Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A20833 | 25705637 | Ann Transl Med | Recent advances in the development of farnesoid X receptor agonists. | 2015 | Details |
| A20834 | 25704646 | Biosci Biotechnol Biochem | Dietary freshwater clam (Corbicula fluminea) extract suppresses accumulation of hepatic lipids and increases in serum cholesterol and aminotransferase activities induced by dietary chloretone in rats. | 2015 | Details |
| A20838 | 25701781 | Biochem Biophys Res Commun | Protective effects of aerobic swimming training on high-fat diet induced nonalcoholic fatty liver disease: regulation of lipid metabolism via PANDER-AKT pathway. | 2015 | Details |
| A20840 | 25697178 | Br J Nutr | Dietary trans-10, cis-12-conjugated linoleic acid alters fatty acid metabolism and microbiota composition in mice. | 2015 | Details |
| A20874 | 25671834 | Ann Hepatol | Granulocyte-colony stimulating factor prevents the development of hepatic steatosis in rats. | 2015 | Details |
| A20890 | 25659874 | Atheroscler Suppl | The effect of ezetimibe on NAFLD. | 2015 | Details |
| A20894 | 25658238 | Nutrients | 6-gingerol protects against nutritional steatohepatitis by regulating key genes related to inflammation and lipid metabolism. | 2015 | Details |
| A20902 | 25654291 | Zhonghua Gan Zang Bing Za Zhi | [Impact of JNK inhibitor XG-102 in a diet-induced rat model of non-alcoholic steatohepatitis]. | 2014 | Details |
| A20915 | 25646886 | J Hepatol | Hepatic STAMP2 alleviates high fat diet-induced hepatic steatosis and insulin resistance. | 2015 | Details |
| A20916 | 25646773 | PLoS One | Livers with constitutive mTORC1 activity resist steatosis independent of feedback suppression of Akt. | 2015 | Details |
| A20932 | 25632750 | Zhongguo Zhong Xi Yi Jie He Za Zhi | [Effect of Shugan Jianpi Recipe on LXRα/FAS signaling pathway mediated hepatocyte fatty deposits in NAFLD rats]. | 2014 | Details |
| A20938 | 25631376 | IUBMB Life | Modulation of hepatic lipid metabolism by olive oil and its phenols in nonalcoholic fatty liver disease. | 2015 | Details |
| A20942 | 25624996 | World J Hepatol | Adiponectin serum level in chronic hepatitis C infection and therapeutic profile. | 2015 | Details |
| A20944 | 25624712 | World J Gastroenterol | PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis. | 2015 | Details |
| A20946 | 25623823 | J Hepatol | Xanthine oxidase in non-alcoholic fatty liver disease and hyperuricemia: One stone hits two birds. | 2015 | Details |
| A20949 | 25622557 | Int J Biochem Cell Biol | Activation of mTORC1 disrupted LDL receptor pathway: a potential new mechanism for the progression of non-alcoholic fatty liver disease. | 2015 | Details |
| A20959 | 25617503 | J Hepatol | Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity. | 2015 | Details |
| A20973 | 25609431 | FASEB J | Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH. | 2015 | Details |
| A20977 | 25606341 | Med Gas Res | Exogenous hydrogen sulfide mitigates the fatty liver in obese mice through improving lipid metabolism and antioxidant potential. | 2015 | Details |
| A20980 | 25605057 | Int J Mol Med | Puerarin ameliorates hepatic steatosis by activating the PPARα and AMPK signaling pathways in hepatocytes. | 2015 | Details |
| A20982 | 25603556 | Biochim Biophys Acta | Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis. | 2015 | Details |
| A20985 | 25602171 | Antioxid Redox Signal | Reactive oxygen species-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation. | 2015 | Details |
| A20996 | 25595882 | J Hepatol | Two non-psychoactive cannabinoids reduce intracellular lipid levels and inhibit hepatosteatosis. | 2015 | Details |
| A21007 | 25581263 | Hepatology | Altered hepatic gene expression in nonalcoholic fatty liver disease is associated with lower hepatic n-3 and n-6 polyunsaturated fatty acids. | 2015 | Details |
| A21012 | 25577300 | Dig Liver Dis | Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: a randomized controlled trial. | 2014 | Details |
| A21023 | 25571645 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | [Effect of Nrf2 and related factors on the progression of nonalcoholic steatohepatitis]. | 2014 | Details |
| A21037 | 25562616 | Endocrinology | Prevention and reversal of lipotoxicity-induced hepatic insulin resistance and steatohepatitis in mice by an antioxidant carotenoid, β-cryptoxanthin. | 2015 | Details |
| A21044 | 25559563 | J Gastroenterol Hepatol | MiR-146b attenuates high-fat diet-induced non-alcoholic steatohepatitis in mice. | 2015 | Details |
| A21051 | 25553772 | Expert Opin Drug Metab Toxicol | Farnesoid x receptor in human metabolism and disease: the interplay between gene polymorphisms, clinical phenotypes and disease susceptibility. | 2015 | Details |
| A21077 | 25548489 | World J Gastroenterol | MicroRNA-185 regulates expression of lipid metabolism genes and improves insulin sensitivity in mice with non-alcoholic fatty liver disease. | 2014 | Details |
| A21080 | 25547779 | Expert Opin Ther Targets | Targeting fibroblast growth factor 19 in liver disease: a potential biomarker and therapeutic target. | 2014 | Details |
| A21098 | 25536650 | Ann Hepatol | Lifestyle changes associated with a new antioxidant formulation in non-alcoholic fatty liver disease: a case series. | 2015 | Details |
| A21110 | 25533124 | Biochim Biophys Acta | Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPARα. | 2014 | Details |
| A21114 | 25532016 | PLoS One | Normocaloric low cholesterol diet modulates Th17/Treg balance in patients with chronic hepatitis C virus infection. | 2014 | Details |
| A21143 | 25516477 | Metabolism | The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy. | 2014 | Details |
| A21156 | 25514555 | J Hepatol | Mirtoselect, an anthocyanin-rich bilberry extract, attenuates non-alcoholic steatohepatitis and associated fibrosis in ApoE(∗)3Leiden mice. | 2014 | Details |
| A21157 | 25514415 | Int J Mol Sci | Irisin, a link among fatty liver disease, physical inactivity and insulin resistance. | 2014 | Details |
| A21166 | 25509888 | Ter Arkh | [Adiponectin and parameters of glucose and lipid metabolism at different clinical and morphological stages of non-alcoholic fatty liver disease in patients with abdominal obesity]. | 2014 | Details |
| A21174 | 25500885 | J Clin Invest | Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. | 2014 | Details |
| A21197 | 25484079 | Autophagy | Calcium channel blockers as potential therapeutics for obesity-associated autophagy defects and fatty liver pathologies. | 2014 | Details |
| A21198 | 25484077 | Autophagy | Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway. | 2015 | Details |
| A21216 | 25474087 | Int J Mol Sci | Altered fatty acid metabolism-related gene expression in liver from morbidly obese women with non-alcoholic fatty liver disease. | 2014 | Details |
| A21217 | 25473159 | World J Gastroenterol | Gut microbiota and metabolic syndrome. | 2014 | Details |
| A21218 | 25470667 | Expert Opin Ther Pat | Acyltransferase inhibitors: a patent review (2010-present). | 2014 | Details |
| A21257 | 25451254 | Biochem Biophys Res Commun | Apolipoprotein A-I expression suppresses COX-2 expression by reducing reactive oxygen species in hepatocytes. | 2014 | Details |
| A21258 | 25451038 | Obesity (Silver Spring) | A dietary phytochemical blend prevents liver damage associated with adipose tissue mobilization in ovariectomized rats. | 2014 | Details |
| A21264 | 25450203 | J Hepatol | Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. | 2014 | Details |
| A21300 | 25422863 | Biochem J | Steatosis inhibits liver cell store-operated Ca²⁺ entry and reduces ER Ca²⁺ through a protein kinase C-dependent mechanism. | 2015 | Details |
| A21311 | 25413954 | J Inherit Metab Dis | The clinical spectrum of inherited diseases involved in the synthesis and remodeling of complex lipids. A tentative overview. | 2014 | Details |
| A21314 | 25413054 | Nan Fang Yi Ke Da Xue Xue Bao | [Effect of electro-acupuncture on hepatic Toll-like receptor 4 and nuclear factor κB expressions in rats with non-alcoholic fatty liver disease]. | 2014 | Details |
| A21321 | 25406988 | Lipids Health Dis | Inhibiting CB1 receptors improves lipogenesis in an in vitro non-alcoholic fatty liver disease model. | 2014 | Details |
| A21323 | 25405502 | J Clin Endocrinol Metab | Liver fat content and hepatic insulin sensitivity in overweight patients with type 1 diabetes. | 2014 | Details |
| A21324 | 25404949 | Evid Based Complement Alternat Med | Treatment of Nonalcoholic Fatty Liver Disease with Total Alkaloids in Rubus aleaefolius Poir through Regulation of Fat Metabolism. | 2014 | Details |
| A21330 | 25400762 | Int J Clin Exp Pathol | Mechanism of the promotion of steatotic HepG2 cell apoptosis by cholesterol. | 2014 | Details |
| A21348 | 25386055 | World J Gastroenterol | Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease. | 2014 | Details |
| A21349 | 25385252 | J Clin Lab Anal | AdipoQ T45 G and G276 T Polymorphisms and Susceptibility to Nonalcoholic Fatty Liver Disease Among Asian Populations: A Meta-Analysis and Meta-Regression. | 2014 | Details |
| A21351 | 25383453 | J Agric Food Chem | Viscothionin isolated from Korean mistletoe improves nonalcoholic fatty liver disease via the activation of adenosine monophosphate-activated protein kinase. | 2014 | Details |
| A21356 | 25380481 | Mol Nutr Food Res | Identification of master genes involved in liver key functions through transcriptomics and epigenomics of methyl donor deficiency in rat: relevance to nonalcoholic liver disease. | 2014 | Details |
| A21365 | 25371775 | Oxid Med Cell Longev | Nonalcoholic Fatty liver disease: pathogenesis and therapeutics from a mitochondria-centric perspective. | 2014 | Details |
| A21373 | 25367327 | Food Funct | Effects of Callistephus chinensis flower polyphones on improving metabolic disorders in high-fat diet-induced mice. | 2014 | Details |
| A21374 | 25364750 | Front Cell Dev Biol | Acquisition of lipid metabolic capability in hepatocyte-like cells directly induced from mouse fibroblasts. | 2014 | Details |
| A21376 | 25361925 | Ann Clin Lab Sci | Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. | 2014 | Details |
| A21384 | 25356056 | World J Gastroenterol | Therapeutic effects of globular adiponectin in diabetic rats with nonalcoholic fatty liver disease. | 2014 | Details |
| A21390 | 25353341 | Arch Physiol Biochem | Phosphorylation of sterol regulatory element-binding protein (SREBP)-1c by p38 kinases, ERK and JNK influences lipid metabolism and the secretome of human liver cell line HepG2. | 2014 | Details |
| A21393 | 25352434 | Am J Physiol Endocrinol Metab | From whole body to cellular models of hepatic triglyceride metabolism: man has got to know his limitations. | 2014 | Details |
| A21395 | 25351290 | Liver Int | The UCP2 -866 G>A promoter region polymorphism is associated with nonalcoholic steatohepatitis. | 2014 | Details |
| A21399 | 25349437 | Proc Natl Acad Sci U S A | DLK1/PREF1 regulates nutrient metabolism and protects from steatosis. | 2014 | Details |
| A21401 | 25348739 | J Sci Food Agric | Carnosic acid attenuates obesity-induced glucose intolerance and hepatic fat accumulation by modulating genes of lipid metabolism in C57BL/6J-ob/ob mice. | 2014 | Details |
| A21413 | 25339808 | World J Gastroenterol | Non-alcoholic fatty liver disease: what has changed in the treatment since the beginning? | 2014 | Details |
| A21426 | 25328157 | Br J Nutr | Astaxanthin lowers plasma TAG concentrations and increases hepatic antioxidant gene expression in diet-induced obesity mice. | 2014 | Details |
| A21437 | 25318054 | Int J Mol Sci | Effects of the olive-derived polyphenol oleuropein on human health. | 2014 | Details |
| A21438 | 25317840 | Food Funct | Lactobacillus plantarum NCU116 improves liver function, oxidative stress and lipid metabolism in rats with high fat diet induced non-alcoholic fatty liver disease. | 2014 | Details |
| A21441 | 25316683 | JPEN J Parenter Enteral Nutr | Branched-Chain Amino Acid-Rich Supplements Containing Microelements Have Antioxidant Effects on Nonalcoholic Steatohepatitis in Mice. | 2014 | Details |
| A21444 | 25312970 | J Mol Endocrinol | Aberrant miR199a-5p/caveolin1/PPARα axis in hepatic steatosis. | 2014 | Details |
| A21451 | 25310357 | Mol Med Rep | Ezetimibe prevents the development of non‑alcoholic fatty liver disease induced by high‑fat diet in C57BL/6J mice. | 2014 | Details |
| A21454 | 25309079 | World J Gastroenterol | Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease. | 2014 | Details |
| A21455 | 25309067 | World J Gastroenterol | Nonalcoholic fatty liver disease and vascular disease: state-of-the-art. | 2014 | Details |
| A21468 | 25298375 | Eur J Endocrinol | External validation of the fatty liver index and lipid accumulation product indices, using 1H-magnetic resonance spectroscopy, to identify hepatic steatosis in healthy controls and obese, insulin-resistant individuals. | 2014 | Details |
| A21477 | 25294219 | Toxicol Sci | Activation of the Nrf2-ARE pathway in hepatocytes protects against steatosis in nutritionally induced non-alcoholic steatohepatitis in mice. | 2014 | Details |
| A21491 | 25281858 | J Hepatol | TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice. | 2014 | Details |
| A21495 | 25278690 | World J Gastroenterol | Hepatocellular carcinoma in nonalcoholic fatty liver: role of environmental and genetic factors. | 2014 | Details |
| A21500 | 25271296 | J Lipid Res | A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice. | 2014 | Details |
| A21510 | 25267016 | Metabolism | Adipocyte cell size, free fatty acids and apolipoproteins are associated with non-alcoholic liver injury progression in severely obese patients. | 2014 | Details |
| A21522 | 25256142 | J Cell Mol Med | ASPP2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non-alcoholic fatty liver disease. | 2014 | Details |
| A21535 | 25246029 | Acta Diabetol | Genome-wide analysis of hepatic lipid content in extreme obesity. | 2014 | Details |
| A21545 | 25241023 | Eur J Nutr | The effect of tomato juice supplementation on biomarkers and gene expression related to lipid metabolism in rats with induced hepatic steatosis. | 2014 | Details |
| A21551 | 25234945 | J Hepatol | Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesis. | 2014 | Details |
| A21553 | 25233430 | Biochem Soc Trans | Deciphering non-alcoholic fatty liver disease through metabolomics. | 2014 | Details |
| A21554 | 25233423 | Biochem Soc Trans | Histone variants and lipid metabolism. | 2014 | Details |
| A21568 | 25222487 | PLoS One | Exposure to a northern contaminant mixture (NCM) alters hepatic energy and lipid metabolism exacerbating hepatic steatosis in obese JCR rats. | 2014 | Details |
| A21569 | 25220580 | Sleep Med Rev | Impact of obstructive sleep apnea treatment by continuous positive airway pressure on cardiometabolic biomarkers: a systematic review from sham CPAP randomized controlled trials. | 2014 | Details |
| A21571 | 25219574 | Liver Int | Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis. | 2014 | Details |
| A21586 | 25205520 | Biochim Biophys Acta | Creatine reduces hepatic TG accumulation in hepatocytes by stimulating fatty acid oxidation. | 2014 | Details |
| A21607 | 25191732 | Probl Radiac Med Radiobiol | Clinical importance of the nonalcoholic fatty liver disease: a review. | 2013 | Details |
| A21619 | 25183267 | J Biomed Sci | Flavonoid ingredients of Ginkgo biloba leaf extract regulate lipid metabolism through Sp1-mediated carnitine palmitoyltranferase 1A up-regulation. | 2014 | Details |
| A21629 | 25170079 | J Biol Chem | Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis. | 2014 | Details |
| A21635 | 25164277 | Expert Opin Investig Drugs | GFT505 for the treatment of nonalcoholic steatohepatitis and type 2 diabetes. | 2014 | Details |
| A21641 | 25160499 | Br J Nutr | A high-protein diet is anti-steatotic and has no pro-inflammatory side effects in dyslipidaemic APOE2 knock-in mice. | 2014 | Details |
| A21643 | 25157160 | Proc Natl Acad Sci U S A | Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARγ signaling pathway. | 2014 | Details |
| A21648 | 25154569 | J Nutr Biochem | Postnatal overfeeding promotes early onset and exaggeration of high-fat diet-induced nonalcoholic fatty liver disease through disordered hepatic lipid metabolism in rats. | 2014 | Details |