Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Insulin resistance7794 records.
Article ID | PMID | Source | Title | Publish Year | |
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A28817 | 34944770 | Biomedicines | Butyrate Protects against Diet-Induced NASH and Liver Fibrosis and Suppresses Specific Non-Canonical TGF-β Signaling Pathways in Human Hepatic Stellate Cells. | 2021 | Details |
A28895 | 34855620 | J Clin Invest | Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice. | 2022 | Details |
A28936 | 34797360 | Food Funct | Effects of Salvia hispanica L. (chia) seed on blood coagulation, endothelial dysfunction and liver fibrosis in an experimental model of Metabolic Syndrome. | 2021 | Details |
A29044 | 34659107 | Front Endocrinol (Lausanne) | NDUFB6 Polymorphism Is Associated With Physical Activity-Mediated Metabolic Changes in Type 2 Diabetes. | 2021 | Details |
A29226 | 34390210 | FEBS Open Bio | Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways. | 2021 | Details |
A29345 | 34221233 | Oxid Med Cell Longev | Protein Phosphatase 4 Promotes Hepatocyte Lipoapoptosis by Regulating RAC1/MLK3/JNK Pathway. | 2021 | Details |
A29435 | 34073868 | Cancers (Basel) | Mitochondrial Dynamics and Liver Cancer. | 2021 | Details |
A29609 | 33802238 | Cancers (Basel) | Cache Domain Containing 1 Is a Novel Marker of Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis. | 2021 | Details |
A29753 | 33564498 | Cureus | A Review of Pirfenidone as an Anti-Fibrotic in Idiopathic Pulmonary Fibrosis and Its Probable Role in Other Diseases. | 2021 | Details |
A29792 | 33513920 | Biomedicines | Magnesium, Little Known But Possibly Relevant: A Link between NASH and Related Comorbidities. | 2021 | Details |
A29876 | 33354276 | Oxid Med Cell Longev | Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway. | 2020 | Details |
A29879 | 33344141 | Adv Sci (Weinh) | Triantennary GalNAc Molecular Imaging Probes for Monitoring Hepatocyte Function in a Rat Model of Nonalcoholic Steatohepatitis. | 2020 | Details |
A29919 | 33277568 | Sci Rep | Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effects. | 2020 | Details |
A30134 | 32923834 | Hepatol Commun | The Selective Peroxisome Proliferator-Activated Receptor Gamma Modulator CHS-131 Improves Liver Histopathology and Metabolism in a Mouse Model of Obesity and Nonalcoholic Steatohepatitis. | 2020 | Details |
A30204 | 32821335 | World J Hepatol | Anti-inflammatory and anti-oxidant effects of aloe vera in rats with non-alcoholic steatohepatitis. | 2020 | Details |
A30237 | 32764725 | Nat Rev Endocrinol | The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic. | 2020 | Details |
A30300 | 32682196 | Eur J Med Chem | A novel long-acting oxyntomodulin analogue eliminates diabetes and obesity in mice. | 2020 | Details |
A30564 | 32205234 | Pharmacol Res | Obesity and NRF2-mediated cytoprotection: Where is the missing link? | 2020 | Details |
A30599 | 32140659 | Hepatol Commun | Pirfenidone Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK. | 2020 | Details |
A30617 | 32099031 | Sci Rep | Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunction. | 2020 | Details |
A30665 | 32025605 | Hepatol Commun | Icosabutate Exerts Beneficial Effects Upon Insulin Sensitivity, Hepatic Inflammation, Lipotoxicity, and Fibrosis in Mice. | 2019 | Details |
A30825 | 31717307 | Cancers (Basel) | The mRNA-binding Protein TTP/ZFP36 in Hepatocarcinogenesis and Hepatocellular Carcinoma. | 2019 | Details |
A30956 | 31479766 | Nitric Oxide | Hydrogen sulfide potentiates the favorable metabolic effects of inorganic nitrite in type 2 diabetic rats. | 2019 | Details |
A31229 | 31001415 | F1000Res | Recent advances in managing/understanding the metabolic syndrome. | 2019 | Details |
A31304 | 30846912 | Gastroenterol Hepatol (N Y) | Pharmacologic Management of Nonalcoholic Steatohepatitis. | 2018 | Details |
A31310 | 30826467 | Biochim Biophys Acta Mol Basis Dis | Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity. | 2019 | Details |
A31375 | 30705600 | Diabetes Metab Syndr Obes | Effects of duodenal-jejunal bypass surgery in ameliorating nonalcoholic steatohepatitis in diet-induced obese rats. | 2019 | Details |
A31407 | 30631398 | World J Hepatol | Non-invasive prediction of non-alcoholic steatohepatitis in Japanese patients with morbid obesity by artificial intelligence using rule extraction technology. | 2018 | Details |
A31417 | 30615497 | FASEB J | A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling. | 2019 | Details |
A31455 | 30523261 | Nat Commun | An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma. | 2018 | Details |
A31565 | 30283282 | Case Rep Gastroenterol | A Young Adult Patient with Nonalcoholic Steatohepatitis Developed Severe Gastroesophageal Varices Associated with Severe Obesity and Diabetes Mellitus. | 2018 | Details |
A31583 | 30248539 | Biomed Pharmacother | Effect of silibinin on CFLAR-JNK pathway in oleic acid-treated HepG2 cells. | 2018 | Details |
A31600 | 30218427 | Dig Dis Sci | PNPLA3 Gene Polymorphisms in HCV/HIV-Coinfected Individuals. | 2018 | Details |
A31673 | 30057822 | Int J Hepatol | Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress. | 2018 | Details |
A31806 | 29780857 | Technology (Singap World Sci) | Multi-omic network-based interrogation of rat liver metabolism following gastric bypass surgery featuring SWATH proteomics. | 2017 | Details |
A31886 | 29619418 | Hepatol Commun | The Role of Intestinal C-type Regenerating Islet Derived-3 Lectins for Nonalcoholic Steatohepatitis. | 2018 | Details |
A31979 | 29404484 | Hepatol Commun | The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice. | 2017 | Details |
A31981 | 29404476 | Hepatol Commun | The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis. | 2017 | Details |
A31996 | 29369831 | Curr Opin Lipidol | Novel metabolic phenotypes in lecithin cholesterol acyltyransferase-deficient mice. | 2018 | Details |
A32019 | 30906835 | Genes Dis | Neonatal overfeeding in mice aggravates the development of methionine and choline-deficient diet-induced steatohepatitis in adulthood. | 2018 | Details |
A32137 | 29124251 | Hepatol Commun | TRAIL Deletion Prevents Liver, but Not Adipose Tissue, Inflammation during Murine Diet-Induced Obesity. | 2017 | Details |
A32142 | 29118935 | Gastroenterol Hepatol Bed Bench | A systems biology analysis protein-protein interaction of NASH and IBD based on comprehensive gene information. | 2017 | Details |
A32173 | 29057935 | Sci Rep | Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice. | 2017 | Details |
A32197 | 28981243 | Rev Med Brux | [Treatments of non-alcoholic steatohepatitis]. | 2019 | Details |
A32297 | 28768902 | JCI Insight | Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis. | 2017 | Details |
A32362 | 28630652 | Diabetol Metab Syndr | Verification of B-lymphocyte activating factor's involvement in the exacerbation of insulin resistance as well as an autoimmune response in patients with nonalcoholic steatohepatitis and patients with HCV-related chronic liver disease. | 2017 | Details |
A32449 | 28424556 | Onco Targets Ther | Nonalcoholic steatohepatitis-related hepatocellular carcinoma: is there a role for the androgen receptor pathway? | 2017 | Details |
A32879 | 27182456 | J Clin Cell Immunol | Role of Serum Biomarkers in Early Detection of Non-Alcoholic Steatohepatitis and Fibrosis in West Virginian Children. | 2016 | Details |
A32906 | 27114939 | J Tradit Complement Med | Extract of a polyherbal formulation ameliorates experimental nonalcoholic steatohepatitis. | 2015 | Details |
A33033 | 26828506 | Int J Environ Res Public Health | Biomarker-Based Approaches for Assessing Alcohol Use Disorders. | 2016 | Details |
A33269 | 26330343 | Am J Physiol Endocrinol Metab | Tracer-based assessments of hepatic anaplerotic and TCA cycle flux: practicality, stoichiometry, and hidden assumptions. | 2015 | Details |
A33270 | 26329544 | Yakugaku Zasshi | [SREBP-1c and Elovl6 as Targets for Obesity-related Disorders]. | 2015 | Details |
A33285 | 26301053 | World J Hepatol | Recent advances in mouse models of obesity- and nonalcoholic steatohepatitis-associated hepatocarcinogenesis. | 2015 | Details |
A33388 | 26082668 | Hepat Med | Tyrosine levels are associated with insulin resistance in patients with nonalcoholic fatty liver disease. | 2015 | Details |
A33441 | 25979814 | Aging (Albany NY) | High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice. | 2015 | Details |
A33443 | 25977701 | Evid Based Complement Alternat Med | Metabolomics profiling to investigate the pharmacologic mechanisms of berberine for the treatment of high-fat diet-induced nonalcoholic steatohepatitis. | 2015 | Details |
A33484 | 25903417 | Handb Exp Pharmacol | Immune Cells and Metabolism. | 2016 | Details |
A33490 | 25888330 | Gastroenterology | Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice. | 2015 | Details |
A33517 | 25826083 | Oncotarget | PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis. | 2015 | Details |
A33687 | 25412903 | J Viral Hepat | Oral anti-CD3 immunotherapy for HCV-nonresponders is safe, promotes regulatory T cells and decreases viral load and liver enzyme levels: results of a phase-2a placebo-controlled trial. | 2014 | Details |
A33696 | 25385666 | Ir J Med Sci | Liver injury attenuation by curcumin in a rat NASH model: an Nrf2 activation-mediated effect? | 2014 | Details |
A33735 | 25279794 | Endocrinology | Osteocalcin protects against nonalcoholic steatohepatitis in a mouse model of metabolic syndrome. | 2014 | Details |
A33799 | 25132496 | Cancer Cell | ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. | 2014 | Details |
A33828 | 25066692 | Gastroenterology | Roles for chemokines in liver disease. | 2014 | Details |
A33907 | 24910242 | Cell Metab | Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. | 2014 | Details |
A33966 | 24763197 | Exp Mol Med | Oleuropein prevents the progression of steatohepatitis to hepatic fibrosis induced by a high-fat diet in mice. | 2014 | Details |
A34076 | 24471744 | J Pharm Pharmacol | Bupropion effects on high-fat diet-induced steatohepatitis and endothelial dysfunction in rats: role of tumour necrosis factor-alpha. | 2014 | Details |
A34156 | 26202298 | Hepatol Int | Pharmacological agents for nonalcoholic steatohepatitis. | 2013 | Details |
A34157 | 26202296 | Hepatol Int | Insulin resistance: mechanism and implications for carcinogenesis and hepatocellular carcinoma in NASH. | 2013 | Details |
A34199 | 24145238 | Lab Invest | A novel mouse model of nonalcoholic steatohepatitis with significant insulin resistance. | 2013 | Details |
A34296 | 23828575 | Cell Death Dis | Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells. | 2013 | Details |
A34334 | 26201790 | Hepatol Int | The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH). | 2012 | Details |
A34488 | 23337159 | Endocr Pract | Bone mineral density in patients with nonalcoholic steatohepatitis among end-stage liver disease patients awaiting liver transplantation. | 2014 | Details |
A34504 | 23294302 | J Toxicol Environ Health A | Polybrominated diphenyl ethers alter hepatic phosphoenolpyruvate carboxykinase enzyme kinetics in male Wistar rats: implications for lipid and glucose metabolism. | 2013 | Details |
A34505 | 23293533 | J Inflamm Res | Alleviation of insulin resistance and liver damage by oral administration of Imm124-E is mediated by increased Tregs and associated with increased serum GLP-1 and adiponectin: results of a phase I/II clinical trial in NASH. | 2012 | Details |
A34512 | 23275357 | Diabetes Care | The association between hepatic fat content and liver injury in obese children and adolescents: effects of ethnicity, insulin resistance, and common gene variants. | 2012 | Details |
A34514 | 27335818 | ISRN Hepatol | Murine Models of Nonalcoholic Fatty Liver Disease and Steatohepatitis. | 2012 | Details |
A34545 | 23233000 | Surg Endosc | Resistin expression correlates with steatohepatitis in morbidly obese patients. | 2012 | Details |
A34552 | 23219586 | Metabolism | A case report and review of the literature of laparoscopic sleeve gastrectomy in morbidly obese adolescents: beyond metabolic surgery and visceral fat reduction. | 2012 | Details |
A34583 | 23147115 | Int J Obes (Lond) | Increased insulin receptor substrate 2 expression is associated with steatohepatitis and altered lipid metabolism in obese subjects. | 2012 | Details |
A34631 | 23029000 | PLoS One | VSL#3 resets insulin signaling and protects against NASH and atherosclerosis in a model of genetic dyslipidemia and intestinal inflammation. | 2012 | Details |
A34657 | 22977616 | Exp Ther Med | Adiponectin suppresses endoplasmic reticulum stress in nonalcoholic steatohepatitis. | 2011 | Details |
A34698 | 22846857 | Semin Oncol | Surveillance for hepatocellular carcinoma. | 2012 | Details |
A34711 | 22804755 | J Pineal Res | Plasma insulin, leptin, adiponectin, resistin, ghrelin, and melatonin in nonalcoholic steatohepatitis patients treated with melatonin. | 2012 | Details |
A34756 | 22690069 | World J Gastroenterol | Leaky gut and the liver: a role for bacterial translocation in nonalcoholic steatohepatitis. | 2012 | Details |
A34846 | 22442158 | Am J Physiol Gastrointest Liver Physiol | Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. | 2012 | Details |
A34925 | 24829630 | Middle East J Dig Dis | Metformin in nonalcoholic steatohepatitis: a randomized controlled trial. | 2012 | Details |
A35022 | 21933146 | Curr Pharm Des | Metabolic therapy: lessons from liver diseases. | 2011 | Details |
A35029 | 21922031 | Therap Adv Gastroenterol | Glitazones for human nonalcoholic steatohepatitis. | 2011 | Details |
A35052 | 21865331 | Am J Clin Nutr | Effect of lectin-like oxidized LDL receptor-1 polymorphism on liver disease, glucose homeostasis, and postprandial lipoprotein metabolism in nonalcoholic steatohepatitis. | 2011 | Details |
A35053 | 21865094 | Surg Obes Relat Dis | Serologic predictors of nonalcoholic steatohepatitis in a population undergoing bariatric surgery. | 2011 | Details |
A35059 | 21845516 | J Clin Immunol | Altered phenotype and functionality of circulating immune cells characterize adult patients with nonalcoholic steatohepatitis. | 2011 | Details |
A35111 | 21711428 | Hepatol Res | Pharmacological therapy for non-alcoholic steatohepatitis: How efficient are thiazolidinediones? | 2011 | Details |
A35124 | 21689613 | Clin Liver Dis | Insulin resistance and other metabolic risk factors in the pathogenesis of hepatocellular carcinoma. | 2011 | Details |
A35179 | 21519329 | Lab Invest | Oncostatin M produced in Kupffer cells in response to PGE2: possible contributor to hepatic insulin resistance and steatosis. | 2011 | Details |
A35249 | 21299162 | Acta Gastroenterol Belg | Why should the gastroenterologist bother about obesity? An oncologic point of view. | 2011 | Details |
A35260 | 21274277 | J Obes | Influence of Sleeve Gastrectomy on NASH and Type 2 Diabetes Mellitus. | 2010 | Details |
A35307 | 21146362 | Int J Oral Maxillofac Surg | Non-alcoholic steatohepatitis (NASH) and oral lichen planus: a rare occurrence. | 2010 | Details |
A35316 | 21119028 | Am J Physiol Endocrinol Metab | Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis. | 2010 | Details |
A35317 | 21114431 | Scand J Gastroenterol | Non-alcoholic steatohepatitis (NASH) in patients with polycystic ovarian syndrome (PCOS). | 2010 | Details |