Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Insulin resistance7794 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A01377 | 34769060 | Int J Mol Sci | Pathophysiological Molecular Mechanisms of Obesity: A Link between MAFLD and NASH with Cardiovascular Diseases. | 2021 | Details |
| A01378 | 34768942 | Int J Mol Sci | In a Prediabetic Model, Empagliflozin Improves Hepatic Lipid Metabolism Independently of Obesity and before Onset of Hyperglycemia. | 2021 | Details |
| A01381 | 34768440 | J Clin Med | Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study. | 2021 | Details |
| A01386 | 34764881 | Front Physiol | Green Plant Pigment, Chlorophyllin, Ameliorates Non-alcoholic Fatty Liver Diseases (NAFLDs) Through Modulating Gut Microbiome in Mice. | 2021 | Details |
| A01389 | 34763561 | J Int Med Res | Does the FT3-to-FT4 ratio easily predict the progression of NAFLD and NASH cirrhosis? | 2021 | Details |
| A01401 | 34759311 | Nat Commun | Elevated circulating follistatin associates with an increased risk of type 2 diabetes. | 2021 | Details |
| A01403 | 34758930 | Arch Pediatr | The role of nutrition in non-alcoholic fatty liver disease treatment in obese children. | 2021 | Details |
| A01413 | 34757046 | Mol Metab | Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis. | 2021 | Details |
| A01433 | 34749354 | Hum Hered | Association of PNPLA3 I148M with Liver Disease Biomarkers in Latinos. | 2021 | Details |
| A01443 | 34743980 | Eur J Pharmacol | Preventive and therapeutic role of betaine in liver disease: A review on molecular mechanisms. | 2021 | Details |
| A01470 | 34736334 | Ceska Gynekol | Conservative possibilities influencing PCOS syndrome - the importance of nutrition. | 2021 | Details |
| A01472 | 34734674 | Pediatr Obes | Exercise dose on hepatic fat and cardiovascular health in adolescents with excess of adiposity. | 2021 | Details |
| A01473 | 34734480 | J Cell Mol Med | Exercise ameliorates insulin resistance and improves ASK1-mediated insulin signalling in obese rats. | 2021 | Details |
| A01476 | 34734090 | J Immunol Res | Mangiferin Ameliorates HFD-Induced NAFLD through Regulation of the AMPK and NLRP3 Inflammasome Signal Pathways. | 2021 | Details |
| A01485 | 34728268 | Presse Med | Complications of lipodystrophy syndromes. | 2021 | Details |
| A01490 | 34726357 | J Pediatr Endocrinol Metab | Increased hepcidin levels and non-alcoholic fatty liver disease in obese prepubertal children: a further piece to the complex puzzle of metabolic derangements. | 2021 | Details |
| A01492 | 34726148 | Proc Nutr Soc | Dysregulation of hepatic metabolism with obesity: factors influencing glucose and lipid metabolism. | 2021 | Details |
| A01501 | 34722019 | Cureus | Decoding the Pathophysiology of Non-alcoholic Fatty Liver Disease Progressing to Non-alcoholic Steatohepatitis: A Systematic Review. | 2021 | Details |
| A01504 | 34719614 | J Nutr Sci Vitaminol (Tokyo) | Effect of Hyperbaric Oxygen Therapy (HBOT) on Insulin Resistance Associated with Abdominal Obesity in Wistar Rats with Dietary Sucrose-Induced Metabolic Syndrome. | 2021 | Details |
| A01513 | 34712528 | Cureus | An Emerging Facet of Diabetes Mellitus: The Nexus of Gastrointestinal Disorders. | 2021 | Details |
| A01518 | 34711595 | BMJ Open | Association between complement C3 and the prevalence of metabolic-associated fatty liver disease in a Chinese population: a cross-sectional study. | 2021 | Details |
| A01520 | 34710482 | J Hepatol | Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease. | 2021 | Details |
| A01530 | 34707570 | Front Endocrinol (Lausanne) | Hepatic Steatosis Contributes to the Development of Muscle Atrophy via Inter-Organ Crosstalk. | 2021 | Details |
| A01537 | 34706542 | J Agric Food Chem | Sulforaphane Regulates Glucose and Lipid Metabolisms in Obese Mice by Restraining JNK and Activating Insulin and FGF21 Signal Pathways. | 2021 | Details |
| A01540 | 34704339 | Trop Med Int Health | Hepatic steatosis is associated with anthropometry, cardio-metabolic disease risk, sex, age and urbanisation, but not with ethnicity in adult Kenyans. | 2021 | Details |
| A01544 | 34703257 | Diabetes Metab Syndr Obes | QSHY Granules Promote White Adipose Tissue Browning and Correct BCAAs Metabolic Disorder in NAFLD Mice. | 2021 | Details |
| A01546 | 34699301 | Adipocyte | Verapamil induces autophagy to improve liver regeneration in non-alcoholic fatty liver mice. | 2021 | Details |
| A01550 | 34697666 | Handb Exp Pharmacol | Obesity and Obstructive Sleep Apnea. | 2021 | Details |
| A01555 | 34695228 | Eur J Clin Invest | Adipose tissue insulin resistance and lipidome alterations as the characterizing factors of non-alcoholic steatohepatitis. | 2021 | Details |
| A01564 | 34692725 | Front Med (Lausanne) | PNPLA3, TM6SF2, and MBOAT7 Influence on Nutraceutical Therapy Response for Non-alcoholic Fatty Liver Disease: A Randomized Controlled Trial. | 2021 | Details |
| A01577 | 34687092 | Biofactors | Perspectives in liver redox imbalance: Toxicological and pharmacological aspects underlying iron overloading, nonalcoholic fatty liver disease, and thyroid hormone action. | 2021 | Details |
| A01584 | 34684698 | Molecules | Natural Aporphine Alkaloids with Potential to Impact Metabolic Syndrome. | 2021 | Details |
| A01586 | 34684586 | Nutrients | Time-Restricted Feeding during Puberty Ameliorates Adiposity and Prevents Hepatic Steatosis in a Mouse Model of Childhood Obesity. | 2021 | Details |
| A01587 | 34684533 | Nutrients | Supplementation with a Specific Combination of Metabolic Cofactors Ameliorates Non-Alcoholic Fatty Liver Disease, Hepatic Fibrosis, and Insulin Resistance in Mice. | 2021 | Details |
| A01591 | 34684404 | Nutrients | Association between Fasting Ketonuria and Advanced Liver Fibrosis in Non-Alcoholic Fatty Liver Disease Patients without Prediabetes and Diabetes Mellitus. | 2021 | Details |
| A01599 | 34681787 | Int J Mol Sci | The Interplay between Insulin Resistance, Inflammation, Oxidative Stress, Base Excision Repair and Metabolic Syndrome in Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A01612 | 34680476 | Biomedicines | Genetics Is of the Essence to Face NAFLD. | 2021 | Details |
| A01613 | 34680463 | Biomedicines | Non-Alcoholic Fatty Liver Disease in Lean and Non-Obese Individuals: Current and Future Challenges. | 2021 | Details |
| A01622 | 34678374 | Toxicol Appl Pharmacol | Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3. | 2021 | Details |
| A01623 | 34678296 | Clin Chim Acta | The potential pathophysiological role of altered lipid metabolism and electronegative low-density lipoprotein (LDL) in non-alcoholic fatty liver disease and cardiovascular diseases. | 2021 | Details |
| A01624 | 34677420 | Metabolites | Molecular Mechanisms of the SLC13A5 Gene Transcription. | 2021 | Details |
| A01627 | 34677008 | Hepatol Commun | Low Lipoprotein(a) Levels Predict Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A01635 | 34675003 | Diabetes | Hepatic CPT1A Facilitates Liver-Adipose Cross-Talk via Induction of FGF21 in Mice. | 2021 | Details |
| A01637 | 34674510 | Endocrinol Metab (Seoul) | Changes in Insulin Resistance Index and the Risk of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease without Diabetes: Kangbuk Samsung Health Study. | 2021 | Details |
| A01649 | 34668765 | J Med Food | Ameliorative Effect of Myricetin on Nonalcoholic Fatty Liver Disease in ob/ob Mice. | 2021 | Details |
| A01654 | 34666041 | J Biol Chem | Human CEACAM1-LF regulates lipid storage in HepG2 cells via fatty acid transporter CD36. | 2021 | Details |
| A01657 | 34665236 | J Mol Cell Biol | cGAS‒STING signaling and function in metabolism and kidney diseases. | 2021 | Details |
| A01662 | 34663576 | Diabetes | Active Brown Adipose Tissue is Associated With a Healthier Metabolic Phenotype in Obesity. | -- | Details |
| A01675 | 34659125 | Front Endocrinol (Lausanne) | Predictive Modeling of MAFLD Based on Hsp90α and the Therapeutic Application of Teprenone in a Diet-Induced Mouse Model. | 2021 | Details |
| A01680 | 34656650 | J Hepatol | Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling. | 2021 | Details |
| A01684 | 34654976 | Curr Gastroenterol Rep | Dietary Approaches for Management of Non-Alcoholic Fatty Liver Disease: A Clinician's Guide. | 2021 | Details |
| A01688 | 34653686 | Ann Hepatol | Prevalence and predictors of elevated liver enzyme levels in Mexico: The Mexican National Health and Nutrition Survey, 2016. | 2021 | Details |
| A01715 | 34646017 | Nature | Convergent somatic mutations in metabolism genes in chronic liver disease. | 2021 | Details |
| A01731 | 34634561 | Biomed Pharmacother | Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice. | 2021 | Details |
| A01742 | 34630901 | World J Diabetes | Non-alcoholic fatty liver disease in diabetes: When to refer to the hepatologist? | 2021 | Details |
| A01760 | 34627696 | Nutr Metab Cardiovasc Dis | Association between non-alcoholic fatty liver disease and impaired cardiac sympathetic/parasympathetic balance in subjects with and without type 2 diabetes-The Cooperative Health Research in South Tyrol (CHRIS)-NAFLD sub-study. | 2021 | Details |
| A01774 | 34621822 | World J Clin Cases | Influencing factors for hepatic fat accumulation in patients with type 2 diabetes mellitus. | 2021 | Details |
| A01778 | 34621052 | Nat Med | Aramchol in patients with nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase 2b trial. | 2021 | Details |
| A01780 | 34620653 | BMJ Open | Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): a study protocol of an efficacy mechanism evaluation. | 2021 | Details |
| A01783 | 34619074 | Cell Metab | Molecular aspects of fructose metabolism and metabolic disease. | 2021 | Details |
| A01800 | 34610720 | Diabetes Metab J | Rho-Kinase as a Therapeutic Target for Nonalcoholic Fatty Liver Diseases. | 2021 | Details |
| A01802 | 34609305 | Turk J Gastroenterol | Histological Characteristics of Non-alcoholic Steatohepatitis in NAFLD Patients With Low Degree of Hepatocyte Apoptosis. | 2021 | Details |
| A01818 | 34604973 | Eur Rev Med Pharmacol Sci | Multifaceted pathogenesis of liver steatosis in inflammatory bowel disease: a systematic review. | 2021 | Details |
| A01833 | 34601002 | Mol Cell Endocrinol | Patchouli alcohol ameliorates skeletal muscle insulin resistance and NAFLD via AMPK/SIRT1-mediated suppression of inflammation. | 2021 | Details |
| A01840 | 34595203 | Front Nutr | Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial. | 2021 | Details |
| A01846 | 34591986 | Hepatology | OTUB1 alleviates NASH through inhibition of the TRAF6-ASK1 signaling pathways. | 2021 | Details |
| A01863 | 34584580 | Prz Gastroenterol | Association of non-alcoholic fatty liver disease with coronary artery calcification progression: a systematic review and meta-analysis. | 2021 | Details |
| A01867 | 34579641 | Endocr Metab Immune Disord Drug Targets | Adiponectin is Inversely Associated with Insulin Resistance in Adolescents with Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A01869 | 34579016 | Nutrients | Pancreatic β-Cell Dysfunction Is Associated with Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A01872 | 34578867 | Nutrients | Amelioration of Hepatic Steatosis in Mice through Bacteroides uniformis CBA7346-Mediated Regulation of High-Fat Diet-Induced Insulin Resistance and Lipogenesis. | 2021 | Details |
| A01874 | 34578806 | Nutrients | Independent Dose-Response Associations between Fetuin-A and Lean Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A01881 | 34574647 | Int J Environ Res Public Health | Bone Mineral Density in Congenital Generalized Lipodystrophy: The Role of Bone Marrow Tissue, Adipokines, and Insulin Resistance. | 2021 | Details |
| A01887 | 34572442 | Biomedicines | Dietary Patterns Influence Target Gene Expression through Emerging Epigenetic Mechanisms in Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A01893 | 34571189 | J Nutr Biochem | Grape pomace reduces the severity of non-alcoholic hepatic steatosis and the development of steatohepatitis by improving insulin sensitivity and reducing ectopic fat deposition in mice. | 2021 | Details |
| A01908 | 34565261 | Int J Food Sci Nutr | The effect of a Mediterranean diet vs. a low-fat diet on non-alcoholic fatty liver disease in children: a randomized trial. | 2021 | Details |
| A01909 | 34565074 | Rev Cardiovasc Med | Pathophysiological mechanisms and clinical evidence of relationship between Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease. | 2021 | Details |
| A01912 | 34564899 | J Intern Med | Inflammatory and fibrotic mechanisms in NAFLD-Implications for new treatment strategies. | 2021 | Details |
| A01931 | 34558856 | Hepatol Commun | Role of Cholesterol-Associated Steatohepatitis in the Development of NASH. | 2021 | Details |
| A01948 | 34557367 | Cureus | Non-Alcoholic Fatty Liver Disease and Its Association With Diabetes Mellitus. | 2021 | Details |
| A01949 | 34557366 | Cureus | The Troubling Link Between Non-alcoholic Fatty Liver Disease (NAFLD) and Extrahepatic Cancers (EHC). | 2021 | Details |
| A01961 | 34552561 | Front Endocrinol (Lausanne) | GLP-1 and Underlying Beneficial Actions in Alzheimer's Disease, Hypertension, and NASH. | 2021 | Details |
| A01964 | 34550043 | Adipocyte | Sodium glucose cotransporter 2 inhibitor dapagliflozin depressed adiposity and ameliorated hepatic steatosis in high-fat diet induced obese mice. | 2021 | Details |
| A01972 | 34547171 | Liver Int | The role of hepatic lipid composition in obesity-related metabolic disease. | 2021 | Details |
| A01977 | 34543756 | Clin Res Hepatol Gastroenterol | Adipose tissue dysfunction and MAFLD in obesity on the scene of COVID-19. | 2021 | Details |
| A01980 | 34543583 | Arch Physiol Biochem | Dipeptedyl peptidase-4 (DPP-4) inhibitor downregulates HMGB1/TLR4/NF-κB signaling pathway in a diabetic rat model of non-alcoholic fatty liver disease. | 2021 | Details |
| A01998 | 34534913 | Redox Biol | Hepatic Regulator of G Protein Signaling 6 (RGS6) drives non-alcoholic fatty liver disease by promoting oxidative stress and ATM-dependent cell death. | 2021 | Details |
| A01999 | 34534894 | Clin Nutr | Dairy protein intake is inversely related to development of non-alcoholic fatty liver disease. | 2021 | Details |
| A02005 | 34533252 | J Biochem Mol Toxicol | Omarigliptin protects against nonalcoholic fatty liver disease by ameliorating oxidative stress and inflammation. | 2021 | Details |
| A02013 | 34530928 | Microbiome | Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice. | 2021 | Details |
| A02018 | 34529585 | Physiol Int | The "GG" genotype of rs26802 variant in the ghrelin gene is a potential protective factor against nonalcoholic fatty liver disease. | 2021 | Details |
| A02025 | 34528223 | Horm Metab Res | Clinical Value and Role of miR-129-5p in Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A02028 | 34526911 | Front Physiol | Metabolic Changes of Hepatocytes in NAFLD. | 2021 | Details |
| A02031 | 34525916 | Curr Med Chem | Beneficial Effects of Dietary Polyphenols in the Prevention and Treatment of NAFLD: Cell-Signaling Pathways Underlying Health Effects. | 2022 | Details |
| A02042 | 34522493 | Cureus | The Role of Vitamins in Non-Alcoholic Fatty Liver Disease: A Systematic Review. | 2021 | Details |
| A02047 | 34521152 | Liver Int | Higher dietary insulinaemic potential is associated with increased risk of liver steatosis and fibrosis. | 2021 | Details |
| A02057 | 34517466 | Zhonghua Gan Zang Bing Za Zhi | [New development for targeted therapy of non-alcoholic fatty liver disease with thyroid hormone receptor beta]. | 2021 | Details |
| A02074 | 34511814 | J Clin Exp Hepatol | Nonalcoholic Fatty Liver in Lean Individuals: Clinicobiochemical Correlates of Histopathology in 157 Liver Biopsies from Healthy Liver Donors. | 2021 | Details |
| A02080 | 34511460 | Georgian Med News | [METABOLIC FEATURES OF ADIPOSE TISSUE AND CLINICAL SIGNIFICANCE OF ADIPOKINS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE (REVIEW)]. | 2021 | Details |
| A02090 | 34509375 | Surg Obes Relat Dis | Bariatric surgery improves metabolic and nonalcoholic fatty liver disease markers in metabolically healthy patients with morbid obesity at 5 years. | 2021 | Details |
| A02094 | 34508810 | Pharmacol Res | GADD45β stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation. | 2021 | Details |