Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A50569 | 35335339 | Molecules | Garcinia Biflavonoid 1 Improves Lipid Metabolism in HepG2 Cells via Regulating PPARα. | 2022 | Details |
| A50590 | 35331900 | J Nutr Biochem | Intermittent fasting, high-intensity interval training, or a combination of both have beneficial effects in obese mice with nonalcoholic fatty liver disease. | 2022 | Details |
| A50603 | 35328352 | Int J Mol Sci | Beneficial Effects of Dietary Nitrite on a Model of Nonalcoholic Steatohepatitis Induced by High-Fat/High-Cholesterol Diets in SHRSP5/Dmcr Rats: A Preliminary Study. | 2022 | Details |
| A50615 | 35325502 | J Hepatobiliary Pancreat Sci | Defective endoplasmic reticulum stress response via X box-binding protein 1 is a major cause of poor liver regeneration after partial hepatectomy in mice with non-alcoholic steatohepatitis. | 2022 | Details |
| A50618 | 35324769 | Toxics | Double-Sided Nano-ZnO: Superior Antibacterial Properties and Induced Hepatotoxicity in Zebrafish Embryos. | 2022 | Details |
| A50620 | 35324083 | Chem Biodivers | Effect of Jiangan-Jiangzhi Pill on Gut Microbiota and Chronic Inflammatory Response in Rats with Non-Alcoholic Fatty Liver. | 2022 | Details |
| A50621 | 35323719 | Medicines (Basel) | Salubrious Effects of Green Tea Catechins on Fatty Liver Disease: A Systematic Review. | 2022 | Details |
| A50643 | 35317606 | Thyroid | Thyroid Hormone Decreases Hepatic Steatosis, Inflammation, and Fibrosis in a Dietary Mouse Model of Nonalcoholic Steatohepatitis. | 2022 | Details |
| A50646 | 35317178 | World J Hepatol | Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn? | 2022 | Details |
| A50662 | 35309311 | Front Immunol | Mesenchymal Stem Cell-Derived Extracellular Vesicles in Liver Immunity and Therapy. | 2022 | Details |
| A50663 | 35308892 | Metabol Open | Could gut mycobiome play a role in NAFLD pathogenesis? Insights and therapeutic perspectives. | 2022 | Details |
| A50665 | 35308549 | Front Med (Lausanne) | Oral and Gut Microbial Dysbiosis and Non-alcoholic Fatty Liver Disease: The Central Role of Porphyromonas gingivalis. | 2022 | Details |
| A50667 | 35308229 | Front Pharmacol | Inflammation and Cancer: From the Development of Personalized Indicators to Novel Therapeutic Strategies. | 2022 | Details |
| A50694 | 35297348 | Curr Mol Med | Natural Compounds as Integrative Therapy for Liver Protection against Inflammatory and Carcinogenic Mechanisms: From Induction to Molecular Biology Advancement | 2022 | Details |
| A50700 | 35295576 | Front Physiol | Polyene Phosphatidylcholine Ameliorates High Fat Diet-Induced Non-alcoholic Fatty Liver Disease via Remodeling Metabolism and Inflammation. | 2022 | Details |
| A50702 | 35294774 | Eur J Clin Invest | The role of microbiota in nonalcoholic fatty liver disease. | 2022 | Details |
| A50708 | 35292355 | Prostaglandins Other Lipid Mediat | The role of Resolvin D1 in liver diseases. | 2022 | Details |
| A50720 | 35287671 | J Transl Med | The monomer TEC of blueberry improves NASH by augmenting tRF-47-mediated autophagy/pyroptosis signaling pathway. | 2022 | Details |
| A50721 | 35287643 | BMC Endocr Disord | Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss. | 2022 | Details |
| A50753 | 35277075 | Nutrients | Simvastatin Improves Microcirculatory Function in Nonalcoholic Fatty Liver Disease and Downregulates Oxidative and ALE-RAGE Stress. | 2022 | Details |
| A50754 | 35277054 | Nutrients | Beneficial Activities of Alisma orientale Extract in a Western Diet-Induced Murine Non-Alcoholic Steatohepatitis and Related Fibrosis Model via Regulation of the Hepatic Adiponectin and Farnesoid X Receptor Pathways. | 2022 | Details |
| A50758 | 35276916 | Nutrients | A Lard and Soybean Oil Mixture Alleviates Low-Fat-High-Carbohydrate Diet-Induced Nonalcoholic Fatty Liver Disease in Mice. | 2022 | Details |
| A50767 | 35274325 | Aliment Pharmacol Ther | Meta-analysis: prevalence of, and risk factors for, non-alcoholic fatty liver disease in patients with inflammatory bowel disease. | 2022 | Details |
| A50771 | 35272137 | Biomed Pharmacother | The contribution of sterile inflammation to the fatty liver disease and the potential therapies. | 2022 | Details |
| A50780 | 35269515 | Cells | Transcriptomics Reveals Discordant Lipid Metabolism Effects between In Vitro Models Exposed to Elafibranor and Liver Samples of NAFLD Patients after Bariatric Surgery. | 2022 | Details |
| A50799 | 35261562 | Int J Biol Sci | Lipotoxic hepatocytes promote nonalcoholic fatty liver disease progression by delivering microRNA-9-5p and activating macrophages. | 2021 | Details |
| A50800 | 35261068 | Fundam Clin Pharmacol | Inhibition of plasminogen suppresses fibrosis and macrophage foaming in a nonalcoholic steatohepatitis mouse model. | 2022 | Details |
| A50812 | 35212695 | Food Funct | Citrus depressa Hayata peel ameliorates nonalcoholic fatty liver and modulates the activity of hepatic drug-metabolizing enzymes and transporters in rats fed a high-fat diet. | 2022 | Details |
| A50943 | 35540668 | RSC Adv | Nifuroxazide ameliorates lipid and glucose metabolism in palmitate-induced HepG2 cells. | 2019 | Details |
| A50957 | 35520738 | RSC Adv | GVS-12 attenuates non-alcoholic steatohepatitis by suppressing inflammatory responses via PPARγ/STAT3 signaling pathways. | 2019 | Details |
| A50966 | 35548751 | RSC Adv | Therapeutic efficacy of polydatin for nonalcoholic fatty liver disease via regulating inflammatory response in obese mice. | 2018 | Details |
| A51030 | 23465229 | Int J Cardiol | Genetic influence in liver steatosis prevalence and proatherothrombotic/inflammatory profile in familial combined hyperlipoproteinemia. | 2013 | Details |
| A51085 | 840124 | Med Klin | [Quantitative serum immunoglobulin determination: differential diagnostic significance for liver disease (author's transl)s]. | 1977 | Details |
| A51106 | 35736002 | mSystems | Identification and Characterization of Major Bile Acid 7α-Dehydroxylating Bacteria in the Human Gut. | 2022 | Details |
| A51110 | 35723657 | Child Obes | Probiotic Use in Children and Adolescents with Overweight or Obesity: A Scoping Review. | 2022 | Details |
| A51115 | 35678694 | Curr Issues Mol Biol | Lycopus lucidus Turcz Water Extract Ameliorates the Metabolic Disorder by Up-Regulated Major Urinary Protein Expression in High-Fat Diet-Induced Obesity. | 2022 | Details |
| A51116 | 35678690 | Curr Issues Mol Biol | The Protective Role of 4-Acetylarylquinolinol B in Different Pathological Processes. | 2022 | Details |
| A51120 | 35662709 | Front Pharmacol | Role of IKKε in the Metabolic Diseases: Physiology, Pathophysiology, and Pharmacology. | 2022 | Details |
| A51122 | 35658240 | Biomed Pharmacother | Bicyclol ameliorates advanced liver diseases in murine models via inhibiting the IL-6/STAT3 signaling pathway. | 2022 | Details |
| A51125 | 35617705 | J Med Food | Partial Replacement of High-Fat Diet with Beef Tallow Attenuates Dyslipidemia and Endoplasmic Reticulum Stress in db/db Mice. | 2022 | Details |
| A51139 | 35516840 | J Toxicol Pathol | CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet. | 2021 | Details |
| A51145 | 35491473 | Alcohol Clin Exp Res | Chronic ethanol consumption plus an atherogenic diet cause metabolic steatohepatitis with advanced liver fibrosis in apolipoprotein E/low-density lipoprotein receptor double-knockout mice. | 2022 | Details |
| A51148 | 35470867 | J Food Biochem | Dietary sinapic acid attenuated high-fat diet-induced lipid metabolism and oxidative stress in male Syrian hamsters. | 2022 | Details |
| A51167 | 35395857 | J Exp Clin Cancer Res | The role of TBK1 in cancer pathogenesis and anticancer immunity. | 2022 | Details |
| A51173 | 35356278 | Front Cell Dev Biol | Editorial: The Role of Microbiota in the Onset and Development of Intestine and Liver Diseases and Cancer: Molecular and Cell Mechanisms. | 2022 | Details |
| A51179 | 35344087 | Histochem Cell Biol | Early unhealthy eating habits underlie morpho-functional changes in the liver and adipose tissue in male rats. | 2022 | Details |
| A51184 | 35317174 | World J Hepatol | Hepatobiliary manifestations in inflammatory bowel disease: A practical approach. | 2022 | Details |
| A51246 | 35663960 | Front Immunol | Acute Intoxication With Alcohol Reduces Trauma-Induced Proinflammatory Response and Barrier Breakdown in the Lung via the Wnt/β-Catenin Signaling Pathway. | 2022 | Details |
| A51250 | 35318125 | Biochim Biophys Acta Mol Basis Dis | Kupffer cells are protective in alcoholic steatosis. | 2022 | Details |
| A51251 | 35280676 | Int J Biol Sci | Hepatocyte-specific deletion of cellular repressor of E1A-stimulated genes 1 exacerbates alcohol-induced liver injury by activating stress kinases. | 2022 | Details |
| A51295 | 35830432 | Gut Microbes | Alteration of the gut microbiota's composition and metabolic output correlates with COVID-19-like severity in obese NASH hamsters. | 2022 | Details |
| A51305 | 35749425 | PLoS Pathog | Rationale of using the dual chemokine receptor CCR2/CCR5 inhibitor cenicriviroc for the treatment of COVID-19. | 2022 | Details |
| A51309 | 35711841 | J Cancer | Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer. | 2022 | Details |
| A51312 | 35700043 | J Clin Invest | Myeloid FoxO1 depletion attenuates hepatic inflammation and prevents nonalcoholic steatohepatitis. | 2022 | Details |
| A51314 | 35696549 | J Cell Physiol | Dynein light chain LC8 alleviates nonalcoholic steatohepatitis by inhibiting NF-κB signaling and reducing oxidative stress. | 2022 | Details |
| A51319 | 35644437 | J Ethnopharmacol | Uncovering the mechanism of Huanglian-Wuzhuyu herb pair in treating nonalcoholic steatohepatitis based on network pharmacology and experimental validation. | 2022 | Details |
| A51322 | 35625520 | Biology (Basel) | PPAR Alpha as a Metabolic Modulator of the Liver: Role in the Pathogenesis of Nonalcoholic Steatohepatitis (NASH). | 2022 | Details |
| A51323 | 35624663 | Antioxidants (Basel) | Empagliflozin-Enhanced Antioxidant Defense Attenuates Lipotoxicity and Protects Hepatocytes by Promoting FoxO3a- and Nrf2-Mediated Nuclear Translocation via the CAMKK2/AMPK Pathway. | 2022 | Details |
| A51328 | 35588918 | Pharmacol Res | The effects of sodium-glucose cotransporter 2 inhibitors on hepatocellular carcinoma: From molecular mechanisms to potential clinical implications. | 2022 | Details |
| A51331 | 35545547 | Nihon Shokakibyo Gakkai Zasshi | [A case of advanced hepatocellular carcinoma wherein readministration was made possible due to successful transcatheter arterial embolization for intratumoral hemorrhage during Lenvatinib administration]. | 2022 | Details |
| A51340 | 35490239 | Inflamm Regen | Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome. | 2022 | Details |
| A51348 | 35419738 | Inflammation | Melatonin Attenuates Inflammation, Oxidative Stress, and DNA Damage in Mice with Nonalcoholic Steatohepatitis Induced by a Methionine- and Choline-Deficient Diet. | 2022 | Details |
| A51357 | 35332108 | Aging (Albany NY) | Mitophagy and mitochondrial dynamics in type 2 diabetes mellitus treatment. | 2022 | Details |
| A51359 | 35308208 | Front Pharmacol | Therapeutic Effects of Berberine on Liver Fibrosis are associated With Lipid Metabolism and Intestinal Flora. | 2022 | Details |
| A51360 | 35294987 | Cancer Sci | Histone H1.2 promotes hepatocarcinogenesis by regulating signal transducer and activator of transcription 3 signaling. | 2022 | Details |
| A51361 | 35294954 | PLoS One | Cardiovascular disease risk in liver transplant recipients transplanted due to chronic viral hepatitis. | 2022 | Details |
| A51388 | 30623143 | JACC Basic Transl Sci | The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE-/- and LDLr-/- Mice by a Mechanism That Includes Inflammatory Pathways. | 2018 | Details |
| A51389 | 30191979 | J Cell Physiol | Endotoxin regulates matrix genes increasing reactive oxygen species generation by intercellular communication between palmitate-treated hepatocyte and stellate cell. | 2018 | Details |
| A51391 | 29790591 | J Labelled Comp Radiopharm | Synthesis of 13 C6 -labeled, dual-target inhibitor of cannabinoid-1 receptor (CB1 R) and inducible nitric oxide synthase (iNOS). | 2018 | Details |
| A51395 | 35830259 | FASEB J | Intervention with isoleucine or valine corrects hyperinsulinemia and reduces intrahepatic diacylglycerols, liver steatosis, and inflammation in Ldlr-/-.Leiden mice with manifest obesity-associated NASH. | 2022 | Details |
| A51398 | 35814685 | Front Microbiol | Saccharomyces Boulardii Ameliorates Non-alcoholic Steatohepatitis in Mice Induced by a Methionine-Choline-Deficient Diet Through Gut-Liver Axis. | 2022 | Details |
| A51409 | 35749827 | Phytomedicine | Kinsenoside alleviates inflammation and fibrosis in experimental NASH mice by suppressing the NF-κB/NLRP3 signaling pathway. | 2022 | Details |
| A51412 | 35709720 | Semin Liver Dis | Non-Alcoholic Steatohepatitis Drug Development Pipeline: An Update. | 2022 | Details |
| A51428 | 35514019 | Dig Liver Dis | Rifaximin and lubiprostone mitigate liver fibrosis development by repairing gut barrier function in diet-induced rat steatohepatitis. | 2022 | Details |
| A51431 | 35455781 | Healthcare (Basel) | Disease-Specific Health Disparities: A Targeted Review Focusing on Race and Ethnicity. | 2022 | Details |
| A51434 | 35421426 | J Hepatol | Mitochondrial protease ClpP supplementation ameliorates diet-induced NASH in mice. | 2022 | Details |
| A51437 | 35369074 | Front Nutr | Ammonia Scavenger Restores Liver and Muscle Injury in a Mouse Model of Non-alcoholic Steatohepatitis With Sarcopenic Obesity. | 2022 | Details |
| A51452 | 35292349 | J Hepatol | Role of XBP1 in regulating the progression of non-alcoholic steatohepatitis. | 2022 | Details |
| A51477 | 30627433 | J Nutr Sci | Hot water extract of turmeric (Curcuma longa) prevents non-alcoholic steatohepatitis in mice by inhibiting hepatic oxidative stress and inflammation. | 2018 | Details |
| A51508 | 35741222 | Diagnostics (Basel) | Urine Proteome in Distinguishing Hepatic Steatosis in Patients with Metabolic-Associated Fatty Liver Disease. | 2022 | Details |
| A51524 | 35620390 | Front Endocrinol (Lausanne) | High-Sensitive CRP Correlates With the Severity of Liver Steatosis and Fibrosis in Obese Patients With Metabolic Dysfunction Associated Fatty Liver Disease. | 2022 | Details |
| A51529 | 35566397 | J Clin Med | Clinical Progression of Metabolic-Associated Fatty Liver Disease Is Rare in a Danish Tertiary Liver Center. | 2022 | Details |
| A51541 | 35444532 | Front Pharmacol | Celastrol: An Update on Its Hepatoprotective Properties and the Linked Molecular Mechanisms. | 2022 | Details |
| A51542 | 35409324 | Int J Mol Sci | Meta-Inflammation and De Novo Lipogenesis Markers Are Involved in Metabolic Associated Fatty Liver Disease Progression in BTBR ob/ob Mice. | 2022 | Details |
| A51547 | 35359076 | Zhonghua Gan Zang Bing Za Zhi | [Berberine alleviates programmed necrosis of metabolic-associated fatty liver disease via activating Nrf2 pathway in mice]. | 2022 | Details |
| A51560 | 35128832 | Adv Sci (Weinh) | Multiomics Analysis Reveals the Impact of Microbiota on Host Metabolism in Hepatic Steatosis. | 2022 | Details |
| A51562 | 35124272 | Clin Gastroenterol Hepatol | Increased risk of MAFLD and Liver Fibrosis in Inflammatory Bowel Disease Independent of Classic Metabolic Risk Factors. | 2022 | Details |
| A51569 | 35052876 | Biomedicines | Unveiling the Role of the Fatty Acid Binding Protein 4 in the Metabolic-Associated Fatty Liver Disease. | 2022 | Details |
| A51574 | 34975521 | Front Physiol | Monocyte to High-Density Lipoprotein Cholesterol Ratio at the Nexus of Type 2 Diabetes Mellitus Patients With Metabolic-Associated Fatty Liver Disease. | 2021 | Details |
| A51585 | 34817168 | J Agric Food Chem | Estrogen Receptor α Regulates Metabolic-Associated Fatty Liver Disease by Targeting NLRP3-GSDMD Axis-Mediated Hepatocyte Pyroptosis. | 2021 | Details |
| A51609 | 35679608 | J Crohns Colitis | Faecal metabolomics in paediatric inflammatory bowel disease: a systematic review. | 2022 | Details |
| A51610 | 35675982 | J Vet Med Sci | Comprehensive profiling of lipid metabolites in urine of canine patients with liver mass. | 2022 | Details |
| A51613 | 35660447 | Sci Total Environ | Metabolomics-based safety evaluation of acute exposure to electronic cigarettes in mice. | 2022 | Details |
| A51627 | 35493783 | Anim Reprod | Rodent models in placental research. Implications for fetal origins of adult disease. | 2022 | Details |
| A51631 | 35483188 | Biomed Pharmacother | Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer's disease. | 2022 | Details |
| A51633 | 35473811 | Br J Nutr | Metabolic adaptation to high starch diet in largemouth bass (Micropterus salmoides) was associated with the restoration of metabolic functions via inflammation, bile acid synthesis and energy metabolism. | 2022 | Details |
| A51634 | 35467430 | Viral Immunol | Hepatitis C Virus Alters Macrophage Cholesterol Metabolism Through Interaction with Scavenger Receptors. | 2022 | Details |
| A51650 | 35271353 | Am J Physiol Gastrointest Liver Physiol | Microbial metabolites: cause or consequence in gastrointestinal disease? | 2022 | Details |
| A51655 | 35218813 | J Hepatol | Multi-parametric analysis of human livers reveals variation in intrahepatic inflammation across phases of chronic hepatitis B infection. | 2022 | Details |
| A51657 | 35203398 | Cells | Basal Autophagy Is Necessary for A Pharmacologic PPARα Transactivation. | 2022 | Details |