Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A14375 | 29438776 | Food Chem Toxicol | Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway. | 2018 | Details |
| A14444 | 29404514 | Hepatol Commun | Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice. | 2017 | Details |
| A14460 | 29400692 | J Clin Invest | Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer. | 2018 | Details |
| A14494 | 29382663 | Diabetes | Long Noncoding RNA lncSHGL Recruits hnRNPA1 to Suppress Hepatic Gluconeogenesis and Lipogenesis. | 2018 | Details |
| A14495 | 29381809 | Hepatology | Tumor Progression Locus 2 in Hepatocytes Potentiates Both Liver and Systemic Metabolic Disorders in Mice. | 2018 | Details |
| A14577 | 29343420 | EBioMedicine | AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development. | 2018 | Details |
| A14668 | 29295869 | Endocr Connect | Macrophage activation marker sCD163 correlates with accelerated lipolysis following LPS exposure: a human-randomised clinical trial. | 2018 | Details |
| A14758 | 29251796 | Hepatology | Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation. | 2018 | Details |
| A14953 | 29158183 | Biochim Biophys Acta Mol Basis Dis | Serine prevented high-fat diet-induced oxidative stress by activating AMPK and epigenetically modulating the expression of glutathione synthesis-related genes. | 2017 | Details |
| A15003 | 29128353 | Biochem Biophys Res Commun | Pyruvate dehydrogenase kinase 4 mediates lipogenesis and contributes to the pathogenesis of nonalcoholic steatohepatitis. | 2017 | Details |
| A15042 | 29121675 | PLoS One | Astaxanthin prevents ischemia-reperfusion injury of the steatotic liver in mice. | 2017 | Details |
| A15234 | 29031535 | Chem Biol Interact | Baicalin protects AML-12 cells from lipotoxicity via the suppression of ER stress and TXNIP/NLRP3 inflammasome activation. | 2017 | Details |
| A15315 | 28970254 | FASEB J | Silybin inhibits NLRP3 inflammasome assembly through the NAD+/SIRT2 pathway in mice with nonalcoholic fatty liver disease. | 2018 | Details |
| A15424 | 28919478 | Biochim Biophys Acta Mol Cell Biol Lipids | Atorvastatin reduces lipid accumulation in the liver by activating protein kinase A-mediated phosphorylation of perilipin 5. | 2017 | Details |
| A15468 | 28892558 | Hepatology | The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial. | 2017 | Details |
| A15628 | 28802074 | Hepatology | Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance. | 2017 | Details |
| A15670 | 28775168 | Cancer Res | JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity. | 2017 | Details |
| A15675 | 28771824 | J Cell Biochem | Down-regulation of lncRNA-NEAT1 alleviated the non-alcoholic fatty liver disease via mTOR/S6K1 signaling pathway. | 2017 | Details |
| A15683 | 28763845 | Zhonghua Gan Zang Bing Za Zhi | [Sivelestat alleviates nonalcoholic steatohepatitis in mice through inhibiting activation of Kupffer cells]. | 2017 | Details |
| A15849 | 28683283 | Cell Metab | Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. | 2017 | Details |
| A15893 | 28667176 | J Mol Endocrinol | miR-212-5p suppresses lipid accumulation by targeting FAS and SCD1. | 2017 | Details |
| A16045 | 28595552 | Curr Med Chem | Pigment Epithelium-Derived Factor: A Novel Therapeutic Target for Cardiometabolic Diseases and Related Complications. | 2018 | Details |
| A16160 | 28533219 | Mol Cell Biol | Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver. | 2017 | Details |
| A16179 | 28518142 | Cell Death Dis | MiR-130a-3p attenuates activation and induces apoptosis of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2. | 2017 | Details |
| A16352 | 28442507 | J Endocrinol | Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in mice. | 2017 | Details |
| A16660 | 28258704 | Hepatol Res | Non-alcoholic fatty liver disease phosphoproteomics: A functional piece of the precision puzzle. | 2017 | Details |
| A16668 | 28254760 | Mol Syst Biol | Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD. | 2017 | Details |
| A16809 | 28160259 | J Physiol Biochem | Protein malnutrition during fetal programming induces fatty liver in adult male offspring rats. | 2017 | Details |
| A16861 | 28123944 | Mol Metab | Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1. | 2016 | Details |
| A16987 | 28062946 | J Gastroenterol | Upregulated absorption of dietary palmitic acids with changes in intestinal transporters in non-alcoholic steatohepatitis (NASH). | 2017 | Details |
| A17008 | 28051796 | Ann Hepatol |  Differences in hepatic expression of iron, inflammation and stress-related genes in patients with nonalcoholic steatohepatitis. | 2017 | Details |
| A17068 | 28011404 | Biochim Biophys Acta Mol Cell Biol Lipids | Regulation of SREBP-2 intracellular trafficking improves impaired autophagic flux and alleviates endoplasmic reticulum stress in NAFLD. | 2016 | Details |
| A17089 | 27997977 | Semin Liver Dis | Regulation of Hepatocellular Fatty Acid Uptake in Mouse Models of Fatty Liver Disease with and without Functional Leptin Signaling: Roles of NfKB and SREBP-1C and the Effects of Spexin. | 2016 | Details |
| A17143 | 27959936 | PLoS One | A Low Dose of Dietary Quercetin Fails to Protect against the Development of an Obese Phenotype in Mice. | 2016 | Details |
| A17326 | 27843095 | EBioMedicine | Branched Chain Amino Acids Cause Liver Injury in Obese/Diabetic Mice by Promoting Adipocyte Lipolysis and Inhibiting Hepatic Autophagy. | 2016 | Details |
| A17362 | 27824080 | Sci Rep | Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity. | 2016 | Details |
| A17382 | 27813192 | Clin Exp Pharmacol Physiol | Naltrexone changes the expression of lipid metabolism-related proteins in the endoplasmic reticulum stress induced hepatic steatosis in mice. | 2017 | Details |
| A17383 | 27812974 | Exp Suppl | Structure and Regulation of AMPK. | 2017 | Details |
| A17502 | 27301788 | Hepatology | Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury. | 2016 | Details |
| A17518 | 27760195 | PLoS One | Prolyl Oligopeptidase Inhibition Attenuates Steatosis in the L02 Human Liver Cell Line. | 2016 | Details |
| A17527 | 27738106 | J Biol Chem | Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α. | 2016 | Details |
| A17529 | 27658958 | J Mol Endocrinol | ERK-dependent mTOR pathway is involved in berberine-induced autophagy in hepatic steatosis. | 2016 | Details |
| A17575 | 27739180 | Mol Nutr Food Res | Alterations in the plasma metabolite profile associated with improved hepatic function and glycemia in mice fed lingonberry supplemented high-fat diets. | 2016 | Details |
| A17687 | 27658772 | Gastroenterology | Estrogen Signals Through Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease. | 2016 | Details |
| A17819 | 27562557 | Toxicol Sci | Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis. | 2016 | Details |
| A17994 | 27428872 | Nutr Diabetes | Plasma phospholipids and fatty acid composition differ between liver biopsy-proven nonalcoholic fatty liver disease and healthy subjects. | 2016 | Details |
| A18007 | 27421788 | FASEB J | STK25 is a critical determinant in nonalcoholic steatohepatitis. | 2016 | Details |
| A18029 | 27404485 | FEBS Lett | p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer. | 2016 | Details |
| A18118 | 27343380 | Eur J Pharmacol | (S)YS-51, a novel isoquinoline alkaloid, attenuates obesity-associated non-alcoholic fatty liver disease in mice by suppressing lipogenesis, inflammation and coagulation. | 2016 | Details |
| A18257 | 27261776 | Mol Med | Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance. | 2016 | Details |
| A18326 | 27208776 | Biochem Biophys Res Commun | GLP-1 analogue improves hepatic lipid accumulation by inducing autophagy via AMPK/mTOR pathway. | 2016 | Details |
| A18576 | 27051595 | BBA Clin | Impact of plasma transaminase levels on the peripheral blood glutamate levels and memory functions in healthy subjects. | 2016 | Details |
| A18761 | 26962056 | Toxicol Sci | Vinyl Chloride Metabolites Potentiate Inflammatory Liver Injury Caused by LPS in Mice. | 2016 | Details |
| A18810 | 26926384 | Hepatology | Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. | 2016 | Details |
| A18839 | 26909307 | Mol Metab | High intensity interval training improves liver and adipose tissue insulin sensitivity. | 2015 | Details |
| A18850 | 26903296 | Biochem Biophys Res Commun | Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice. | 2016 | Details |
| A18897 | 26881024 | Oxid Med Cell Longev | Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases. | 2016 | Details |
| A18915 | 26871756 | Can J Physiol Pharmacol | The ergogenic supplement β-hydroxy-β-methylbutyrate (HMB) attenuates insulin resistance through suppressing GLUT-2 in rat liver. | 2015 | Details |
| A18964 | 26846206 | Sci Rep | Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation. | 2016 | Details |
| A18965 | 26845607 | Ann Hepatol |  Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms? | 2017 | Details |
| A19031 | 26811286 | Int Rev Cell Mol Biol | Phosphatidylethanolamine Metabolism in Health and Disease. | 2015 | Details |
| A19045 | 26805874 | Nutrients | Docosahexaenoic Acid Ameliorates Fructose-Induced Hepatic Steatosis Involving ER Stress Response in Primary Mouse Hepatocytes. | 2016 | Details |
| A19126 | 26743335 | Nat Commun | mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2. | 2016 | Details |
| A19213 | 26698881 | J Biol Chem | The Hepatitis C Virus-induced NLRP3 Inflammasome Activates the Sterol Regulatory Element-binding Protein (SREBP) and Regulates Lipid Metabolism. | 2015 | Details |
| A19219 | 26697490 | Biomed Res Int | Quercetin Alleviates High-Fat Diet-Induced Oxidized Low-Density Lipoprotein Accumulation in the Liver: Implication for Autophagy Regulation. | 2015 | Details |
| A19229 | 26687947 | Biochem Biophys Res Commun | Inhibition of mTOR improves the impairment of acidification in autophagic vesicles caused by hepatic steatosis. | 2015 | Details |
| A19242 | 26676813 | Semin Liver Dis | Insights from Genome-Wide Association Analyses of Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A19289 | 26648069 | Curr Drug Targets | Biology, Epidemiology, Clinical Aspects of Hepatocellular Carcinoma and the Role of Sorafenib. | 2016 | Details |
| A19312 | 26634892 | Phytother Res | Gastrodin Ameliorates Oxidative Stress and Proinflammatory Response in Nonalcoholic Fatty Liver Disease through the AMPK/Nrf2 Pathway. | 2015 | Details |
| A19336 | 26621917 | J Lipid Res | Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner. | 2015 | Details |
| A19454 | 26560698 | J Exp Clin Cancer Res | Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice. | 2015 | Details |
| A19480 | 26536464 | PLoS One | Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet. | 2015 | Details |
| A19503 | 26517932 | Biochem Soc Trans | The TRIB3 Q84R polymorphism, insulin resistance and related metabolic alterations. | 2015 | Details |
| A19504 | 26517927 | Biochem Soc Trans | Tribbles-1: a novel regulator of hepatic lipid metabolism in humans. | 2015 | Details |
| A19505 | 26517924 | Biochem Soc Trans | The role of TRIB1 in lipid metabolism; from genetics to pathways. | 2015 | Details |
| A19639 | 26442880 | Am J Physiol Endocrinol Metab | Hydrogen sulfide reduces serum triglyceride by activating liver autophagy via the AMPK-mTOR pathway. | 2015 | Details |
| A19709 | 26400185 | Am J Physiol Regul Integr Comp Physiol | Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism. | 2015 | Details |
| A19814 | 26330688 | Trans Am Clin Climatol Assoc | A Lipidomic Readout of Disease Progression in A Diet-Induced Mouse Model of Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A19827 | 26322888 | PLoS One | Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A19959 | 26240153 | J Biol Chem | Sphingosine Kinase 1 Protects Hepatocytes from Lipotoxicity via Down-regulation of IRE1α Protein Expression. | 2015 | Details |
| A20025 | 26201023 | Clin Sci (Lond) | Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis. | 2015 | Details |
| A20115 | 26147081 | Nature | The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. | 2015 | Details |
| A20283 | 26046396 | Nutrients | Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) Is a Novel Nutritional Therapeutic Target for Hyperlipidemia, Non-Alcoholic Fatty Liver Disease, and Atherosclerosis. | 2015 | Details |
| A20292 | 26042770 | PLoS One | mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). | 2015 | Details |
| A20389 | 25998209 | Hepatology | Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice. | 2015 | Details |
| A20461 | 25947379 | J Biol Chem | 1-Deoxysphingolipids Encountered Exogenously and Made de Novo: Dangerous Mysteries inside an Enigma. | 2015 | Details |
| A20498 | 25921304 | J Lipid Res | Sin3A-associated protein, 18 kDa, a novel binding partner of TRIB1, regulates MTTP expression. | 2015 | Details |
| A20545 | 25896720 | Pharmacology | Fenofibrate treatment attenuated chronic endoplasmic reticulum stress in the liver of nonalcoholic fatty liver disease mice. | 2015 | Details |
| A20644 | 25836944 | Diabetes Res Clin Pract | Lower serum fibroblast activation protein shows promise in the exclusion of clinically significant liver fibrosis due to non-alcoholic fatty liver disease in diabetes and obesity. | 2015 | Details |
| A20669 | 25817233 | Life Sci | AMP-kinase pathway is involved in tumor necrosis factor alpha-induced lipid accumulation in human hepatoma cells. | 2015 | Details |
| A20680 | 25805927 | World J Gastroenterol | Ghrelin-ghrelin O-acyltransferase system in the pathogenesis of nonalcoholic fatty liver disease. | 2015 | Details |
| A20896 | 25655997 | J Ethnopharmacol | Total aralosides of aralia elata (Miq) seem (TASAES) ameliorate nonalcoholic steatohepatitis by modulating IRE1α-mediated JNK and NF-κB pathways in ApoE-/- mice. | 2015 | Details |
| A20916 | 25646773 | PLoS One | Livers with constitutive mTORC1 activity resist steatosis independent of feedback suppression of Akt. | 2015 | Details |
| A20945 | 25623824 | J Hepatol | Regular exercise decreases liver tumors development in hepatocyte-specific PTEN-deficient mice independently of steatosis. | 2015 | Details |
| A20949 | 25622557 | Int J Biochem Cell Biol | Activation of mTORC1 disrupted LDL receptor pathway: a potential new mechanism for the progression of non-alcoholic fatty liver disease. | 2015 | Details |
| A20973 | 25609431 | FASEB J | Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH. | 2015 | Details |
| A20975 | 25607821 | Oncol Rep | Hepatic expression of the Sptlc3 subunit of serine palmitoyltransferase is associated with the development of hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis. | 2015 | Details |
| A21390 | 25353341 | Arch Physiol Biochem | Phosphorylation of sterol regulatory element-binding protein (SREBP)-1c by p38 kinases, ERK and JNK influences lipid metabolism and the secretome of human liver cell line HepG2. | 2014 | Details |
| A21503 | 25269746 | Mol Med Rep | Upregulated microRNA-199a-5p inhibits nuclear receptor corepressor 1 translation in mice with non‑alcoholic steatohepatitis. | 2014 | Details |
| A21528 | 25252208 | Acta Cir Bras | Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats. | 2014 | Details |