation | Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus. | 2009 | Details |
| A52935 | 19318113 | Pharmacol Ther | Significance of peroxisome proliferator-activated receptors in the cardiovascular system in health and disease. | 2009 | Details |
| A52941 | 19148799 | J Gastroenterol | Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection. | 2009 | Details |
| A52943 | 19201949 | Development | TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase. | 2009 | Details |
| A52948 | 20300478 | PPAR Res | PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease. | 2010 | Details |
| A52961 | 18773755 | G Ital Cardiol (Rome) | [Pharmacological therapy of obesity]. | 2008 | Details |
| A52977 | 18459129 | Hepatology | Disturbed hepatic carbohydrate management during high metabolic demand in medium-chain acyl-CoA dehydrogenase (MCAD)-deficient mice. | 2008 | Details |
| A52978 | 18446001 | Endocr J | Molecular mechanism of moderate insulin resistance in adiponectin-knockout mice. | 2008 | Details |
| A52987 | 18230901 | Front Horm Res | 11beta-hydroxysteroid dehydrogenase type 1 and obesity. | 2008 | Details |
| A52989 | 18220945 | Endocr Metab Immune Disord Drug Targets | Does global gene expression analysis in type 2 diabetes provide an opportunity to identify highly promising drug targets? | 2007 | Details |
| A52990 | 18220654 | Curr Diabetes Rev | Peroxisome proliferator-activated receptor (PPAR) in metabolic syndrome and type 2 diabetes mellitus. | 2007 | Details |
| A52999 | 17935055 | Diab Vasc Dis Res | Preventing type 2 diabetes and cardiovascular disease in metabolic syndrome: the role of PPARalpha. | 2007 | Details |
| A53001 | 17933490 | Genomics | Gene expression profiling in livers of mice after acute inhibition of beta-oxidation. | 2007 | Details |
| A53004 | 19124394 | Ther Adv Cardiovasc Dis | Genetics of the cardiometabolic syndrome: new insights and therapeutic implications. | 2007 | Details |
| A53014 | 17466100 | Proc Nutr Soc | The interplay between nutrients and the adipose tissue. | 2007 | Details |
| A53029 | 17016629 | Int J Mol Med | Hemostasis alterations in metabolic syndrome (review). | 2006 | Details |
| A53034 | 16903166 | Clin Cornerstone | Atherogenic dyslipidemia associated with metabolic syndrome and insulin resistance. | 2006 | Details |
| A53039 | 16750656 | Vascul Pharmacol | Adverse hepatic and cardiac responses to rosiglitazone in a new mouse model of type 2 diabetes: relation to dysregulated phosphatidylcholine metabolism. | 2006 | Details |
| A53048 | 16511589 | J Clin Invest | Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. | 2006 | Details |
| A53050 | 16477380 | Mol Cell Biochem | Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice. | 2006 | Details |
| A53053 | 16424352 | Arterioscler Thromb Vasc Biol | Modulation of hepatic inflammatory risk markers of cardiovascular diseases by PPAR-alpha activators: clinical and experimental evidence. | 2006 | Details |
| A53054 | 16409152 | Annu Rev Med | Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. | 2006 | Details |
| A53055 | 16339123 | Obes Res | (+)-Z-Bisdehydrodoisynolic acid ameliorates obesity and the metabolic syndrome in female ZDF rats. | 2005 | Details |
| A53057 | 16248830 | Curr Drug Targets Cardiovasc Haematol Disord | Role of PPAR- gamma agonist thiazolidinediones in treatment of pre-diabetic and diabetic individuals: a cardiovascular perspective. | 2005 | Details |
| A53060 | 16183630 | Am J Physiol Regul Integr Comp Physiol | Tesaglitazar, a dual PPAR{alpha}/{gamma} agonist, ameliorates glucose and lipid intolerance in obese Zucker rats. | 2005 | Details |
| A53063 | 16109719 | J Biol Chem | Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways. | 2005 | Details |
| A53073 | 15672115 | Int J Obes (Lond) | Childhood obesity and insulin resistance in a Yucatan mini-piglet model: putative roles of IGF-1 and muscle PPARs in adipose tissue activity and development. | 2005 | Details |
| A53084 | 15297448 | Endocrinology | Small-molecule insulin mimetic reduces hyperglycemia and obesity in a nongenetic mouse model of type 2 diabetes. | 2004 | Details |
| A53086 | 15230153 | Przegl Lek | [Adiponectin--adipocytokine with a broad clinical spectrum]. | 2004 | Details |
| A53098 | 14739074 | Biochimie | Central role of the adipocyte in the insulin-sensitising and cardiovascular risk modifying actions of the thiazolidinediones. | 2003 | Details |
| A53110 | 12793594 | Int J Clin Pract Suppl | The relationship of obesity to the metabolic syndrome. | 2003 | Details |
| A53118 | 12401884 | J Lipid Res | AZ 242, a novel PPARalpha/gamma agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats. | 2002 | Details |
| A53123 | 11921433 | Diabetes Metab Res Rev | The mode of action of thiazolidinediones. | 2002 | Details |
| A53155 | 9670624 | Indian J Pathol Microbiol | Observations on hepatic structure and function in fibro-calculous pancreatic diabetes (FCPD) vis-a-vis other diabetic subtypes. | 1998 | Details |
| A53170 | 1579583 | Proc Soc Exp Biol Med | Obesity, lipoproteins, and heart disease. | 1992 | Details |
| A53189 | 201171 | Am J Med | Corticosteroid-responsive skeletal muscle disease associated with partial carnitine deficiency: studies of liver and metabolic alterations. | 1977 | Details |
| A53190 | 857644 | Am J Clin Nutr | Metabolic regulation as a control for lipid disorders. II. Influence of (--)-hydroxycitrate on genetically and experimentally induced hypertriglyceridemia in the rat. | 1977 | Details |