Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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inflammatory5866 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A03418 | 34007294 | Evid Based Complement Alternat Med | Mechanism of Huo-Xue-Qu-Yu Formula in Treating Nonalcoholic Hepatic Steatosis by Regulating Lipid Metabolism and Oxidative Stress in Rats. | 2021 | Details |
| A03421 | 34006921 | Sci Rep | Delineating tesamorelin response pathways in HIV-associated NAFLD using a targeted proteomic and transcriptomic approach. | 2021 | Details |
| A03424 | 34004342 | J Nutr Biochem | Saskatoon berry powder reduces hepatic steatosis and insulin resistance in high fat-high sucrose diet-induced obese mice. | 2021 | Details |
| A03425 | 34004162 | Cell Metab | PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease. | 2021 | Details |
| A03426 | 34004161 | Gastroenterology | Associations Among Adipose Tissue Immunology, Inflammation, Exosomes and Insulin Sensitivity in People With Obesity and Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03427 | 34003729 | Am J Respir Cell Mol Biol | Hepatocyte HIF-1 and Intermittent Hypoxia Independently Impact Liver Fibrosis in Murine Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03432 | 34002097 | Nat Metab | UCP1 governs liver extracellular succinate and inflammatory pathogenesis. | 2021 | Details |
| A03462 | 33992651 | Int J Biol Macromol | Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation. | 2021 | Details |
| A03463 | 33992352 | Food Res Int | Caffeic acid prevents non-alcoholic fatty liver disease induced by a high-fat diet through gut microbiota modulation in mice. | 2021 | Details |
| A03464 | 33992322 | Food Res Int | Long-term supplementation with phenolic compounds from jaboticaba (Plinia jaboticaba (Vell.) Berg) reduces adiposophaty and improves glucose, lipid, and energy metabolism. | 2021 | Details |
| A03465 | 33992031 | Semin Liver Dis | Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: Overlapping Mechanisms. | 2021 | Details |
| A03466 | 33991837 | Bioorg Chem | Anti-inflammatory effect of luteolin is related to the changes in the gut microbiota and contributes to preventing the progression from simple steatosis to nonalcoholic steatohepatitis. | 2021 | Details |
| A03479 | 33989346 | PLoS One | Is there a role for neuregulin 4 in human nonalcoholic fatty liver disease? | 2021 | Details |
| A03482 | 33987427 | Ann Transl Med | Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH)-related liver fibrosis: mechanisms, treatment and prevention. | 2021 | Details |
| A03484 | 33987424 | Ann Transl Med | Non-alcoholic fatty liver diseases: current challenges and future directions. | 2021 | Details |
| A03485 | 33987359 | Ann Transl Med | ENO3 promoted the progression of NASH by negatively regulating ferroptosis via elevation of GPX4 expression and lipid accumulation. | 2021 | Details |
| A03493 | 33984334 | Metabolism | A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage. | 2021 | Details |
| A03494 | 33983857 | Viral Immunol | Liver Damage and Exposure to Toxic Concentrations of Endogenous Retinoids in the Pathogenesis of COVID-19 Disease: Hypothesis. | 2021 | Details |
| A03506 | 33978391 | Minerva Gastroenterol (Torino) | Probiotics and gut health. | 2021 | Details |
| A03507 | 33977953 | Food Funct | Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD. | 2021 | Details |
| A03508 | 33977946 | Food Funct | DHA-enriched phosphatidylserine ameliorates non-alcoholic fatty liver disease and intestinal dysbacteriosis in mice induced by a high-fat diet. | 2021 | Details |
| A03520 | 33972568 | Sci Rep | Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway. | 2021 | Details |
| A03529 | 33967554 | World J Gastroenterol | Coronavirus disease 2019 severity in obesity: Metabolic dysfunction-associated fatty liver disease in the spotlight. | 2021 | Details |
| A03544 | 33961941 | J Hepatol | Glutaminolysis-induced mTORC1 activation drives non-alcoholic steatohepatitis progression. | 2021 | Details |
| A03548 | 33961538 | Nanotoxicology | Iron oxide nanoparticles aggravate hepatic steatosis and liver injury in nonalcoholic fatty liver disease through BMP-SMAD-mediated hepatic iron overload. | 2021 | Details |
| A03549 | 33961302 | Hepatology | The Emerging Role of B Cells in the Pathogenesis of NAFLD. | 2021 | Details |
| A03558 | 33955510 | Mol Med Rep | Parthenolide plays a protective role in the liver of mice with metabolic dysfunction‑associated fatty liver disease through the activation of the HIPPO pathway. | 2021 | Details |
| A03559 | 33953864 | Iran J Basic Med Sci | Gallic acid treats dust-induced NAFLD in rats by improving the liver's anti-oxidant capacity and inhibiting ROS/NFκβ/TNFα inflammatory pathway. | 2021 | Details |
| A03562 | 33953586 | Diabetes Metab Syndr Obes | Astragaloside IV Alleviates Liver Inflammation, Oxidative Stress and Apoptosis to Protect Against Experimental Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A03564 | 33952843 | Nihon Yakurigaku Zasshi | [The roles of gap junctional intercellular communication in non-alcoholic steatohepatitis (NASH) and liver fibrosis]. | 2021 | Details |
| A03578 | 33947572 | Mater Sci Eng C Mater Biol Appl | Nano-encapsulation of hydroxytyrosol into formulated nanogels improves therapeutic effects against hepatic steatosis: An in vitro study. | 2021 | Details |
| A03582 | 33945507 | JCI Insight | Role of MIF in coordinated expression of hepatic chemokines in patients with alcohol-associated hepatitis. | 2021 | Details |
| A03583 | 33943028 | J Diabetes Investig | Liver fibrosis is independently associated with diabetic peripheral neuropathy in type 2 diabetes mellitus. | 2021 | Details |
| A03585 | 33941551 | BMJ Open Diabetes Res Care | Insulin resistance and liver histopathology in metabolically unhealthy subjects do not correlate with the hepatic abundance of NLRP3 inflammasome nor circulating IL-1β levels. | 2021 | Details |
| A03588 | 33940220 | Ann Hepatol | Mineralocorticoid receptor modulation by dietary sodium influences NAFLD development in mice. | 2021 | Details |
| A03593 | 33939118 | Drugs | Targeting AMPK by Statins: A Potential Therapeutic Approach. | 2021 | Details |
| A03595 | 33938212 | Environ Sci Technol | Nonalcoholic Fatty Liver Disease Development in Zebrafish upon Exposure to Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate, a Novel Brominated Flame Retardant. | 2021 | Details |
| A03603 | 33935770 | Front Pharmacol | Targeting Liver Sinusoidal Endothelial Cells: An Attractive Therapeutic Strategy to Control Inflammation in Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03612 | 33931568 | Sci Immunol | Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases. | 2021 | Details |
| A03615 | 33930586 | Clin Res Hepatol Gastroenterol | Pathogenetic mechanisms of nonalcoholic fatty liver disease and inhibition of the inflammasome as a new therapeutic target. | 2021 | Details |
| A03623 | 33926085 | Genes (Basel) | The Role of Lipid Sensing Nuclear Receptors (PPARs and LXR) and Metabolic Lipases in Obesity, Diabetes and NAFLD. | 2021 | Details |
| A03631 | 33924165 | Int J Mol Sci | Flame Retardants-Mediated Interferon Signaling in the Pathogenesis of Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03638 | 33923255 | Nutrients | Overview of Non-Alcoholic Fatty Liver Disease (NAFLD) and the Role of Sugary Food Consumption and Other Dietary Components in Its Development. | 2021 | Details |
| A03639 | 33923175 | Cells | Adipocyte, Immune Cells, and miRNA Crosstalk: A Novel Regulator of Metabolic Dysfunction and Obesity. | 2021 | Details |
| A03643 | 33922045 | Molecules | Protective Effect of Cudrania tricuspidata Extract against High-Fat Diet Induced Nonalcoholic Fatty Liver Disease through Nrf-2/HO-1 Pathway. | 2021 | Details |
| A03655 | 33918456 | Int J Mol Sci | Relationship between NAFLD and Periodontal Disease from the View of Clinical and Basic Research, and Immunological Response. | 2021 | Details |
| A03660 | 33917360 | Antioxidants (Basel) | Lingonberry Improves Non-Alcoholic Fatty Liver Disease by Reducing Hepatic Lipid Accumulation, Oxidative Stress and Inflammatory Response. | 2021 | Details |
| A03674 | 33909947 | Mol Nutr Food Res | Effects of Insoluble Cereal Fibre on Body Fat Distribution in the Optimal Fibre Trial. | 2021 | Details |
| A03677 | 33907839 | Int J Mol Med | Role of 2‑series prostaglandins in the pathogenesis of type 2 diabetes mellitus and non‑alcoholic fatty liver disease (Review). | 2021 | Details |
| A03686 | 33902193 | Zhonghua Gan Zang Bing Za Zhi | [Phosphonate inhibits steatosis and lobular inflammation of non-alcoholic steatohepatitis through depleting macrophages]. | 2021 | Details |
| A03692 | 33901295 | Hepatology | Functional Characterization of Organoids Derived From Irreversibly Damaged Liver of Patients With NASH. | 2021 | Details |
| A03704 | 33897616 | Front Endocrinol (Lausanne) | Glucagon-Like Peptide-1 Receptor Agonists for Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: A Meta-Analysis. | 2021 | Details |
| A03708 | 33896100 | Liver Int | Definite and indeterminate nonalcoholic steatohepatitis share similar clinical features and prognosis: A longitudinal study of 1893 biopsy-proven nonalcoholic fatty liver disease subjects. | 2021 | Details |
| A03709 | 33895783 | Int J Obes (Lond) | Lampaya Medicinalis Phil. decreases lipid-induced triglyceride accumulation and proinflammatory markers in human hepatocytes and fat body of Drosophila melanogaster. | 2021 | Details |
| A03710 | 33895552 | Biochem Biophys Res Commun | The PDE5 inhibitor udenafil ameliorates nonalcoholic fatty liver disease by improving mitochondrial function. | 2021 | Details |
| A03714 | 33894425 | Cell Mol Gastroenterol Hepatol | Caspase-11-Mediated Hepatocytic Pyroptosis Promotes the Progression of Nonalcoholic Steatohepatitis. | 2021 | Details |
| A03729 | 33887577 | Int Immunopharmacol | Neutrophil: An emerging player in the occurrence and progression of metabolic associated fatty liver disease. | 2021 | Details |
| A03732 | 33885128 | Food Funct | Modulation of the fecal microbiome and metabolome by resistant dextrin ameliorates hepatic steatosis and mitochondrial abnormalities in mice. | 2021 | Details |
| A03736 | 33883616 | Sci Rep | Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients. | 2021 | Details |
| A03740 | 33882758 | Expert Rev Clin Pharmacol | Effects of anti-diabetic treatments in type 2 diabetes and fatty liver disease. | 2021 | Details |
| A03752 | 33878116 | PLoS One | Leaf powder supplementation of Senna alexandrina ameliorates oxidative stress, inflammation, and hepatic steatosis in high-fat diet-fed obese rats. | 2021 | Details |
| A03756 | 33875327 | Trends Endocrinol Metab | RIPK1 targeting protects against obesity and atherosclerosis. | 2021 | Details |
| A03758 | 33872860 | Mol Metab | Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload. | 2021 | Details |
| A03760 | 33872605 | J Lipid Res | Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease. | 2021 | Details |
| A03774 | 33868403 | J Oncol | The Gene Signature Associated with Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03784 | 33865013 | Biomed Pharmacother | Salvia-Nelumbinis naturalis extract protects mice against MCD diet-induced steatohepatitis via activation of colonic FXR-FGF15 pathway. | 2021 | Details |
| A03788 | 33862553 | Int Immunopharmacol | Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis. | 2021 | Details |
| A03796 | 33861449 | Adv Exp Med Biol | Beneficial Effects of Plant-Derived Natural Products on Non-alcoholic Fatty Liver Disease. | 2021 | Details |
| A03797 | 33861444 | Adv Exp Med Biol | Medicinal Plants and Phytochemicals Regulating Insulin Resistance and Glucose Homeostasis in Type 2 Diabetic Patients: A Clinical Review. | 2021 | Details |
| A03800 | 33860630 | FEBS J | Liver macrophages and inflammation in physiology and physiopathology of non-alcoholic fatty liver disease. | 2021 | Details |
| A03801 | 33860590 | Phytother Res | Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2-CREB-SIRT1 axis. | 2021 | Details |
| A03802 | 33860214 | ACS Pharmacol Transl Sci | Differential Therapeutic Effects of FXR Activation, sEH Inhibition, and Dual FXR/sEH Modulation in NASH in Diet-Induced Obese Mice. | 2021 | Details |
| A03818 | 33857628 | Free Radic Biol Med | Hepatocyte-specific deletion of Nlrp6 in mice exacerbates the development of non-alcoholic steatohepatitis. | 2021 | Details |
| A03820 | 33857511 | Int J Biol Macromol | Walnut green husk polysaccharides prevent obesity, chronic inflammatory responses, nonalcoholic fatty liver disease and colonic tissue damage in high-fat diet fed rats. | 2021 | Details |
| A03828 | 33855952 | Acta Medica (Hradec Kralove) | The Connection between MicroRNAs from Visceral Adipose Tissue and Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A03833 | 33854482 | Front Endocrinol (Lausanne) | SHBG as a Marker of NAFLD and Metabolic Impairments in Women Referred for Oligomenorrhea and/or Hirsutism and in Women With Sexual Dysfunction. | 2021 | Details |
| A03838 | 33852613 | PLoS One | Intrahepatic distribution of nerve fibers and alterations due to fibrosis in diseased liver. | 2021 | Details |
| A03841 | 33851883 | Expert Rev Gastroenterol Hepatol | NAFLD and renal function in children: is there a genetic link? | 2021 | Details |
| A03854 | 33845089 | J Lipid Res | The lipidome in nonalcoholic fatty liver disease: actionable targets. | 2021 | Details |
| A03869 | 33838673 | Nutr J | Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-controlled, clinical trial. | 2021 | Details |
| A03896 | 33827700 | BMC Pharmacol Toxicol | The efficacy of calcitriol treatment in non-alcoholic fatty liver patients with different genotypes of vitamin D receptor FokI polymorphism. | 2021 | Details |
| A03903 | 33824675 | Evid Based Complement Alternat Med | Jian-Gan-Xiao-Zhi Decoction Alleviates Inflammatory Response in Nonalcoholic Fatty Liver Disease Model Rats through Modulating Gut Microbiota. | 2021 | Details |
| A03910 | 33822497 | Int J Med Mushrooms | Bioactive Components and Possible Activities of Medicinal Mushrooms in Alleviating the Pathogenesis of Nonalcoholic Fatty Liver Disease (Review). | 2021 | Details |
| A03912 | 33822104 | J Pharm Pharmacol | Eugenol modulates insulin sensitivity by upregulating insulin receptor substrate-2 in non-alcoholic fatty liver disease in rats. | 2021 | Details |
| A03918 | 33818349 | Nutr Res Rev | Effects of betaine on non-alcoholic liver disease. | 2021 | Details |
| A03929 | 33815271 | Front Endocrinol (Lausanne) | Cholesterol Accumulation as a Driver of Hepatic Inflammation Under Translational Dietary Conditions Can Be Attenuated by a Multicomponent Medicine. | 2021 | Details |
| A03930 | 33813878 | Am J Physiol Endocrinol Metab | Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis. | 2021 | Details |
| A03940 | 33811372 | J Gastroenterol Hepatol | Gut-liver-axis: Barrier function of liver sinusoidal endothelial cell. | 2021 | Details |
| A03943 | 33811139 | Proc Natl Acad Sci U S A | Active p38α causes macrovesicular fatty liver in mice. | 2021 | Details |
| A03947 | 33810566 | Int J Mol Sci | Hepatic Senescence Accompanies the Development of NAFLD in Non-Aged Mice Independently of Obesity. | 2021 | Details |
| A03953 | 33809062 | Mar Drugs | Fucoidan and Fucoxanthin Attenuate Hepatic Steatosis and Inflammation of NAFLD through Modulation of Leptin/Adiponectin Axis. | 2021 | Details |
| A03959 | 33807927 | Nutrients | Ginseng Saponin Enriched in Rh1 and Rg2 Ameliorates Nonalcoholic Fatty Liver Disease by Inhibiting Inflammasome Activation. | 2021 | Details |
| A03963 | 33807573 | Int J Mol Sci | An Overview of the Molecular Mechanisms Contributing to Musculoskeletal Disorders in Chronic Liver Disease: Osteoporosis, Sarcopenia, and Osteoporotic Sarcopenia. | 2021 | Details |
| A03966 | 33806955 | Biomedicines | Tanshinone IIA Downregulates Lipogenic Gene Expression and Attenuates Lipid Accumulation through the Modulation of LXRα/SREBP1 Pathway in HepG2 Cells. | 2021 | Details |
| A03968 | 33806527 | Pharmaceuticals (Basel) | The Evaluation of Drug Delivery Nanocarrier Development and Pharmacological Briefing for Metabolic-Associated Fatty Liver Disease (MAFLD): An Update. | 2021 | Details |
| A03970 | 33805912 | Int J Mol Sci | Potential of Nutraceutical Supplementation in the Modulation of White and Brown Fat Tissues in Obesity-Associated Disorders: Role of Inflammatory Signalling. | 2021 | Details |
| A03972 | 33805795 | Nutrients | The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials. | 2021 | Details |
| A03982 | 33802455 | Nutrients | Fructo-Oligosaccharides and Pectins Enhance Beneficial Effects of Raspberry Polyphenols in Rats with Nonalcoholic Fatty Liver. | 2021 | Details |
| A03992 | 33799862 | Int J Mol Sci | A Scoping Review on Lipocalin-2 and Its Role in Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma. | 2021 | Details |
| A04016 | 33788377 | Liver Int | Elafibranor and liraglutide improve differentially liver health and metabolism in a mouse model of non-alcoholic steatohepatitis. | 2021 | Details |