Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Choline1715 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A07720 | 32376414 | J Hepatol | Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation. | 2020 | Details |
| A07722 | 32376267 | Life Sci | Heme oxygenase-1 alleviated non-alcoholic fatty liver disease via suppressing ROS-dependent endoplasmic reticulum stress. | 2020 | Details |
| A07731 | 32373213 | Theranostics | PTPROt aggravates inflammation by enhancing NF-κB activation in liver macrophages during nonalcoholic steatohepatitis. | 2020 | Details |
| A07735 | 32371503 | BMJ Open Gastroenterol | SIRT1-dependent mechanisms and effects of resveratrol for amelioration of muscle wasting in NASH mice. | 2020 | Details |
| A07748 | 32365632 | Cells | L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men. | 2020 | Details |
| A07750 | 32365405 | J Gastroenterol Hepatol | Periostin antisense oligonucleotide prevents hepatic steatosis and fibrosis in a mouse model of non-alcoholic steatohepatitis. | 2020 | Details |
| A07769 | 32360434 | J Hepatol | Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages☆. | 2020 | Details |
| A07788 | 32354858 | Diabetes | The Effects of B1344, a Novel Fibroblast Growth Factor 21 Analog, on Nonalcoholic Steatohepatitis in Nonhuman Primates. | 2020 | Details |
| A07793 | 32353385 | Toxicol Appl Pharmacol | Metabolomic-based assessment reveals dysregulation of lipid profiles in human liver cells exposed to environmental obesogens. | 2020 | Details |
| A07808 | 32350181 | J Nutr Sci Vitaminol (Tokyo) | Coleus forskohlii Extract Attenuated the Beneficial Effect of Diet-Treatment on NASH in Mouse Model. | 2020 | Details |
| A07817 | 32346447 | Exp Ther Med | Analysis of piRNA expression spectra in a non-alcoholic fatty liver disease mouse model induced by a methionine- and choline-deficient diet. | 2020 | Details |
| A07822 | 32344934 | J Clin Med | Lipidomics Reveals Reduced Inflammatory Lipid Species and Storage Lipids after Switching from EFV/FTC/TDF to RPV/FTC/TDF: A Randomized Open-Label Trial. | 2020 | Details |
| A07827 | 32343209 | Radiology | Advanced MRI of Liver Fibrosis and Treatment Response in a Rat Model of Nonalcoholic Steatohepatitis. | 2020 | Details |
| A07844 | 32337059 | BMJ Open Gastroenterol | Effectiveness of phosphatidylcholine as adjunctive therapy in improving liver function tests in patients with non-alcoholic fatty liver disease and metabolic comorbidities: real-life observational study from Russia. | 2020 | Details |
| A07861 | 32331258 | Nutrients | Lemon Balm and Its Constituent, Rosmarinic Acid, Alleviate Liver Damage in an Animal Model of Nonalcoholic Steatohepatitis. | 2020 | Details |
| A07870 | 32329085 | Hepatology | The L-α-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis. | 2020 | Details |
| A07880 | 32325178 | J Ethnopharmacol | Qiang-Gan formula extract improves non-alcoholic steatohepatitis via regulating bile acid metabolism and gut microbiota in mice. | 2020 | Details |
| A07901 | 32317079 | BMB Rep | GPx7 ameliorates non-alcoholic steatohepatitis by regulating oxidative stress. | 2020 | Details |
| A07904 | 32316419 | Int J Mol Sci | Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome. | 2020 | Details |
| A07921 | 32309295 | Kidney Dis (Basel) | Plasma Metabolomics Profiling in Maintenance Hemodialysis Patients Based on Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry. | 2020 | Details |
| A07936 | 32305523 | Life Sci | Cystathionine gamma-lyase/H2S system suppresses hepatic acetyl-CoA accumulation and nonalcoholic fatty liver disease in mice. | 2020 | Details |
| A07946 | 32302970 | J Endocrinol | SCFAs alleviated steatosis and inflammation in mice with NASH induced by MCD. | 2020 | Details |
| A07966 | 32296880 | J Mol Med (Berl) | HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD. | 2020 | Details |
| A07995 | 32284169 | Biochem Biophys Res Commun | Effect of methionine/choline-deficient diet and high-fat diet-induced steatohepatitis on mitochondrial homeostasis in mice. | 2020 | Details |
| A08017 | 32279997 | Biochem Biophys Res Commun | Potential use of C-phycocyanin in non-alcoholic fatty liver disease. | 2020 | Details |
| A08026 | 32277923 | Mol Metab | Functional changes of the liver in the absence of growth hormone (GH) action - Proteomic and metabolomic insights from a GH receptor deficient pig model. | 2020 | Details |
| A08074 | 32257903 | Lab Anim Res | Comparative study of liver injury induced by high-fat methionine- and choline-deficient diet in ICR mice originating from three different sources. | 2019 | Details |
| A08075 | 32257815 | Mol Genet Metab Rep | Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice. | 2020 | Details |
| A08081 | 32255515 | Lipids | Lipid Profiles of Five Essential Phospholipid Preparations for the Treatment of Nonalcoholic Fatty Liver Disease: A Comparative Study. | 2020 | Details |
| A08104 | 32245205 | Int J Mol Sci | Combined Treatment with Sodium-Glucose Cotransporter-2 Inhibitor (Canagliflozin) and Dipeptidyl Peptidase-4 Inhibitor (Teneligliptin) Alleviates NASH Progression in A Non-Diabetic Rat Model of Steatohepatitis. | 2020 | Details |
| A08109 | 32244182 | Mol Metab | Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice. | 2020 | Details |
| A08126 | 32238704 | Biol Pharm Bull | Reduced Serum Cholesterol and Triglyceride Levels in a Choline-Deficient L-Amino Acid-Defined High-Fat Diet (CDAHFD)-Induced Mouse Model of Non-alcoholic Steatohepatitis (NASH). | 2020 | Details |
| A08169 | 32220030 | J Biochem Mol Toxicol | Chrysin ameliorates hepatic steatosis induced by a diet deficient in methionine and choline by inducing the secretion of hepatocyte nuclear factor 4α-dependent very low-density lipoprotein. | 2020 | Details |
| A08301 | 32161197 | JCI Insight | Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease. | 2020 | Details |
| A08305 | 32158763 | Front Med (Lausanne) | Attenuation of the Hepatoprotective Effects of Ileal Apical Sodium Dependent Bile Acid Transporter (ASBT) Inhibition in Choline-Deficient L-Amino Acid-Defined (CDAA) Diet-Fed Mice. | 2020 | Details |
| A08316 | 32155178 | PLoS One | Gender differences in diet-induced steatotic disease in Cyp2b-null mice. | 2020 | Details |
| A08356 | 32145145 | Liver Int | Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity. | 2020 | Details |
| A08396 | 32126269 | Biochim Biophys Acta Mol Basis Dis | Chemical hypoxia induces pro-inflammatory signals in fat-laden hepatocytes and contributes to cellular crosstalk with Kupffer cells through extracellular vesicles. | 2020 | Details |
| A08417 | 32119738 | J Nutr | One-Carbon Metabolism in Fatty Liver Disease and Fibrosis: One-Carbon to Rule Them All. | 2020 | Details |
| A08477 | 32095253 | BMJ Open Gastroenterol | Effectiveness of phosphatidylcholine in alleviating steatosis in patients with non-alcoholic fatty liver disease and cardiometabolic comorbidities (MANPOWER study). | 2020 | Details |
| A08482 | 32092735 | Biomed Res | Placental extract ameliorates liver fibrosis in a methionine- and choline-deficient diet-induced mouse model of non-alcoholic steatohepatitis. | 2020 | Details |
| A08501 | 32084378 | Cell Metab | Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly. | 2020 | Details |
| A08575 | 32054840 | Cell Death Dis | Antagonizing circRNA_002581-miR-122-CPEB1 axis alleviates NASH through restoring PTEN-AMPK-mTOR pathway regulated autophagy. | 2020 | Details |
| A08583 | 32051143 | J Biol Chem | Vitamin D receptor targets hepatocyte nuclear factor 4α and mediates protective effects of vitamin D in nonalcoholic fatty liver disease. | 2020 | Details |
| A08600 | 32044522 | Biomaterials | Efficacy of primary liver organoid culture from different stages of non-alcoholic steatohepatitis (NASH) mouse model. | 2020 | Details |
| A08619 | 32039405 | JHEP Rep | A blocking monoclonal antibody to CCL24 alleviates liver fibrosis and inflammation in experimental models of liver damage. | 2020 | Details |
| A08657 | 32030821 | J Gastroenterol Hepatol | Aging exacerbates high-fat diet-induced steatohepatitis through alteration in hepatic lipid metabolism in mice. | 2020 | Details |
| A08658 | 32029710 | Cell Death Dis | Hepatocyte caveolin-1 modulates metabolic gene profiles and functions in non-alcoholic fatty liver disease. | 2020 | Details |
| A08745 | 32003601 | Am J Physiol Gastrointest Liver Physiol | Dysregulated FXR-FGF19 signaling and choline metabolism are associated with gut dysbiosis and hyperplasia in a novel pig model of pediatric NASH. | 2020 | Details |
| A08755 | 32000066 | Biomed Pharmacother | Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway in macrophages. | 2020 | Details |
| A08760 | 31998283 | Front Immunol | Absence of the Caspases 1/11 Modulates Liver Global Lipid Profile and Gut Microbiota in High-Fat-Diet-Induced Obese Mice. | 2020 | Details |
| A08764 | 31993306 | Acta Pharm Sin B | Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications. | 2019 | Details |
| A08767 | 31992752 | Sci Rep | Biomarker discovery for chronic liver diseases by multi-omics - a preclinical case study. | 2020 | Details |
| A08771 | 31991181 | Life Sci | Role of hepatic neuropeptide Y-Y1 receptors in a methionine-choline-deficient model of non-alcoholic steatohepatitis. | 2020 | Details |
| A08789 | 31984635 | Neurogastroenterol Motil | Ghrelin-insulin-like growth factor-1 axis is activated via autonomic neural circuits in the non-alcoholic fatty liver disease. | 2020 | Details |
| A08873 | 31955065 | Int Immunopharmacol | Baicalin and its nanoliposomes ameliorates nonalcoholic fatty liver disease via suppression of TLR4 signaling cascade in mice. | 2020 | Details |
| A08975 | 31919231 | Gut | S100A11/ANXA2 belongs to a tumour suppressor/oncogene network deregulated early with steatosis and involved in inflammation and hepatocellular carcinoma development. | 2020 | Details |
| A08977 | 31918130 | Environ Pollut | Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice. | 2019 | Details |
| A09012 | 31905025 | Am J Physiol Gastrointest Liver Physiol | Investigating fibrosis and inflammation in an ex vivo NASH murine model. | 2020 | Details |
| A09032 | 31898379 | NMR Biomed | Mapping of fatty acid composition with free-breathing MR spectroscopic imaging and compressed sensing. | 2020 | Details |
| A09044 | 31891606 | PLoS One | Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH). | 2019 | Details |
| A09087 | 31881201 | Exp Mol Pathol | Alpha-syntrophin deficiency protects against non-alcoholic steatohepatitis associated increase of macrophages, CD8+ T-cells and galectin-3 in the liver. | 2019 | Details |
| A09088 | 31881192 | Biochem Pharmacol | Interaction of Oatp1b2 expression and nonalcoholic steatohepatitis on pravastatin plasma clearance. | 2019 | Details |
| A09094 | 31879571 | PeerJ | Comparative RNA-sequencing profiled the differential gene expression of liver in response to acetyl-CoA carboxylase inhibitor GS-0976 in a mouse model of NASH. | 2019 | Details |
| A09114 | 31869736 | Nucl Med Biol | Preclinical investigation of potential use of thymidine phosphorylase-targeting tracer for diagnosis of nonalcoholic steatohepatitis. | 2019 | Details |
| A09123 | 31866798 | Contrast Media Mol Imaging | Imaging Fibrogenesis in a Diet-Induced Model of Nonalcoholic Steatohepatitis (NASH). | 2019 | Details |
| A09151 | 31857195 | J Hepatol | ARRB1 inhibits non-alcoholic steatohepatitis progression by promoting GDF15 maturation. | 2019 | Details |
| A09163 | 31852298 | Artif Cells Nanomed Biotechnol | Osteopontin acts as a negative regulator of autophagy accelerating lipid accumulation during the development of nonalcoholic fatty liver disease. | 2020 | Details |
| A09179 | 31846961 | Lifestyle Genom | One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics. | 2019 | Details |
| A09210 | 31835339 | Metabolites | Acupuncture on ST36, CV4 and KI1 Suppresses the Progression of Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease in Mice. | 2019 | Details |
| A09290 | 31804025 | Environ Toxicol | Burdock (Arctium lappa L.) root attenuates preneoplastic lesion development in a diet and thioacetamide-induced model of steatohepatitis-associated hepatocarcinogenesis. | 2019 | Details |
| A09312 | 31795496 | Cells | Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins. | 2019 | Details |
| A09316 | 31793324 | Nutr Hosp | Immunonutritional contribution of gut microbiota to fatty liver disease. | 2020 | Details |
| A09375 | 31771244 | Nutrients | Fat and Sugar-A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A09379 | 31770275 | Medicine (Baltimore) | Association between iron metabolism and cognitive impairment in older non-alcoholic fatty liver disease individuals: A cross-sectional study in patients from a Chinese center. | 2019 | Details |
| A09407 | 31758699 | Br J Pharmacol | Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice. | 2020 | Details |
| A09408 | 31758647 | Liver Int | Hepatic NK cells attenuate fibrosis progression of non-alcoholic steatohepatitis in dependent of CXCL10-mediated recruitment. | 2019 | Details |
| A09413 | 31757759 | Mol Ther | HLSC-Derived Extracellular Vesicles Attenuate Liver Fibrosis and Inflammation in a Murine Model of Non-alcoholic Steatohepatitis. | 2019 | Details |
| A09432 | 31752378 | Nutrients | Role of Probiotics in Non-alcoholic Fatty Liver Disease: Does Gut Microbiota Matter? | 2019 | Details |
| A09480 | 31728041 | Sci Rep | Multi-technique comparison of atherogenic and MCD NASH models highlights changes in sphingolipid metabolism. | 2019 | Details |
| A09498 | 31718984 | J Pharm Biomed Anal | Metabolic impact of partial hepatectomy in the non-alcoholic steatohepatitis animal model of methionine-choline deficient diet. | 2019 | Details |
| A09506 | 31717385 | Cells | Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis. | 2019 | Details |
| A09509 | 31717261 | Nutrients | Curcumin Ameliorates Nonalcoholic Fatty Liver Disease through Inhibition of O-GlcNAcylation. | 2019 | Details |
| A09526 | 31709254 | Front Cell Dev Biol | Fatty Liver Due to Increased de novo Lipogenesis: Alterations in the Hepatic Peroxisomal Proteome. | 2019 | Details |
| A09534 | 31705800 | Hepatology | Interleukin-22 Ameliorates Neutrophil-Driven Nonalcoholic Steatohepatitis Through Multiple Targets. | 2020 | Details |
| A09546 | 31699440 | Environ Int | Hepatotoxic effects of inhalation exposure to polycyclic aromatic hydrocarbons on lipid metabolism of C57BL/6 mice. | 2019 | Details |
| A09558 | 31695245 | J Clin Exp Hepatol | Whole-Exome Sequencing Identifies a Variant in Phosphatidylethanolamine N-Methyltransferase Gene to be Associated With Lean-Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A09561 | 31694365 | Gut Liver | Downregulation of GNAI3 Promotes the Pathogenesis of Methionine/Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A09578 | 31689560 | Cell Mol Gastroenterol Hepatol | A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target. | 2019 | Details |
| A09602 | 31678261 | Food Chem Toxicol | Cigarette smoking differentially regulates inflammatory responses in a mouse model of nonalcoholic steatohepatitis depending on exposure time point. | 2019 | Details |
| A09603 | 31678070 | Metabolism | Downregulation of PHGDH expression and hepatic serine level contribute to the development of fatty liver disease. | 2019 | Details |
| A09622 | 31671785 | Nutrients | mir-101-3p Downregulation Promotes Fibrogenesis by Facilitating Hepatic Stellate Cell Transdifferentiation During Insulin Resistance. | 2019 | Details |
| A09646 | 31660146 | Food Sci Nutr | Fermented black radish (Raphanus sativus L. var. niger) attenuates methionine and choline deficient diet-induced nonalcoholic fatty liver disease in mice. | 2019 | Details |
| A09693 | 31645659 | Acta Pharmacol Sin | WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice. | 2019 | Details |
| A09706 | 31638173 | Int J Mol Med | Role and mechanisms of action of microRNA‑21 as regards the regulation of the WNT/β‑catenin signaling pathway in the pathogenesis of non‑alcoholic fatty liver disease. | 2019 | Details |
| A09739 | 31630534 | Am J Physiol Gastrointest Liver Physiol | Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction, and rapid progression to cirrhosis and cancer. | 2019 | Details |
| A09787 | 31610178 | Am J Pathol | Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation-Mediated Cell Death in Mice. | 2019 | Details |
| A09796 | 31607566 | Dig Liver Dis | L-carnitine supplementation attenuates NAFLD progression and cardiac dysfunction in a mouse model fed with methionine and choline-deficient diet. | 2019 | Details |
| A09853 | 31591383 | Cell Death Dis | Progranulin attenuates liver fibrosis by downregulating the inflammatory response. | 2019 | Details |
| A09888 | 31574193 | Mol Nutr Food Res | Green Tea Extract Treatment in Obese Mice with Nonalcoholic Steatohepatitis Restores the Hepatic Metabolome in Association with Limiting Endotoxemia-TLR4-NFκB-Mediated Inflammation. | 2019 | Details |