Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Choline1715 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A09916 | 31562685 | J Hepatobiliary Pancreat Sci | Decrease in major secondary bile acid, hyodeoxycholic acid, was the main alteration in hepatic bile acid compositions in a hypertensive nonalcoholic fatty liver disease model. | 2019 | Details |
| A09929 | 31555950 | Gastric Cancer | Risk factors for nonalcoholic fatty liver disease after gastrectomy for gastric cancer. | 2019 | Details |
| A09934 | 31554528 | Br J Nutr | Randomised trial of chronic supplementation with a nutraceutical mixture in subjects with non-alcoholic fatty liver disease. | 2020 | Details |
| A10018 | 31523440 | BMJ Open Gastroenterol | Real-world comorbidities and treatment patterns among patients with non-alcoholic fatty liver disease receiving phosphatidylcholine as adjunctive therapy in Russia. | 2019 | Details |
| A10023 | 31521175 | Lipids Health Dis | Variations in hepatic lipid species of age-matched male mice fed a methionine-choline-deficient diet and housed in different animal facilities. | 2019 | Details |
| A10041 | 31516268 | J Clin Exp Hepatol | Drug Development for Nonalcoholic Fatty Liver Disease: Landscape and Challenges. | 2019 | Details |
| A10057 | 31506634 | Lab Invest | Automated computerized image analysis for the user-independent evaluation of disease severity in preclinical models of NAFLD/NASH. | 2019 | Details |
| A10062 | 31505462 | J Endocrinol | Mice lacking adenosine 2A receptor reveal increased severity of MCD-induced NASH. | 2019 | Details |
| A10068 | 31503515 | Am J Physiol Endocrinol Metab | HDL flux is higher in patients with nonalcoholic fatty liver disease. | 2019 | Details |
| A10088 | 31492960 | Sci Rep | Cerium oxide nanoparticles display antilipogenic effect in rats with non-alcoholic fatty liver disease. | 2019 | Details |
| A10124 | 31474633 | Yakugaku Zasshi | [Involvement of the Free Fatty Acid Receptor GPR120/FFAR4 in the Development of Nonalcoholic Steatohepatitis]. | 2019 | Details |
| A10141 | 31470620 | Molecules | Study of Methionine Choline Deficient Diet-Induced Steatosis in Mice Using Endogenous Fluorescence Spectroscopy. | 2019 | Details |
| A10192 | 31440998 | Dig Dis Sci | Baseline and Post-treatment 18F-Fluorocholine PET/CT Predicts Outcomes in Hepatocellular Carcinoma Following Locoregional Therapy. | 2019 | Details |
| A10205 | 31433301 | J Hepatol | Integrin β1-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH. | 2019 | Details |
| A10226 | 31421545 | Int Immunopharmacol | Scoparone alleviates inflammation, apoptosis and fibrosis of non-alcoholic steatohepatitis by suppressing the TLR4/NF-κB signaling pathway in mice. | 2019 | Details |
| A10229 | 31420528 | J Pharmacol Exp Ther | Withaferin A Improves Nonalcoholic Steatohepatitis in Mice. | 2019 | Details |
| A10230 | 31420525 | J Pharmacol Exp Ther | A Pharmacokinetic Natural Product-Disease-Drug Interaction: A Double Hit of Silymarin and Nonalcoholic Steatohepatitis on Hepatic Transporters in a Rat Model. | 2019 | Details |
| A10233 | 31419514 | J Hepatol | Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development. | 2019 | Details |
| A10256 | 31409057 | Cells | iPla2β Deficiency Suppresses Hepatic ER UPR, Fxr, and Phospholipids in Mice Fed with MCD Diet, Resulting in Exacerbated Hepatic Bile Acids and Biliary Cell Proliferation. | 2019 | Details |
| A10257 | 31408914 | Mol Nutr Food Res | In Utero One-Carbon Metabolism Interplay and Metabolic Syndrome in Cardiovascular Disease Risk Reduction. | 2019 | Details |
| A10323 | 31388096 | Int J Obes (Lond) | Circulating microbiota-derived metabolites: a "liquid biopsy? | 2019 | Details |
| A10337 | 31384535 | Acta Pharm Sin B | Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway. | 2019 | Details |
| A10398 | 31355279 | Biomed Res Int | Hepatoprotective Effect of Jianpi Huoxue Formula on Nonalcoholic Fatty Liver Disease Induced by Methionine-Choline-Deficient Diet in Rat. | 2019 | Details |
| A10471 | 31323923 | Toxins (Basel) | Sub-Chronic Microcystin-LR Liver Toxicity in Preexisting Diet-Induced Nonalcoholic Steatohepatitis in Rats. | 2019 | Details |
| A10474 | 31322255 | Mol Med Rep | Adenovirus‑mediated overexpression of bone morphogenetic protein‑9 promotes methionine choline deficiency‑induced non‑alcoholic steatohepatitis in non‑obese mice. | 2019 | Details |
| A10484 | 31316716 | Oxid Med Cell Longev | Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model. | 2019 | Details |
| A10516 | 31306673 | Toxicol Appl Pharmacol | Altered bile acid composition and disposition in a mouse model of non-alcoholic steatohepatitis. | 2019 | Details |
| A10518 | 31305223 | J Am Coll Nutr | Adiposity May Moderate the Link Between Choline Intake and Non-alcoholic Fatty Liver Disease. | 2019 | Details |
| A10536 | 31297627 | Dig Dis Sci | A Cholecystokinin Receptor Antagonist Halts Nonalcoholic Steatohepatitis and Prevents Hepatocellular Carcinoma. | 2019 | Details |
| A10570 | 31284753 | FASEB J | Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance. | 2019 | Details |
| A10617 | 31269941 | BMC Complement Altern Med | Qianggan extract improved nonalcoholic steatohepatitis by modulating lncRNA/circRNA immune ceRNA networks. | 2019 | Details |
| A10678 | 31239664 | Int J Nanomedicine | Mixed micelles loaded with the 5-benzylidenethiazolidine-2,4-dione derivative SKLB023 for efficient treatment of non-alcoholic steatohepatitis. | 2019 | Details |
| A10754 | 31209199 | Cell Death Dis | Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis. | 2019 | Details |
| A10774 | 31199045 | Liver Int | Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression. | 2019 | Details |
| A10822 | 31173200 | Mol Med Rep | Diallyl disulfide attenuates non‑alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, lipid peroxidation and inflammation in mice. | 2019 | Details |
| A10835 | 31165837 | Food Funct | Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota. | 2019 | Details |
| A10840 | 31163617 | Int J Mol Sci | Exogenous Administration of Low-Dose Lipopolysaccharide Potentiates Liver Fibrosis in a Choline-Deficient l-Amino-Acid-Defined Diet-Induced Murine Steatohepatitis Model. | 2019 | Details |
| A10856 | 31153716 | Ultrasound Med Biol | The Speed of Sound in Rat Liver With Steatohepatitis: Ex Vivo Analysis Using Two Types of Ultrasound Systems. | 2019 | Details |
| A10885 | 31141073 | Arq Gastroenterol | 18F-FDG PET/CT AS AN ASSESSMENT TOOL OF HEPATOCELLULAR CARCINOMA SECONDARY TO NON-ALCOHOLIC FATTY LIVER DISEASE DEVELOPMENT IN EXPERIMENTAL MODEL. | 2019 | Details |
| A10904 | 31132306 | Scand J Immunol | Epoxyeicosatrienoic acids alleviate methionine-choline-deficient diet-induced non-alcoholic steatohepatitis in mice. | 2019 | Details |
| A10911 | 31129048 | Biochem Pharmacol | A dual farnesoid X receptor/soluble epoxide hydrolase modulator treats non-alcoholic steatohepatitis in mice. | 2019 | Details |
| A10952 | 31105592 | Front Physiol | Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway. | 2019 | Details |
| A10960 | 31101783 | Georgian Med News | RESULTS OF CORRECTION OF THE HEPATIC STEATOSIS ON THE BACKGROUND OF HYPERTENSION AND OVERWEIGHT WITH HELP OF ESSENTIAL PHOSPHOLIPID COMPLEX. | 2019 | Details |
| A10975 | 31095863 | Mol Nutr Food Res | Trimethylamine N-Oxide Aggravates Liver Steatosis through Modulation of Bile Acid Metabolism and Inhibition of Farnesoid X Receptor Signaling in Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A10996 | 31086990 | Toxicol Sci | Gene Expression and DNA Methylation Alterations in the Glycine N-Methyltransferase Gene in Diet-Induced Nonalcoholic Fatty Liver Disease-Associated Carcinogenesis. | 2019 | Details |
| A10997 | 31086120 | Int J Mol Sci | Hepatoprotective Effect of Kombucha Tea in Rodent Model of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis. | 2019 | Details |
| A11024 | 31078624 | Gastroenterology | Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis. | 2019 | Details |
| A11025 | 31078545 | Life Sci | Histological evaluation of nintedanib in non-alcoholic steatohepatitis mice. | 2019 | Details |
| A11114 | 31035991 | BMC Complement Altern Med | The Alisma and Rhizoma decoction abates nonalcoholic steatohepatitis-associated liver injuries in mice by modulating oxidative stress and autophagy. | 2019 | Details |
| A11148 | 31023717 | Biol Open | Longitudinal characterization of diet-induced genetic murine models of non-alcoholic steatohepatitis with metabolic, histological, and transcriptomic hallmarks of human patients. | 2019 | Details |
| A11185 | 31008094 | Prev Nutr Food Sci | Long-Term Feeding of Soy Protein Attenuates Choline Deficient-Induced Adverse Effects in Wild Type Mice and Prohibitin 1 Deficient Mice Response More Sensitively. | 2019 | Details |
| A11252 | 30973211 | J Cell Mol Med | The phytochemical polydatin ameliorates non-alcoholic steatohepatitis by restoring lysosomal function and autophagic flux. | 2019 | Details |
| A11268 | 30965590 | Nutrients | Fatty Acid Desaturase Involvement in Non-Alcoholic Fatty Liver Disease Rat Models: Oxidative Stress Versus Metalloproteinases. | 2019 | Details |
| A11295 | 30951375 | FASEB J | The immunoregulatory effects of CD8 T-cell-derived perforin on diet-induced nonalcoholic steatohepatitis. | 2019 | Details |
| A11309 | 30945293 | J Pathol | Bone marrow-derived macrophage contributes to fibrosing steatohepatitis through activating hepatic stellate cells. | 2019 | Details |
| A11311 | 30944821 | J Clin Transl Hepatol | Fatty Liver Disease and Gut Microbiota: A Comprehensive Update. | 2018 | Details |
| A11331 | 30935688 | Biochem Biophys Res Commun | Metformin alleviates inflammatory response in non-alcoholic steatohepatitis by restraining signal transducer and activator of transcription 3-mediated autophagy inhibition in vitro and in vivo. | 2019 | Details |
| A11380 | 30918325 | Lab Invest | Human relaxin-2 attenuates hepatic steatosis and fibrosis in mice with non-alcoholic fatty liver disease. | 2019 | Details |
| A11385 | 30917489 | Int J Mol Sci | MicroRNA-29a Disrupts DNMT3b to Ameliorate Diet-Induced Non-Alcoholic Steatohepatitis in Mice. | 2019 | Details |
| A11396 | 30914267 | J Hepatol | Macrophage p38α promotes nutritional steatohepatitis through M1 polarization. | 2019 | Details |
| A11433 | 30896960 | Rev Esp Enferm Dig | Metabolic characterization of two different non-alcoholic fatty liver disease pre-clinical mouse models. | 2019 | Details |
| A11461 | 30887659 | Int J Exp Pathol | Vitronectin deficiency attenuates hepatic fibrosis in a non-alcoholic steatohepatitis-induced mouse model. | 2019 | Details |
| A11463 | 30885145 | BMC Gastroenterol | The FATZO mouse, a next generation model of type 2 diabetes, develops NAFLD and NASH when fed a Western diet supplemented with fructose. | 2019 | Details |
| A11534 | 30854350 | Can J Gastroenterol Hepatol | Animal Models of Steatosis (NAFLD) and Steatohepatitis (NASH) Exhibit Hepatic Lobe-Specific Gelatinases Activity and Oxidative Stress. | 2019 | Details |
| A11546 | 30849452 | Toxicon | Nonalcoholic fatty liver disease alters microcystin-LR toxicokinetics and acute toxicity. | 2019 | Details |
| A11595 | 30825110 | Dig Dis Sci | Antifibrotic Effects of 1,25(OH)2D3 on Nonalcoholic Steatohepatitis in Female Mice. | 2019 | Details |
| A11621 | 30815318 | Food Sci Biotechnol | Effect of Kombucha on gut-microbiota in mouse having non-alcoholic fatty liver disease. | 2018 | Details |
| A11668 | 30796899 | Clin Chim Acta | Composition of plasmalogens in serum lipoproteins from patients with non-alcoholic steatohepatitis and their susceptibility to oxidation. | 2019 | Details |
| A11670 | 30796508 | Eur J Nutr | Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial. | 2019 | Details |
| A11671 | 30794826 | Toxicol Appl Pharmacol | Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis. | 2019 | Details |
| A11693 | 30789804 | Int J Vitam Nutr Res | Liver Histological Improvement After Administration of High-Dose Vitamin C in Guinea Pig with Nonalcoholic Steatohepatitis. | 2019 | Details |
| A11719 | 30778201 | Cell Death Differ | The transcription factor c-Jun/AP-1 promotes liver fibrosis during non-alcoholic steatohepatitis by regulating Osteopontin expression. | 2019 | Details |
| A11756 | 30765737 | Sci Rep | Nutritional and lipidomics biomarkers of docosahexaenoic acid-based multivitamin therapy in pediatric NASH. | 2019 | Details |
| A11769 | 30758417 | Rev Assoc Med Bras (1992) | The efficacy of saxagliptin in T2DM patients with non-alcoholic fatty liver disease: preliminary data. | 2019 | Details |
| A11779 | 30747091 | Curr Mol Pharmacol | Activation of GLP-1 and Glucagon Receptors Regulates Bile Homeostasis Independent of Thyroid Hormone. | 2019 | Details |
| A11786 | 30745416 | J Pharmacol Exp Ther | RLA8-A New and Highly Effective Quadruple PPAR-α/γ/δ and GPR40 Agonist to Reverse Nonalcoholic Steatohepatitis and Fibrosis. | 2019 | Details |
| A11790 | 30744124 | Mar Drugs | Inhibitory Effects of Sodium Alginate on Hepatic Steatosis in Mice Induced by a Methionine- and Choline-deficient Diet. | 2019 | Details |
| A11799 | 30735855 | Biochim Biophys Acta Mol Cell Biol Lipids | Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling. | 2019 | Details |
| A11800 | 30735854 | Biochim Biophys Acta Mol Cell Biol Lipids | iPla2β deficiency in mice fed with MCD diet does not correct the defect of phospholipid remodeling but attenuates hepatocellular injury via an inhibition of lipid uptake genes. | 2019 | Details |
| A11825 | 30720095 | Mol Med Rep | Comprehensive circular RNA expression profiles in a mouse model of nonalcoholic steatohepatitis. | 2019 | Details |
| A11827 | 30719448 | Biomed Res Int | Gut Microbiota-Derived Mediators as Potential Markers in Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A11897 | 30689995 | Eur J Pharmacol | Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease. | 2019 | Details |
| A11898 | 30689994 | Eur J Pharmacol | Evaluating the therapeutic potential of one-carbon donors in nonalcoholic fatty liver disease. | 2019 | Details |
| A11900 | 30689650 | PLoS One | Conophylline inhibits high fat diet-induced non-alcoholic fatty liver disease in mice. | 2019 | Details |
| A11910 | 30684890 | Redox Biol | Adropin protects against liver injury in nonalcoholic steatohepatitis via the Nrf2 mediated antioxidant capacity. | 2018 | Details |
| A11921 | 30681159 | J Inherit Metab Dis | Choline-related-inherited metabolic diseases-A mini review. | 2019 | Details |
| A12010 | 30646522 | Int J Mol Sci | Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis. | 2019 | Details |
| A12026 | 30636945 | J Korean Med Sci | Feasibility and Stability of Liver Biopsy before Treatment for Preclinical Nonalcoholic Fatty Liver Studies. | 2019 | Details |
| A12028 | 30635917 | Br J Pharmacol | Betulinic acid alleviates endoplasmic reticulum stress-mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice. | 2019 | Details |
| A12053 | 30621707 | Lipids Health Dis | Plasma lipidomic signatures of spontaneous obese rhesus monkeys. | 2019 | Details |
| A12090 | 30606928 | Yakugaku Zasshi | [The Investigation of Genes, Using an Improved Adenovirus Vector, and Food for the Treatment and Prevention of Type 2 Diabetes Mellitus]. | 2019 | Details |
| A12155 | 30579258 | Biomed Pharmacother | Administration of methyl palmitate prevents non-alcoholic steatohepatitis (NASH) by induction of PPAR-α. | 2018 | Details |
| A12182 | 30572788 | Biosci Biotechnol Biochem | A review of the studies on food-derived factors which regulate energy metabolism via the modulation of lipid-sensing nuclear receptors. | 2018 | Details |
| A12207 | 30561388 | J Clin Invest | STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis. | 2018 | Details |
| A12211 | 30560362 | Eur Radiol | Quantitative ultrasound and machine learning for assessment of steatohepatitis in a rat model. | 2018 | Details |
| A12225 | 30556037 | Hepatol Commun | Inhibition of Plasminogen Activator Inhibitor 1 Attenuates Hepatic Steatosis but Does Not Prevent Progressive Nonalcoholic Steatohepatitis in Mice. | 2018 | Details |
| A12271 | 30539788 | Cell Mol Gastroenterol Hepatol | Macrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis. | 2018 | Details |
| A12273 | 30538805 | Oxid Med Cell Longev | c-Met Signaling Protects from Nonalcoholic Steatohepatitis- (NASH-) Induced Fibrosis in Different Liver Cell Types. | 2018 | Details |
| A12277 | 30537674 | Biomed Pharmacother | Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway. | 2018 | Details |
| A12295 | 30522014 | Biomed Pharmacother | Wuzhi capsule (Schisandra Sphenanthera extract) attenuates liver steatosis and inflammation during non-alcoholic fatty liver disease development. | 2018 | Details |