Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A10904 | 31132306 | Scand J Immunol | Epoxyeicosatrienoic acids alleviate methionine-choline-deficient diet-induced non-alcoholic steatohepatitis in mice. | 2019 | Details |
| A10934 | 31114547 | Front Endocrinol (Lausanne) | Hepatic Gene Expression Profiles Differentiate Steatotic and Non-steatotic Grafts in Liver Transplant Recipients. | 2019 | Details |
| A10943 | 31111657 | Obes Rev | The effects of oleoylethanolamide, an endogenous PPAR-α agonist, on risk factors for NAFLD: A systematic review. | 2019 | Details |
| A10979 | 31094171 | Ter Arkh | Comparative analysis of bile acid spectrum in non-alcoholic fatty liver disease and cholelithiasis. | 2019 | Details |
| A10985 | 31090336 | Zhongguo Zhong Yao Za Zhi | [Analysis on mechanisms and medication rules of herbal prescriptions for nonalcoholic fatty liver disease based on methods of data mining and biological information]. | 2019 | Details |
| A11053 | 31064820 | Biosci Rep | LncRNA-H19 promotes hepatic lipogenesis by directly regulating miR-130a/PPARγ axis in non-alcoholic fatty liver disease. | 2019 | Details |
| A11056 | 31064103 | Nutrients | Fermented Cordyceps militaris Extract Prevents Hepatosteatosis and Adipocyte Hypertrophy in High Fat Diet-Fed Mice. | 2019 | Details |
| A11059 | 31063640 | Hepatology | Pharmacologic Inhibition of Epidermal Growth Factor Receptor Suppresses Nonalcoholic Fatty Liver Disease in a Murine Fast-Food Diet Model. | 2019 | Details |
| A11110 | 31037218 | J Nutr Sci | Coffee prevents fatty liver disease induced by a high-fat diet by modulating pathways of the gut-liver axis. | 2019 | Details |
| A11124 | 31032705 | Autophagy | Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels. | 2019 | Details |
| A11132 | 31028903 | Pharmacol Res | Elafibranor restricts lipogenic and inflammatory responses in a human skin stem cell-derived model of NASH. | 2019 | Details |
| A11136 | 31026873 | Planta Med | Preventive Effects of Total Flavonoid C-Glycosides from Abrus mollis on Nonalcoholic Fatty Liver Disease through Activating the PPARα Signaling Pathway. | 2019 | Details |
| A11154 | 31020720 | Exp Physiol | Combined treatment of dipeptidyl peptidase-4 inhibitor and exercise training improves lipid profile in KK/Ta mice. | 2019 | Details |
| A11221 | 30987865 | Clin Investig Arterioscler | Pharmacological PPARβ/δ activation upregulates VLDLR in hepatocytes. | 2019 | Details |
| A11223 | 30987167 | Int J Mol Sci | Ameliorative Effect of Spinach on Non-Alcoholic Fatty Liver Disease Induced in Rats by a High-Fat Diet. | 2019 | Details |
| A11231 | 30983568 | Elife | Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis. | 2019 | Details |
| A11238 | 30978698 | J Mol Endocrinol | Humulus japonicus stimulates thermogenesis and ameliorates oxidative stress in mouse adipocytes. | 2019 | Details |
| A11245 | 30975991 | Nat Commun | Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα. | 2019 | Details |
| A11246 | 30975380 | Prostaglandins Leukot Essent Fatty Acids | Fish oil protects the liver from parenteral nutrition-induced injury via GPR120-mediated PPARγ signaling. | 2019 | Details |
| A11276 | 30962743 | Yonago Acta Med | Gene Expression Analysis of the Activating Factor 3/Nuclear Protein 1 Axis in a Non-alcoholic Steatohepatitis Mouse Model. | 2019 | Details |
| A11279 | 30961499 | Curr Vasc Pharmacol | Non-Alcoholic Fatty Liver Disease Treatment in Patients with Type 2 Diabetes Mellitus; New Kids on the Block. | 2020 | Details |
| A11286 | 30957185 | Mol Med Rep | Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA‑treated HepG2 cells. | 2019 | Details |
| A11297 | 30950217 | J Cell Mol Med | Aucubin inhibited lipid accumulation and oxidative stress via Nrf2/HO-1 and AMPK signalling pathways. | 2019 | Details |
| A11307 | 30945694 | J Genet | Genetics of nonalcoholic fatty liver disease in Asian populations. | 2019 | Details |
| A11321 | 30939745 | Int J Mol Sci | 2, 3, 4', 5-tetrahydroxystilbene-2-0-β-d Glycoside Attenuates Age- and Diet-Associated Non-Alcoholic Steatohepatitis and Atherosclerosis in LDL Receptor Knockout Mice and Its Possible Mechanisms. | 2019 | Details |
| A11323 | 30937936 | J Cell Physiol | Morin reduces inflammatory responses and alleviates lipid accumulation in hepatocytes. | 2019 | Details |
| A11359 | 30923554 | Cell Mol Biol Lett | The Pro12Ala polymorphism in the PPAR-γ2 gene is not associated with an increased risk of NAFLD in Iranian patients with type 2 diabetes mellitus. | 2019 | Details |
| A11413 | 30905315 | Adipocyte | Adipocytes as lipid sensors of oleic acid transport through a functional Caco-2/HT29-MTX intestinal barrier. | 2019 | Details |
| A11440 | 30894137 | BMC Gastroenterol | The role of Small Intestinal Bacterial Overgrowth (SIBO) in Non-alcoholic Fatty Liver Disease (NAFLD) patients evaluated using Controlled Attenuation Parameter (CAP) Transient Elastography (TE): a tertiary referral center experience. | 2019 | Details |
| A11477 | 30879920 | EBioMedicine | Arid1a regulates insulin sensitivity and lipid metabolism. | 2019 | Details |
| A11480 | 30878016 | J Endocrinol | Short-term strength training reduces gluconeogenesis and NAFLD in obese mice. | 2019 | Details |
| A11497 | 30871035 | Nutrients | Eicosapentaenoic Acid Improves Hepatic Metabolism and Reduces Inflammation Independent of Obesity in High-Fat-Fed Mice and in HepG2 Cells. | 2019 | Details |
| A11528 | 30856468 | J Nutr Biochem | Tissue-dependent effects of cis-9,trans-11- and trans-10,cis-12-CLA isomers on glucose and lipid metabolism in adult male mice. | 2019 | Details |
| A11539 | 30851372 | J Ethnopharmacol | Protective effect and mechanism of Qiwei Tiexie capsule on 3T3-L1 adipocytes cells and rats with nonalcoholic fatty liver disease by regulating LXRα, PPARγ, and NF-κB-iNOS-NO signaling pathways. | 2019 | Details |
| A11542 | 30850637 | Sci Rep | Connectivity mapping of angiotensin-PPAR interactions involved in the amelioration of non-alcoholic steatohepatitis by Telmisartan. | 2019 | Details |
| A11551 | 30847736 | Curr Obes Rep | Changes in Bile Acid Metabolism, Transport, and Signaling as Central Drivers for Metabolic Improvements After Bariatric Surgery. | 2019 | Details |
| A11557 | 30841472 | Biomed Pharmacother | Biochemical and histological characterisation of an experimental rodent model of non-alcoholic steatohepatitis - Effects of a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist and a glucagon-like peptide-1 analogue. | 2019 | Details |
| A11580 | 30832407 | Nutrients | Dietary Polyphenols Protect Against Oleic Acid-Induced Steatosis in an in Vitro Model of NAFLD by Modulating Lipid Metabolism and Improving Mitochondrial Function. | 2019 | Details |
| A11624 | 30814493 | Cell Death Dis | PPARδ attenuates hepatic steatosis through autophagy-mediated fatty acid oxidation. | 2019 | Details |
| A11625 | 30813654 | Nutrients | Lonicera caerulea Extract Attenuates Non-Alcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Hepatocytes and in High Fat Diet-Fed Mice. | 2019 | Details |
| A11626 | 30813440 | Nutrients | Effect of Fish Oil Supplementation on Hepatic and Visceral Fat in Overweight Men: A Randomized Controlled Trial. | 2019 | Details |
| A11645 | 30807179 | J Proteome Res | Proteomic Analysis Reveals Novel Mechanisms by Which Polychlorinated Biphenyls Compromise the Liver Promoting Diet-Induced Steatohepatitis. | 2019 | Details |
| A11666 | 30797009 | Int J Biol Macromol | Mussel polysaccharide α-D-glucan (MP-A) protects against non-alcoholic fatty liver disease via maintaining the homeostasis of gut microbiota and regulating related gut-liver axis signaling pathways. | 2019 | Details |
| A11675 | 30793973 | Genet Test Mol Biomarkers | Interaction Between AGTR1 and PPARγ Gene Polymorphisms on the Risk of Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A11679 | 30792450 | Sci Rep | Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1. | 2019 | Details |
| A11680 | 30792163 | Arch Med Res | Therapeutic Intranasal Vaccine HB-ATV-8 Prevents Atherogenesis and Non-alcoholic Fatty Liver Disease in a Pig Model of Atherosclerosis. | 2019 | Details |
| A11693 | 30789804 | Int J Vitam Nutr Res | Liver Histological Improvement After Administration of High-Dose Vitamin C in Guinea Pig with Nonalcoholic Steatohepatitis. | 2019 | Details |
| A11724 | 30776032 | Food Funct | Myricetin alleviated hepatic steatosis by acting on microRNA-146b/thyroid hormone receptor b pathway in high-fat diet fed C57BL/6J mice. | 2019 | Details |
| A11739 | 30770098 | Biochem Biophys Res Commun | Genetic deletion of β2 adrenergic receptors exacerbates hepatocellular lipid accumulation in high-fat diet mice. | 2019 | Details |
| A11766 | 32598624 | Ter Arkh | [Comparative analysis of bile acid spectrum in non-alcoholic fatty liver disease and cholelithiasis]. | 2019 | Details |
| A11778 | 30748020 | Hepatology | Hepatic Interferon Regulatory Factor 6 Alleviates Liver Steatosis and Metabolic Disorder by Transcriptionally Suppressing Peroxisome Proliferator-Activated Receptor γ in Mice. | 2019 | Details |
| A11786 | 30745416 | J Pharmacol Exp Ther | RLA8-A New and Highly Effective Quadruple PPAR-α/γ/δ and GPR40 Agonist to Reverse Nonalcoholic Steatohepatitis and Fibrosis. | 2019 | Details |
| A11796 | 30737662 | Inflammation | Saroglitazar Deactivates the Hepatic LPS/TLR4 Signaling Pathway and Ameliorates Adipocyte Dysfunction in Rats with High-Fat Emulsion/LPS Model-Induced Non-alcoholic Steatohepatitis. | 2019 | Details |
| A11806 | 30732555 | Eur J Sport Sci | Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation. | 2019 | Details |
| A11826 | 30719457 | J Immunol Res | The Crosstalk between Fat Homeostasis and Liver Regional Immunity in NAFLD. | 2019 | Details |
| A11836 | 30713255 | Biol Pharm Bull | Preventive Effect of Citrus aurantium Peel Extract on High-Fat Diet-Induced Non-alcoholic Fatty Liver in Mice. | 2019 | Details |
| A11839 | 30711707 | Toxicology | The effects of perfluorooctanoate on high fat diet induced non-alcoholic fatty liver disease in mice. | 2019 | Details |
| A11843 | 30711017 | Lipids Health Dis | Triglycerides to high-density lipoprotein cholesterol ratio as a surrogate for nonalcoholic fatty liver disease: a cross-sectional study. | 2019 | Details |
| A11900 | 30689650 | PLoS One | Conophylline inhibits high fat diet-induced non-alcoholic fatty liver disease in mice. | 2019 | Details |
| A11926 | 30680004 | Exp Ther Med | Gemfibrozil reduces lipid accumulation in SMMC-7721 cells via the involvement of PPARα and SREBP1. | 2018 | Details |
| A11932 | 30675881 | Food Funct | Coenzyme Q10 attenuates high-fat diet-induced non-alcoholic fatty liver disease through activation of the AMPK pathway. | 2019 | Details |
| A11967 | 30664220 | Int J Mol Med | SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPARα/FoxO1 signaling pathway. | 2019 | Details |
| A11973 | 30660906 | Chemosphere | Long-term bisphenol S exposure induces fat accumulation in liver of adult male zebrafish (Danio rerio) and slows yolk lipid consumption in F1 offspring. | 2019 | Details |
| A11978 | 30659956 | Exp Gerontol | Osthole inhibits oleic acid/lipopolysaccharide-induced lipid accumulation and inflammatory response through activating PPARα signaling pathway in cultured hepatocytes. | 2019 | Details |
| A11985 | 30658440 | Int J Mol Sci | Interactions between Host PPARs and Gut Microbiota in Health and Disease. | 2019 | Details |
| A12054 | 30621686 | Lipids Health Dis | Crocin ameliorates hepatic steatosis through activation of AMPK signaling in db/db mice. | 2019 | Details |
| A12071 | 30615941 | Metab Eng | Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function. | 2019 | Details |
| A12076 | 30611993 | Biomed Pharmacother | Plumbagin reduces obesity and nonalcoholic fatty liver disease induced by fructose in rats through regulation of lipid metabolism, inflammation and oxidative stress. | 2019 | Details |
| A12077 | 30611723 | Toxicol Appl Pharmacol | Farnesol induces fatty acid oxidation and decreases triglyceride accumulation in steatotic HepaRG cells. | 2019 | Details |
| A12078 | 30611703 | Alcohol | Effect of nanoformulated copper/zinc superoxide dismutase on chronic ethanol-induced alterations in liver and adipose tissue. | 2019 | Details |
| A12080 | 30611282 | Lipids Health Dis | Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-γ and genes involved in the beta-oxidation of fatty acids in ApoE-KO mice fed a high-fat diet. | 2019 | Details |
| A12131 | 30590197 | J Ethnopharmacol | Chronic treatment with the modified Longdan Xiegan Tang attenuates olanzapine-induced fatty liver in rats by regulating hepatic de novo lipogenesis and fatty acid beta-oxidation-associated gene expression mediated by SREBP-1c, PPAR-alpha and AMPK-alpha. | 2018 | Details |
| A12137 | 30588181 | Int J Med Sci | Phenotypic Alteration of Hepatocytes in Non-Alcoholic Fatty Liver Disease. | 2018 | Details |
| A12152 | 30580553 | Crit Rev Food Sci Nutr | n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review. | 2018 | Details |
| A12155 | 30579258 | Biomed Pharmacother | Administration of methyl palmitate prevents non-alcoholic steatohepatitis (NASH) by induction of PPAR-α. | 2018 | Details |
| A12177 | 30573812 | Acta Pharmacol Sin | A novel ASBT inhibitor, IMB17-15, repressed nonalcoholic fatty liver disease development in high-fat diet-fed Syrian golden hamsters. | 2018 | Details |
| A12182 | 30572788 | Biosci Biotechnol Biochem | A review of the studies on food-derived factors which regulate energy metabolism via the modulation of lipid-sensing nuclear receptors. | 2018 | Details |
| A12192 | 30568000 | Biochem J | ZNF300 stimulates fatty acid oxidation and alleviates hepatosteatosis through regulating PPARα. | 2019 | Details |
| A12195 | 30567368 | Int J Mol Sci | Effective Food Ingredients for Fatty Liver: Soy Protein β-Conglycinin and Fish Oil. | 2018 | Details |
| A12198 | 30566427 | PLoS Biol | Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis. | 2018 | Details |
| A12206 | 30562559 | Biochim Biophys Acta Mol Basis Dis | Hepatic mTOR-AKT2-Insig2 signaling pathway contributes to the improvement of hepatic steatosis after Roux-en-Y Gastric Bypass in mice. | 2018 | Details |
| A12209 | 30561132 | Basic Clin Pharmacol Toxicol | A role of peroxisome proliferator-activated receptor γ in non-alcoholic fatty liver disease. | 2019 | Details |
| A12218 | 30558790 | Biochem Biophys Res Commun | Upregulation of miR-181a impairs lipid metabolism by targeting PPARα expression in nonalcoholic fatty liver disease. | 2018 | Details |
| A12223 | 30556145 | Hepatology | Modulation of Insulin Resistance in Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A12228 | 30555521 | Nutr Metab (Lond) | Amelioration of hepatic steatosis is associated with modulation of gut microbiota and suppression of hepatic miR-34a in Gynostemma pentaphylla (Thunb.) Makino treated mice. | 2018 | Details |
| A12240 | 30551380 | Biomed Pharmacother | Preventive effect of trans-chalcone on non-alcoholic steatohepatitis: Improvement of hepatic lipid metabolism. | 2018 | Details |
| A12249 | 30547786 | BMC Med Genomics | Genomics of lipid-laden human hepatocyte cultures enables drug target screening for the treatment of non-alcoholic fatty liver disease. | 2018 | Details |
| A12295 | 30522014 | Biomed Pharmacother | Wuzhi capsule (Schisandra Sphenanthera extract) attenuates liver steatosis and inflammation during non-alcoholic fatty liver disease development. | 2018 | Details |
| A12302 | 30518830 | Nat Rev Gastroenterol Hepatol | Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators. | 2019 | Details |
| A12310 | 30504232 | J Lipid Res | Hepatic transcriptome analysis from HFD-fed mice defines a long noncoding RNA regulating cellular cholesterol levels. | 2018 | Details |
| A12321 | 30516003 | Physiol Rep | Exercise training suppresses scavenger receptor CD36 expression in kupffer cells of nonalcoholic steatohepatitis model mice. | 2018 | Details |
| A12334 | 30510994 | Cell Mol Gastroenterol Hepatol | Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice. | 2018 | Details |
| A12374 | 30482436 | J Pharmacol Sci | Lipid-modulate activity of Cichorium glandulosum Boiss. et Huet polysaccharide in nonalcoholic fatty liver disease larval zebrafish model. | 2018 | Details |
| A12389 | 30473364 | Lancet | Gathering momentum for the way ahead: fifth report of the Lancet Standing Commission on Liver Disease in the UK. | 2018 | Details |
| A12390 | 30473057 | Metabolism | Adiponectin homolog novel osmotin protects obesity/diabetes-induced NAFLD by upregulating AdipoRs/PPARα signaling in ob/ob and db/db transgenic mouse models. | 2018 | Details |
| A12392 | 30472977 | J Pharm Pharm Sci | Non-alcoholic Steatohepatitis (NASH) Drug Discovery - Building a Consensus on ADME Screening Tools and Clinical Pharmacology Strategies to Aid Candidate Development. | 2018 | Details |
| A12433 | 30457067 | Proc Nutr Soc | Hepatic fatty acid synthesis and partitioning: the effect of metabolic and nutritional state. | 2018 | Details |
| A12450 | 30451987 | Eur J Clin Nutr | Diet with greater inflammatory potential is associated with higher prevalence of fatty liver among US adults. | 2018 | Details |
| A12486 | 30428868 | Lipids Health Dis | Changes in peroxisome proliferator-activated receptor alpha target gene expression in peripheral blood mononuclear cells associated with non-alcoholic fatty liver disease. | 2018 | Details |
| A12513 | 30413815 | Lab Invest | Sex-associated preventive effects of low-dose aspirin on obesity and non-alcoholic fatty liver disease in mouse offspring with over-nutrition in utero. | 2018 | Details |