Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A14772 | 29247122 | FASEB J | Prostaglandin I2 suppresses the development of diet-induced nonalcoholic steatohepatitis in mice. | 2017 | Details |
| A14786 | 29234202 | J Clin Exp Hepatol | Matrix Metalloproteinases (MMPs) in Liver Diseases. | 2017 | Details |
| A14796 | 29227477 | Nat Med | The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis. | 2017 | Details |
| A14864 | 29201040 | PPAR Res | Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice. | 2017 | Details |
| A14865 | 29200733 | Pharmacogn Mag | Amelioration of Intestinal Barrier Dysfunction by Berberine in the Treatment of Nonalcoholic Fatty Liver Disease in Rats. | 2017 | Details |
| A14896 | 29187142 | BMC Gastroenterol | Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis. | 2017 | Details |
| A14904 | 29181663 | Bull Exp Biol Med | Gene TNF Polymorphism -308G>A (rs1800629) and Its Relationship with the Efficiency of Ursodeoxycholic Acid Therapy in Patients with Nonalcoholic Stetohepatitis. | 2017 | Details |
| A14940 | 29164820 | Liver Int | Dual PPARα/γ agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models. | 2017 | Details |
| A14956 | 29158052 | Life Sci | Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice. | 2017 | Details |
| A14999 | 29129819 | Metabolism | Nicotinic acetylcholine receptor α7 subunit improves energy homeostasis and inhibits inflammation in nonalcoholic fatty liver disease. | 2017 | Details |
| A15062 | 29113741 | Cytokine | Low serum CTRP3 levels are associated with nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. | 2017 | Details |
| A15064 | 29113135 | Nutrients | Nonalcoholic Fatty Liver Disease Is Exacerbated in High-Fat Diet-Fed Gnotobiotic Mice by Colonization with the Gut Microbiota from Patients with Nonalcoholic Steatohepatitis. | 2017 | Details |
| A15112 | 29089335 | Am J Physiol Endocrinol Metab | Effects of periconceptional maternal alcohol intake and a postnatal high-fat diet on obesity and liver disease in male and female rat offspring. | 2017 | Details |
| A15157 | 29069580 | Eur J Pharmacol | Nicotinamide prevents sweet beverage-induced hepatic steatosis in rats by regulating the G6PD, NADPH/NADP+ and GSH/GSSG ratios and reducing oxidative and inflammatory stress. | 2017 | Details |
| A15193 | 29056000 | Zhonghua Gan Zang Bing Za Zhi | [The progress of studying the mechanisms of immune cells in the regulation of non-alcoholic fatty liver diseases]. | 2017 | Details |
| A15223 | 29037210 | Lipids Health Dis | A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease. | 2017 | Details |
| A15224 | 29036959 | Zhonghua Nei Ke Za Zhi | [The study of liver macrophages polarization in patients with autoimmune hepatitis]. | 2017 | Details |
| A15270 | 28993096 | Transl Res | Altered expression of MALAT1 lncRNA in nonalcoholic steatohepatitis fibrosis regulates CXCL5 in hepatic stellate cells. | 2017 | Details |
| A15275 | 28990215 | J Ultrasound Med | Ultrasonic Perfluorohexane-Loaded Monocyte Imaging: Toward a Minimally Invasive Technique for Selective Detection of Liver Inflammation in Fatty Liver Disease. | 2017 | Details |
| A15312 | 28971098 | Front Nutr | The Nutraceutic Silybin Counteracts Excess Lipid Accumulation and Ongoing Oxidative Stress in an In Vitro Model of Non-Alcoholic Fatty Liver Disease Progression. | 2017 | Details |
| A15367 | 28942443 | Cell Physiol Biochem | A Novel Role of SIRT1/ FGF-21 in Taurine Protection Against Cafeteria Diet-Induced Steatohepatitis in Rats. | 2017 | Details |
| A15402 | 28929125 | Open Forum Infect Dis | The Association of Inflammatory Markers With Nonalcoholic Fatty Liver Disease Differs by Human Immunodeficiency Virus Serostatus. | 2017 | Details |
| A15418 | 28923316 | Acta Histochem | Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring. | 2017 | Details |
| A15419 | 28922680 | Horm Metab Res | Pivotal Role of TNF-α in the Development and Progression of Nonalcoholic Fatty Liver Disease in a Murine Model. | 2017 | Details |
| A15447 | 28902579 | Islets | Effect of liver histopathology on islet cell engraftment in the model mimicking autologous islet cell transplantation. | 2017 | Details |
| A15482 | 28881825 | Oncotarget | Development of hepatocellular cancer induced by long term low fat-high carbohydrate diet in a NAFLD/NASH mouse model. | 2017 | Details |
| A15485 | 28880231 | Nutrients | The Impact of Sex and 25(OH)D Deficiency on Metabolic Function in Mice. | 2017 | Details |
| A15541 | 28852433 | Oxid Med Cell Longev | Cytokines Genotype-Phenotype Correlation in Nonalcoholic Steatohepatitis. | 2017 | Details |
| A15558 | 28844958 | Biochim Biophys Acta Mol Basis Dis | Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet. | 2017 | Details |
| A15564 | 28842175 | Clin Chim Acta | Metabonomics screening of serum identifies pyroglutamate as a diagnostic biomarker for nonalcoholic steatohepatitis. | 2017 | Details |
| A15567 | 28840697 | Zhongguo Zhong Yao Za Zhi | [Effect of Psoralea corylifolia in treating fatty liver disease in juvenal mouse by inhibiting hepatic NF-κB activation]. | 2017 | Details |
| A15633 | 28797988 | Turk J Gastroenterol | Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease. | 2017 | Details |
| A15678 | 28768719 | FASEB J | The specialized proresolving lipid mediator maresin 1 protects hepatocytes from lipotoxic and hypoxia-induced endoplasmic reticulum stress. | 2017 | Details |
| A15683 | 28763845 | Zhonghua Gan Zang Bing Za Zhi | [Sivelestat alleviates nonalcoholic steatohepatitis in mice through inhibiting activation of Kupffer cells]. | 2017 | Details |
| A15701 | 28752050 | Mol Metab | Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders. | 2017 | Details |
| A15734 | 28737815 | Food Funct | Isofraxidin, a coumarin component improves high-fat diet induced hepatic lipid homeostasis disorder and macrophage inflammation in mice. | 2017 | Details |
| A15739 | 28734553 | Clin Nutr | Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial. | 2017 | Details |
| A15930 | 28647291 | Clin Nutr | Genistein supplementation improves insulin resistance and inflammatory state in non-alcoholic fatty liver patients: A randomized, controlled trial. | 2017 | Details |
| A15979 | 28628674 | PLoS One | Hepatic microvascular dysfunction and increased advanced glycation end products are components of non-alcoholic fatty liver disease. | 2017 | Details |
| A15985 | 28626963 | Exp Physiol | Exercise training modulates the hepatic renin-angiotensin system in fructose-fed rats. | 2017 | Details |
| A16042 | 28596431 | Eur Respir J | Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease. | 2017 | Details |
| A16050 | 28593786 | Rev Esp Enferm Dig | Characterization of liver changes in ZSF1 rats, an animal model of metabolic syndrome. | 2017 | Details |
| A16054 | 28592311 | Trials | The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial. | 2017 | Details |
| A16073 | 28585211 | Adv Exp Med Biol | Non-Alcoholic Fatty Liver Disease. | 2017 | Details |
| A16087 | 28577437 | Int Immunopharmacol | Rutin exhibits hepatoprotective effects in a mouse model of non-alcoholic fatty liver disease by reducing hepatic lipid levels and mitigating lipid-induced oxidative injuries. | 2017 | Details |
| A16114 | 28559541 | Int J Obes (Lond) | Adiponectin deficiency rescues high-fat diet-induced hepatic injury, apoptosis and autophagy loss despite persistent steatosis. | 2017 | Details |
| A16119 | 28555525 | Immunopharmacol Immunotoxicol | Hepatoprotective effect of parthenolide in rat model of nonalcoholic fatty liver disease. | 2017 | Details |
| A16130 | 28547778 | FEBS Lett | Deletion of HNF1α in hepatocytes results in fatty liver-related hepatocellular carcinoma in mice. | 2017 | Details |
| A16148 | 28538192 | Biomed Pharmacother | Hepatic anti-inflammatory effect of hexane extracts of Dioscorea batatas Decne: Possible suppression of toll-like receptor 4-mediated signaling. | 2017 | Details |
| A16199 | 28508193 | Endocrine | Neutrophil depletion improves diet-induced non-alcoholic fatty liver disease in mice. | 2017 | Details |
| A16203 | 28507473 | EXCLI J | Effects of symbiotic and vitamin E supplementation on blood pressure, nitric oxide and inflammatory factors in non-alcoholic fatty liver disease. | 2017 | Details |
| A16245 | 28486193 | Biomed Pharmacother | Wogonin mitigates nonalcoholic fatty liver disease via enhancing PPARα/AdipoR2, in vivo and in vitro. | 2017 | Details |
| A16282 | 28471828 | Eur J Gastroenterol Hepatol | Nonalcoholic fatty liver disease can be predicted by retinal vascular changes in patients with obesity without hypertension or diabetes. | 2017 | Details |
| A16317 | 28462384 | Cell Mol Gastroenterol Hepatol | TRIF Differentially Regulates Hepatic Steatosis and Inflammation/Fibrosis in Mice. | 2017 | Details |
| A16360 | 28437890 | Biomed Pharmacother | Does propolis have any effect on non-alcoholic fatty liver disease? | 2017 | Details |
| A16438 | 28388904 | BMC Complement Altern Med | Effect of traditional Chinese medicine formula Sinisan on chronic restraint stress-induced nonalcoholic fatty liver disease: a rat study. | 2017 | Details |
| A16540 | 28325574 | J Chin Med Assoc | Decoy receptor 3 analogous supplement protects steatotic rat liver from ischemia-reperfusion injury. | 2017 | Details |
| A16549 | 28322783 | Biochem Biophys Res Commun | Elevation of liver endoplasmic reticulum stress in a modified choline-deficient l-amino acid-defined diet-fed non-alcoholic steatohepatitis mouse model. | 2017 | Details |
| A16557 | 28318525 | Actas Dermosifiliogr | Psoriasis and Nonalcoholic Fatty Liver Disease. | 2017 | Details |
| A16560 | 28317281 | Mol Nutr Food Res | Comparison of dietary polyphenols for protection against molecular mechanisms underlying nonalcoholic fatty liver disease in a cell model of steatosis. | 2017 | Details |
| A16565 | 28303974 | Sci Rep | Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis. | 2017 | Details |
| A16581 | 28297801 | Zhonghua Gan Zang Bing Za Zhi | [Effect of curcumin on intestinal mucosal mechanical barrier in rats with non-alcoholic fatty liver disease]. | 2017 | Details |
| A16591 | 28294699 | J Med Food | Chia Oil-Enriched Restructured Pork Effects on Oxidative and Inflammatory Status of Aged Rats Fed High Cholesterol/High Fat Diets. | 2017 | Details |
| A16609 | 28285394 | Inflamm Res | HCV-induced regulatory alterations of IL-1β, IL-6, TNF-α, and IFN-ϒ operative, leading liver en-route to non-alcoholic steatohepatitis. | 2017 | Details |
| A16617 | 28281516 | Ter Arkh | [Features of a necrotic and inflammatory process in different forms of nonalcoholic fatty liver disease]. | 2017 | Details |
| A16652 | 28264426 | Nutrients | The Combination of Blueberry Juice and Probiotics Ameliorate Non-Alcoholic Steatohepatitis (NASH) by Affecting SREBP-1c/PNPLA-3 Pathway via PPAR-α. | 2017 | Details |
| A16657 | 28260907 | Ther Clin Risk Manag | Effect of orlistat on periostin, adiponectin, inflammatory markers and ultrasound grades of fatty liver in obese NAFLD patients. | 2017 | Details |
| A16663 | 28257515 | PLoS One | New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans. | 2017 | Details |
| A16676 | 28251449 | Inflammation | A20 Attenuates Liver Fibrosis in NAFLD and Inhibits Inflammation Responses. | 2017 | Details |
| A16727 | 28220495 | J Pharm Pharmacol | Influence of hyperglycemia on liver inflammatory conditions in the early phase of non-alcoholic fatty liver disease in mice. | 2017 | Details |
| A16731 | 28218919 | Nat Med | Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates. | 2017 | Details |
| A16737 | 28216552 | Mar Drugs | Protective Effects and Mechanism of Meretrix meretrix Oligopeptides against Nonalcoholic Fatty Liver Disease. | 2017 | Details |
| A16757 | 28203453 | Iran Red Crescent Med J | Association of Osteoprotegerin with Obesity, Insulin Resistance and Non-Alcoholic Fatty Liver Disease in Children. | 2016 | Details |
| A16767 | 28193580 | J Nutr Biochem | Astaxanthin inhibits inflammation and fibrosis in the liver and adipose tissue of mouse models of diet-induced obesity and nonalcoholic steatohepatitis. | 2016 | Details |
| A16804 | 28163820 | Oxid Med Cell Longev | Apolipoprotein CIII Overexpression-Induced Hypertriglyceridemia Increases Nonalcoholic Fatty Liver Disease in Association with Inflammation and Cell Death. | 2017 | Details |
| A16825 | 28146130 | Nutrients | Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD). | 2017 | Details |
| A16839 | 28133993 | Appl Physiol Nutr Metab | A "healthy diet-optimal sleep" lifestyle pattern is inversely associated with liver stiffness and insulin resistance in patients with nonalcoholic fatty liver disease. | 2016 | Details |
| A16862 | 28123936 | Mol Metab | Metabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose metabolism. | 2016 | Details |
| A16880 | 28112681 | J Clin Invest | Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance. | 2017 | Details |
| A16900 | 28104981 | World J Gastroenterol | Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier. | 2017 | Details |
| A16908 | 28099601 | An Bras Dermatol | Psoriasis comorbidities: complications and benefits of immunobiological treatment. | 2017 | Details |
| A16910 | 28098910 | Mol Med Rep | Hydrogen-rich saline improves non‑alcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPARα and PPARγ. | 2017 | Details |
| A16920 | 28091912 | Bull Exp Biol Med | Caspase 3, 6, 8, and 9 Gene Expression in Peripheral Blood Leukocytes and Plasma Concentrations of IL-6 and TNF-α in Carriers of Different Polymorphic Marker -174G>C Genotypes of IL6 Gene Associated with the Risk of Nonalcoholic Steatohepatitis. | 2017 | Details |
| A16933 | 28086768 | BMC Complement Altern Med | Probiotic mixture improves fatty liver disease by virtue of its action on lipid profiles, leptin, and inflammatory biomarkers. | 2017 | Details |
| A16935 | 28084795 | Appl Physiol Nutr Metab | Moderate physical activity promotes basal hepatic autophagy in diet-induced obese mice. | 2016 | Details |
| A16940 | 28082742 | Exp Mol Med | Gene-metabolite network analysis in different nonalcoholic fatty liver disease phenotypes. | 2017 | Details |
| A16962 | 28073414 | Zhonghua Gan Zang Bing Za Zhi | [Protective effect of Saccharomyces boulardii against intestinal mucosal barrier injury in rats with nonalcoholic fatty liver disease]. | 2016 | Details |
| A17008 | 28051796 | Ann Hepatol |  Differences in hepatic expression of iron, inflammation and stress-related genes in patients with nonalcoholic steatohepatitis. | 2017 | Details |
| A17015 | 28044208 | J Gastroenterol | Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis. | 2017 | Details |
| A17037 | 28038359 | J Nutr Biochem | Green tea extract treatment reduces NFκB activation in mice with diet-induced nonalcoholic steatohepatitis by lowering TNFR1 and TLR4 expression and ligand availability. | 2016 | Details |
| A17042 | 28033294 | Medicine (Baltimore) | The expression of thymosin β4 in chronic hepatitis B combined nonalcoholic fatty liver disease. | 2016 | Details |
| A17049 | 28028366 | World J Gastroenterol | Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat. | 2016 | Details |
| A17054 | 28025996 | Int J Mol Med | Rosuvastatin as a potential preventive drug for the development of hepatocellular carcinoma associated with non-alcoholic fatty liver disease in mice. | 2016 | Details |
| A17069 | 28011152 | Transl Res | Adenosine A2a receptor stimulation blocks development of nonalcoholic steatohepatitis in mice by multilevel inhibition of signals that cause immunolipotoxicity. | 2016 | Details |
| A17087 | 27998724 | Am J Pathol | Global Deletion of Glutathione S-Transferase A4 Exacerbates Developmental Nonalcoholic Steatohepatitis. | 2016 | Details |
| A17163 | 27938563 | Zhonghua Gan Zang Bing Za Zhi | [Effect of nicotinic acetylcholine receptor α7 subunit gene on liver inflammatory reaction in mice with nonalcoholic steatohepatitis and related mechanisms]. | 2016 | Details |
| A17170 | 27935258 | Mol Nutr Food Res | Polyphenols from Lonicera caerulea L. berry attenuate experimental nonalcoholic steatohepatitis by inhibiting proinflammatory cytokines productions and lipid peroxidation. | 2017 | Details |
| A17189 | 27920819 | Res Pharm Sci | Co-administration of metformin and N-acetylcysteine with dietary control improves the biochemical and histological manifestations in rats with non-alcoholic fatty liver. | 2016 | Details |
| A17251 | 27889747 | Cell Physiol Biochem | Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells. | 2016 | Details |
| A17262 | 27881164 | BMC Endocr Disord | Administration of anti-receptor activator of nuclear factor-kappa B ligand (RANKL) antibody for the treatment of osteoporosis was associated with amelioration of hepatitis in a female patient with growth hormone deficiency: a case report. | 2016 | Details |