Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Choline1715 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A14687 | 30853754 | Trends Cell Mol Biol | Upregulation of non-canonical Wnt ligands and oxidative glucose metabolism in NASH induced by methionine-choline deficient diet. | 2018 | Details |
| A14701 | 29281143 | Br J Pharmacol | The soluble guanylate cyclase stimulator IW-1973 prevents inflammation and fibrosis in experimental non-alcoholic steatohepatitis. | 2018 | Details |
| A14718 | 29273476 | J Hepatol | Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice. | 2017 | Details |
| A14735 | 29266399 | Hepatology | Hypoxia-inducible factor 2α drives nonalcoholic fatty liver progression by triggering hepatocyte release of histidine-rich glycoprotein. | 2018 | Details |
| A14772 | 29247122 | FASEB J | Prostaglandin I2 suppresses the development of diet-induced nonalcoholic steatohepatitis in mice. | 2017 | Details |
| A14774 | 29244873 | PLoS One | Fatty acids in non-alcoholic steatohepatitis: Focus on pentadecanoic acid. | 2017 | Details |
| A14793 | 29229391 | Biochem Biophys Res Commun | Hepatocyte-specific clusterin overexpression attenuates diet-induced nonalcoholic steatohepatitis. | 2017 | Details |
| A14817 | 29221950 | Eur J Pharmacol | DHA supplementation prevent the progression of NASH via GPR120 signaling. | 2017 | Details |
| A14833 | 29214510 | J Cell Commun Signal | Myeloid deficiency of CCN3 exacerbates liver injury in a mouse model of nonalcoholic fatty liver disease. | 2017 | Details |
| A14838 | 29209997 | EJNMMI Res | [18F]-BMS-747158-02PET imaging for evaluating hepatic mitochondrial complex 1dysfunction in a mouse model of non-alcoholic fatty liver disease. | 2017 | Details |
| A14902 | 29182572 | Int J Mol Sci | Aberrant Lipid Metabolism in Hepatocellular Carcinoma Revealed by Liver Lipidomics. | 2017 | Details |
| A14940 | 29164820 | Liver Int | Dual PPARα/γ agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models. | 2017 | Details |
| A14950 | 29159325 | Hepatol Commun | Role of Aramchol in steatohepatitis and fibrosis in mice. | 2017 | Details |
| A14951 | 29158819 | Theranostics | Pro-Inflammatory CXCR3 Impairs Mitochondrial Function in Experimental Non-Alcoholic Steatohepatitis. | 2017 | Details |
| A14956 | 29158052 | Life Sci | Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice. | 2017 | Details |
| A14959 | 29155718 | J Vis Exp | The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury. | 2017 | Details |
| A14963 | 29154964 | J Hepatol | Lipotoxicity and the gut-liver axis in NASH pathogenesis. | 2017 | Details |
| A14980 | 29145614 | Toxicol Sci | Asking the Right Questions With Animal Models: Methionine- and Choline-Deficient Model in Predicting Adverse Drug Reactions in Human NASH. | 2018 | Details |
| A14999 | 29129819 | Metabolism | Nicotinic acetylcholine receptor α7 subunit improves energy homeostasis and inhibits inflammation in nonalcoholic fatty liver disease. | 2017 | Details |
| A15003 | 29128353 | Biochem Biophys Res Commun | Pyruvate dehydrogenase kinase 4 mediates lipogenesis and contributes to the pathogenesis of nonalcoholic steatohepatitis. | 2017 | Details |
| A15023 | 29126873 | Mol Metab | Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis. | 2017 | Details |
| A15042 | 29121675 | PLoS One | Astaxanthin prevents ischemia-reperfusion injury of the steatotic liver in mice. | 2017 | Details |
| A15068 | 29111158 | Cell Immunol | Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool. | 2017 | Details |
| A15100 | 29096730 | Gene Expr | Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights. | 2017 | Details |
| A15103 | 29093267 | JCI Insight | Loss of miR-141/200c ameliorates hepatic steatosis and inflammation by reprogramming multiple signaling pathways in NASH. | 2017 | Details |
| A15158 | 29067443 | Mol Med Rep | Role of ADAMTS13 in diet-induced liver steatosis. | 2017 | Details |
| A15257 | 29022011 | Heliyon | Placental extract ameliorates non-alcoholic steatohepatitis (NASH) by exerting protective effects on endothelial cells. | 2017 | Details |
| A15281 | 28988798 | Free Radic Biol Med | Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH. | 2017 | Details |
| A15291 | 28983453 | Curr Pharmacol Rep | Remote Sensing between Liver and Intestine: Importance of Microbial Metabolites. | 2017 | Details |
| A15303 | 28973659 | Toxicol Sci | Perfluorooctane Sulfonate-Induced Hepatic Steatosis in Male Sprague Dawley Rats Is Not Attenuated by Dietary Choline Supplementation. | 2017 | Details |
| A15304 | 28973532 | Toxicol Sci | Editor's Highlight: PCB126 Exposure Increases Risk for Peripheral Vascular Diseases in a Liver Injury Mouse Model. | 2017 | Details |
| A15335 | 28962213 | Exp Ther Med | Effects of telmisartan on improving leptin resistance and inhibiting hepatic fibrosis in rats with non-alcoholic fatty liver disease. | 2017 | Details |
| A15379 | 28937622 | Metabolites | Specificities of Human Hepatocellular Carcinoma Developed on Non-Alcoholic Fatty Liver Disease in Absence of Cirrhosis Revealed by Tissue Extracts ¹H-NMR Spectroscopy. | 2017 | Details |
| A15446 | 28903486 | Toxicol Sci | Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice. | 2017 | Details |
| A15462 | 28895242 | Int J Exp Pathol | Hepatocellular carcinoma in a mouse model fed a choline-deficient, L-amino acid-defined, high-fat diet. | 2017 | Details |
| A15475 | 28887301 | J Biol Chem | The phospholipase PNPLA7 functions as a lysophosphatidylcholine hydrolase and interacts with lipid droplets through its catalytic domain. | 2017 | Details |
| A15488 | 28878811 | Nutr Metab (Lond) | Serum metabolites in non-alcoholic fatty-liver disease development or reversion; a targeted metabolomic approach within the PREDIMED trial. | 2017 | Details |
| A15498 | 28875318 | Eur J Nutr | Influence of gut microbiota on the development and progression of nonalcoholic steatohepatitis. | 2017 | Details |
| A15503 | 28873429 | PLoS One | CD18 deficiency improves liver injury in the MCD model of steatohepatitis. | 2017 | Details |
| A15558 | 28844958 | Biochim Biophys Acta Mol Basis Dis | Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet. | 2017 | Details |
| A15591 | 28824700 | Nutr Metab (Lond) | Recombinant SFRP5 protein significantly alleviated intrahepatic inflammation of nonalcoholic steatohepatitis. | 2017 | Details |
| A15604 | 28816082 | J Asian Nat Prod Res | Zeaxanthin dipalmitate alleviates hepatic injury induced by superimposed chronic hepatitis B and non-alcoholic steatohepatitis in non-obese mice. | 2017 | Details |
| A15612 | 28811572 | Sci Rep | Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice. | 2017 | Details |
| A15687 | 28759733 | Can J Physiol Pharmacol | Protective effect of rimonabant, a canabinoid receptor 1 antagonist, on nonalcoholic fatty liver disease in a rat model through modulation of the hepatic expression of activin A and follistatin. | 2017 | Details |
| A15696 | 28754826 | J Lipid Res | Osteopontin regulates the cross-talk between phosphatidylcholine and cholesterol metabolism in mouse liver. | 2017 | Details |
| A15715 | 28747982 | Lab Anim Res | Comparative study of fatty liver induced by methionine and choline-deficiency in C57BL/6N mice originating from three different sources. | 2017 | Details |
| A15742 | 28733574 | Sci Rep | Metabolomic characteristics of cholesterol-induced non-obese nonalcoholic fatty liver disease in mice. | 2017 | Details |
| A15749 | 28730512 | Inflammation | NLRP3 Deletion Inhibits the Non-alcoholic Steatohepatitis Development and Inflammation in Kupffer Cells Induced by Palmitic Acid. | 2017 | Details |
| A15771 | 28718703 | Nanomedicine (Lond) | Nanoliposome improves inhibitory effects of naringenin on nonalcoholic fatty liver disease in mice. | 2017 | Details |
| A15783 | 28711489 | Life Sci | Time-course microarrays reveal early activation of the immune transcriptome in a choline-deficient mouse model of liver injury. | 2017 | Details |
| A15839 | 28687713 | Clin Sci (Lond) | TLR9 is up-regulated in human and murine NASH: pivotal role in inflammatory recruitment and cell survival. | 2017 | Details |
| A15867 | 28676836 | Oxid Med Cell Longev | Genetic Nrf2 Overactivation Inhibits the Deleterious Effects Induced by Hepatocyte-Specific c-met Deletion during the Progression of NASH. | 2017 | Details |
| A15900 | 28662136 | PLoS One | Influence of nicotine on choline-deficient, L-amino acid-defined diet-induced non-alcoholic steatohepatitis in rats. | 2017 | Details |
| A15921 | 28652427 | In Vivo | A Long-term Treatment with Silybin in Patients with Non-alcoholic Steatohepatitis Stimulates Catalase Activity in Human Endothelial Cells. | 2018 | Details |
| A15931 | 28646856 | BMC Immunol | The imbalance of Th17/Treg cells is involved in the progression of nonalcoholic fatty liver disease in mice. | 2017 | Details |
| A15966 | 28635324 | Antioxid Redox Signal | Gliptins Suppress Inflammatory Macrophage Activation to Mitigate Inflammation, Fibrosis, Oxidative Stress, and Vascular Dysfunction in Models of Nonalcoholic Steatohepatitis and Liver Fibrosis. | 2017 | Details |
| A15970 | 28632778 | PLoS One | Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice. | 2017 | Details |
| A15971 | 28632732 | PLoS One | Fructo-oligosaccharides and intestinal barrier function in a methionine-choline-deficient mouse model of nonalcoholic steatohepatitis. | 2017 | Details |
| A16006 | 28615649 | Sci Rep | Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis. | 2017 | Details |
| A16049 | 28594915 | PLoS One | Conophylline inhibits non-alcoholic steatohepatitis in mice. | 2017 | Details |
| A16066 | 28586195 | ACS Chem Biol | Ex Vivo Cell-Based Screening Platform for Modulators of Hepatosteatosis. | 2017 | Details |
| A16085 | 28578014 | Free Radic Biol Med | Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway. | 2017 | Details |
| A16139 | 28544208 | Liver Int | Ultra-high-field magnetic resonance spectroscopy in non-alcoholic fatty liver disease: Novel mechanistic and diagnostic insights of energy metabolism in non-alcoholic steatohepatitis and advanced fibrosis. | 2017 | Details |
| A16179 | 28518142 | Cell Death Dis | MiR-130a-3p attenuates activation and induces apoptosis of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2. | 2017 | Details |
| A16193 | 28511023 | Appl Physiol Nutr Metab | Efficacy of docosahexaenoic acid-choline-vitamin E in paediatric NASH: a randomized controlled clinical trial. | 2017 | Details |
| A16227 | 28499273 | Oncotarget | Inhibition of NLRP3 inflammasome by thioredoxin-interacting protein in mouse Kupffer cells as a regulatory mechanism for non-alcoholic fatty liver disease development. | 2017 | Details |
| A16300 | 28468951 | Clin Sci (Lond) | Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease. | 2017 | Details |
| A16309 | 28465696 | J Res Med Sci | Pimpinella anisum L. fruit: Chemical composition and effect on rat model of nonalcoholic fatty liver disease. | 2017 | Details |
| A16317 | 28462384 | Cell Mol Gastroenterol Hepatol | TRIF Differentially Regulates Hepatic Steatosis and Inflammation/Fibrosis in Mice. | 2017 | Details |
| A16330 | 28456640 | Arch Biochem Biophys | Adrenic acid as an inflammation enhancer in non-alcoholic fatty liver disease. | 2017 | Details |
| A16335 | 28452429 | Obesity (Silver Spring) | Metabolomic profiling distinction of human nonalcoholic fatty liver disease progression from a common rat model. | 2017 | Details |
| A16378 | 28428116 | Pharmacol Res | Cycloastragenol improves hepatic steatosis by activating farnesoid X receptor signalling. | 2017 | Details |
| A16384 | 28425467 | Sci Rep | Hyperpolarized 13C Spectroscopic Evaluation of Oxidative Stress in a Rodent Model of Steatohepatitis. | 2017 | Details |
| A16392 | 28421320 | Histochem Cell Biol | Hepatocyte-specific depletion of ubiquitin regulatory X domain containing protein 8 accelerates fibrosis in a mouse non-alcoholic steatohepatitis model. | 2017 | Details |
| A16405 | 28414763 | PLoS One | Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations. | 2017 | Details |
| A16412 | 28411170 | Biochim Biophys Acta Biomembr | The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease. | 2017 | Details |
| A16490 | 28358240 | Radiology | Molecular MR Imaging of Myeloperoxidase Distinguishes Steatosis from Steatohepatitis in Nonalcoholic Fatty Liver Disease. | 2017 | Details |
| A16540 | 28325574 | J Chin Med Assoc | Decoy receptor 3 analogous supplement protects steatotic rat liver from ischemia-reperfusion injury. | 2017 | Details |
| A16547 | 28323124 | J Hepatol | CD44 is a key player in non-alcoholic steatohepatitis. | 2017 | Details |
| A16549 | 28322783 | Biochem Biophys Res Commun | Elevation of liver endoplasmic reticulum stress in a modified choline-deficient l-amino acid-defined diet-fed non-alcoholic steatohepatitis mouse model. | 2017 | Details |
| A16554 | 28319060 | Oncogene | The anti-diabetic drug exenatide, a glucagon-like peptide-1 receptor agonist, counteracts hepatocarcinogenesis through cAMP-PKA-EGFR-STAT3 axis. | 2017 | Details |
| A16564 | 28306139 | Br J Pharmacol | The TIR/BB-loop mimetic AS-1 prevents non-alcoholic steatohepatitis and hepatic insulin resistance by inhibiting NLRP3-ASC inflammasome activation. | 2017 | Details |
| A16578 | 28298269 | Adv Nutr | Nonalcoholic Fatty Liver Disease, the Gut Microbiome, and Diet. | 2017 | Details |
| A16582 | 28297799 | Zhonghua Gan Zang Bing Za Zhi | [A serum lipidomic study of patients with non-alcoholic fatty liver disease]. | 2017 | Details |
| A16605 | 28286271 | Biochem Biophys Res Commun | p16 deficiency promotes nonalcoholic steatohepatitis via regulation of hepatic oxidative stress. | 2017 | Details |
| A16608 | 28285648 | Metabolism | Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice. | 2017 | Details |
| A16641 | 28270609 | Proc Natl Acad Sci U S A | Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis. | 2017 | Details |
| A16654 | 28262979 | J Cell Biochem | Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism During Hepatocyte Lipotoxicity. | 2017 | Details |
| A16676 | 28251449 | Inflammation | A20 Attenuates Liver Fibrosis in NAFLD and Inhibits Inflammation Responses. | 2017 | Details |
| A16700 | 28235613 | J Hepatol | Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD. | 2017 | Details |
| A16727 | 28220495 | J Pharm Pharmacol | Influence of hyperglycemia on liver inflammatory conditions in the early phase of non-alcoholic fatty liver disease in mice. | 2017 | Details |
| A16768 | 28192190 | J Hepatol | β7-Integrin and MAdCAM-1 play opposing roles during the development of non-alcoholic steatohepatitis. | 2017 | Details |
| A16771 | 28190475 | Phytomedicine | Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor. | 2016 | Details |
| A16786 | 28177750 | Appl Physiol Nutr Metab | Modulatory role of Co-enzyme Q10 on methionine and choline deficient diet-induced non-alcoholic steatohepatitis (NASH) in albino rats. | 2016 | Details |
| A16798 | 28167322 | J Hepatol | NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. | 2017 | Details |
| A16811 | 28159867 | J Lipid Res | Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase. | 2017 | Details |
| A16824 | 28148637 | J Pharmacol Exp Ther | Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice. | 2017 | Details |
| A16862 | 28123936 | Mol Metab | Metabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose metabolism. | 2016 | Details |
| A16881 | 28112179 | Acta Pharmacol Sin | Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse non-alcoholic steatohepatitis. | 2017 | Details |
| A16892 | 28108233 | J Hepatol | Murine CD103+ dendritic cells protect against steatosis progression towards steatohepatitis. | 2017 | Details |