Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Polyunsaturated Fatty Acids353 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A22028 | 24868294 | Prz Gastroenterol | Dietary recommendations for patients with nonalcoholic fatty liver disease. | 2014 | Details |
| A22104 | 24818764 | Gastroenterology | No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial. | 2014 | Details |
| A22154 | 24784707 | Mol Cell Endocrinol | Resolvin D1 reduces ER stress-induced apoptosis and triglyceride accumulation through JNK pathway in HepG2 cells. | 2014 | Details |
| A22310 | 24673432 | Expert Opin Pharmacother | Treatment options for managing atherogenic dyslipidemia and fatty liver disease. | 2014 | Details |
| A22382 | 24628836 | Liver Int | n-3 polyunsaturated fatty acids worsen inflammation and fibrosis in experimental nonalcoholic steatohepatitis. | 2014 | Details |
| A22388 | 24627299 | Lipids | Effects of a diet rich in n-3 polyunsaturated fatty acids on hepatic lipogenesis and beta-oxidation in mice. | 2014 | Details |
| A22426 | 24587653 | World J Gastroenterol | Dietary habits and behaviors associated with nonalcoholic fatty liver disease. | 2014 | Details |
| A22429 | 24587650 | World J Gastroenterol | Clinical approaches to non-alcoholic fatty liver disease. | 2014 | Details |
| A22431 | 24583757 | J Clin Gastroenterol | Double-blind randomized placebo-controlled clinical trial of omega 3 fatty acids for the treatment of diabetic patients with nonalcoholic steatohepatitis. | 2015 | Details |
| A22509 | 24505350 | PLoS One | Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease. | 2014 | Details |
| A22518 | 24496399 | Food Funct | The role of n - 6 and n - 3 polyunsaturated fatty acids in the manifestation of the metabolic syndrome in cardiovascular disease and non-alcoholic fatty liver disease. | 2014 | Details |
| A22642 | 24388885 | J Physiol Pharmacol | Apolipoprotein E4 allele is associated with substantial changes in the plasma lipids and hyaluronic acid content in patients with nonalcoholic fatty liver disease. | 2013 | Details |
| A22770 | 24321090 | BMC Gastroenterol | Role of serotonin in fatty acid-induced non-alcoholic fatty liver disease in mice. | 2013 | Details |
| A22799 | 24295779 | Biochim Biophys Acta | Omega-3 phospholipids from fish suppress hepatic steatosis by integrated inhibition of biosynthetic pathways in dietary obese mice. | 2014 | Details |
| A22978 | 24148001 | Nutr Rev | Potential treatment of human nonalcoholic fatty liver disease with long-chain omega-3 polyunsaturated fatty acids. | 2013 | Details |
| A22981 | 24140006 | Prostaglandins Leukot Essent Fatty Acids | A diet high in α-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats. | 2013 | Details |
| A23284 | 26405460 | Clin Lipidol | Oxidized metabolites of linoleic acid as biomarkers of liver injury in nonalcoholic steatohepatitis. | 2013 | Details |
| A23334 | 23862644 | Annu Rev Nutr | Omega-3 fatty acids, hepatic lipid metabolism, and nonalcoholic fatty liver disease. | 2013 | Details |
| A23472 | 23749645 | Cancer Res | Proteomic and lipidomic signatures of lipid metabolism in NASH-associated hepatocellular carcinoma. | 2013 | Details |
| A23555 | 23686653 | Obes Surg | Preoperative 4-week supplementation with omega-3 polyunsaturated fatty acids reduces liver volume and facilitates bariatric surgery in morbidly obese patients. | 2013 | Details |
| A23600 | 23641933 | BMC Infect Dis | Plasma metabolomics identifies lipid abnormalities linked to markers of inflammation, microbial translocation, and hepatic function in HIV patients receiving protease inhibitors. | 2013 | Details |
| A23775 | 23492103 | Gut | Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis. | 2013 | Details |
| A23825 | 26064833 | J Lifestyle Med | Regulation of Cholesterol Metabolism in Liver: Link to NAFLD and Impact of n-3 PUFAs. | 2013 | Details |
| A23863 | 23420151 | Clinics (Sao Paulo) | Dietary patterns in Brazilian patients with nonalcoholic fatty liver disease: a cross-sectional study. | 2013 | Details |
| A23906 | 23394094 | Curr Pharm Des | Antioxidant therapy and drugs interfering with lipid metabolism: could they be effective in NAFLD patients? | 2013 | Details |
| A24008 | 23304532 | Int J Hepatol | Multidisciplinary pharmacotherapeutic options for nonalcoholic Fatty liver disease. | 2012 | Details |
| A24112 | 23220074 | Nutr Metab Cardiovasc Dis | Docosahexaenoic acid for the treatment of fatty liver: randomised controlled trial in children. | 2012 | Details |
| A24189 | 23139599 | World J Gastroenterol | Omega-3 fatty acids for the treatment of non-alcoholic fatty liver disease. | 2012 | Details |
| A24304 | 23023705 | J Clin Invest | Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis. | 2012 | Details |
| A24345 | 22981383 | Biochem Pharmacol | Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease. | 2012 | Details |
| A24528 | 22806626 | Hepatology | Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia. | 2012 | Details |
| A24601 | 22706383 | Prostaglandins Other Lipid Mediat | Lipidic last breath of life in patients with alcoholic liver disease. | 2012 | Details |
| A24615 | 22689144 | J Bioenerg Biomembr | Dietary fatty acids modulate liver mitochondrial cardiolipin content and its fatty acid composition in rats with non alcoholic fatty liver disease. | 2012 | Details |
| A24711 | 22570770 | J Nutr Metab | Health implications of high dietary omega-6 polyunsaturated Fatty acids. | 2012 | Details |
| A24808 | 22469640 | J Clin Gastroenterol | The role of nutrients in the development, progression, and treatment of nonalcoholic fatty liver disease. | 2012 | Details |
| A24984 | 22278337 | Diabetologia | Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials. | 2012 | Details |
| A25055 | 22209679 | Clin Nutr | Increased erythrocytes n-3 and n-6 polyunsaturated fatty acids is significantly associated with a lower prevalence of steatosis in patients with type 2 diabetes. | 2011 | Details |
| A25217 | 22087137 | Hepat Mon | HCC, diet and metabolic factors: Diet and HCC. | 2011 | Details |
| A25292 | 21989716 | Mol Cell Biochem | Ω3-Polyunsaturated fatty acids prevent lipoperoxidation, modulate antioxidant enzymes, and reduce lipid content but do not alter glycogen metabolism in the livers of diabetic rats fed on a high fat thermolyzed diet. | 2011 | Details |
| A25298 | 21986673 | Eur J Nutr | Dietary supplementation of herring roe and milt enhances hepatic fatty acid catabolism in female mice transgenic for hTNFα. | 2011 | Details |
| A25398 | 21892559 | Nutr Hosp | Molecular mechanisms of steatosis in nonalcoholic fatty liver disease. | 2012 | Details |
| A25777 | 21470125 | Curr Pharm Biotechnol | Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD). | 2012 | Details |
| A25938 | 21299150 | Acta Gastroenterol Belg | Dietary lipids and NAFLD: suggestions for improved nutrition. | 2011 | Details |
| A26301 | 20683463 | Eur J Clin Nutr | Intake of n-3 polyunsaturated fatty acids and non-alcoholic fatty liver disease: a cross-sectional study in Japanese men and women. | 2010 | Details |
| A26348 | 20619513 | Clin Nutr | The therapeutic potential of long-chain omega-3 fatty acids in nonalcoholic fatty liver disease. | 2010 | Details |
| A26386 | 20553760 | Prog Lipid Res | Biosynthesis and bioavailability of long-chain polyunsaturated fatty acids in non-alcoholic fatty liver disease. | 2010 | Details |
| A26432 | 20465434 | Int J Food Sci Nutr | Effects of a 1-year dietary intervention with n-3 polyunsaturated fatty acid-enriched olive oil on non-alcoholic fatty liver disease patients: a preliminary study. | 2010 | Details |
| A26546 | 20227267 | Prostaglandins Leukot Essent Fatty Acids | Regulation of hepatic gene expression by saturated fatty acids. | 2010 | Details |
| A26574 | 20185414 | J Lipid Res | Dietary fatty acids modulate antigen presentation to hepatic NKT cells in nonalcoholic fatty liver disease. | 2010 | Details |
| A26638 | 20042103 | Lipids Health Dis | Transgenic fat-1 mouse as a model to study the pathophysiology of cardiovascular, neurological and psychiatric disorders. | 2009 | Details |
| A26673 | 20010099 | Curr Opin Gastroenterol | Implications of diet on nonalcoholic fatty liver disease. | 2010 | Details |
| A26737 | 19875987 | Obesity (Silver Spring) | Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients. | 2009 | Details |
| A26789 | 19781663 | Biochim Biophys Acta | n-3 PUFA and lipotoxicity. | 2009 | Details |
| A27164 | 19058085 | Scand J Gastroenterol | Nutritional investigation of non-obese patients with non-alcoholic fatty liver disease: the significance of dietary cholesterol. | 2009 | Details |
| A27195 | 19009658 | World J Gastroenterol | Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia. | 2008 | Details |
| A27234 | 18938777 | Scand J Gastroenterol | Blood oxidative stress markers in non-alcoholic steatohepatitis and how it correlates with diet. | 2008 | Details |
| A27635 | 17868330 | J Gastroenterol Hepatol | Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation. | 2007 | Details |
| A27859 | 17230603 | World J Gastroenterol | Monounsaturated fat decreases hepatic lipid content in non-alcoholic fatty liver disease in rats. | 2007 | Details |
| A28043 | 16611275 | Aliment Pharmacol Ther | Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study. | 2006 | Details |
| A28338 | 15603755 | Mutat Res | Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. | 2005 | Details |
| A28366 | 15454290 | Free Radic Biol Med | Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease. | 2004 | Details |
| A28442 | 14720121 | Clin Sci (Lond) | Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. | 2004 | Details |
| A28524 | 12127930 | Clin Nutr | Plasma total and free fatty acids composition in human non-alcoholic steatohepatitis. | 2002 | Details |
| A28570 | 10422091 | Nutrition | Nutritional and metabolic effects of alcoholism: their relationship with alcoholic liver disease. | 1999 | Details |
| A28766 | 35036409 | Front Nutr | Relationship Between Fish Oil Use and Incidence of Primary Liver Cancer: Findings From a Population-Based Prospective Cohort Study. | 2021 | Details |
| A33915 | 24885871 | Lipids Health Dis | Linoleate appears to protect against palmitate-induced inflammation in Huh7 cells. | 2014 | Details |
| A34247 | 23974795 | Mol Pharmacol | Ursodeoxycholyl lysophosphatidylethanolamide inhibits lipoapoptosis by shifting fatty acid pools toward monosaturated and polyunsaturated fatty acids in mouse hepatocytes. | 2013 | Details |
| A34824 | 22515414 | Nutr Metab (Lond) | Docosahexaenoic acid ameliorates palmitate-induced lipid accumulation and inflammation through repressing NLRC4 inflammasome activation in HepG2 cells. | 2012 | Details |
| A35556 | 20371730 | Dis Model Mech | Medaka as a model for human nonalcoholic steatohepatitis. | 2010 | Details |
| A36404 | 18277895 | J Clin Gastroenterol | Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis. | 2008 | Details |
| A37282 | 16075645 | Klin Med (Mosk) | [Some parameters of carbohydrate and lipid metabolism in patients with non-alcoholic steatohepatitis]. | 2005 | Details |
| A42337 | 34825869 | Curr Drug Metab | Regulatory Effects of N-3 PUFAs on Pancreatic β-cells and Insulin-sensitive Tissues. | 2021 | Details |
| A42710 | 33681679 | Hepatol Commun | Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPARα-FGF21 Axis. | 2020 | Details |
| A42770 | 33525643 | Nutrients | The Marine Microalga, Tisochrysis lutea, Protects against Metabolic Disorders Associated with Metabolic Syndrome and Obesity. | 2021 | Details |
| A43551 | 31434800 | JCI Insight | Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids. | 2019 | Details |
| A43797 | 30862039 | Molecules | Tea Seed Oil Prevents Obesity, Reduces Physical Fatigue, and Improves Exercise Performance in High-Fat-Diet-Induced Obese Ovariectomized Mice. | 2019 | Details |
| A44096 | 29767698 | Adv Nutr | Mechanisms by Which Dietary Fatty Acids Regulate Mitochondrial Structure-Function in Health and Disease. | 2018 | Details |
| A44212 | 29373534 | Nutrients | Betaine Supplementation Enhances Lipid Metabolism and Improves Insulin Resistance in Mice Fed a High-Fat Diet. | 2018 | Details |
| A44511 | 28409336 | Lipids | Dietary Docosahexaenoic Acid and trans-10, cis-12-Conjugated Linoleic Acid Differentially Alter Oxylipin Profiles in Mouse Periuterine Adipose Tissue. | 2017 | Details |
| A44815 | 27208083 | Toxicol Sci | 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) Decreases Hepatic and Systemic Ratios of Epoxide to Diol Metabolites of Unsaturated Fatty Acids in Male Rats. | 2016 | Details |
| A45345 | 25104498 | Am J Physiol Gastrointest Liver Physiol | Activation of N-methyl-d-aspartate receptor downregulates inflammasome activity and liver inflammation via a β-arrestin-2 pathway. | 2014 | Details |
| A45361 | 24993917 | J Nutr Biochem | Reversal of high-fat diet-induced hepatic steatosis by n-3 LCPUFA: role of PPAR-α and SREBP-1c. | 2014 | Details |
| A45408 | 24763554 | Am J Physiol Gastrointest Liver Physiol | Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells. | 2014 | Details |
| A45713 | 23144998 | PLoS One | Type 2 diabetes associated changes in the plasma non-esterified fatty acids, oxylipins and endocannabinoids. | 2012 | Details |
| A46051 | 21409429 | Lipids | Supplementation of monounsaturated and polyunsaturated fatty acids in non-alcoholic fatty liver disease and metabolic syndrome. | 2011 | Details |
| A46068 | 21300117 | J Hepatol | Effect of treatment with polyunsaturated fatty acids on HCV- or diet-induced fatty liver. | 2011 | Details |
| A46114 | 21034259 | Clin Chem Lab Med | Low concentrations of serum n-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease patients with liver injury. | 2010 | Details |
| A46200 | 20402505 | J Proteome Res | Metabolomic assessment of the effect of dietary cholesterol in the progressive development of fatty liver disease. | 2010 | Details |
| A46416 | 18827582 | Curr Opin Clin Nutr Metab Care | Nonalcoholic fatty liver disease: the potential role of nutritional management. | 2008 | Details |
| A46427 | 18752901 | Med Hypotheses | Omega-3 polyunsaturated fatty acids: a specific liver drug for non-alcoholic fatty liver disease (NAFLD). | 2008 | Details |
| A46517 | 18054848 | Dig Liver Dis | Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease. | 2007 | Details |
| A46765 | 15730035 | Ned Tijdschr Geneeskd | [Nonalcoholic steatohepatitis: diagnosis, pathogenesis, treatment and prognosis]. | 2005 | Details |
| A46951 | 32879433 | Commun Biol | Oxidation of fish oil exacerbates alcoholic liver disease by enhancing intestinal dysbiosis in mice. | 2020 | Details |
| A47033 | 28847514 | Biochim Biophys Acta Mol Basis Dis | Omega-3 polyunsaturated fatty acids ameliorate ethanol-induced adipose hyperlipolysis: A mechanism for hepatoprotective effect against alcoholic liver disease. | 2017 | Details |
| A47044 | 28228158 | Lipids Health Dis | Flaxseed oil ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota in mice. | 2017 | Details |
| A47065 | 27220557 | Sci Rep | Dietary α-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissue-liver axis in mice. | 2016 | Details |
| A47077 | 26637972 | Biofactors | Endogenously elevated n-3 polyunsaturated fatty acids alleviate acute ethanol-induced liver steatosis. | 2015 | Details |
| A47185 | 23907024 | Food Chem Toxicol | A role for lipid rafts in the protection afforded by docosahexaenoic acid against ethanol toxicity in primary rat hepatocytes. | 2013 | Details |
| A47215 | 22538404 | Am J Physiol Gastrointest Liver Physiol | Arachidonic acid stimulates TNFα production in Kupffer cells via a reactive oxygen species-pERK1/2-Egr1-dependent mechanism. | 2012 | Details |
| A47240 | 21763219 | J Chromatogr B Analyt Technol Biomed Life Sci | Metabolomics study of alcohol-induced liver injury and hepatocellular carcinoma xenografts in mice. | 2011 | Details |