Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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apoptosis1710 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A15818 | 28694658 | World J Gastroenterol | Anti-steatotic and anti-fibrotic effects of the KCa3.1 channel inhibitor, Senicapoc, in non-alcoholic liver disease. | 2017 | Details |
| A15848 | 28683306 | Cell Rep | RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis. | 2017 | Details |
| A15860 | 28677866 | J Appl Toxicol | Increased incidence of non-alcoholic fatty liver disease in male rat offspring exposed to fluoxetine during fetal and neonatal life involves the NLRP3 inflammasome and augmented de novo hepatic lipogenesis. | 2017 | Details |
| A15862 | 28677333 | Aliment Pharmacol Ther | Review article: new treatments in non-alcoholic fatty liver disease. | 2017 | Details |
| A15881 | 28673968 | Proc Natl Acad Sci U S A | Hepatic ZIP14-mediated zinc transport is required for adaptation to endoplasmic reticulum stress. | 2017 | Details |
| A15911 | 28655714 | Am J Physiol Endocrinol Metab | Epidermal growth factor receptor restoration rescues the fatty liver regeneration in mice. | 2017 | Details |
| A15946 | 28641031 | Expert Opin Drug Saf | Treatment options for nonalcoholic steatohepatitis - a safety evaluation. | 2017 | Details |
| A15959 | 28637104 | Korean J Gastroenterol | [Treatment Options in Non-alcoholic Fatty Liver Disease]. | 2017 | Details |
| A15961 | 28637102 | Korean J Gastroenterol | [The Progression of Liver Fibrosis in Non-alcoholic Fatty Liver Disease]. | 2017 | Details |
| A15966 | 28635324 | Antioxid Redox Signal | Gliptins Suppress Inflammatory Macrophage Activation to Mitigate Inflammation, Fibrosis, Oxidative Stress, and Vascular Dysfunction in Models of Nonalcoholic Steatohepatitis and Liver Fibrosis. | 2017 | Details |
| A15981 | 28628039 | J Clin Invest | ChREBP refines the hepatic response to fructose to protect the liver from injury. | 2017 | Details |
| A16018 | 28608850 | Nat Commun | Cellular senescence drives age-dependent hepatic steatosis. | 2017 | Details |
| A16026 | 28603092 | Hepatobiliary Pancreat Dis Int | Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance. | 2017 | Details |
| A16047 | 28595079 | Int Immunopharmacol | Curcumin reduces the risk of chronic kidney damage in mice with nonalcoholic steatohepatitis by modulating endoplasmic reticulum stress and MAPK signaling. | 2017 | Details |
| A16073 | 28585211 | Adv Exp Med Biol | Non-Alcoholic Fatty Liver Disease. | 2017 | Details |
| A16086 | 28577569 | Lipids Health Dis | Overexpression of apolipoprotein A-I alleviates endoplasmic reticulum stress in hepatocytes. | 2017 | Details |
| A16114 | 28559541 | Int J Obes (Lond) | Adiponectin deficiency rescues high-fat diet-induced hepatic injury, apoptosis and autophagy loss despite persistent steatosis. | 2017 | Details |
| A16179 | 28518142 | Cell Death Dis | MiR-130a-3p attenuates activation and induces apoptosis of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2. | 2017 | Details |
| A16197 | 28508477 | Hepatology | The novel intracellular protein CREG inhibits hepatic steatosis, obesity, and insulin resistance. | 2017 | Details |
| A16204 | 28507343 | Sci Rep | Non-alcoholic fatty liver disease, vascular inflammation and insulin resistance are exacerbated by TRAIL deletion in mice. | 2017 | Details |
| A16207 | 28506744 | Adv Drug Deliv Rev | Hepatic stellate cells as key target in liver fibrosis. | 2017 | Details |
| A16224 | 28501537 | Clin Gastroenterol Hepatol | Effects of Exercise on Liver Fat and Metabolism in Alcohol Drinkers. | 2017 | Details |
| A16231 | 28496045 | J Atheroscler Thromb | Cholic Acid Enhances Visceral Adiposity, Atherosclerosis and Nonalcoholic Fatty Liver Disease in Microminipigs. | 2017 | Details |
| A16238 | 28490707 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | [Effect of NF-κB on the pathogenic course of non-alcoholic fatty liver disease]. | 2017 | Details |
| A16259 | 28481357 | Nat Med | Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4. | 2017 | Details |
| A16317 | 28462384 | Cell Mol Gastroenterol Hepatol | TRIF Differentially Regulates Hepatic Steatosis and Inflammation/Fibrosis in Mice. | 2017 | Details |
| A16333 | 28454323 | Oncol Lett | MicroRNA-29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia-reperfusion rat model of non-alcoholic fatty liver disease. | 2017 | Details |
| A16341 | 28446627 | J Nutr | Silicon Alleviates Nonalcoholic Steatohepatitis by Reducing Apoptosis in Aged Wistar Rats Fed a High-Saturated Fat, High-Cholesterol Diet. | 2017 | Details |
| A16352 | 28442507 | J Endocrinol | Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in mice. | 2017 | Details |
| A16362 | 28437863 | Hepatology | Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity. | 2017 | Details |
| A16366 | 28436198 | Mol Nutr Food Res | Effects of selenium on apoptosis and abnormal amino acid metabolism induced by excess fatty acid in isolated rat hepatocytes. | 2017 | Details |
| A16393 | 28420164 | Int J Mol Sci | The Angiogenesis Inhibitor ALS-L1023 from Lemon-Balm Leaves Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease through Regulating the Visceral Adipose-Tissue Function. | 2017 | Details |
| A16414 | 28406477 | Cell Death Dis | miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice. | 2017 | Details |
| A16462 | 28373874 | Front Immunol | Immunoregulatory Role of NK Cells in Tissue Inflammation and Regeneration. | 2017 | Details |
| A16463 | 28373762 | World J Gastroenterol | Traditional Chinese herbal extracts inducing autophagy as a novel approach in therapy of nonalcoholic fatty liver disease. | 2017 | Details |
| A16498 | 28351752 | Exp Cell Res | Deficiency of CKIP-1 aggravates high-fat diet-induced fatty liver in mice. | 2017 | Details |
| A16514 | 28346483 | PLoS One | Effect of miR-146 targeted HDMCP up-regulation in the pathogenesis of nonalcoholic steatohepatitis. | 2017 | Details |
| A16515 | 28346237 | Curr Opin Gastroenterol | Current and future pharmacologic treatment of nonalcoholic steatohepatitis. | 2017 | Details |
| A16529 | 28334911 | Hum Mol Genet | MERTK rs4374383 variant predicts incident nonalcoholic fatty liver disease and diabetes: role of mononuclear cell activation and adipokine response to dietary fat. | 2017 | Details |
| A16540 | 28325574 | J Chin Med Assoc | Decoy receptor 3 analogous supplement protects steatotic rat liver from ischemia-reperfusion injury. | 2017 | Details |
| A16554 | 28319060 | Oncogene | The anti-diabetic drug exenatide, a glucagon-like peptide-1 receptor agonist, counteracts hepatocarcinogenesis through cAMP-PKA-EGFR-STAT3 axis. | 2017 | Details |
| A16559 | 28317891 | Sci Rep | Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa). | 2017 | Details |
| A16565 | 28303974 | Sci Rep | Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis. | 2017 | Details |
| A16588 | 28297775 | Zhonghua Gan Zang Bing Za Zhi | [Effect of calcium-independent phospholipase A(2) inhibitor in reducing hepatocyte lipoapoptosis and improving insulin resistance]. | 2017 | Details |
| A16601 | 28288414 | Redox Biol | Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells. | 2017 | Details |
| A16617 | 28281516 | Ter Arkh | [Features of a necrotic and inflammatory process in different forms of nonalcoholic fatty liver disease]. | 2017 | Details |
| A16622 | 28278289 | PLoS One | Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice. | 2017 | Details |
| A16628 | 28276774 | Expert Rev Clin Pharmacol | Pharmacological management of nonalcoholic fatty liver disease in type 2 diabetes. | 2017 | Details |
| A16652 | 28264426 | Nutrients | The Combination of Blueberry Juice and Probiotics Ameliorate Non-Alcoholic Steatohepatitis (NASH) by Affecting SREBP-1c/PNPLA-3 Pathway via PPAR-α. | 2017 | Details |
| A16653 | 28263100 | Autoimmunity | Decreased serum DNase1-activity in patients with autoimmune liver diseases. | 2017 | Details |
| A16661 | 28257781 | Food Chem Toxicol | Diet high in fructose promotes liver steatosis and hepatocyte apoptosis in C57BL/6J female mice: Role of disturbed lipid homeostasis and increased oxidative stress. | 2017 | Details |
| A16684 | 28245087 | Hepatol Res | Hepatic nucleotide binding oligomerization domain-like receptors pyrin domain-containing 3 inflammasomes are associated with the histologic severity of non-alcoholic fatty liver disease. | 2017 | Details |
| A16696 | 28239368 | Front Endocrinol (Lausanne) | Connection of Nicotine to Diet-Induced Obesity and Non-Alcoholic Fatty Liver Disease: Cellular and Mechanistic Insights. | 2017 | Details |
| A16731 | 28218919 | Nat Med | Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates. | 2017 | Details |
| A16732 | 28218651 | Int J Mol Sci | Proteome Characteristics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas. | 2017 | Details |
| A16737 | 28216552 | Mar Drugs | Protective Effects and Mechanism of Meretrix meretrix Oligopeptides against Nonalcoholic Fatty Liver Disease. | 2017 | Details |
| A16745 | 28212548 | Oncotarget | Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model. | 2017 | Details |
| A16793 | 28170108 | Hepatology | Caspase-cleaved keratin-18 fragments increase during alcohol withdrawal and predict liver-related death in patients with alcoholic liver disease. | 2017 | Details |
| A16804 | 28163820 | Oxid Med Cell Longev | Apolipoprotein CIII Overexpression-Induced Hypertriglyceridemia Increases Nonalcoholic Fatty Liver Disease in Association with Inflammation and Cell Death. | 2017 | Details |
| A16806 | 28162008 | Expert Rev Gastroenterol Hepatol | Clinical implications of understanding the association between oxidative stress and pediatric NAFLD. | 2017 | Details |
| A16809 | 28160259 | J Physiol Biochem | Protein malnutrition during fetal programming induces fatty liver in adult male offspring rats. | 2017 | Details |
| A16831 | 28142119 | Biomed Pharmacother | Ginkgolide A ameliorates non-alcoholic fatty liver diseases on high fat diet mice. | 2017 | Details |
| A16880 | 28112681 | J Clin Invest | Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance. | 2017 | Details |
| A16892 | 28108233 | J Hepatol | Murine CD103+ dendritic cells protect against steatosis progression towards steatohepatitis. | 2017 | Details |
| A16897 | 28106137 | Sci Rep | Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats. | 2017 | Details |
| A16906 | 28100771 | J Biol Chem | Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. | 2017 | Details |
| A16963 | 28073183 | Hepatology | A liver-specific long noncoding RNA with a role in cell viability is elevated in human nonalcoholic steatohepatitis. | 2017 | Details |
| A17028 | 30802390 | Klin Lab Diagn | [The phylogenetic theory of general pathology. The development of seven biological functions, seven specific ones and etiological factors of metabolic epidemics, millions years' common pathogenesis and basics of prevention.] | 2019 | Details |
| A17120 | 27981809 | Mol Nutr Food Res | Chicoric acid attenuate a nonalcoholic steatohepatitis by inhibiting key regulators of lipid metabolism, fibrosis, oxidation, and inflammation in mice with methionine and choline deficiency. | 2017 | Details |
| A17123 | 27980597 | Nutr Metab (Lond) | Alpha-mangostin from mangosteen (Garcinia mangostana Linn.) pericarp extract reduces high fat-diet induced hepatic steatosis in rats by regulating mitochondria function and apoptosis. | 2016 | Details |
| A17199 | 27917437 | Cell Tissue Res | Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. | 2016 | Details |
| A17227 | 27901086 | Sci Rep | Glycycoumarin inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress/GSK-3-mediated mitochondrial pathway. | 2016 | Details |
| A17229 | 27899042 | Int J Food Sci Nutr | Hepatic rhythmicity of endoplasmic reticulum stress is disrupted in perinatal and adult mice models of high-fat diet-induced obesity. | 2016 | Details |
| A17264 | 27880981 | Hepatology | A novel glucagon-like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice. | 2017 | Details |
| A17286 | 27862769 | Cancer Sci | NS5ABP37 inhibits liver cancer by impeding lipogenesis and cholesterogenesis. | 2017 | Details |
| A17326 | 27843095 | EBioMedicine | Branched Chain Amino Acids Cause Liver Injury in Obese/Diabetic Mice by Promoting Adipocyte Lipolysis and Inhibiting Hepatic Autophagy. | 2016 | Details |
| A17332 | 31435207 | J Taibah Univ Med Sci | The role of elevated alanine aminotransferase (ALT), FasL and atherogenic dyslipidemia in type II diabetes mellitus. | 2016 | Details |
| A17335 | 27836788 | Chem Biol Interact | Regression of fibrosis/cirrhosis by Glycine propionyl-l-carnitine treatment in d-Galactosamine induced chronic liver damage. | 2016 | Details |
| A17449 | 27784003 | Oncotarget | Glycine protects against high sucrose and high fat-induced non-alcoholic steatohepatitis in rats. | 2016 | Details |
| A17453 | 27672081 | J Pharmacol Exp Ther | Akebia Saponin D Decreases Hepatic Steatosis through Autophagy Modulation. | 2016 | Details |
| A17474 | 27732911 | J Nutr Biochem | Preventive effects of dietary walnuts on high-fat-induced hepatic fat accumulation, oxidative stress and apoptosis in mice. | 2016 | Details |
| A17476 | 27693777 | Toxicol Lett | Myclobutanil worsens nonalcoholic fatty liver disease: An in vitro study of toxicity and apoptosis on HepG2 cells. | 2016 | Details |
| A17481 | 27490779 | Biomed Pharmacother | Swertiamarin ameliorates oleic acid induced lipid accumulation and oxidative stress by attenuating gluconeogenesis and lipogenesis in hepatic steatosis. | 2016 | Details |
| A17486 | 27634173 | Free Radic Biol Med | Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. | 2016 | Details |
| A17497 | 27637015 | Hepatology | Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice. | 2016 | Details |
| A17502 | 27301788 | Hepatology | Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury. | 2016 | Details |
| A17518 | 27760195 | PLoS One | Prolyl Oligopeptidase Inhibition Attenuates Steatosis in the L02 Human Liver Cell Line. | 2016 | Details |
| A17526 | 27756518 | Nutr Metab Cardiovasc Dis | Intracellular and extracellular miRNome deregulation in cellular models of NAFLD or NASH: Clinical implications. | 2016 | Details |
| A17609 | 27719652 | Curr Mol Med | Non-Invasive Assessment of Liver Injury in Non-Alcoholic Fatty Liver Disease: A Review of Literature. | 2016 | Details |
| A17659 | 27680976 | Front Med | miRNAs in non-alcoholic fatty liver disease. | 2016 | Details |
| A17673 | 27669973 | Expert Rev Mol Med | C-X-C motif chemokine 10 in non-alcoholic steatohepatitis: role as a pro-inflammatory factor and clinical implication. | 2016 | Details |
| A17686 | 27659347 | J Genet | Comparative analysis of gene expression profiles of OPN signaling pathway in four kinds of liver diseases. | 2016 | Details |
| A17694 | 27651333 | Biochem Biophys Res Commun | Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity. | 2016 | Details |
| A17785 | 27594839 | Front Physiol | Roux-En Y Gastric Bypass Results in Long-Term Remission of Hepatocyte Apoptosis and Hepatic Histological Features of Non-alcoholic Steatohepatitis. | 2016 | Details |
| A17809 | 27570425 | World J Gastroenterol | Herbal medicines and nonalcoholic fatty liver disease. | 2016 | Details |
| A17866 | 27514483 | Am J Physiol Gastrointest Liver Physiol | Hepatocellular autophagy modulates the unfolded protein response and fasting-induced steatosis in mice. | 2016 | Details |
| A17898 | 27492250 | Hepatol Res | Role of thrombospondin 1 in liver diseases. | 2016 | Details |
| A17900 | 27488610 | Eur J Nutr | The in vivo antineoplastic and therapeutic efficacy of troxerutin on rat preneoplastic liver: biochemical, histological and cellular aspects. | 2016 | Details |
| A17953 | 27456850 | BMC Complement Altern Med | Anti-lipoapoptotic effects of Alisma orientalis extract on non-esterified fatty acid-induced HepG2 cells. | 2016 | Details |
| A17959 | 27452109 | Antioxid Redox Signal | Oxidative Stress as a Critical Factor in Nonalcoholic Fatty Liver Disease Pathogenesis. | 2016 | Details |