Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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fibrosis10255 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A31531 | 30367397 | J Gastrointest Surg | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. | 2018 | Details |
| A31565 | 30283282 | Case Rep Gastroenterol | A Young Adult Patient with Nonalcoholic Steatohepatitis Developed Severe Gastroesophageal Varices Associated with Severe Obesity and Diabetes Mellitus. | 2018 | Details |
| A31571 | 30271738 | J Clin Transl Hepatol | Future Pharmacotherapy for Non-alcoholic Steatohepatitis (NASH): Review of Phase 2 and 3 Trials. | 2018 | Details |
| A31600 | 30218427 | Dig Dis Sci | PNPLA3 Gene Polymorphisms in HCV/HIV-Coinfected Individuals. | 2018 | Details |
| A31606 | 31696159 | ACS Pharmacol Transl Sci | Inhibition of Hepatotoxicity by a LXR Inverse Agonist in a Model of Alcoholic Liver Disease. | 2018 | Details |
| A31619 | 30186272 | Front Microbiol | Butyrate Protects Mice Against Methionine-Choline-Deficient Diet-Induced Non-alcoholic Steatohepatitis by Improving Gut Barrier Function, Attenuating Inflammation and Reducing Endotoxin Levels. | 2018 | Details |
| A31624 | 30178093 | Indian J Gastroenterol | Non-invasive aspartate aminotransferase to platelet ratio index correlates well with invasive hepatic venous pressure gradient in cirrhosis. | 2018 | Details |
| A31673 | 30057822 | Int J Hepatol | Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress. | 2018 | Details |
| A31699 | 30014266 | EJNMMI Res | Sensitive and early detection of mitochondrial dysfunction in the liver of NASH model mice by PET imaging with 18F-BCPP-BF. | 2018 | Details |
| A31722 | 29983886 | Oncotarget | Oral administration of fructose exacerbates liver fibrosis and hepatocarcinogenesis via increased intestinal permeability in a rat steatohepatitis model. | 2018 | Details |
| A31725 | 29978150 | J Endocr Soc | Transcriptomic Profiling of Obesity-Related Nonalcoholic Steatohepatitis Reveals a Core Set of Fibrosis-Specific Genes. | 2018 | Details |
| A31749 | 29930864 | Eur Med J Hepatol | Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe? | 2018 | Details |
| A31812 | 29774570 | Hepatology | High Mobility Group Box-1 Drives Fibrosis Progression Signaling via the Receptor for Advanced Glycation End Products in Mice. | 2018 | Details |
| A31816 | 29765319 | Front Pharmacol | Progression and Regression of Hepatic Lesions in a Mouse Model of NASH Induced by Dietary Intervention and Its Implications in Pharmacotherapy. | 2018 | Details |
| A31819 | 29761169 | Hepatol Commun | Prolonged cenicriviroc therapy reduces hepatic fibrosis despite steatohepatitis in a diet-induced mouse model of nonalcoholic steatohepatitis. | 2018 | Details |
| A31821 | 29753082 | Clin Gastroenterol Hepatol | Criteria to Determine Reliability of Noninvasive Assessment of Liver Fibrosis With Virtual Touch Quantification. | 2018 | Details |
| A31831 | 29740327 | Front Pharmacol | Extracellular Vesicles as Carriers of Non-coding RNAs in Liver Diseases. | 2018 | Details |
| A31832 | 29740221 | Hepat Med | Effect of sitagliptin on hepatic histological activity and fibrosis of nonalcoholic steatohepatitis patients: a 1-year randomized control trial. | 2018 | Details |
| A31886 | 29619418 | Hepatol Commun | The Role of Intestinal C-type Regenerating Islet Derived-3 Lectins for Nonalcoholic Steatohepatitis. | 2018 | Details |
| A31927 | 29537660 | Hepatology | Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis. | 2018 | Details |
| A31933 | 29527177 | Front Physiol | Key Inflammatory Processes in Human NASH Are Reflected in Ldlr-/-.Leiden Mice: A Translational Gene Profiling Study. | 2018 | Details |
| A31939 | 29515450 | Front Pharmacol | Chymase Inhibitor as a Novel Therapeutic Agent for Non-alcoholic Steatohepatitis. | 2018 | Details |
| A31978 | 29404501 | Hepatol Commun | Effect of combined farnesoid X receptor agonist and angiotensin II type 1 receptor blocker on hepatic fibrosis. | 2017 | Details |
| A31979 | 29404484 | Hepatol Commun | The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice. | 2017 | Details |
| A31981 | 29404476 | Hepatol Commun | The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis. | 2017 | Details |
| A31982 | 29404462 | Hepatol Commun | Intermittent hypoxia is a proinflammatory stimulus resulting in IL-6 expression and M1 macrophage polarization. | 2017 | Details |
| A31985 | 29399274 | World J Hepatol | Preserved liver regeneration capacity after partial hepatectomy in rats with non-alcoholic steatohepatitis. | 2018 | Details |
| A32016 | 29316085 | Hepatol Res | Deletion of endoplasmic reticulum stress-responsive co-chaperone p58IPK protects mice from diet-induced steatohepatitis. | 2018 | Details |
| A32019 | 30906835 | Genes Dis | Neonatal overfeeding in mice aggravates the development of methionine and choline-deficient diet-induced steatohepatitis in adulthood. | 2018 | Details |
| A32060 | 29278707 | Biochem Biophys Res Commun | Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition. | 2017 | Details |
| A32096 | 29197066 | Br J Pharmacol | Characterization of the properties of a selective, orally bioavailable autotaxin inhibitor in preclinical models of advanced stages of liver fibrosis. | 2018 | Details |
| A32097 | 29196931 | Calcif Tissue Int | Metabolic Syndrome and Bone: Pharmacologically Induced Diabetes has Deleterious Effect on Bone in Growing Obese Rats. | 2017 | Details |
| A32111 | 29180269 | Exp Mol Pathol | Dysregulation of antioxidant responses in patients diagnosed with concomitant Primary Sclerosing Cholangitis/Inflammatory Bowel Disease. | 2017 | Details |
| A32137 | 29124251 | Hepatol Commun | TRAIL Deletion Prevents Liver, but Not Adipose Tissue, Inflammation during Murine Diet-Induced Obesity. | 2017 | Details |
| A32145 | 29116096 | Sci Rep | AQP3 is regulated by PPARγ and JNK in hepatic stellate cells carrying PNPLA3 I148M. | 2017 | Details |
| A32152 | 29097836 | J Toxicol Pathol | The effect of β-caryophyllene on nonalcoholic steatohepatitis. | 2017 | Details |
| A32178 | 29046730 | Diabetol Metab Syndr | Aliskiren effect on non-alcoholic steatohepatitis in metabolic syndrome. | 2017 | Details |
| A32197 | 28981243 | Rev Med Brux | [Treatments of non-alcoholic steatohepatitis]. | 2019 | Details |
| A32226 | 28933629 | Autophagy | Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition. | 2017 | Details |
| A32227 | 28933417 | Diseases | Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases. | 2016 | Details |
| A32234 | 28912806 | Gastroenterol Res Pract | Associations of Fatty Liver Disease with Hypertension, Diabetes, and Dyslipidemia: Comparison between Alcoholic and Nonalcoholic Steatohepatitis. | 2017 | Details |
| A32260 | 28832872 | JAMA Dermatol | Noninvasive Testing for Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Patients With Psoriasis Receiving Long-term Methotrexate Sodium Therapy. | 2017 | Details |
| A32269 | 28816020 | Liver Int | Real-world efficacy and safety of ombitasvir, paritaprevir/r+dasabuvir+ribavirin in genotype 1b patients with hepatitis C virus cirrhosis. | 2017 | Details |
| A32273 | 28811860 | J Clin Med Res | The Apelin Receptor APJ in Hematopoietic Stem Cells/Progenitor Cells in the Early Stage of Non-Alcoholic Steatohepatitis. | 2017 | Details |
| A32276 | 28808187 | J Biomed Res | G-Aminobutyric acid promotes methionine-choline deficient diet-induced nonalcoholic steatohepatitis. | 2016 | Details |
| A32284 | 28792647 | Liver Int | Ultra-short bowel is an independent risk factor for liver fibrosis in adults with home parenteral nutrition. | 2017 | Details |
| A32297 | 28768902 | JCI Insight | Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis. | 2017 | Details |
| A32304 | 31966728 | Int J Clin Exp Pathol | The pathological appearance of hyaline droplets in Kupffer cells is not specific to patients with autoimmune hepatitis. | 2017 | Details |
| A32305 | 31966664 | Int J Clin Exp Pathol | Obeticholic acid improves hepatic steatosis and inflammation by inhibiting NLRP3 inflammasome activation. | 2017 | Details |
| A32340 | 28680839 | J Transl Int Med | Early Detection of Liver Damage in Mexican Patients with Chronic Liver Disease. | 2017 | Details |
| A32342 | 28679947 | JCI Insight | Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin. | 2017 | Details |
| A32362 | 28630652 | Diabetol Metab Syndr | Verification of B-lymphocyte activating factor's involvement in the exacerbation of insulin resistance as well as an autoimmune response in patients with nonalcoholic steatohepatitis and patients with HCV-related chronic liver disease. | 2017 | Details |
| A32371 | 28616586 | Mol Cell Oncol | The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer. | 2017 | Details |
| A32373 | 28614995 | Ther Adv Respir Dis | Ease of use of tobramycin inhalation powder compared with nebulized tobramycin and colistimethate sodium: a crossover study in cystic fibrosis patients with pulmonary Pseudomonas aeruginosa infection. | 2017 | Details |
| A32378 | 28603781 | JACC Basic Transl Sci | Genome-Wide Association Studies Candidate Gene to Dual Modifier of Nonalcoholic Steatohepatitis and Atherosclerosis. | 2016 | Details |
| A32399 | 28538834 | Braz J Med Biol Res | Characteristics of liver fibrosis with different etiologies using a fully quantitative fibrosis assessment tool. | 2017 | Details |
| A32421 | 28487545 | Nat Rev Gastroenterol Hepatol | Mechanisms of hepatic stellate cell activation. | 2017 | Details |
| A32462 | 28386316 | Am J Transl Res | Energy intake correlates with the levels of fatty acid synthase and insulin-like growth factor-1 in male and female C57BL/6 mice. | 2017 | Details |
| A32468 | 28365916 | Dig Dis Sci | Pigment Epithelium-Derived Factor (PEDF) Prevents Hepatic Fat Storage, Inflammation, and Fibrosis in Dietary Steatohepatitis of Mice. | 2017 | Details |
| A32479 | 28340131 | Am J Clin Pathol | Interobserver Variability in Histologic Evaluation of Liver Fibrosis Using Categorical and Quantitative Scores. | 2017 | Details |
| A32493 | 28298638 | Sci Rep | pNaKtide Attenuates Steatohepatitis and Atherosclerosis by Blocking Na/K-ATPase/ROS Amplification in C57Bl6 and ApoE Knockout Mice Fed a Western Diet. | 2017 | Details |
| A32548 | 28133511 | Toxicol Res | Evaluating the Influence of Side Stream Cigarette Smoke at an Early Stage of Non-Alcoholic Steatohepatitis Progression in Mice. | 2017 | Details |
| A32599 | 29511482 | Gastroenterol Hepatol Bed Bench | Development of experimental fibrotic liver diseases animal model by Carbon Tetracholoride. | 2017 | Details |
| A32601 | 28029729 | Hepatol Res | Combined treatment with dipeptidyl peptidase-4 inhibitor (sitagliptin) and angiotensin-II type 1 receptor blocker (losartan) suppresses progression in a non-diabetic rat model of steatohepatitis. | 2017 | Details |
| A32627 | 27924068 | J Biomed Res | Protein inhibitor of activated STAT 4 (PIAS4) regulates liver fibrosis through modulating SMAD3 activity. | 2016 | Details |
| A32645 | 27853646 | Oncoimmunology | Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1αinduced IL-10. | 2016 | Details |
| A32689 | 27760889 | J Biomed Res | G-Aminobutyric acid promotes methionine-choline deficient diet-induced nonalcoholic steatohepatitis. | 2016 | Details |
| A32695 | 27754931 | J Pharmacol Exp Ther | Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis. | 2016 | Details |
| A32710 | 27729955 | World J Hepatol | DNA methylation of angiotensin II receptor gene in nonalcoholic steatohepatitis-related liver fibrosis. | 2016 | Details |
| A32733 | 27657051 | Int J Mol Sci | Molecular Pathogenesis of NASH. | 2016 | Details |
| A32748 | 27605885 | World J Gastroenterol | c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning. | 2016 | Details |
| A32756 | 30609460 | Rinsho Byori | [Recent Progress of Therapeutic Strategy and Laboratory Examination Against Chronic Liver Diseases]. | 2016 | Details |
| A32768 | 27533769 | Braz J Med Biol Res | Transient elastography and APRI score: looking at false positives and false negatives. Diagnostic performance and association to fibrosis staging in chronic hepatitis C. | 2016 | Details |
| A32800 | 27457348 | Rev Recent Clin Trials | Hepatocellular Carcinoma in Alcoholic Liver Disease: Current Management and Recent Advances. | 2016 | Details |
| A32811 | 27421062 | Hepatol Res | Pharmacological evaluation of pioglitazone and candesartan cilexetil in a novel mouse model of non-alcoholic steatohepatitis, modified choline-deficient, amino acid-defined diet fed low-density lipoprotein receptor knockout mice. | 2016 | Details |
| A32879 | 27182456 | J Clin Cell Immunol | Role of Serum Biomarkers in Early Detection of Non-Alcoholic Steatohepatitis and Fibrosis in West Virginian Children. | 2016 | Details |
| A32891 | 27158326 | Am J Transl Res | Ameliorative effects of glycine in an experimental nonalcoholic steatohepatitis and its correlation between TREM-1 and TREM-2. | 2016 | Details |
| A32899 | 27134167 | Cell Rep | Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling. | 2016 | Details |
| A32945 | 27021876 | Toxicol In Vitro | Chebulic acid prevents hepatic fibrosis induced by advanced glycation end-products in LX-2 cell by modulating Nrf2 translocation via ERK pathway. | 2016 | Details |
| A32956 | 26992446 | Hepatol Res | Non-alcoholic steatohepatitis-associated hepatic fibrosis and hepatocellular carcinoma in a combined mouse model of genetic modification and dietary challenge. | 2016 | Details |
| A32958 | 26990427 | PLoS One | The Impact of Liver Cell Injury on Health-Related Quality of Life in Patients with Chronic Liver Disease. | 2016 | Details |
| A32967 | 26966436 | Int J Endocrinol | Intrahepatic Fat Content and Markers of Hepatic Fibrosis in Obese Children. | 2016 | Details |
| A32991 | 26895661 | J Nutr Biochem | Astaxanthin prevents and reverses the activation of mouse primary hepatic stellate cells. | 2015 | Details |
| A32992 | 26895398 | PLoS One | The VITRO Score (Von Willebrand Factor Antigen/Thrombocyte Ratio) as a New Marker for Clinically Significant Portal Hypertension in Comparison to Other Non-Invasive Parameters of Fibrosis Including ELF Test. | 2016 | Details |
| A33009 | 26869935 | Front Physiol | The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. | 2016 | Details |
| A33029 | 26836229 | Hepatol Res | Clinical significance of serum Wisteria floribunda agglutinin positive Mac-2-binding protein level in non-alcoholic steatohepatitis. | 2016 | Details |
| A33033 | 26828506 | Int J Environ Res Public Health | Biomarker-Based Approaches for Assessing Alcohol Use Disorders. | 2016 | Details |
| A33044 | 26799785 | Hepatology | A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice. | 2016 | Details |
| A33064 | 26758786 | Nat Rev Gastroenterol Hepatol | Immunology in the liver--from homeostasis to disease. | 2016 | Details |
| A33076 | 26734629 | Hepatobiliary Surg Nutr | Detection of carcinogenic etheno-DNA adducts in children and adolescents with non-alcoholic steatohepatitis (NASH). | 2015 | Details |
| A33136 | 26622825 | Oncol Lett | Clinicopathological characteristics of hepatitis B surface antigen-negative and hepatitis C antibody-negative hepatocellular carcinoma. | 2015 | Details |
| A33159 | 26579446 | Acta Pharm Sin B | Kallistatin, a new and reliable biomarker for the diagnosis of liver cirrhosis. | 2015 | Details |
| A33184 | 26523773 | Drug Discov Today | Emerging therapeutic targets for the treatment of hepatic fibrosis. | 2015 | Details |
| A33199 | 26483867 | World J Hepatol | Contribution of the toxic advanced glycation end-products-receptor axis in nonalcoholic steatohepatitis-related hepatocellular carcinoma. | 2015 | Details |
| A33217 | 26436354 | Ann Hepatol | Diagnostic performance of controlled attenuation parameter for predicting steatosis grade in chronic hepatitis B. | 2016 | Details |
| A33270 | 26329544 | Yakugaku Zasshi | [SREBP-1c and Elovl6 as Targets for Obesity-related Disorders]. | 2015 | Details |
| A33285 | 26301053 | World J Hepatol | Recent advances in mouse models of obesity- and nonalcoholic steatohepatitis-associated hepatocarcinogenesis. | 2015 | Details |
| A33318 | 26244065 | World J Hepatol | Cross talk of the immune system in the adipose tissue and the liver in non-alcoholic steatohepatitis: Pathology and beyond. | 2015 | Details |
| A33365 | 26122702 | Cancer Sci | Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice. | 2015 | Details |
| A33377 | 26101777 | Biomed Res Int | The Sea Lamprey as an Etiological Model for Biliary Atresia. | 2015 | Details |