Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Toll-like receptor 4290 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A24913 | 22367065 | Dig Dis Sci | Innate immune reactivity of the ileum-liver axis in nonalcoholic steatohepatitis. | 2012 | Details |
| A24968 | 22297845 | Nature | Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. | 2012 | Details |
| A24972 | 22294100 | Cell Mol Life Sci | A role for sphingolipids in the pathophysiology of obesity-induced inflammation. | 2012 | Details |
| A25004 | 22253482 | Gut | Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice. | 2012 | Details |
| A25415 | 25755327 | J Clin Exp Hepatol | Nuclear Factor High-mobility Group Box1 Mediating the Activation of Toll-like Receptor 4 Signaling in Hepatocytes in the Early Stage of Non-alcoholic Fatty Liver Disease in Mice. | 2011 | Details |
| A25459 | 21809356 | Hepatology | Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. | 2011 | Details |
| A25570 | 21703208 | J Hepatol | DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH. | 2011 | Details |
| A25745 | 21488066 | Hepatology | Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. | 2011 | Details |
| A25781 | 21463337 | Alcohol Clin Exp Res | A new model of interactive effects of alcohol and high-fat diet on hepatic fibrosis. | 2011 | Details |
| A25808 | 21439567 | Atherosclerosis | Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type 2 diabetes and non-alcoholic fatty liver disease. | 2011 | Details |
| A25988 | 21233280 | Am J Physiol Gastrointest Liver Physiol | Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice. | 2011 | Details |
| A26185 | 20940109 | Clin Immunol | Status of bacterial colonization, Toll-like receptor expression and nuclear factor-kappa B activation in normal and diseased human livers. | 2010 | Details |
| A26403 | 20509914 | BMC Gastroenterol | Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis. | 2010 | Details |
| A26647 | 21525758 | Dig Dis | Gut-liver axis and sensing microbes. | 2011 | Details |
| A26859 | 19637282 | Hepatology | Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. | 2009 | Details |
| A26966 | 19447517 | J Hepatol | Kupffer cells in non-alcoholic fatty liver disease: the emerging view. | 2009 | Details |
| A27106 | 19165171 | Obesity (Silver Spring) | Liver NF-kappaB and AP-1 DNA binding in obese patients. | 2009 | Details |
| A27137 | 19115316 | Hepatology | VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice. | 2009 | Details |
| A27175 | 19034968 | World J Gastroenterol | Innate immune reactivity of the liver in rats fed a choline-deficient L-amino-acid-defined diet. | 2008 | Details |
| A27325 | 18641190 | J Nutr | Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. | 2008 | Details |
| A27485 | 18302012 | Inflammation | Effects of traditional chinese medicine on endotoxin and its receptors in rats with non-alcoholic steatohepatitis. | 2008 | Details |
| A27522 | 18198478 | J Toxicol Sci | Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis. | 2007 | Details |
| A28221 | 16092984 | Zhonghua Gan Zang Bing Za Zhi | [A study of the changes of hepatic gene expression in the process of nonalcoholic fatty liver disease development using U230A oligonucleotide microarray]. | 2005 | Details |
| A28698 | 35116066 | Evid Based Complement Alternat Med | Evaluation of the Mechanism of Modified Lingguizhugan Decoction in the Treatment of Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A29183 | 34441565 | Foods | White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice. | 2021 | Details |
| A30360 | 32575352 | Microorganisms | Bile Acid Sequestrant, Sevelamer Ameliorates Hepatic Fibrosis with Reduced Overload of Endogenous Lipopolysaccharide in Experimental Nonalcoholic Steatohepatitis. | 2020 | Details |
| A30893 | 31610032 | Hepatology | Yes-Associated Protein in Kupffer Cells Enhances the Production of Proinflammatory Cytokines and Promotes the Development of Nonalcoholic Steatohepatitis. | 2020 | Details |
| A31018 | 31388630 | Hepatol Commun | Lipoprotein Lipase Up-regulation in Hepatic Stellate Cells Exacerbates Liver Fibrosis in Nonalcoholic Steatohepatitis in Mice. | 2019 | Details |
| A31144 | 31177586 | Hepatol Res | Combined effect of a farnesoid X receptor agonist and dipeptidyl peptidase-4 inhibitor on hepatic fibrosis. | 2019 | Details |
| A31384 | 30675167 | Stem Cells Int | Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats. | 2018 | Details |
| A31978 | 29404501 | Hepatol Commun | Effect of combined farnesoid X receptor agonist and angiotensin II type 1 receptor blocker on hepatic fibrosis. | 2017 | Details |
| A32208 | 31966360 | Int J Clin Exp Pathol | Glycine protects against non-alcoholic hepatitis by downregulation of the TLR4 signaling pathway. | 2017 | Details |
| A34295 | 23832448 | Hepatology | Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice. | 2013 | Details |
| A35342 | 21046243 | Dig Dis Sci | Small intestinal bacterial overgrowth in nonalcoholic steatohepatitis: association with toll-like receptor 4 expression and plasma levels of interleukin 8. | 2010 | Details |
| A43060 | 32668973 | Am J Chin Med | Gastrodin Pretreatment Protects Liver Against Ischemia-Reperfusion Injury via Activation of the Nrf2/HO-1 Pathway. | 2020 | Details |
| A43073 | 32626927 | Mol Med Rep | TLR4 mediates inflammation and hepatic fibrosis induced by chronic intermittent hypoxia in rats. | 2020 | Details |
| A43573 | 31378113 | J Int Med Res | Tanshinone IIA ameliorates non-alcoholic fatty liver disease through targeting peroxisome proliferator-activated receptor gamma and toll-like receptor 4. | 2019 | Details |
| A43623 | 31264285 | J Cell Biochem | Effect of oleic acid on induction of steatosis and cytotoxicity in BRL 3A cells. | 2019 | Details |
| A43660 | 31162673 | Alcohol Clin Exp Res | Chalcone Derivative L6H21 Reduces EtOH + LPS-Induced Liver Injury Through Inhibition of NLRP3 Inflammasome Activation. | 2019 | Details |
| A43974 | 30265151 | Am J Physiol Heart Circ Physiol | Western diet triggers Toll-like receptor 4 signaling-induced endothelial dysfunction in female Wistar rats. | 2018 | Details |
| A44910 | 26858005 | Alcohol Clin Exp Res | Chronic Alcohol Consumption Causes Liver Injury in High-Fructose-Fed Male Mice Through Enhanced Hepatic Inflammatory Response. | 2016 | Details |
| A44938 | 26676812 | Semin Liver Dis | Genetics of Alcoholic Liver Disease. | 2015 | Details |
| A45186 | 25774554 | Endocrinology | Vitamin d deficiency attenuates high-fat diet-induced hyperinsulinemia and hepatic lipid accumulation in male mice. | 2015 | Details |
| A45461 | 24445036 | J Nutr Biochem | Bifidobacterium adolescentis protects from the development of nonalcoholic steatohepatitis in a mouse model. | 2013 | Details |
| A45773 | 22823912 | J Gastroenterol Hepatol | Enhancing organ pool by statins: is this the future? | 2012 | Details |
| A45924 | 22045668 | Hepatology | Pathogen- or damage-associated molecular patterns during nonalcoholic fatty liver disease development. | 2011 | Details |
| A46069 | 21286336 | Hepatol Int | The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases. | 2010 | Details |
| A46116 | 20967824 | Hepatology | Activation of the endotoxin/toll-like receptor 4 pathway: the way to go from nonalcoholic steatohepatitis up to hepatocellular carcinoma. | 2010 | Details |
| A46289 | 19763702 | J Gastrointest Surg | Downregulation of adiponectin/AdipoR2 is associated with steatohepatitis in obese mice. | 2009 | Details |
| A46342 | 19440711 | Semin Immunopathol | The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis: two triggers for one disease? | 2009 | Details |
| A46747 | 15976528 | Alcohol Clin Exp Res | Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression. | 2005 | Details |
| A46925 | 34068838 | Nutrients | Markers of Intestinal Permeability Are Rapidly Improved by Alcohol Withdrawal in Patients with Alcohol-Related Liver Disease. | 2021 | Details |
| A47015 | 29884546 | Mol Metab | Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease. | 2018 | Details |
| A47140 | 25132354 | Hepatology | Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice. | 2014 | Details |
| A47181 | 24020403 | Int J Exp Pathol | Experimental rat model for alcohol-induced osteonecrosis of the femoral head. | 2013 | Details |
| A47197 | 23277536 | J Pharmacol Exp Ther | Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression. | 2012 | Details |
| A47333 | 16439473 | Am J Physiol Gastrointest Liver Physiol | Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity. | 2006 | Details |
| A47705 | 33297569 | Cells | Function of TREM1 and TREM2 in Liver-Related Diseases. | 2020 | Details |
| A47769 | 32220799 | Biomaterials | The αC helix of TIRAP holds therapeutic potential in TLR-mediated autoimmune diseases. | 2020 | Details |
| A47878 | 30202816 | Hepatol Commun | High-Mobility Group Box-1 and Liver Disease. | 2018 | Details |
| A48006 | 26781175 | Mol Med Rep | TLR4‑dependent signaling pathway modulation: A novel mechanism by which pioglitazone protects against nutritional fibrotic steatohepatitis in mice. | 2016 | Details |
| A48048 | 25715168 | J Interferon Cytokine Res | Interferon-β Mediates Signaling Pathways Uniquely Regulated in Hepatic Stellate Cells and Attenuates the Progression of Hepatic Fibrosis in a Dietary Mouse Model. | 2015 | Details |
| A48272 | 17916356 | Gastroenterology | Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection. | 2007 | Details |
| A48331 | 16344599 | Alcohol Clin Exp Res | Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4. | 2005 | Details |
| A48754 | 29687200 | Probiotics Antimicrob Proteins | Are Probiotics Effective in Targeting Alcoholic Liver Diseases? | 2019 | Details |
| A48907 | 24824124 | Zhonghua Gan Zang Bing Za Zhi | [TLR4 contributes to intestinal hyperpermeability in alcoholic liver disease]. | 2014 | Details |
| A48921 | 24400890 | J Cell Mol Med | The functional role of microRNAs in alcoholic liver injury. | 2014 | Details |
| A48936 | 23871536 | Alcohol | Toll-like receptor 4 increases intestinal permeability through up-regulation of membrane PKC activity in alcoholic steatohepatitis. | 2013 | Details |
| A49010 | 21463341 | Alcohol Clin Exp Res | Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. | 2011 | Details |
| A49101 | 17644211 | J Hepatol | Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. | 2007 | Details |
| A49234 | 35813333 | Ann Transl Med | Yinzhihuang oral liquid protects against non-alcoholic steatohepatitis via modulation of the gut-liver axis in mice. | 2022 | Details |
| A49377 | 35769208 | Mediators Inflamm | MFG-E8 Knockout Aggravated Nonalcoholic Steatohepatitis by Promoting the Activation of TLR4/NF-κB Signaling in Mice. | 2022 | Details |
| A49524 | 35726797 | Food Funct | Astragalus mongholicus polysaccharides ameliorate hepatic lipid accumulation and inflammation as well as modulate gut microbiota in NAFLD rats. | 2022 | Details |
| A49739 | 35654114 | Metabolism | GW9662, a peroxisome proliferator-activated receptor gamma antagonist, attenuates the development of non-alcoholic fatty liver disease. | 2022 | Details |
| A49823 | 35628290 | Int J Mol Sci | Oxy210, a Semi-Synthetic Oxysterol, Exerts Anti-Inflammatory Effects in Macrophages via Inhibition of Toll-like Receptor (TLR) 4 and TLR2 Signaling and Modulation of Macrophage Polarization. | 2022 | Details |
| A49846 | 35623174 | Biomed Pharmacother | Corydalis saxicola Bunting Total Alkaloids ameliorate diet-induced non-alcoholic steatohepatitis by regulating hepatic PI3K/Akt and TLR4/NF-κB pathways in mice. | 2022 | Details |
| A50273 | 35447899 | Mar Drugs | Fucoxanthin Attenuates Free Fatty Acid-Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism/Oxidative Stress/Inflammation via the AMPK/Nrf2/TLR4 Signaling Pathway. | 2022 | Details |
| A50299 | 35439472 | Chem Biol Interact | Obeticholic acid orchestrates the crosstalk between ileal autophagy and tight junctions in non-alcoholic steatohepatitis: Role of TLR4/TGF-β1 axis. | 2022 | Details |
| A50338 | 35429042 | FASEB J | Serpina3c deficiency induced necroptosis promotes non-alcoholic fatty liver disease through β-catenin/Foxo1/TLR4 signaling. | 2022 | Details |
| A50428 | 35396090 | J Pediatr Surg | The preventive effect of recombinant human hepatocyte growth factor for hepatic steatosis in a rat model of short bowel syndrome. | 2022 | Details |
| A50747 | 35279807 | Indian J Gastroenterol | Effect of combined farnesoid X receptor agonist and angiotensin II type 1 receptor blocker on ongoing hepatic fibrosis. | 2022 | Details |
| A50771 | 35272137 | Biomed Pharmacother | The contribution of sterile inflammation to the fatty liver disease and the potential therapies. | 2022 | Details |
| A51340 | 35490239 | Inflamm Regen | Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome. | 2022 | Details |
| A51428 | 35514019 | Dig Liver Dis | Rifaximin and lubiprostone mitigate liver fibrosis development by repairing gut barrier function in diet-induced rat steatohepatitis. | 2022 | Details |
| A51851 | 33680863 | Toxicol Rep | Alcohol-associated liver disease: A review on its pathophysiology, diagnosis and drug therapy. | 2021 | Details |
| A52056 | 31822562 | J Biol Chem | Distinct alterations of gut morphology and microbiota characterize accelerated diabetes onset in nonobese diabetic mice. | 2019 | Details |
| A52636 | 24425726 | Adv Nutr | Impact of new-generation lipid emulsions on cellular mechanisms of parenteral nutrition-associated liver disease. | 2014 | Details |
| A52678 | 23687413 | World J Gastroenterol | Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats. | 2013 | Details |
| A52685 | 23551521 | J Intern Med | Ectopic lipid storage and insulin resistance: a harmful relationship. | 2013 | Details |
| A52857 | 20592272 | Endocr Rev | Gut microbiota, lipopolysaccharides, and innate immunity in the pathogenesis of obesity and cardiovascular risk. | 2010 | Details |