Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A35765 | 19748164 | Clin Nutr | Inhibition of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats. | 2009 | Details |
| A35770 | 19729473 | Am J Pathol | Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis. | 2009 | Details |
| A35812 | 19638084 | J Gastroenterol Hepatol | Open-labeled pilot study of cysteine-rich whey protein isolate supplementation for nonalcoholic steatohepatitis patients. | 2009 | Details |
| A35822 | 19606393 | Scand J Gastroenterol | Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental non-alcoholic steatohepatitis in mice. | 2009 | Details |
| A35838 | 19571235 | Am J Physiol Gastrointest Liver Physiol | Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusion. | 2009 | Details |
| A35856 | 19552763 | J Pineal Res | Melatonin ameliorates methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in rats. | 2009 | Details |
| A35858 | 19551842 | Int J Cancer | Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats. | 2010 | Details |
| A35865 | 19539747 | Free Radic Biol Med | Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha. | 2009 | Details |
| A35878 | 19513529 | Int J Mol Med | Epigallocatechin-3-gallate improves nonalcoholic steatohepatitis model mice expressing nuclear sterol regulatory element binding protein-1c in adipose tissue. | 2009 | Details |
| A35896 | 19473437 | Hepatol Res | Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization. | 2009 | Details |
| A35912 | 19430612 | J Clin Biochem Nutr | Beneficial Effects of Fermented Green Tea Extract in a Rat Model of Non-alcoholic Steatohepatitis. | 2009 | Details |
| A35913 | 19424798 | Dig Dis Sci | Protective effects of the carotenoid zeaxanthin in experimental nonalcoholic steatohepatitis. | 2009 | Details |
| A35919 | 19404342 | Acta Med Okayama | Beneficial effects of Vitis coignetiae Pulliat leaves on nonalcoholic steatohepatitis in a rat model. | 2009 | Details |
| A35943 | 19374265 | Indian J Biochem Biophys | Antioxidant potential of the root of Vetiveria zizanioides (L.) Nash. | 2009 | Details |
| A35969 | 19299451 | Endocrinology | Curcumin eliminates leptin's effects on hepatic stellate cell activation via interrupting leptin signaling. | 2009 | Details |
| A36018 | 19195795 | Med Hypotheses | Getting the iron out: phlebotomy for Alzheimer's disease? | 2009 | Details |
| A36019 | 19195626 | Diabetes Metab | Insulin resistance and steatosis in humans. | 2008 | Details |
| A36021 | 19190144 | Cancer Epidemiol Biomarkers Prev | Iron overload is associated with hepatic oxidative damage to DNA in nonalcoholic steatohepatitis. | 2009 | Details |
| A36089 | 19030170 | Hepatology | Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression. | 2008 | Details |
| A36106 | 19000661 | Chem Biol Interact | Fructose and carbonyl metabolites as endogenous toxins. | 2008 | Details |
| A36116 | 18986378 | Alcohol Clin Exp Res | Nitric oxide plays a crucial role in the development/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model. | 2009 | Details |
| A36118 | 18984468 | Clin Liver Dis | Disease-specific mechanisms of fibrosis: hepatitis C virus and nonalcoholic steatohepatitis. | 2008 | Details |
| A36179 | 18806095 | J Nutr | N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis. | 2008 | Details |
| A36180 | 18806094 | J Nutr | Increased apoptosis in high-fat diet-induced nonalcoholic steatohepatitis in rats is associated with c-Jun NH2-terminal kinase activation and elevated proapoptotic Bax. | 2008 | Details |
| A36192 | 18769506 | Nutr Res | The Combination of S-adenosylmethionine and Dilinoleoylphosphatidylcholine Attenuates Non-alcoholic Steatohepatitis Produced in Rats by a High-Fat Diet. | 2007 | Details |
| A36228 | 18689562 | J Am Coll Nutr | Prevention and reversion of nonalcoholic steatohepatitis in OB/OB mice by S-nitroso-N-acetylcysteine treatment. | 2008 | Details |
| A36270 | 18571789 | Hepatology | Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis. | 2008 | Details |
| A36291 | 18513333 | Hepatol Res | Bezafibrate prevents hepatic stellate cell activation and fibrogenesis in a murine steatohepatitis model, and suppresses fibrogenic response induced by transforming growth factor-beta1 in a cultured stellate cell line. | 2008 | Details |
| A36302 | 18501395 | Toxicol Appl Pharmacol | Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARalpha with clofibrate. | 2008 | Details |
| A36326 | 18456456 | J Autoimmun | Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study. | 2008 | Details |
| A36330 | 21479420 | Mol Med Rep | A high glucose condition sensitizes human hepatocytes to hydrogen peroxide-induced cell death. | 2012 | Details |
| A36345 | 18397235 | Liver Int | Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis. | 2008 | Details |
| A36366 | 18355262 | Hepatol Res | Serum neopterin levels in patients with non-alcoholic steatohepatitis. | 2008 | Details |
| A36404 | 18277895 | J Clin Gastroenterol | Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis. | 2008 | Details |
| A36439 | 18197877 | Hepatol Res | Combination of N-acetylcysteine and metformin improves histological steatosis and fibrosis in patients with non-alcoholic steatohepatitis. | 2008 | Details |
| A36462 | 18091316 | Appl Immunohistochem Mol Morphol | Cytoplasmic fine granular expression of 8-hydroxydeoxyguanosine reflects early mitochondrial oxidative DNA damage in nonalcoholic fatty liver disease. | 2008 | Details |
| A36483 | 18036573 | Biochem Pharmacol | The pathogenesis of ethanol versus methionine and choline deficient diet-induced liver injury. | 2007 | Details |
| A36516 | 17947452 | Am J Physiol Gastrointest Liver Physiol | A new model for nonalcoholic steatohepatitis in the rat utilizing total enteral nutrition to overfeed a high-polyunsaturated fat diet. | 2007 | Details |
| A36534 | 17929294 | Hepatology | Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. | 2007 | Details |
| A36550 | 17876880 | World J Gastroenterol | N-acetylcysteine attenuates oxidative stress and liver pathology in rats with non-alcoholic steatohepatitis. | 2007 | Details |
| A36570 | 17721935 | J Biochem Mol Toxicol | Genes of the antioxidant response undergo upregulation in a rodent model of nonalcoholic steatohepatitis. | 2007 | Details |
| A36576 | 17710676 | Scand J Gastroenterol | Importance of cytokines, oxidative stress and expression of BCL-2 in the pathogenesis of non-alcoholic steatohepatitis. | 2007 | Details |
| A36582 | 17690174 | Am J Physiol Gastrointest Liver Physiol | Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liver. | 2007 | Details |
| A36583 | 17681180 | Gastroenterology | Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis. | 2007 | Details |
| A36585 | 17680645 | Hepatology | Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes. | 2007 | Details |
| A36615 | 17610500 | Hepatol Res | Clinicopathological significance of antinuclear antibodies in non-alcoholic steatohepatitis. | 2007 | Details |
| A36633 | 17566588 | J Hepatol | The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? | 2007 | Details |
| A36654 | 17518368 | Hepatology | Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis. | 2007 | Details |
| A36674 | 17477913 | Clin Biochem | Oxidative stress and antioxidant defenses in serum of patients with non-alcoholic steatohepatitis. | 2007 | Details |
| A36686 | 17464987 | Hepatology | CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis. | 2007 | Details |
| A36688 | 17459514 | J Hepatol | Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model. | 2007 | Details |
| A36702 | 17429733 | Dig Dis Sci | The serum endothelin-1 level in steatosis and NASH, and its relation with severity of liver fibrosis. | 2007 | Details |
| A36707 | 17415655 | Dig Dis Sci | Amelioration of steatohepatitis with pentoxifylline in a novel nonalcoholic steatohepatitis model induced by high-fat diet. | 2007 | Details |
| A36718 | 17393512 | Hepatology | Chronic intermittent hypoxia predisposes to liver injury. | 2007 | Details |
| A36722 | 17388862 | Intern Med J | Effects of vitamin E treatment on peroxisome proliferator-activated receptor-alpha expression and insulin resistance in patients with non-alcoholic steatohepatitis: results of a pilot study. | 2007 | Details |
| A36726 | 17379003 | Metabolism | Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis. | 2007 | Details |
| A36751 | 17335677 | Curr Gastroenterol Rep | Treatment of fibrosis in nonalcoholic fatty liver disease. | 2007 | Details |
| A36753 | 17331168 | Alcohol Clin Exp Res | Mitochondrial abnormality and oxidative stress in nonalcoholic steatohepatitis. | 2007 | Details |
| A36760 | 17322381 | Am J Pathol | Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis. | 2007 | Details |
| A36765 | 17311618 | Liver Int | Yo jyo hen shi ko, a novel Chinese herbal, prevents nonalcoholic steatohepatitis in ob/ob mice fed a high fat or methionine-choline-deficient diet. | 2007 | Details |
| A36775 | 17292824 | Cancer Cell | Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. | 2007 | Details |
| A36789 | 17275126 | J Hepatol | Identification of a gene-pathway associated with non-alcoholic steatohepatitis. | 2006 | Details |
| A36810 | 17211854 | J Cell Biochem | Fat-loaded HepG2 spheroids exhibit enhanced protection from Pro-oxidant and cytokine induced damage. | 2007 | Details |
| A36854 | 17080243 | Dig Dis Sci | The restorative effect of taurine on experimental nonalcoholic steatohepatitis. | 2006 | Details |
| A36882 | 17023119 | Med Hypotheses | The role of triiodothyronine-induced substrate cycles in the hepatic response to overnutrition: thyroid hormone as an antioxidant. | 2006 | Details |
| A36886 | 17006938 | Hepatology | Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats. | 2006 | Details |
| A36893 | 16988759 | J Gastroenterol | Clinical features of nonalcoholic steatohepatitis in Japan: Evidence from the literature. | 2006 | Details |
| A36925 | 16936261 | Am J Pathol | A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury. | 2006 | Details |
| A36991 | 16768117 | Nihon Rinsho | [Non-alcoholic steatohepatitis : pathology and pathogenesis]. | 2006 | Details |
| A36994 | 16768114 | Nihon Rinsho | [PPAR and NASH]. | 2006 | Details |
| A36996 | 16768112 | Nihon Rinsho | [Role of oxidative stress in non-alcoholic steatohepatitis]. | 2006 | Details |
| A36998 | 16768108 | Nihon Rinsho | [Mouse NASH model using retinoic acid receptor alpha]. | 2006 | Details |
| A36999 | 16768106 | Nihon Rinsho | [Hepatocyte-specific Pten deficient mice]. | 2006 | Details |
| A37062 | 16540767 | J Clin Gastroenterol | Bariatric surgery: a promising solution for nonalcoholic steatohepatitis in the very obese. | 2006 | Details |
| A37065 | 16535923 | Recenti Prog Med | [Oxidative stress in metabolic syndrome and nonalcoholic steatohepatitis. Is it possible a role for vitamins in clinical practice?]. | 2006 | Details |
| A37081 | 16672825 | J Clin Gastroenterol | Bariatric Surgery: A Promising Solution for Nonalcoholic Steatohepatitis in the Very Obese. | 2006 | Details |
| A37130 | 16406828 | Mitochondrion | Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. | 2006 | Details |
| A37208 | 16257259 | Hepatol Res | Elevation of serum thioredoxin levels in patients with nonalcoholic steatohepatitis. | 2005 | Details |
| A37231 | 16214393 | Hepatol Res | The role of oxidative stress in NASH and fatty liver model. | 2005 | Details |
| A37314 | 15980672 | Korean J Hepatol | [Antioxidant status in nonalcoholic steatohepatitis]. | 2005 | Details |
| A37338 | 15922116 | Med Hypotheses | Acarbose is a promising therapeutic strategy for the treatment of patients with nonalcoholic steatohepatitis (NASH). | 2005 | Details |
| A37360 | 15868369 | J Gastroenterol | Metabolic aspects of hepatitis C viral infection: steatohepatitis resembling but distinct from NASH. | 2005 | Details |
| A37379 | 15820484 | Clin Chim Acta | Glutathione metabolism and antioxidant enzymes in patients affected by nonalcoholic steatohepatitis. | 2005 | Details |
| A37385 | 15800693 | Rom J Gastroenterol | The emerging problem of nonalcoholic steatohepatitis (NASH). | 2005 | Details |
| A37463 | 15625656 | Clin Gastroenterol Hepatol | A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis. | 2004 | Details |
| A37506 | 15526543 | Rom J Intern Med | The risk factors of fibrosis in nonalcoholic steatohepatitis. | 2002 | Details |
| A37595 | 15307867 | Am J Gastroenterol | Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis. | 2004 | Details |
| A37680 | 15122772 | Hepatology | The zonal distribution of megamitochondria with crystalline inclusions in nonalcoholic steatohepatitis. | 2004 | Details |
| A37683 | 24672082 | Curr Ther Res Clin Exp | Vitamin E treatment in patients with nonalcoholic steatohepatitis: A six-month, open-label study of sixteen patients. | 2004 | Details |
| A37708 | 15066643 | Eur J Intern Med | Non-alcoholic steatohepatitis: review of a growing medical problem. | 2004 | Details |
| A37714 | 15057900 | Hepatology | Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosis. | 2004 | Details |
| A37721 | 15044174 | Am J Physiol Gastrointest Liver Physiol | Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model. | 2004 | Details |
| A37724 | 15038668 | Ann Clin Lab Sci | Oxidative stress and enzymatic antioxidant status in patients with nonalcoholic steatohepatitis. | 2004 | Details |
| A37737 | 14985228 | Am J Clin Nutr | Model of nonalcoholic steatohepatitis. | 2004 | Details |
| A37853 | 12946435 | Int Immunopharmacol | T cell proliferative responses to malondialdehyde-acetaldehyde haptenated protein are scavenger receptor mediated. | 2003 | Details |
| A37895 | 12836490 | Acta Clin Belg | Nonalcoholic steatohepatitis and insulin resistance: interface between gastroenterologists and endocrinologists. | 2003 | Details |
| A37988 | 12590240 | J Clin Gastroenterol | Probucol in the treatment of nonalcoholic steatohepatitis: an open-labeled study. | 2003 | Details |
| A37997 | 12541180 | Z Gastroenterol | [NASH -- nonalcoholic steatohepatitis]. | 2003 | Details |
| A38020 | 12480557 | J Hepatol | Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease. | 2003 | Details |
| A38041 | 12425538 | Am J Gastroenterol | Nonalcoholic steatohepatitis: what we know in the new millennium. | 2002 | Details |