Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
stats1
stats2
stats3
stats4
Search for:
Fatty acid synthase594 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A19950 | 26246323 | J Nutr | Citrulline and Nonessential Amino Acids Prevent Fructose-Induced Nonalcoholic Fatty Liver Disease in Rats. | 2015 | Details |
| A19953 | 26242978 | Lipids Health Dis | Prevention and treatment effect of total flavonoids in Stellera chamaejasme L. on nonalcoholic fatty liver in rats. | 2015 | Details |
| A20005 | 26214517 | PLoS One | PDIA3 Knockdown Exacerbates Free Fatty Acid-Induced Hepatocyte Steatosis and Apoptosis. | 2015 | Details |
| A20053 | 26190035 | Hepatol Res | Amelioration of free fatty acid-induced fatty liver by quercetin-3-O-β-D-glucuronide through modulation of peroxisome proliferator-activated receptor-alpha/sterol regulatory element-binding protein-1c signaling. | 2015 | Details |
| A20071 | 26176317 | J Agric Food Chem | Fermented Rhus verniciflua Stokes Extract Exerts an Antihepatic Lipogenic Effect in Oleic-Acid-Induced HepG2 Cells via Upregulation of AMP-Activated Protein Kinase. | 2015 | Details |
| A20170 | 26113868 | Evid Based Complement Alternat Med | Effects on Liver Lipid Metabolism of the Naturally Occurring Dietary Flavone Luteolin-7-glucoside. | 2015 | Details |
| A20195 | 26090419 | Biomed Res Int | Individual CLA Isomers, c9t11 and t10c12, Prevent Excess Liver Glycogen Storage and Inhibit Lipogenic Genes Expression Induced by High-Fructose Diet in Rats. | 2015 | Details |
| A20311 | 26035386 | Dis Model Mech | Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice. | 2015 | Details |
| A20313 | 26033743 | J Nutr Biochem | Nutrigenomics analysis reveals that copper deficiency and dietary sucrose up-regulate inflammation, fibrosis and lipogenic pathways in a mature rat model of nonalcoholic fatty liver disease. | 2015 | Details |
| A20336 | 26024755 | Metabolism | Niacin inhibits fat accumulation, oxidative stress, and inflammatory cytokine IL-8 in cultured hepatocytes: Impact on non-alcoholic fatty liver disease. | 2015 | Details |
| A20352 | 26019041 | Ann Hepatol | Combined high-fat diet and sustained high sucrose consumption promotes NAFLD in a murine model. | 2016 | Details |
| A20360 | 26017330 | Mol Med Rep | Lycium ruthenicum extract alleviates high-fat diet-induced nonalcoholic fatty liver disease via enhancing the AMPK signaling pathway. | 2015 | Details |
| A20491 | 25925967 | Phytomedicine | [6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis. | 2015 | Details |
| A20555 | 25890430 | Obes Res Clin Pract | Soy β-conglycinin improves obesity-induced metabolic abnormalities in a rat model of nonalcoholic fatty liver disease. | 2014 | Details |
| A20655 | 25827944 | J Physiol Biochem | Liver delipidating effect of a combination of resveratrol and quercetin in rats fed an obesogenic diet. | 2015 | Details |
| A20739 | 25766252 | Sci Rep | Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers. | 2015 | Details |
| A20834 | 25704646 | Biosci Biotechnol Biochem | Dietary freshwater clam (Corbicula fluminea) extract suppresses accumulation of hepatic lipids and increases in serum cholesterol and aminotransferase activities induced by dietary chloretone in rats. | 2015 | Details |
| A20977 | 25606341 | Med Gas Res | Exogenous hydrogen sulfide mitigates the fatty liver in obese mice through improving lipid metabolism and antioxidant potential. | 2015 | Details |
| A20980 | 25605057 | Int J Mol Med | Puerarin ameliorates hepatic steatosis by activating the PPARα and AMPK signaling pathways in hepatocytes. | 2015 | Details |
| A21014 | 25576095 | J Nutr Biochem | Maternal taurine supplementation attenuates maternal fructose-induced metabolic and inflammatory dysregulation and partially reverses adverse metabolic programming in offspring. | 2014 | Details |
| A21022 | 25573131 | Zhonghua Yu Fang Yi Xue Za Zhi | [Study of synergistic effect of free fatty acid and iron on the establishment of nonalcoholic fatty liver disease model]. | 2014 | Details |
| A21077 | 25548489 | World J Gastroenterol | MicroRNA-185 regulates expression of lipid metabolism genes and improves insulin sensitivity in mice with non-alcoholic fatty liver disease. | 2014 | Details |
| A21351 | 25383453 | J Agric Food Chem | Viscothionin isolated from Korean mistletoe improves nonalcoholic fatty liver disease via the activation of adenosine monophosphate-activated protein kinase. | 2014 | Details |
| A21376 | 25361925 | Ann Clin Lab Sci | Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. | 2014 | Details |
| A21401 | 25348739 | J Sci Food Agric | Carnosic acid attenuates obesity-induced glucose intolerance and hepatic fat accumulation by modulating genes of lipid metabolism in C57BL/6J-ob/ob mice. | 2014 | Details |
| A21426 | 25328157 | Br J Nutr | Astaxanthin lowers plasma TAG concentrations and increases hepatic antioxidant gene expression in diet-induced obesity mice. | 2014 | Details |
| A21499 | 25272018 | Pharm Biol | Houttuynia cordata alleviates high-fat diet-induced non-alcoholic fatty liver in experimental rats. | 2014 | Details |
| A21500 | 25271296 | J Lipid Res | A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice. | 2014 | Details |
| A21514 | 25261688 | J Ethnopharmacol | Magnolia officinalis attenuates free fatty acid-induced lipogenesis via AMPK phosphorylation in hepatocytes. | 2014 | Details |
| A21576 | 25216251 | PLoS One | IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis. | 2014 | Details |
| A21580 | 25214402 | Am J Physiol Gastrointest Liver Physiol | Vitamin D deficiency promotes nonalcoholic steatohepatitis through impaired enterohepatic circulation in animal model. | 2014 | Details |
| A21697 | 25111690 | Lab Invest | Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes. | 2014 | Details |
| A21706 | 25105012 | Cell Biosci | Regulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver. | 2014 | Details |
| A21751 | 25072708 | PLoS One | Identification of novel regulatory cholesterol metabolite, 5-cholesten, 3β,25-diol, disulfate. | 2014 | Details |
| A21765 | 25061561 | Mol Metab | Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels. | 2014 | Details |
| A21772 | 25057104 | Nutrients | Pinus densiflora Sieb. et Zucc. alleviates lipogenesis and oxidative stress during oleic acid-induced steatosis in HepG2 cells. | 2014 | Details |
| A21813 | 25028495 | Proc Natl Acad Sci U S A | Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease. | 2014 | Details |
| A21860 | 24993341 | Int Immunopharmacol | Involvement of hepatic peroxisome proliferator-activated receptor α/γ in the therapeutic effect of osthole on high-fat and high-sucrose-induced steatohepatitis in rats. | 2014 | Details |
| A21880 | 24983336 | Med Sci Sports Exerc | Treating NAFLD in OLETF rats with vigorous-intensity interval exercise training. | 2015 | Details |
| A21909 | 24968200 | Br J Nutr | Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats. | 2014 | Details |
| A21910 | 24967351 | Biomed Res Int | Enhanced amelioration of high-fat diet-induced fatty liver by docosahexaenoic acid and lysine supplementations. | 2014 | Details |
| A21935 | 24953607 | Life Sci | Testosterone suppresses the expression of regulatory enzymes of fatty acid synthesis and protects against hepatic steatosis in cholesterol-fed androgen deficient mice. | 2014 | Details |
| A21949 | 24944601 | Exp Ther Med | Ethanol extract of Cirsium japonicum attenuates hepatic lipid accumulation via AMPK activation in human HepG2 cells. | 2014 | Details |
| A22040 | 24857364 | J Agric Food Chem | Garlic essential oil protects against obesity-triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress. | 2014 | Details |
| A22070 | 24841999 | Food Funct | Persimmon tannin accounts for hypolipidemic effects of persimmon through activating of AMPK and suppressing NF-κB activation and inflammatory responses in high-fat diet rats. | 2014 | Details |
| A22111 | 24814684 | Metabolism | De novo lipogenesis in health and disease. | 2014 | Details |
| A22114 | 24811405 | Appl Microbiol Biotechnol | Preventing non-alcoholic fatty liver disease through Lactobacillus johnsonii BS15 by attenuating inflammation and mitochondrial injury and improving gut environment in obese mice. | 2014 | Details |
| A22141 | 24793377 | Food Chem Toxicol | Comparative study of bisphenol A and its analogue bisphenol S on human hepatic cells: a focus on their potential involvement in nonalcoholic fatty liver disease. | 2014 | Details |
| A22272 | 24699882 | Endocrine | Identification and validation co-differentially expressed genes with NAFLD and insulin resistance. | 2014 | Details |
| A22278 | 24695736 | J Biol Chem | Deficiency of oncostatin M receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice. | 2014 | Details |
| A22368 | 24634829 | Mol Metab | Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice. | 2014 | Details |
| A22482 | 24523491 | J Nutr | Bitter gourd inhibits the development of obesity-associated fatty liver in C57BL/6 mice fed a high-fat diet. | 2014 | Details |
| A22495 | 24517411 | Metab Syndr Relat Disord | Comparative effects of the renin-angiotensin system blockers on nonalcoholic fatty liver disease and insulin resistance in C57BL/6 mice. | 2014 | Details |
| A22571 | 24456353 | J Med Food | Cooked rice inhibits hepatic fat accumulation by regulating lipid metabolism-related gene expression in mice fed a high-fat diet. | 2014 | Details |
| A22604 | 24418870 | J Nutr Sci Vitaminol (Tokyo) | Transgenerational effects on the liver and pancreas resulting from maternal vitamin D restriction in mice. | 2013 | Details |
| A22664 | 24376752 | PLoS One | COH-SR4 reduces body weight, improves glycemic control and prevents hepatic steatosis in high fat diet-induced obese mice. | 2013 | Details |
| A22723 | 24356885 | Am J Physiol Gastrointest Liver Physiol | Therapeutic role of niacin in the prevention and regression of hepatic steatosis in rat model of nonalcoholic fatty liver disease. | 2013 | Details |
| A22746 | 24335764 | Int J Obes (Lond) | Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice. | 2013 | Details |
| A22832 | 24275555 | Biochim Biophys Acta | Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring. | 2013 | Details |
| A22833 | 24275089 | Food Chem Toxicol | Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice. | 2013 | Details |
| A22834 | 24275070 | Toxicol Appl Pharmacol | Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats. | 2013 | Details |
| A22921 | 24209497 | Lipids Health Dis | Nonalcoholic fatty liver disease: molecular pathways and therapeutic strategies. | 2013 | Details |
| A22979 | 24142602 | Eur Rev Med Pharmacol Sci | Curcumin decreases oleic acid-induced lipid accumulation via AMPK phosphorylation in hepatocarcinoma cells. | 2013 | Details |
| A23002 | 24121055 | Toxicol Appl Pharmacol | Accumulation of lipids and oxidatively damaged DNA in hepatocytes exposed to particles. | 2013 | Details |
| A23119 | 24027117 | J Sci Food Agric | The inhibition of oleic acid induced hepatic lipogenesis and the promotion of lipolysis by caffeic acid via up-regulation of AMP-activated kinase. | 2013 | Details |
| A23152 | 24002036 | Endocrinology | Maternal hypoxia increases the susceptibility of adult rat male offspring to high-fat diet-induced nonalcoholic fatty liver disease. | 2013 | Details |
| A23163 | 23994574 | Free Radic Biol Med | Free radical biology for medicine: learning from nonalcoholic fatty liver disease. | 2013 | Details |
| A23249 | 23928105 | Metabolism | Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice. | 2013 | Details |
| A23258 | 23922466 | World J Gastroenterol | Garcinia Cambogia attenuates diet-induced adiposity but exacerbates hepatic collagen accumulation and inflammation. | 2013 | Details |
| A23289 | 23896376 | Biochimie | Ectopic lipid accumulation: A potential cause for metabolic disturbances and a contributor to the alteration of kidney function. | 2013 | Details |
| A23426 | 23792031 | J Hepatol | The role of hepassocin in the development of non-alcoholic fatty liver disease. | 2013 | Details |
| A23431 | 23791610 | Eur J Pharmacol | Oxymatrine attenuates hepatic steatosis in non-alcoholic fatty liver disease rats fed with high fructose diet through inhibition of sterol regulatory element binding transcription factor 1 (Srebf1) and activation of peroxisome proliferator activated receptor alpha (Pparα). | 2013 | Details |
| A23519 | 23715726 | Am J Physiol Endocrinol Metab | Ezetimibe prevents hepatic steatosis induced by a high-fat but not a high-fructose diet. | 2013 | Details |
| A23533 | 23703028 | Mol Cell Biochem | Endoplasmic reticulum stress leads to lipid accumulation through upregulation of SREBP-1c in normal hepatic and hepatoma cells. | 2013 | Details |
| A23535 | 23702383 | Metabolism | Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway. | 2013 | Details |
| A23595 | 23651738 | Toxicol Appl Pharmacol | Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction. | 2013 | Details |
| A23596 | 23647015 | Br J Pharmacol | Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats. | 2013 | Details |
| A23627 | 23618531 | J Nutr Biochem | Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice. | 2013 | Details |
| A23639 | 23605066 | Pflugers Arch | Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor δ activation. | 2013 | Details |
| A23802 | 23465592 | J Nutr Biochem | S-allyl cysteine attenuates free fatty acid-induced lipogenesis in human HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway. | 2013 | Details |
| A23842 | 23432843 | Liver Int | GLP-1 analogue prevents NAFLD in ApoE KO mice with diet and Acrp30 knockdown by inhibiting c-JNK. | 2013 | Details |
| A23880 | 23406154 | Lipids Health Dis | Effect of Mukitake mushroom (Panellus serotinus) on the pathogenesis of lipid abnormalities in obese, diabetic ob/ob mice. | 2013 | Details |
| A23888 | 23401753 | J Obes | Altered hepatic lipid metabolism contributes to nonalcoholic fatty liver disease in leptin-deficient Ob/Ob mice. | 2013 | Details |
| A24036 | 23293202 | Ann Hepatol | Therapeutic effects of granulocyte-colony stimulating factor on non-alcoholic hepatic steatosis in the rat. | 2013 | Details |
| A24066 | 24648896 | Biomed Rep | Quercetin improves insulin resistance and hepatic lipid accumulation in vitro in a NAFLD cell model. | 2012 | Details |
| A24078 | 23258548 | Mol Pharmacol | 5-cholesten-3β,25-diol 3-sulfate decreases lipid accumulation in diet-induced nonalcoholic fatty liver disease mouse model. | 2012 | Details |
| A24200 | 23127599 | Food Chem Toxicol | Alleviative effects of resveratrol on nonalcoholic fatty liver disease are associated with up regulation of hepatic low density lipoprotein receptor and scavenger receptor class B type I gene expressions in rats. | 2012 | Details |
| A24286 | 23038002 | J Toxicol Sci | Hepatoprotective effect of tamoxifen on steatosis and non-alcoholic steatohepatitis in mouse models. | 2012 | Details |
| A24299 | 23026700 | Food Chem Toxicol | Cassia tora (Leguminosae) seed extract alleviates high-fat diet-induced nonalcoholic fatty liver. | 2012 | Details |
| A24365 | 22964849 | Lab Invest | Stimulation of fat accumulation in hepatocytes by PGE₂-dependent repression of hepatic lipolysis, β-oxidation and VLDL-synthesis. | 2012 | Details |
| A24458 | 22876038 | World J Gastroenterol | Moro orange juice prevents fatty liver in mice. | 2012 | Details |
| A24473 | 22858825 | Mol Med Rep | Polydatin alleviates non-alcoholic fatty liver disease in rats by inhibiting the expression of TNF-α and SREBP-1c. | 2012 | Details |
| A24548 | 22768070 | PLoS One | Palmitoleate induces hepatic steatosis but suppresses liver inflammatory response in mice. | 2012 | Details |
| A24567 | 22742899 | Eur J Pharmacol | Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis. | 2012 | Details |
| A24577 | 22734967 | Clin Sci (Lond) | Kupffer cell depletion attenuates leptin-mediated methoxamine-stimulated portal perfusion pressure and thromboxane A2 release in a rodent model of NASH-cirrhosis. | 2012 | Details |
| A24607 | 22698815 | Toxicol Lett | Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice. | 2012 | Details |
| A24651 | 22648174 | Genes Nutr | Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet. | 2012 | Details |
| A24708 | 22576368 | Mol Med | Apolipoprotein A-I modulates processes associated with diet-induced nonalcoholic fatty liver disease in mice. | 2012 | Details |
| A24715 | 22569330 | Lipids Health Dis | Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats. | 2012 | Details |
| A24806 | 22469867 | Int J Mol Med | Therapeutic effects of angiotensin II type 1 receptor blocker, irbesartan, on non-alcoholic steatohepatitis using FLS-ob/ob male mice. | 2012 | Details |