Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A21657 | 25145475 | Hepatology | The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease. | 2014 | Details |
| A21663 | 25140191 | Nutr Metab (Lond) | Effects and mechanisms of resveratrol on the amelioration of oxidative stress and hepatic steatosis in KKAy mice. | 2014 | Details |
| A21666 | 25138021 | J Pharmacol Exp Ther | Thrombin inhibition with dabigatran protects against high-fat diet-induced fatty liver disease in mice. | 2014 | Details |
| A21668 | 25136608 | Biomed Res Int | Ruscogenin ameliorates experimental nonalcoholic steatohepatitis via suppressing lipogenesis and inflammatory pathway. | 2014 | Details |
| A21673 | 25130427 | Hepatology | Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting. | 2014 | Details |
| A21676 | 25127738 | Trends Endocrinol Metab | Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism. | 2014 | Details |
| A21682 | 25123088 | Toxicology | Genotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver. | 2014 | Details |
| A21693 | 25116118 | Planta Med | Ruscogenin protects against high-fat diet-induced nonalcoholic steatohepatitis in hamsters. | 2014 | Details |
| A21695 | 25112833 | J Endocrinol | Perinatal exposure to bisphenol A exacerbates nonalcoholic steatohepatitis-like phenotype in male rat offspring fed on a high-fat diet. | 2014 | Details |
| A21709 | 25102981 | Dig Dis Sci | Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease. | 2014 | Details |
| A21733 | 25083607 | Gastroenterology | Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets. | 2014 | Details |
| A21734 | 25083081 | World J Gastroenterol | Potential roles of glucagon-like peptide-1-based therapies in treating non-alcoholic fatty liver disease. | 2014 | Details |
| A21750 | 25072743 | J Med Food | Functional and metabolic disorders in celiac disease: new implications for nutritional treatment. | 2014 | Details |
| A21751 | 25072708 | PLoS One | Identification of novel regulatory cholesterol metabolite, 5-cholesten, 3β,25-diol, disulfate. | 2014 | Details |
| A21753 | 25071327 | World J Gastroenterol | Non-alcoholic fatty liver disease and obesity: biochemical, metabolic and clinical presentations. | 2014 | Details |
| A21759 | 25066109 | Diabetes Metab Res Rev | GLP-1 receptor agonists: effects on the progression of non-alcoholic fatty liver disease. | 2014 | Details |
| A21760 | 25065280 | Arch Iran Med | Regulation of adipokines by polyunsaturated fatty acids in a rat model of non-alcoholic steatohepatitis. | 2014 | Details |
| A21767 | 25060692 | Metabolism | Shifts in dietary carbohydrate-lipid exposure regulate expression of the non-alcoholic fatty liver disease-associated gene PNPLA3/adiponutrin in mouse liver and HepG2 human liver cells. | 2014 | Details |
| A21787 | 25045276 | Clin Exp Gastroenterol | Molecular pathways in non-alcoholic fatty liver disease. | 2014 | Details |
| A21799 | 25036839 | Biosci Biotechnol Biochem | Attenuation by a Vigna nakashimae extract of nonalcoholic fatty liver disease in high-fat diet-fed mice. | 2014 | Details |
| A21800 | 25035929 | Biochem Biophys Res Commun | PKCδ regulates hepatic triglyceride accumulation and insulin signaling in Lepr(db/db) mice. | 2014 | Details |
| A21801 | 25035342 | Arterioscler Thromb Vasc Biol | Links between ectopic fat and vascular disease in humans. | 2014 | Details |
| A21813 | 25028495 | Proc Natl Acad Sci U S A | Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease. | 2014 | Details |
| A21815 | 25026599 | Biochem Pharmacol | Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice. | 2014 | Details |
| A21841 | 25009382 | World J Gastroenterol | Non-alcoholic fatty liver disease and thyroid dysfunction: a systematic review. | 2014 | Details |
| A21842 | 25008241 | Mol Cell Endocrinol | Role of aquaglyceroporins and caveolins in energy and metabolic homeostasis. | 2014 | Details |
| A21847 | 25003671 | Turk J Gastroenterol | Role of gut microbiota: obesity and NAFLD. | 2014 | Details |
| A21850 | 25003023 | FEBS Open Bio | Senescence marker protein-30/superoxide dismutase 1 double knockout mice exhibit increased oxidative stress and hepatic steatosis. | 2014 | Details |
| A21854 | 24998389 | Sci Rep | Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model. | 2014 | Details |
| A21860 | 24993341 | Int Immunopharmacol | Involvement of hepatic peroxisome proliferator-activated receptor α/γ in the therapeutic effect of osthole on high-fat and high-sucrose-induced steatohepatitis in rats. | 2014 | Details |
| A21875 | 24987492 | Oxid Med Cell Longev | Serum oxidative stress markers and lipidomic profile to detect NASH patients responsive to an antioxidant treatment: a pilot study. | 2014 | Details |
| A21877 | 24985011 | Nutrition | Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation. | 2013 | Details |
| A21891 | 24976401 | Biochem Biophys Res Commun | NHE1 deficiency in liver: implications for non-alcoholic fatty liver disease. | 2014 | Details |
| A21910 | 24967351 | Biomed Res Int | Enhanced amelioration of high-fat diet-induced fatty liver by docosahexaenoic acid and lysine supplementations. | 2014 | Details |
| A21912 | 24966608 | World J Gastroenterol | Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease. | 2014 | Details |
| A21913 | 24966607 | World J Gastroenterol | Effects of resveratrol and other polyphenols in hepatic steatosis. | 2014 | Details |
| A21917 | 24966603 | World J Gastroenterol | Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease: a controversial issue. | 2014 | Details |
| A21920 | 24966582 | World J Gastroenterol | Pathogenesis and significance of hepatitis C virus steatosis: an update on survival strategy of a successful pathogen. | 2014 | Details |
| A21924 | 24962805 | Diabetes Obes Metab | Abdominal subcutaneous adipose tissue insulin resistance and lipolysis in patients with non-alcoholic steatohepatitis. | 2014 | Details |
| A21930 | 24958099 | Mol Cell Biol | Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance. | 2014 | Details |
| A21966 | 24927063 | Mol Med Rep | Radix Hedysari polysaccharide suppresses lipid metabolism dysfunction in a rat model of non‑alcoholic fatty liver disease via adenosine monophosphate‑activated protein kinase pathway activation. | 2014 | Details |
| A21979 | 24918580 | PLoS One | Gallic acid ameliorated impaired glucose and lipid homeostasis in high fat diet-induced NAFLD mice. | 2014 | Details |
| A21981 | 24917523 | Hepatology | Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis. | 2014 | Details |
| A21995 | 24903159 | Pediatr Obes | Predicting hepatic steatosis and liver fat content in obese children based on biochemical parameters and anthropometry. | 2014 | Details |
| A22001 | 24900988 | Biomed Res Int | ATF4- and CHOP-dependent induction of FGF21 through endoplasmic reticulum stress. | 2014 | Details |
| A22003 | 24899308 | Nature | The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. | 2014 | Details |
| A22017 | 24887406 | BMC Pharmacol Toxicol | Uridine prevents tamoxifen-induced liver lipid droplet accumulation. | 2014 | Details |
| A22032 | 24864249 | Biomed Res Int | Endocannabinoid receptors gene expression in morbidly obese women with nonalcoholic fatty liver disease. | 2014 | Details |
| A22038 | 24858832 | PLoS One | β-Cryptoxanthin alleviates diet-induced nonalcoholic steatohepatitis by suppressing inflammatory gene expression in mice. | 2014 | Details |
| A22040 | 24857364 | J Agric Food Chem | Garlic essential oil protects against obesity-triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress. | 2014 | Details |
| A22043 | 24854865 | FEBS J | Overexpression of juxtaposed with another zinc finger gene 1 reduces proinflammatory cytokine release via inhibition of stress-activated protein kinases and nuclear factor-κB. | 2014 | Details |
| A22049 | 24850609 | Georgian Med News | [Effect of gene polymorphism of PPARgamma2 regulatory proteins on the metabolic syndrome in children with nonalcoholic fatty liver disease and obesity]. | 2014 | Details |
| A22062 | 24845341 | Liver Int | Reduced hepatic lipid content in Pten-haplodeficient mice because of enhanced AKT2/PKBβ activation in skeletal muscle. | 2014 | Details |
| A22067 | 24843703 | J Diabetes Investig | Role of thiazolidinediones, insulin sensitizers, in non-alcoholic fatty liver disease. | 2013 | Details |
| A22069 | 24842304 | J Hepatol | Homozygous MTTP and APOB mutations may lead to hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia. | 2014 | Details |
| A22077 | 24834836 | Biol Rev Camb Philos Soc | Intracellular role of exchangeable apolipoproteins in energy homeostasis, obesity and non-alcoholic fatty liver disease. | 2014 | Details |
| A22082 | 24830603 | Exp Mol Pathol | Lipidomic analysis of the liver from high-fat diet induced obese mice identifies changes in multiple lipid classes. | 2014 | Details |
| A22091 | 24828988 | Eur J Clin Invest | Hepatic steatosis and PNPLA3 I148M variant are associated with serum Fetuin-A independently of insulin resistance. | 2014 | Details |
| A22092 | 24827819 | Mol Nutr Food Res | Effect of methionine-deficient and methionine-supplemented diets on the hepatic one-carbon and lipid metabolism in mice. | 2014 | Details |
| A22102 | 24819989 | Steroids | Bile acids are nutrient signaling hormones. | 2014 | Details |
| A22103 | 24819229 | Metab Syndr Relat Disord | Interrelationships of serum androgens, omental adipose tissue metabolism, and nonalcoholic fatty liver disease in obese premenopausal women. | 2014 | Details |
| A22105 | 24816759 | Horm Metab Res | Effect of fructose and 3,5-diiodothyronine (3,5-T(2)) on lipid accumulation and insulin signalling in non-alcoholic fatty liver disease (NAFLD)-like rat primary hepatocytes. | 2014 | Details |
| A22115 | 24806753 | Hepatology | FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis. | 2014 | Details |
| A22117 | 24803983 | Oxid Med Cell Longev | BL153 partially prevents high-fat diet induced liver damage probably via inhibition of lipid accumulation, inflammation, and oxidative stress. | 2014 | Details |
| A22124 | 24799985 | World J Hepatol | Lipid lowering effects of iodothyronines: In vivo and in vitro studies on rat liver. | 2014 | Details |
| A22141 | 24793377 | Food Chem Toxicol | Comparative study of bisphenol A and its analogue bisphenol S on human hepatic cells: a focus on their potential involvement in nonalcoholic fatty liver disease. | 2014 | Details |
| A22146 | 24789994 | Am J Physiol Regul Integr Comp Physiol | Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity. | 2014 | Details |
| A22165 | 24775093 | J Nutr Biochem | Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome. | 2014 | Details |
| A22170 | 24769275 | Clin Biochem | Low normal thyroid function attenuates serum alanine aminotransferase elevations in the context of metabolic syndrome and insulin resistance in white people. | 2014 | Details |
| A22176 | 24766298 | Expert Opin Drug Discov | Evolving therapies for non-alcoholic steatohepatitis. | 2014 | Details |
| A22185 | 24760992 | Am J Physiol Endocrinol Metab | Mice lacking NOX2 are hyperphagic and store fat preferentially in the liver. | 2014 | Details |
| A22219 | 24743428 | Arterioscler Thromb Vasc Biol | Ectopic fat, insulin resistance, and nonalcoholic fatty liver disease: implications for cardiovascular disease. | 2014 | Details |
| A22220 | 24743120 | Georgian Med News | [Mechanisms of formation and progression of non-alcoholic fatty liver disease in type 2 diabetics]. | 2014 | Details |
| A22222 | 24742471 | J Nutr Biochem | Insight into the impact of dietary saturated fat on tissue-specific cellular processes underlying obesity-related diseases. | 2014 | Details |
| A22226 | 24740208 | Am J Clin Nutr | Dairy fat intake is associated with glucose tolerance, hepatic and systemic insulin sensitivity, and liver fat but not β-cell function in humans. | 2014 | Details |
| A22229 | 24738611 | Clin Sci (Lond) | Ectopic lipid storage in non-alcoholic fatty liver disease is not mediated by impaired mitochondrial oxidative capacity in skeletal muscle. | 2014 | Details |
| A22239 | 24731656 | Lancet Diabetes Endocrinol | Effects of iron overload on chronic metabolic diseases. | 2013 | Details |
| A22256 | 24716162 | J Tradit Complement Med | Recent advances in the herbal treatment of non-alcoholic Fatty liver disease. | 2013 | Details |
| A22266 | 24705404 | Diabetes | Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates. | 2014 | Details |
| A22271 | 24702768 | FEBS J | Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease. | 2014 | Details |
| A22294 | 24688217 | J Clin Biochem Nutr | Role of Nrf2 in the alteration of cholesterol and bile acid metabolism-related gene expression by dietary cholesterol in high fat-fed mice. | 2014 | Details |
| A22301 | 24680992 | J Ethnopharmacol | In vitro effects of active components of Polygonum Multiflorum Radix on enzymes involved in the lipid metabolism. | 2014 | Details |
| A22302 | 24680680 | Biochem Biophys Res Commun | Adiponutrin: a multimeric plasma protein. | 2014 | Details |
| A22307 | 24677249 | Hepatology | Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia. | 2014 | Details |
| A22308 | 24675715 | Int J Obes (Lond) | Mapping of the circulating metabolome reveals α-ketoglutarate as a predictor of morbid obesity-associated non-alcoholic fatty liver disease. | 2014 | Details |
| A22311 | 24672641 | World J Hepatol | Thyroid hormone analogues and derivatives: Actions in fatty liver. | 2014 | Details |
| A22322 | 24665739 | Sheng Li Ke Xue Jin Zhan | [Progress in research of the mechanisms related with the hepatic steatosis in the nonalcoholic fatty liver disease]. | 2013 | Details |
| A22334 | 24653580 | Afr J Tradit Complement Altern Med | p38 MAPK signal pathway involved in anti-inflammatory effect of Chaihu-Shugan-San and Shen-ling-bai-zhu-San on hepatocyte in non-alcoholic steatohepatitis rats. | 2013 | Details |
| A22339 | 24651520 | PLoS One | Rapid development of non-alcoholic steatohepatitis in Psammomys obesus (Israeli sand rat). | 2014 | Details |
| A22342 | 24650559 | Am J Pathol | Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle. | 2014 | Details |
| A22352 | 24645314 | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi | [Protective effects of rhein on hepatic progression in HBV-transgenic mice with nonalcoholic steatohepatitis induced by a high-fat diet]. | 2013 | Details |
| A22353 | 24645313 | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi | [Activation of Kupffer cell and related signal pathway proteins in the liver of high fat and high fructose diet induced NAFLD mice]. | 2013 | Details |
| A22359 | 24638096 | PLoS One | Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques. | 2014 | Details |
| A22370 | 24633463 | Arch Pharm Res | Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase. | 2014 | Details |
| A22385 | 24627601 | World J Gastroenterol | Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats. | 2014 | Details |
| A22392 | 24622832 | J Physiol Pharmacol | Effects of treatment with melatonin and tryptophan on liver enzymes, parameters of fat metabolism and plasma levels of cytokines in patients with non-alcoholic fatty liver disease--14 months follow up. | 2014 | Details |
| A22407 | 24607340 | Prog Lipid Res | Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes. | 2014 | Details |
| A22415 | 24597775 | Antioxid Redox Signal | RORα decreases oxidative stress through the induction of SOD2 and GPx1 expression and thereby protects against nonalcoholic steatohepatitis in mice. | 2014 | Details |
| A22418 | 24594481 | Biochim Biophys Acta | Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH). | 2014 | Details |
| A22425 | 24587654 | World J Gastroenterol | Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease. | 2014 | Details |