Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Insulin9623 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A01627 | 34677008 | Hepatol Commun | Low Lipoprotein(a) Levels Predict Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A01635 | 34675003 | Diabetes | Hepatic CPT1A Facilitates Liver-Adipose Cross-Talk via Induction of FGF21 in Mice. | 2021 | Details |
| A01637 | 34674510 | Endocrinol Metab (Seoul) | Changes in Insulin Resistance Index and the Risk of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease without Diabetes: Kangbuk Samsung Health Study. | 2021 | Details |
| A01641 | 34671102 | Nat Rev Endocrinol | Metabolic implications of pancreatic fat accumulation. | 2021 | Details |
| A01649 | 34668765 | J Med Food | Ameliorative Effect of Myricetin on Nonalcoholic Fatty Liver Disease in ob/ob Mice. | 2021 | Details |
| A01654 | 34666041 | J Biol Chem | Human CEACAM1-LF regulates lipid storage in HepG2 cells via fatty acid transporter CD36. | 2021 | Details |
| A01657 | 34665236 | J Mol Cell Biol | cGAS‒STING signaling and function in metabolism and kidney diseases. | 2021 | Details |
| A01662 | 34663576 | Diabetes | Active Brown Adipose Tissue is Associated With a Healthier Metabolic Phenotype in Obesity. | -- | Details |
| A01675 | 34659125 | Front Endocrinol (Lausanne) | Predictive Modeling of MAFLD Based on Hsp90α and the Therapeutic Application of Teprenone in a Diet-Induced Mouse Model. | 2021 | Details |
| A01680 | 34656650 | J Hepatol | Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling. | 2021 | Details |
| A01684 | 34654976 | Curr Gastroenterol Rep | Dietary Approaches for Management of Non-Alcoholic Fatty Liver Disease: A Clinician's Guide. | 2021 | Details |
| A01685 | 34654875 | Acta Pharmacol Sin | Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway. | 2021 | Details |
| A01688 | 34653686 | Ann Hepatol | Prevalence and predictors of elevated liver enzyme levels in Mexico: The Mexican National Health and Nutrition Survey, 2016. | 2021 | Details |
| A01698 | 34651285 | J Physiol Biochem | Astaxanthin attenuates hepatic steatosis in high-fat diet-fed rats by suppressing microRNA-21 via transactivation of nuclear factor erythroid 2-related factor 2. | 2021 | Details |
| A01702 | 34650394 | Food Nutr Res | Chronic liquid fructose supplementation does not cause liver tumorigenesis but elicits clear sex differences in the metabolic response in Sprague-Dawley rats. | 2021 | Details |
| A01715 | 34646017 | Nature | Convergent somatic mutations in metabolism genes in chronic liver disease. | 2021 | Details |
| A01731 | 34634561 | Biomed Pharmacother | Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice. | 2021 | Details |
| A01742 | 34630901 | World J Diabetes | Non-alcoholic fatty liver disease in diabetes: When to refer to the hepatologist? | 2021 | Details |
| A01745 | 34630157 | Front Physiol | Effect of Exercise Training on Fat Loss-Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution. | 2021 | Details |
| A01760 | 34627696 | Nutr Metab Cardiovasc Dis | Association between non-alcoholic fatty liver disease and impaired cardiac sympathetic/parasympathetic balance in subjects with and without type 2 diabetes-The Cooperative Health Research in South Tyrol (CHRIS)-NAFLD sub-study. | 2021 | Details |
| A01774 | 34621822 | World J Clin Cases | Influencing factors for hepatic fat accumulation in patients with type 2 diabetes mellitus. | 2021 | Details |
| A01775 | 34621326 | Evid Based Complement Alternat Med | A Novel Identified Peptide Hormone "Metabolitin" Attenuates Lipid Absorption in the Small Intestine of Diabetic Mice with Nonalcoholic Fatty Liver Disease by Regulating Neurotensin and AMPK Signaling Pathway. | 2021 | Details |
| A01778 | 34621052 | Nat Med | Aramchol in patients with nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase 2b trial. | 2021 | Details |
| A01780 | 34620653 | BMJ Open | Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): a study protocol of an efficacy mechanism evaluation. | 2021 | Details |
| A01783 | 34619074 | Cell Metab | Molecular aspects of fructose metabolism and metabolic disease. | 2021 | Details |
| A01800 | 34610720 | Diabetes Metab J | Rho-Kinase as a Therapeutic Target for Nonalcoholic Fatty Liver Diseases. | 2021 | Details |
| A01802 | 34609305 | Turk J Gastroenterol | Histological Characteristics of Non-alcoholic Steatohepatitis in NAFLD Patients With Low Degree of Hepatocyte Apoptosis. | 2021 | Details |
| A01811 | 34606980 | Endocr Pract | Antidiabetic Medications for Type 2 Diabetics with Nonalcoholic Fatty Liver Disease: Evidence From a Network Meta-Analysis of Randomized Controlled Trials. | 2021 | Details |
| A01818 | 34604973 | Eur Rev Med Pharmacol Sci | Multifaceted pathogenesis of liver steatosis in inflammatory bowel disease: a systematic review. | 2021 | Details |
| A01833 | 34601002 | Mol Cell Endocrinol | Patchouli alcohol ameliorates skeletal muscle insulin resistance and NAFLD via AMPK/SIRT1-mediated suppression of inflammation. | 2021 | Details |
| A01840 | 34595203 | Front Nutr | Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial. | 2021 | Details |
| A01846 | 34591986 | Hepatology | OTUB1 alleviates NASH through inhibition of the TRAF6-ASK1 signaling pathways. | 2021 | Details |
| A01863 | 34584580 | Prz Gastroenterol | Association of non-alcoholic fatty liver disease with coronary artery calcification progression: a systematic review and meta-analysis. | 2021 | Details |
| A01867 | 34579641 | Endocr Metab Immune Disord Drug Targets | Adiponectin is Inversely Associated with Insulin Resistance in Adolescents with Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A01869 | 34579016 | Nutrients | Pancreatic β-Cell Dysfunction Is Associated with Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A01870 | 34579012 | Nutrients | Positive Effects of Exercise Intervention without Weight Loss and Dietary Changes in NAFLD-Related Clinical Parameters: A Systematic Review and Meta-Analysis. | 2021 | Details |
| A01872 | 34578867 | Nutrients | Amelioration of Hepatic Steatosis in Mice through Bacteroides uniformis CBA7346-Mediated Regulation of High-Fat Diet-Induced Insulin Resistance and Lipogenesis. | 2021 | Details |
| A01874 | 34578806 | Nutrients | Independent Dose-Response Associations between Fetuin-A and Lean Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A01881 | 34574647 | Int J Environ Res Public Health | Bone Mineral Density in Congenital Generalized Lipodystrophy: The Role of Bone Marrow Tissue, Adipokines, and Insulin Resistance. | 2021 | Details |
| A01887 | 34572442 | Biomedicines | Dietary Patterns Influence Target Gene Expression through Emerging Epigenetic Mechanisms in Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A01893 | 34571189 | J Nutr Biochem | Grape pomace reduces the severity of non-alcoholic hepatic steatosis and the development of steatohepatitis by improving insulin sensitivity and reducing ectopic fat deposition in mice. | 2021 | Details |
| A01902 | 34566663 | Front Pharmacol | Preclinical Evidence of Berberine on Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Animal Studies. | 2021 | Details |
| A01908 | 34565261 | Int J Food Sci Nutr | The effect of a Mediterranean diet vs. a low-fat diet on non-alcoholic fatty liver disease in children: a randomized trial. | 2021 | Details |
| A01909 | 34565074 | Rev Cardiovasc Med | Pathophysiological mechanisms and clinical evidence of relationship between Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease. | 2021 | Details |
| A01912 | 34564899 | J Intern Med | Inflammatory and fibrotic mechanisms in NAFLD-Implications for new treatment strategies. | 2021 | Details |
| A01927 | 34560015 | Lancet Gastroenterol Hepatol | Efficacy and safety of PXL770, a direct AMP kinase activator, for the treatment of non-alcoholic fatty liver disease (STAMP-NAFLD): a randomised, double-blind, placebo-controlled, phase 2a study. | 2021 | Details |
| A01931 | 34558856 | Hepatol Commun | Role of Cholesterol-Associated Steatohepatitis in the Development of NASH. | 2021 | Details |
| A01937 | 34558835 | Hepatol Commun | Ipragliflozin Improves the Hepatic Outcomes of Patients With Diabetes with NAFLD. | 2021 | Details |
| A01948 | 34557367 | Cureus | Non-Alcoholic Fatty Liver Disease and Its Association With Diabetes Mellitus. | 2021 | Details |
| A01949 | 34557366 | Cureus | The Troubling Link Between Non-alcoholic Fatty Liver Disease (NAFLD) and Extrahepatic Cancers (EHC). | 2021 | Details |
| A01961 | 34552561 | Front Endocrinol (Lausanne) | GLP-1 and Underlying Beneficial Actions in Alzheimer's Disease, Hypertension, and NASH. | 2021 | Details |
| A01964 | 34550043 | Adipocyte | Sodium glucose cotransporter 2 inhibitor dapagliflozin depressed adiposity and ameliorated hepatic steatosis in high-fat diet induced obese mice. | 2021 | Details |
| A01972 | 34547171 | Liver Int | The role of hepatic lipid composition in obesity-related metabolic disease. | 2021 | Details |
| A01977 | 34543756 | Clin Res Hepatol Gastroenterol | Adipose tissue dysfunction and MAFLD in obesity on the scene of COVID-19. | 2021 | Details |
| A01980 | 34543583 | Arch Physiol Biochem | Dipeptedyl peptidase-4 (DPP-4) inhibitor downregulates HMGB1/TLR4/NF-κB signaling pathway in a diabetic rat model of non-alcoholic fatty liver disease. | 2021 | Details |
| A01998 | 34534913 | Redox Biol | Hepatic Regulator of G Protein Signaling 6 (RGS6) drives non-alcoholic fatty liver disease by promoting oxidative stress and ATM-dependent cell death. | 2021 | Details |
| A01999 | 34534894 | Clin Nutr | Dairy protein intake is inversely related to development of non-alcoholic fatty liver disease. | 2021 | Details |
| A02005 | 34533252 | J Biochem Mol Toxicol | Omarigliptin protects against nonalcoholic fatty liver disease by ameliorating oxidative stress and inflammation. | 2021 | Details |
| A02013 | 34530928 | Microbiome | Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice. | 2021 | Details |
| A02018 | 34529585 | Physiol Int | The "GG" genotype of rs26802 variant in the ghrelin gene is a potential protective factor against nonalcoholic fatty liver disease. | 2021 | Details |
| A02025 | 34528223 | Horm Metab Res | Clinical Value and Role of miR-129-5p in Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A02026 | 34527673 | Front Cell Dev Biol | Lack of miR-379/miR-544 Cluster Resists High-Fat Diet-Induced Obesity and Prevents Hepatic Triglyceride Accumulation in Mice. | 2021 | Details |
| A02028 | 34526911 | Front Physiol | Metabolic Changes of Hepatocytes in NAFLD. | 2021 | Details |
| A02031 | 34525916 | Curr Med Chem | Beneficial Effects of Dietary Polyphenols in the Prevention and Treatment of NAFLD: Cell-Signaling Pathways Underlying Health Effects. | 2022 | Details |
| A02033 | 34524971 | Endocr Connect | IGFBP-2 as a biomarker in NAFLD improves hepatic steatosis: an integrated bioinformatics and experimental study. | 2021 | Details |
| A02042 | 34522493 | Cureus | The Role of Vitamins in Non-Alcoholic Fatty Liver Disease: A Systematic Review. | 2021 | Details |
| A02047 | 34521152 | Liver Int | Higher dietary insulinaemic potential is associated with increased risk of liver steatosis and fibrosis. | 2021 | Details |
| A02057 | 34517466 | Zhonghua Gan Zang Bing Za Zhi | [New development for targeted therapy of non-alcoholic fatty liver disease with thyroid hormone receptor beta]. | 2021 | Details |
| A02074 | 34511814 | J Clin Exp Hepatol | Nonalcoholic Fatty Liver in Lean Individuals: Clinicobiochemical Correlates of Histopathology in 157 Liver Biopsies from Healthy Liver Donors. | 2021 | Details |
| A02080 | 34511460 | Georgian Med News | [METABOLIC FEATURES OF ADIPOSE TISSUE AND CLINICAL SIGNIFICANCE OF ADIPOKINS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE (REVIEW)]. | 2021 | Details |
| A02090 | 34509375 | Surg Obes Relat Dis | Bariatric surgery improves metabolic and nonalcoholic fatty liver disease markers in metabolically healthy patients with morbid obesity at 5 years. | 2021 | Details |
| A02094 | 34508810 | Pharmacol Res | GADD45β stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation. | 2021 | Details |
| A02099 | 34508436 | JNMA J Nepal Med Assoc | Carotid Intima-media Thickness in Patients with Non-alcoholic Fatty Liver Disease Attending a Tertiary Care Center: A Descriptive Cross-sectional Study. | 2021 | Details |
| A02100 | 34508238 | Nat Rev Gastroenterol Hepatol | Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests. | 2021 | Details |
| A02110 | 34503976 | Mol Pharmacol | Construction and Characterization of CRISPR/Cas9 Knockout Rat Model of Carboxylesterase 2a Gene. | 2021 | Details |
| A02118 | 34500407 | Curr Opin Pharmacol | A double-edged sword: The Kelch-like ECH-associated protein 1-nuclear factor erythroid-derived 2-related factor 2-antioxidant response element pathway targeted pharmacological modulation in nonalcoholic fatty liver disease. | 2021 | Details |
| A02123 | 34498307 | Phytother Res | The effect of pomegranate extract on anthropometric indices, serum lipids, glycemic indicators, and blood pressure in patients with nonalcoholic fatty liver disease: A randomized double-blind clinical trial. | 2021 | Details |
| A02126 | 34497431 | World J Gastroenterol | Brain-gut-liver interactions across the spectrum of insulin resistance in metabolic fatty liver disease. | 2021 | Details |
| A02127 | 34497333 | Sci Rep | Toll-like receptor 1 as a possible target in non-alcoholic fatty liver disease. | 2021 | Details |
| A02133 | 34494384 | Hepatol Commun | Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis. | 2021 | Details |
| A02138 | 34491336 | J Clin Endocrinol Metab | Nonalcoholic Fatty Liver Disease in Women and Girls With Polycystic Ovary Syndrome. | 2022 | Details |
| A02139 | 34490745 | Pediatr Obes | Effects of PNPLA3, TM6SF2 and SAMM50 on the development and severity of non-alcoholic fatty liver disease in children. | 2021 | Details |
| A02144 | 34488621 | Mol Med | MiR-100 overexpression attenuates high fat diet induced weight gain, liver steatosis, hypertriglyceridemia and development of metabolic syndrome in mice. | 2021 | Details |
| A02153 | 34484560 | Oxid Med Cell Longev | Dietary Valine Ameliorated Gut Health and Accelerated the Development of Nonalcoholic Fatty Liver Disease of Laying Hens. | 2021 | Details |
| A02157 | 34482357 | Med Sci Monit | Live Combined B. subtilis and E. faecium Alleviate Liver Inflammation, Improve Intestinal Barrier Function, and Modulate Gut Microbiota in Mice with Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A02158 | 34482352 | AIDS | Single nucleotide polymorphisms in PNPLA3, ADAR-1 and IFIH1 are associated with advanced liver fibrosis in patients co-infected with HIV-1//hepatitis C virus. | 2021 | Details |
| A02165 | 34478730 | Arch Biochem Biophys | Luteolin alleviates non-alcoholic fatty liver disease in rats via restoration of intestinal mucosal barrier damage and microbiota imbalance involving in gut-liver axis. | 2021 | Details |
| A02174 | 34474519 | Endocrinol Metab (Seoul) | Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability. | 2021 | Details |
| A02178 | 34473313 | Methods Mol Biol | Therapeutic Effects of Resveratrol on Nonalcoholic Fatty Liver Disease Through Inflammatory, Oxidative Stress, Metabolic, and Epigenetic Modifications. | 2022 | Details |
| A02184 | 34470675 | Br J Nutr | Diet containing dehulled adlay ameliorates hepatic steatosis, inflammation and insulin resistance in rats with non-alcoholic fatty liver disease. | 2021 | Details |
| A02194 | 34465857 | Int J Obes (Lond) | Obese mice weight loss role on nonalcoholic fatty liver disease and endoplasmic reticulum stress treated by a GLP-1 receptor agonist. | 2021 | Details |
| A02196 | 34464909 | Diabetes Metab Syndr | Retrospective analysis (2009-2017) of factors associated with progression and regression of non-alcoholic fatty liver disease (Hepatic steatosis) in patients with type 2 diabetes seen at a tertiary diabetes centre in Southern India. | 2021 | Details |
| A02199 | 34463983 | Periodontol 2000 | Periodontal disease-related nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: An emerging concept of oral-liver axis. | 2021 | Details |
| A02208 | 34459959 | Eur J Pediatr | Vitamin D and nonalcoholic fatty liver disease in children: a randomized controlled clinical trial. | 2021 | Details |
| A02211 | 34459096 | Liver Int | Changing clinical management of NAFLD in Asia. | 2021 | Details |
| A02212 | 34459004 | J Food Biochem | Chlorella vulgaris is an effective supplement in counteracting non-alcoholic fatty liver disease-related complications through modulation of dyslipidemia, insulin resistance, and inflammatory pathways. | 2021 | Details |
| A02214 | 34456873 | Front Endocrinol (Lausanne) | Purinergic Signaling in Liver Pathophysiology. | 2021 | Details |
| A02216 | 34456329 | Med Sci Monit | A Review of the Increasing Prevalence of Metabolic-Associated Fatty Liver Disease (MAFLD) in Children and Adolescents Worldwide and in Mexico and the Implications for Public Health. | 2021 | Details |
| A02221 | 34454994 | J Hepatol | Comparison of ADAPT, FIB-4 and APRI as non-invasive predictors of liver fibrosis and NASH within the CENTAUR screening population. | 2021 | Details |
| A02231 | 34453052 | Nat Commun | The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue. | 2021 | Details |