Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Fatty acid synthase594 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A24829 | 22457136 | Chin J Integr Med | Ping-tang Recipe () improves insulin resistance and attenuates hepatic steatosis in high-fat diet-induced obese rats. | 2012 | Details |
| A24861 | 22425624 | J Hepatol | Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. | 2012 | Details |
| A24992 | 22271167 | Hepatology | Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice. | 2012 | Details |
| A25056 | 33907358 | J Proteomics Bioinform | High Fat Diet-Induced Changes in Hepatic Protein Abundance in Mice. | 2012 | Details |
| A25220 | 22083307 | Mol Cells | Time-dependent changes in lipid metabolism in mice with methionine choline deficiency-induced fatty liver disease. | 2011 | Details |
| A25233 | 22067945 | Lipids Health Dis | Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice. | 2011 | Details |
| A25248 | 22046322 | PLoS One | Protective effects of white button mushroom (Agaricus bisporus) against hepatic steatosis in ovariectomized mice as a model of postmenopausal women. | 2011 | Details |
| A25298 | 21986673 | Eur J Nutr | Dietary supplementation of herring roe and milt enhances hepatic fatty acid catabolism in female mice transgenic for hTNFα. | 2011 | Details |
| A25301 | 21986124 | J Int Med Res | The role of hepatic liver X receptor α- and sterol regulatory element binding protein-1c-mediated lipid disorder in the pathogenesis of non-alcoholic steatohepatitis in rats. | 2011 | Details |
| A25319 | 21958877 | Eur J Pharmacol | Metformin regulates hepatic lipid metabolism through activating AMP-activated protein kinase and inducing ATGL in laying hens. | 2011 | Details |
| A25351 | 21936721 | Scand J Gastroenterol | Short-term inhibition of SREBP-1c expression reverses diet-induced non-alcoholic fatty liver disease in mice. | 2011 | Details |
| A25444 | 21835806 | J Gerontol A Biol Sci Med Sci | Aging is associated with a shift of fatty metabolism toward lipogenesis. | 2011 | Details |
| A25482 | 21781943 | J Hepatol | High fructose feeding induces copper deficiency in Sprague-Dawley rats: a novel mechanism for obesity related fatty liver. | 2011 | Details |
| A25543 | 21733326 | Br J Nutr | Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress. | 2011 | Details |
| A25566 | 21705395 | J Endocrinol | A selective estrogen receptor α agonist ameliorates hepatic steatosis in the male aromatase knockout mouse. | 2011 | Details |
| A25583 | 21689150 | J Pineal Res | Melatonin alleviates lipopolysaccharide-induced hepatic SREBP-1c activation and lipid accumulation in mice. | 2011 | Details |
| A25606 | 21656912 | Proteomics Clin Appl | Utility of formalin-fixed, paraffin-embedded liver biopsy specimens for global proteomic analysis in nonalcoholic steatohepatitis. | 2011 | Details |
| A25630 | 21624329 | Zhonghua Yu Fang Yi Xue Za Zhi | [Effects of soybean isoflavone on liver lipid metabolism in nonalcoholic fatty liver rats]. | 2011 | Details |
| A25635 | 21620823 | Eur J Pharmacol | Osthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol regulatory element-binding protein-1c/2-mediated target gene expression. | 2011 | Details |
| A25860 | 21382219 | Br J Nutr | Neonatal exposure to genistein ameliorates high-fat diet-induced non-alcoholic steatohepatitis in rats. | 2011 | Details |
| A25882 | 21356258 | J Hepatol | Intravenous administration of multipotent stromal cells prevents the onset of non-alcoholic steatohepatitis in obese mice with metabolic syndrome. | 2011 | Details |
| A26196 | 20929443 | Clin Sci (Lond) | Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C. | 2011 | Details |
| A26226 | 20868235 | Biol Chem | Bile acid retention and activation of endogenous hepatic farnesoid-X-receptor in the pathogenesis of fatty liver disease in ob/ob-mice. | 2010 | Details |
| A26252 | 20836990 | Biochem Biophys Res Commun | Nordihydroguaiaretic acid protects against high-fat diet-induced fatty liver by activating AMP-activated protein kinase in obese mice. | 2010 | Details |
| A26318 | 20655714 | J Nutr Biochem | Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice. | 2010 | Details |
| A26352 | 20606731 | Int J Clin Exp Pathol | Expression of fatty acid synthase in nonalcoholic fatty liver disease. | 2010 | Details |
| A26355 | 20602678 | Liver Int | Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes. | 2010 | Details |
| A26561 | 20204561 | AAPS J | Role of cannabinoids in the development of fatty liver (steatosis). | 2010 | Details |
| A26601 | 20112035 | Amino Acids | Methionine limitation results in increased hepatic FAS activity, higher liver 18:1 to 18:0 fatty acid ratio and hepatic TAG accumulation in Atlantic salmon, Salmo salar. | 2010 | Details |
| A26666 | 20025483 | Pathology | Olive leaf extract prevents spontaneous occurrence of non-alcoholic steatohepatitis in SHR/NDmcr-cp rats. | 2010 | Details |
| A26703 | 19929925 | J Gastroenterol Hepatol | Endoplasmic reticulum stress involved in the course of lipogenesis in fatty acids-induced hepatic steatosis. | 2009 | Details |
| A26785 | 19788606 | J Gastroenterol Hepatol | Roles of adipose restriction and metabolic factors in progression of steatosis to steatohepatitis in obese, diabetic mice. | 2009 | Details |
| A26820 | 19724016 | Am J Physiol Endocrinol Metab | Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice. | 2009 | Details |
| A26889 | 19583937 | Zhong Xi Yi Jie He Xue Bao | [Effects of Qushi Huayu Decoction in prevention and treatment of fatty liver in rats based on adiponectin-free fatty acid pathway]. | 2009 | Details |
| A27064 | 19231010 | J Hepatol | Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH. | 2009 | Details |
| A27168 | 19054139 | Hepatol Res | Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease. | 2008 | Details |
| A27179 | 19032865 | Zhonghua Gan Zang Bing Za Zhi | [Expression and action of hepatic sterol regulatory element-binding protein-1c in patients with nonalcoholic fatty liver disease]. | 2008 | Details |
| A27305 | 18684130 | Hepatol Res | Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. | 2008 | Details |
| A27338 | 18617560 | J Physiol | Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. | 2008 | Details |
| A27384 | 18501344 | Eur J Pharmacol | Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects. | 2008 | Details |
| A27434 | 18395287 | J Hepatol | Fructose consumption as a risk factor for non-alcoholic fatty liver disease. | 2008 | Details |
| A27477 | 18317565 | J Clin Invest | Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. | 2008 | Details |
| A27534 | 18174272 | Am J Physiol Gastrointest Liver Physiol | Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats. | 2008 | Details |
| A27657 | 17716660 | FEBS Lett | Role of ChREBP in hepatic steatosis and insulin resistance. | 2007 | Details |
| A27684 | 17671740 | Int J Mol Med | Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. | 2007 | Details |
| A28206 | 16142397 | Int J Mol Med | Evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. | 2005 | Details |
| A28741 | 35076948 | Hepatology | Therapeutic efficacy of FASN inhibition in preclinical models of HCC. | 2022 | Details |
| A29063 | 34638751 | Int J Mol Sci | Anti-Obesity Effect of Polygalin C Isolated from Polygala japonica Houtt. via Suppression of the Adipogenic and Lipogenic Factors in 3T3-L1 Adipocytes. | 2021 | Details |
| A29394 | 34149876 | Exp Ther Med | Co-administration of obeticholic acid and simvastatin protects against high-fat diet-induced non-alcoholic steatohepatitis in mice. | 2021 | Details |
| A29976 | 33178326 | Evid Based Complement Alternat Med | Efficacy and Mechanism of a Chinese Classic Prescription of Yueju in Treating Nonalcoholic Steatohepatitis and Protecting Hepatocytes from Apoptosis. | 2020 | Details |
| A30482 | 32373294 | Iran J Basic Med Sci | Allantoin improves methionine-choline deficient diet-induced nonalcoholic steatohepatitis in mice through involvement in endoplasmic reticulum stress and hepatocytes apoptosis-related genes expressions. | 2019 | Details |
| A31513 | 30411084 | Hepatol Commun | FXR and TGR5 Agonists Ameliorate Liver Injury, Steatosis, and Inflammation After Binge or Prolonged Alcohol Feeding in Mice. | 2018 | Details |
| A31728 | 29973237 | J Exp Clin Cancer Res | Up-regulation of FGF15/19 signaling promotes hepatocellular carcinoma in the background of fatty liver. | 2018 | Details |
| A32019 | 30906835 | Genes Dis | Neonatal overfeeding in mice aggravates the development of methionine and choline-deficient diet-induced steatohepatitis in adulthood. | 2018 | Details |
| A32164 | 29068700 | Nutr Cancer | Silibinin Reduces the Impact of Obesity on Invasive Liver Cancer. | 2017 | Details |
| A32462 | 28386316 | Am J Transl Res | Energy intake correlates with the levels of fatty acid synthase and insulin-like growth factor-1 in male and female C57BL/6 mice. | 2017 | Details |
| A32876 | 27185461 | J Mol Biol | The Nutrient-Dependent O-GlcNAc Modification Controls the Expression of Liver Fatty Acid Synthase. | 2016 | Details |
| A32923 | 27083546 | Poult Sci | Expression and methylation of microsomal triglyceride transfer protein and acetyl-CoA carboxylase are associated with fatty liver syndrome in chicken. | 2016 | Details |
| A33951 | 24793484 | Biochimie | ApoA-I or ABCA1 expression suppresses fatty acid synthesis by reducing 27-hydroxycholesterol levels. | 2014 | Details |
| A35472 | 20566747 | Am J Pathol | Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice. | 2010 | Details |
| A36768 | 17300698 | Hepatol Res | Longitudinal analysis of murine steatohepatitis model induced by chronic exposure to high-fat diet. | 2007 | Details |
| A36801 | 17241878 | Gastroenterology | Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. | 2006 | Details |
| A37309 | 15985534 | FASEB J | Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis. | 2005 | Details |
| A42406 | 34621322 | Evid Based Complement Alternat Med | YiQi YangYin Decoction Attenuates Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Rats. | 2021 | Details |
| A42433 | 34532001 | Food Sci Nutr | L-citrulline inhibits body weight gain and hepatic fat accumulation by improving lipid metabolism in a rat nonalcoholic fatty liver disease model. | 2021 | Details |
| A43023 | 32781957 | Mini Rev Med Chem | Recent Advances in the Development of Fatty Acid Synthase Inhibitors as Anticancer Agents. | 2020 | Details |
| A43197 | 32331890 | J Dairy Sci | Sirtuin 3 improves fatty acid metabolism in response to high nonesterified fatty acids in calf hepatocytes by modulating gene expression. | 2020 | Details |
| A43307 | 32012270 | J Cell Physiol | Effects of different fatty acids on BRL3A rat liver cell damage. | 2020 | Details |
| A43312 | 32007939 | J Lipid Res | Erratum: FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice. | 2020 | Details |
| A43623 | 31264285 | J Cell Biochem | Effect of oleic acid on induction of steatosis and cytotoxicity in BRL 3A cells. | 2019 | Details |
| A43671 | 31142011 | Int J Mol Sci | Involvement of G-Protein-Coupled Receptor 40 in the Inhibitory Effects of Docosahexaenoic Acid on SREBP1-Mediated Lipogenic Enzyme Expression in Primary Hepatocytes. | 2019 | Details |
| A43840 | 30734689 | Endocr Metab Immune Disord Drug Targets | Silibinin Ameliorates Fructose-induced Lipid Accumulation and Activates Autophagy in HepG2 Cells. | 2019 | Details |
| A43874 | 30625338 | Toxicol Appl Pharmacol | Metformin delays AKT/c-Met-driven hepatocarcinogenesis by regulating signaling pathways for de novo lipogenesis and ATP generation. | 2019 | Details |
| A44118 | 29694888 | Cell Rep | Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages. | 2018 | Details |
| A44194 | 29465311 | FASEB J | p32 regulates ER stress and lipid homeostasis by down-regulating GCS1 expression. | 2018 | Details |
| A44262 | 29207074 | Mol Med Rep | Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout. | 2017 | Details |
| A44344 | 28903485 | Toxicol Sci | Editor's Highlight: Mechanistic Toxicity Tests Based on an Adverse Outcome Pathway Network for Hepatic Steatosis. | 2017 | Details |
| A44353 | 28866102 | Life Sci | Liver steatosis in hypothalamic obese rats improves after duodeno-jejunal bypass by reduction in de novo lipogenesis pathway. | 2017 | Details |
| A44505 | 28448873 | Biomed Pharmacother | Osthole attenuates lipid accumulation, regulates the expression of inflammatory mediators, and increases antioxidants in FL83B cells. | 2017 | Details |
| A44506 | 28447751 | Mol Med Rep | Deep sea water improves hypercholesterolemia and hepatic lipid accumulation through the regulation of hepatic lipid metabolic gene expression. | 2017 | Details |
| A44517 | 28386270 | PPAR Res | Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPARδ Regulation in Hyperlipidemic and Hypertensive Conditions. | 2017 | Details |
| A44531 | 28331449 | Ochsner J | Cyclin D1 in the Liver: Role of Noncanonical Signaling in Liver Steatosis and Hormone Regulation. | 2017 | Details |
| A44840 | 27108106 | Food Chem Toxicol | High calcium diet improves the liver oxidative stress and microsteatosis in adult obese rats that were overfed during lactation. | 2016 | Details |
| A44872 | 27013659 | J Biol Chem | Liver MicroRNA-291b-3p Promotes Hepatic Lipogenesis through Negative Regulation of Adenosine 5'-Monophosphate (AMP)-activated Protein Kinase α1. | 2016 | Details |
| A44920 | 26790190 | Pharmazie | Nectandrin B, a lignan isolated from nutmeg, inhibits liver X receptor-α-induced hepatic lipogenesis through AMP-activated protein kinase activation. | 2015 | Details |
| A45089 | 26108684 | Mol Nutr Food Res | Calebin-A inhibits adipogenesis and hepatic steatosis in high-fat diet-induced obesity via activation of AMPK signaling. | 2015 | Details |
| A45095 | 26092479 | Life Sci | Improvement in the expression of hepatic genes involved in fatty acid metabolism in obese rats supplemented with taurine. | 2015 | Details |
| A45338 | 25123628 | J Nutr Biochem | Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. | 2014 | Details |
| A45452 | 24490657 | BMC Complement Altern Med | Isoquercitrin activates the AMP-activated protein kinase (AMPK) signal pathway in rat H4IIE cells. | 2014 | Details |
| A45509 | 24223615 | Evid Based Complement Alternat Med | Zerumbone, a Natural Cyclic Sesquiterpene of Zingiber zerumbet Smith, Attenuates Nonalcoholic Fatty Liver Disease in Hamsters Fed on High-Fat Diet. | 2013 | Details |
| A45528 | 24129500 | Eur J Nutr | Adiponectin receptor 1 enhances fatty acid metabolism and cell survival in palmitate-treated HepG2 cells through the PI3 K/AKT pathway. | 2013 | Details |
| A45592 | 23731091 | J Agric Food Chem | Mulberry anthocyanins inhibit oleic acid induced lipid accumulation by reduction of lipogenesis and promotion of hepatic lipid clearance. | 2013 | Details |
| A45875 | 22243683 | Lipids Health Dis | Cyanidin-3-O-β-glucoside regulates fatty acid metabolism via an AMP-activated protein kinase-dependent signaling pathway in human HepG2 cells. | 2012 | Details |
| A45880 | 22225954 | Metabolism | Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease. | 2012 | Details |
| A45897 | 22154323 | Metabolism | Ursodeoxycholic acid improves insulin sensitivity and hepatic steatosis by inducing the excretion of hepatic lipids in high-fat diet-fed KK-Ay mice. | 2011 | Details |
| A45951 | 21893033 | Biochem Biophys Res Commun | Regular exercise prevents high-sucrose diet-induced fatty liver via improvement of hepatic lipid metabolism. | 2011 | Details |
| A45994 | 21701901 | Hepatol Int | Murine gamma herpes virus 68 infection promotes fatty liver formation and hepatic insulin resistance in C57BL/6J mice. | 2011 | Details |
| A46105 | 21084450 | Endocrinology | GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism. | 2010 | Details |
| A46117 | 20967760 | Hepatology | Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease. | 2010 | Details |
| A46130 | 20860563 | Liver Int | Cross-regulation of cannabinoid CB₁ and CB₂ receptors governs hepatic steatosis. | 2010 | Details |