Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A09079 | 31882668 | Sci Rep | Restoration of liver sinusoidal cell phenotypes by statins improves portal hypertension and histology in rats with NASH. | 2019 | Details |
| A09082 | 31882273 | J Diabetes Complications | Prospective evaluation of non-alcoholic fatty liver disease by elastographic methods of liver steatosis and fibrosis; controlled attenuation parameter and liver stiffness measurements. | 2019 | Details |
| A09083 | 31881781 | Int J Mol Sci | FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease. | 2019 | Details |
| A09084 | 31881392 | Contemp Clin Trials | Cenicriviroc for the treatment of liver fibrosis in adults with nonalcoholic steatohepatitis: AURORA Phase 3 study design. | 2019 | Details |
| A09085 | 31881361 | Cell Mol Gastroenterol Hepatol | Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression. | 2019 | Details |
| A09086 | 31881272 | Pharmacol Res | The gut-liver-kidney axis: Novel regulator of fatty liver associated chronic kidney disease. | 2019 | Details |
| A09090 | 31880680 | J Pediatr Gastroenterol Nutr | Early Obesity: Risk Factor for Fatty Liver Disease. | 2020 | Details |
| A09094 | 31879571 | PeerJ | Comparative RNA-sequencing profiled the differential gene expression of liver in response to acetyl-CoA carboxylase inhibitor GS-0976 in a mouse model of NASH. | 2019 | Details |
| A09096 | 31877771 | Cells | Anti-NASH Drug Development Hitches a Lift on PPAR Agonism. | 2019 | Details |
| A09102 | 31875010 | Sci Rep | The assessment of liver fibrosis in children with obesity on two methods: transient and two dimensional shear wave elastography. | 2019 | Details |
| A09111 | 31870140 | Korean J Gastroenterol | Diagnostic Performance of Serum Asialo-α1-acid Glycoprotein for Advanced Liver Fibrosis or Cirrhosis in Patients with Chronic Hepatitis B or Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A09115 | 31868526 | Expert Opin Investig Drugs | Cyclophilin inhibition as a potential treatment for nonalcoholic steatohepatitis (NASH). | 2019 | Details |
| A09118 | 31867782 | J Gastroenterol Hepatol | When the liver gets stiff, the tough get moving. | 2020 | Details |
| A09123 | 31866798 | Contrast Media Mol Imaging | Imaging Fibrogenesis in a Diet-Induced Model of Nonalcoholic Steatohepatitis (NASH). | 2019 | Details |
| A09132 | 31862949 | Sci Rep | Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis. | 2019 | Details |
| A09133 | 31862937 | Sci Rep | Urinary Levels of Titin-N Fragment, a Skeletal Muscle Damage Marker, are Increased in Subjects with Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A09134 | 31862486 | J Hepatol | Clinical validation of the FLIP algorithm and the SAF score in patients with non-alcoholic fatty liver disease. | 2019 | Details |
| A09135 | 31861914 | Cells | Oncostatin M, A Profibrogenic Mediator Overexpressed in Non-Alcoholic Fatty Liver Disease, Stimulates Migration of Hepatic Myofibroblasts. | 2019 | Details |
| A09136 | 31861818 | Cells | Metabolic Hallmarks of Hepatic Stellate Cells in Liver Fibrosis. | 2019 | Details |
| A09137 | 31861664 | Int J Mol Sci | Sphingolipids in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma: Ceramide Turnover. | 2019 | Details |
| A09143 | 31860081 | Biosci Rep | Proteomic screening of plasma identifies potential noninvasive biomarkers associated with significant/advanced fibrosis in patients with nonalcoholic fatty liver disease. | 2020 | Details |
| A09146 | 31858523 | Histol Histopathol | Hepatocellular carcinoma in non-alcoholic fatty liver disease (NAFLD) - pathological evidence for a predominance of steatohepatitic inflammatory non-proliferative subtype. | 2019 | Details |
| A09147 | 31858390 | Endocrine | Noninvasive assessment of hepatic steatosis and fibrosis in patients with severe obesity. | 2019 | Details |
| A09153 | 31856189 | PLoS One | Nonalcoholic fatty liver disease and hepatic fibrosis among perinatally HIV-monoinfected Asian adolescents receiving antiretroviral therapy. | 2019 | Details |
| A09154 | 31854001 | Alcohol Clin Exp Res | Interaction Between Alcohol Use and Metabolic Risk Factors for Liver Disease: A Critical Review of Epidemiological Studies. | 2020 | Details |
| A09164 | 31852081 | Medicine (Baltimore) | Nonalcoholic steatohepatitis: A scientometric analysis of publications during 1980-2018. | 2019 | Details |
| A09171 | 31850288 | Front Pediatr | Metabolic Syndrome Is Associated With Advanced Liver Fibrosis Among Pediatric Patients With Non-alcoholic Fatty Liver Disease. | 2019 | Details |
| A09172 | 31849997 | Front Immunol | Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases. | 2019 | Details |
| A09175 | 31847612 | Expert Opin Investig Drugs | The molecular basis for current targets of NASH therapies. | 2019 | Details |
| A09178 | 31847157 | Nutrients | Sarcopoterium spinosum Inhibited the Development of Non-Alcoholic Steatosis and Steatohepatitis in Mice. | 2019 | Details |
| A09180 | 31846507 | Swiss Med Wkly | Nonalcoholic fatty liver disease burden - Switzerland 2018-2030. | 2019 | Details |
| A09183 | 31845776 | Am Fam Physician | Cirrhosis: Diagnosis and Management. | 2019 | Details |
| A09184 | 31845054 | J Gastroenterol | Intestinal microbiome and NAFLD: molecular insights and therapeutic perspectives. | 2019 | Details |
| A09195 | 31840358 | Hepatol Res | Gut microbiota in non-alcoholic fatty liver disease and alcohol-related liver disease: Current concepts and perspectives. | 2020 | Details |
| A09197 | 31839486 | Cell Metab | Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis. | 2019 | Details |
| A09202 | 31838050 | Chem Biol Interact | Stearoyl-CoA desaturase and tumorigenesis. | 2019 | Details |
| A09209 | 31835352 | Cells | The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases. | 2019 | Details |
| A09214 | 31834057 | Eur J Gastroenterol Hepatol | Serum visfatin level as a noninvasive marker for nonalcoholic fatty liver disease in children and adolescents with obesity: relation to transient elastography with controlled attenuation parameter. | 2020 | Details |
| A09219 | 31832569 | Hepatol Commun | Fat Accumulation, Liver Fibrosis, and Metabolic Abnormalities in Chinese Patients With Moderate/Severe Versus Mild Hepatic Steatosis. | 2019 | Details |
| A09220 | 31832567 | Hepatol Commun | Designing Clinical Trials in Pediatric Nonalcoholic Steatohepatitis: Tips for Patient Selection and Appropriate Endpoints. | 2019 | Details |
| A09224 | 31831621 | J Biol Chem | Disruption of hepatic small heterodimer partner induces dissociation of steatosis and inflammation in experimental nonalcoholic steatohepatitis. | 2019 | Details |
| A09228 | 31828503 | Langenbecks Arch Surg | A retrospective case control study identifies peripheral blood mononuclear cell albumin RNA expression as a biomarker for non-alcoholic fatty liver disease. | 2019 | Details |
| A09233 | 31826068 | J Gastrointestin Liver Dis | Characterization of Patients with Biopsy-Proven Non-Alcoholic Fatty Liver Disease and Normal Aminotransferase Levels. | 2019 | Details |
| A09237 | 31823449 | Liver Int | Controlled attenuation parameter reflects steatosis in compensated advanced chronic liver disease. | 2019 | Details |
| A09238 | 31822978 | Eur Radiol | Quantification of hepatic steatosis with ultrasound: promising role of attenuation imaging coefficient in a biopsy-proven cohort. | 2019 | Details |
| A09239 | 31822739 | Sci Rep | Pharmacological myeloperoxidase (MPO) inhibition in an obese/hypertensive mouse model attenuates obesity and liver damage, but not cardiac remodeling. | 2019 | Details |
| A09243 | 31820847 | Liver Int | Associations of subclinical atherosclerosis with nonalcoholic fatty liver disease and fibrosis assessed by non-invasive score. | 2019 | Details |
| A09251 | 31817398 | Nutrients | Mediterranean Diet and NAFLD: What We Know and Questions That Still Need to Be Answered. | 2019 | Details |
| A09252 | 31817258 | Cells | Ubiquitin-Like Post-Translational Modifications (Ubl-PTMs): Small Peptides with Huge Impact in Liver Fibrosis. | 2019 | Details |
| A09257 | 31815784 | Curr Opin Endocrinol Diabetes Obes | Gastrointestinal peptides and nonalcoholic fatty liver disease. | 2020 | Details |
| A09259 | 31814783 | Hepat Med | A Review Of Current And Upcoming Treatment Modalities In Non-Alcoholic Fatty Liver Disease And Non-Alcoholic Steatohepatitis. | 2019 | Details |
| A09261 | 31813633 | Lancet | Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial. | 2019 | Details |
| A09263 | 31813265 | Antioxid Redox Signal | Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation. | 2020 | Details |
| A09264 | 31812658 | Clin Gastroenterol Hepatol | Low Testosterone Is Associated With Nonalcoholic Steatohepatitis and Fibrosis Severity in Men. | 2019 | Details |
| A09265 | 31812510 | Gastroenterology | Effects of Belapectin, an Inhibitor of Galectin-3, in Patients With Nonalcoholic Steatohepatitis With Cirrhosis and Portal Hypertension. | 2019 | Details |
| A09268 | 31810868 | Clin Res Hepatol Gastroenterol | Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model. | 2019 | Details |
| A09276 | 31808577 | Hepatology | Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD. | 2020 | Details |
| A09278 | 31808322 | J Korean Med Sci | Correlation of Clinical and Histopathologic Parameters with Ultrasonographic Grades in Pediatric Non-Alcoholic Fatty Liver Disease. | 2019 | Details |
| A09279 | 31808236 | Hepatol Res | Serum soluble sialic acid-binding immunoglobulin-like lectin-7 concentration as an indicator of liver macrophage activation and advanced fibrosis in patients with non-alcoholic fatty liver disease. | 2019 | Details |
| A09281 | 31807383 | Cureus | Effect of Non-alcoholic Fatty Liver Disease on Transaminase Levels and Transient Elastography in Patients with Chronic Hepatitis B. | 2019 | Details |
| A09289 | 31804575 | Sci Rep | Deep learning enables pathologist-like scoring of NASH models. | 2019 | Details |
| A09295 | 31802390 | Hepatol Int | New drugs for NAFLD: lessons from basic models to the clinic. | 2019 | Details |
| A09296 | 31801616 | J Transl Med | Microbiota, type 2 diabetes and non-alcoholic fatty liver disease: protocol of an observational study. | 2019 | Details |
| A09312 | 31795496 | Cells | Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins. | 2019 | Details |
| A09324 | 31790829 | Free Radic Biol Med | Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress in mice. | 2019 | Details |
| A09326 | 31789950 | Eur J Gastroenterol Hepatol | Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes. | 2020 | Details |
| A09327 | 31789772 | J Pediatr Gastroenterol Nutr | The rs72613567: TA Variant in the Hydroxysteroid 17-beta Dehydrogenase 13 Gene Reduces Liver Damage in Obese Children. | 2020 | Details |
| A09328 | 31789757 | J Clin Gastroenterol | The Role of Noninvasive Tests for Differentiating NASH From NAFL and Diagnosing Advanced Fibrosis Among Patients With NAFLD. | 2020 | Details |
| A09329 | 31789677 | Curr Opin Lipidol | Fatty liver, cardiometabolic disease and mortality. | 2020 | Details |
| A09331 | 31788461 | Front Pediatr | Progressive Liver Disease in Patients With Ataxia Telangiectasia. | 2019 | Details |
| A09335 | 31786361 | Diabetes Metab | Screening for non-alcoholic fatty liver disease using liver stiffness measurement and its association with chronic kidney disease and cardiovascular complications in patients with type 2 diabetes. | 2019 | Details |
| A09336 | 31786360 | Diabetes Metab | Higher liver stiffness scores are associated with early kidney dysfunction in patients with histologically proven non-cirrhotic NAFLD. | 2019 | Details |
| A09341 | 31785086 | Obesity (Silver Spring) | Association of Hepatic Global DNA Methylation and Serum One-Carbon Metabolites with Histological Severity in Patients with NAFLD. | 2019 | Details |
| A09342 | 31784293 | Arch Pediatr | Feeding problems and gastrointestinal diseases in Down syndrome. | 2019 | Details |
| A09343 | 31783920 | Syst Rev | Diabetes drugs for nonalcoholic fatty liver disease: a systematic review. | 2019 | Details |
| A09344 | 31783667 | Diagnostics (Basel) | Diet-Induced Rat Model of Gradual Development of Non-Alcoholic Fatty Liver Disease (NAFLD) with Lipopolysaccharides (LPS) Secretion. | 2019 | Details |
| A09349 | 31782258 | Physiol Rep | SGLT2 inhibitor ipragliflozin alone and combined with pioglitazone prevents progression of nonalcoholic steatohepatitis in a type 2 diabetes rodent model. | 2019 | Details |
| A09362 | 31777715 | Pediatr Gastroenterol Hepatol Nutr | New Perspectives in Pediatric Nonalcoholic Fatty Liver Disease: Epidemiology, Genetics, Diagnosis, and Natural History. | 2019 | Details |
| A09363 | 31777643 | Int J Physiol Pathophysiol Pharmacol | Role of mitochondrial depolarization and disrupted mitochondrial homeostasis in non-alcoholic steatohepatitis and fibrosis in mice. | 2019 | Details |
| A09366 | 31776293 | Sci Transl Med | Targeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis. | 2019 | Details |
| A09380 | 31770104 | Eur J Endocrinol | Increased risk of low bone mineral density in patients with non-alcoholic fatty liver disease: a cohort study. | 2020 | Details |
| A09384 | 31767252 | Presse Med | [Pathogenesis of non-alcoholic fatty liver disease]. | 2019 | Details |
| A09385 | 31767251 | Presse Med | [FIB-4 index to rule-out advanced liver fibrosis in NAFLD patients]. | 2019 | Details |
| A09392 | 31762620 | Saudi J Biol Sci | Lifestyle interventions for non-alcoholic fatty liver disease. | 2019 | Details |
| A09394 | 31761566 | Cell Metab | Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. | 2019 | Details |
| A09397 | 31760464 | Cell Mol Life Sci | Fructose-mediated effects on gene expression and epigenetic mechanisms associated with NAFLD pathogenesis. | 2020 | Details |
| A09400 | 31760070 | J Hepatol | Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease. | 2019 | Details |
| A09408 | 31758647 | Liver Int | Hepatic NK cells attenuate fibrosis progression of non-alcoholic steatohepatitis in dependent of CXCL10-mediated recruitment. | 2019 | Details |
| A09410 | 31758299 | Rev Endocr Metab Disord | Ghrelin and liver disease. | 2020 | Details |
| A09413 | 31757759 | Mol Ther | HLSC-Derived Extracellular Vesicles Attenuate Liver Fibrosis and Inflammation in a Murine Model of Non-alcoholic Steatohepatitis. | 2019 | Details |
| A09415 | 31757735 | Presse Med | [Pharmacological treatment of NASH]. | 2019 | Details |
| A09423 | 31755380 | Curr Pharm Des | Combined use of Genetic Polymorphisms and Elastographic Techniques in NAFLD: Fact or Fiction? | 2020 | Details |
| A09433 | 31752351 | Nutrients | Atorvastatin and Vitamin E Accelerates NASH Resolution by Dietary Intervention in a Preclinical Guinea Pig Model. | 2019 | Details |
| A09437 | 31749914 | Gastroenterol Hepatol Bed Bench | The diagnostic and initial approach of the patient with non-alcoholic fatty liver disease: role of the primary care provider. | 2019 | Details |
| A09438 | 31749901 | World J Hepatol | Characterization of patients with both alcoholic and nonalcoholic fatty liver disease in a large United States cohort. | 2019 | Details |
| A09439 | 31749893 | Diabetol Metab Syndr | Long-term treatment with metformin in the prevention of fatty liver in Zucker diabetic fatty rats. | 2019 | Details |
| A09441 | 31749300 | Liver Int | Liver stiffness measurement predicts long-term survival and complications in non-alcoholic fatty liver disease. | 2019 | Details |
| A09446 | 31745210 | Lab Invest | STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease. | 2019 | Details |
| A09448 | 31744629 | Environ Int | Perfluoroalkyl substances and severity of nonalcoholic fatty liver in Children: An untargeted metabolomics approach. | 2019 | Details |
| A09451 | 31743810 | Nutrition | Phase angle as a severity indicator for liver diseases. | 2019 | Details |