Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
stats1
stats2
stats3
stats4
Search for:
Choline1715 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A16897 | 28106137 | Sci Rep | Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats. | 2017 | Details |
| A16906 | 28100771 | J Biol Chem | Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. | 2017 | Details |
| A16919 | 28092182 | Exp Biol Med (Maywood) | An estrogen receptor β-selective agonist inhibits non-alcoholic steatohepatitis in preclinical models by regulating bile acid and xenobiotic receptors. | 2017 | Details |
| A16923 | 28090564 | Cell Mol Gastroenterol Hepatol | Hepatocyte Toll-Like Receptor 5 Promotes Bacterial Clearance and Protects Mice Against High-Fat Diet-Induced Liver Disease. | 2016 | Details |
| A16936 | 28084058 | J Diabetes Investig | Selective peroxisome proliferator-activated receptor-α modulator K-877 efficiently activates the peroxisome proliferator-activated receptor-α pathway and improves lipid metabolism in mice. | 2017 | Details |
| A16940 | 28082742 | Exp Mol Med | Gene-metabolite network analysis in different nonalcoholic fatty liver disease phenotypes. | 2017 | Details |
| A16986 | 28063004 | Mol Cell Biochem | Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes. | 2017 | Details |
| A17015 | 28044208 | J Gastroenterol | Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis. | 2017 | Details |
| A17066 | 28012135 | Lipids | Eicosapentaenoic Acid-Enriched Phosphatidylcholine Attenuated Hepatic Steatosis Through Regulation of Cholesterol Metabolism in Rats with Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A17067 | 28011892 | Gut | Adipose type I interferon signalling protects against metabolic dysfunction. | 2016 | Details |
| A17069 | 28011152 | Transl Res | Adenosine A2a receptor stimulation blocks development of nonalcoholic steatohepatitis in mice by multilevel inhibition of signals that cause immunolipotoxicity. | 2016 | Details |
| A17116 | 27984176 | J Hepatol | PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis. | 2016 | Details |
| A17120 | 27981809 | Mol Nutr Food Res | Chicoric acid attenuate a nonalcoholic steatohepatitis by inhibiting key regulators of lipid metabolism, fibrosis, oxidation, and inflammation in mice with methionine and choline deficiency. | 2017 | Details |
| A17163 | 27938563 | Zhonghua Gan Zang Bing Za Zhi | [Effect of nicotinic acetylcholine receptor α7 subunit gene on liver inflammatory reaction in mice with nonalcoholic steatohepatitis and related mechanisms]. | 2016 | Details |
| A17199 | 27917437 | Cell Tissue Res | Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. | 2016 | Details |
| A17208 | 27913996 | Dig Dis Sci | Altered Gut Microbiota Composition and Immune Response in Experimental Steatohepatitis Mouse Models. | 2016 | Details |
| A17223 | 27904677 | Am J Transl Res | An engineered FGF21 variant, LY2405319, can prevent non-alcoholic steatohepatitis by enhancing hepatic mitochondrial function. | 2016 | Details |
| A17254 | 27889556 | Int Immunopharmacol | Compact bone-derived mesenchymal stem cells attenuate nonalcoholic steatohepatitis in a mouse model by modulation of CD4 cells differentiation. | 2016 | Details |
| A17264 | 27880981 | Hepatology | A novel glucagon-like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice. | 2017 | Details |
| A17297 | 27859493 | Clin Exp Pharmacol Physiol | Connexin32 deficiency is associated with liver injury, inflammation and oxidative stress in experimental non-alcoholic steatohepatitis. | 2017 | Details |
| A17434 | 27613872 | J Biol Chem | Targeting Liver Fibrosis with a Cell-penetrating Protease-activated Receptor-2 (PAR2) Pepducin. | 2016 | Details |
| A17456 | 27779710 | Mol Med Rep | Antihypertensive therapy improves insulin resistance and serum levels of interleukin-6 and -10 in spontaneously hypertensive rats with steatohepatitis. | 2016 | Details |
| A17471 | 27773935 | Acta Pharmacol Sin | Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation. | 2016 | Details |
| A17486 | 27634173 | Free Radic Biol Med | Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. | 2016 | Details |
| A17506 | 27098507 | Diabetes Metab J | Statins Increase Mitochondrial and Peroxisomal Fatty Acid Oxidation in the Liver and Prevent Non-Alcoholic Steatohepatitis in Mice. | 2016 | Details |
| A17508 | 27764896 | J Cell Biochem | New Potential Biomarker Proteins for Alcoholic Liver Disease Identified by a Comparative Proteomics Approach. | 2017 | Details |
| A17543 | 27752155 | Beijing Da Xue Xue Bao Yi Xue Ban | [Nicotine alleviates the liver inflammation of non-alcoholic steatohepatitis induced by high-fat and high-fructose in mice]. | 2016 | Details |
| A17554 | 27266617 | J Hepatol | Lipocalin-2 mediates non-alcoholic steatohepatitis by promoting neutrophil-macrophage crosstalk via the induction of CXCR2. | 2016 | Details |
| A17575 | 27739180 | Mol Nutr Food Res | Alterations in the plasma metabolite profile associated with improved hepatic function and glycemia in mice fed lingonberry supplemented high-fat diets. | 2016 | Details |
| A17600 | 27723801 | PLoS One | Evaluation of Methionine Content in a High-Fat and Choline-Deficient Diet on Body Weight Gain and the Development of Non-Alcoholic Steatohepatitis in Mice. | 2016 | Details |
| A17606 | 27721459 | Sci Rep | IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner. | 2016 | Details |
| A17616 | 27713972 | Food Funct | Vascular- and hepato-protective effects of passion fruit seed extract containing piceatannol in chronic high-fat diet-fed rats. | 2016 | Details |
| A17620 | 27712037 | J Biochem Mol Toxicol | In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice. | 2016 | Details |
| A17666 | 27677588 | Oncotarget | CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis. | 2016 | Details |
| A17680 | 27663419 | J Hepatol | Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease. | 2016 | Details |
| A17739 | 27628106 | Diabetologia | Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice. | 2016 | Details |
| A17772 | 27606822 | J Magn Reson Imaging | Assessment of Nonalcoholic Fatty Liver Disease in Rats Using Quantitative Dynamic Contrast-Enhanced MRI. | 2016 | Details |
| A17776 | 27604106 | Drug Metab Dispos | Nonalcoholic Steatohepatitis Modulates Membrane Protein Retrieval and Insertion Processes. | 2016 | Details |
| A17849 | 27535001 | Sci Rep | Simple steatosis sensitizes cholestatic rats to liver injury and dysregulates bile salt synthesis and transport. | 2016 | Details |
| A17852 | 27527746 | Am J Gastroenterol | Clinical and Metabolic Characterization of Lean Caucasian Subjects With Non-alcoholic Fatty Liver. | 2016 | Details |
| A17868 | 27513850 | Radiology | Detection of Steatohepatitis in a Rat Model by Using Spectroscopic Shear-Wave US Elastography. | 2016 | Details |
| A17875 | 27510159 | Sci Rep | Hepatic and serum lipid signatures specific to nonalcoholic steatohepatitis in murine models. | 2016 | Details |
| A17901 | 27487733 | Food Funct | Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice. | 2016 | Details |
| A17957 | 27454866 | PLoS One | Kupffer Cells Undergo Fundamental Changes during the Development of Experimental NASH and Are Critical in Initiating Liver Damage and Inflammation. | 2016 | Details |
| A17982 | 27438910 | Nanomedicine | Fenofibrate nanoliposome: Preparation and its inhibitory effects on nonalcoholic fatty liver disease in mice. | 2016 | Details |
| A18007 | 27421788 | FASEB J | STK25 is a critical determinant in nonalcoholic steatohepatitis. | 2016 | Details |
| A18021 | 27409675 | Oncotarget | Sex-specific metabolic interactions between liver and adipose tissue in MCD diet-induced non-alcoholic fatty liver disease. | 2016 | Details |
| A18033 | 27401401 | Prostaglandins Other Lipid Mediat | Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis. | 2016 | Details |
| A18054 | 27381944 | Biochem Pharmacol | Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir. | 2016 | Details |
| A18096 | 30263346 | Food Sci Biotechnol | Kombucha tea prevents obese mice from developing hepatic steatosis and liver damage. | 2016 | Details |
| A18097 | 27352342 | Cell Biochem Biophys | Neutrophils Play a Crucial Role in the Early Stage of Nonalcoholic Steatohepatitis via Neutrophil Elastase in Mice. | 2015 | Details |
| A18106 | 27348904 | Zhongguo Zhen Jiu | [Non-alcoholic fatty liver disease of liver stagnation and spleen deficiency pattern treated with acupoint embedding therapy: a randomized controlled trial]. | 2016 | Details |
| A18146 | 27321932 | Biochim Biophys Acta | Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice. | 2016 | Details |
| A18147 | 27321734 | J Agric Food Chem | Effects of Nonalcoholic Fatty Liver Disease on Hepatic CYP2B1 and in Vivo Bupropion Disposition in Rats Fed a High-Fat or Methionine/Choline-Deficient Diet. | 2016 | Details |
| A18150 | 27320964 | Toxicol Lett | MicroRNA-21 is associated with fibrosis in a rat model of nonalcoholic steatohepatitis and serves as a plasma biomarker for fibrotic liver disease. | 2016 | Details |
| A18152 | 27318147 | Gastroenterology | Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues From Patients. | 2016 | Details |
| A18153 | 27317851 | Clin Gastroenterol Hepatol | Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites. | 2016 | Details |
| A18158 | 27313828 | Oxid Med Cell Longev | S-Propargyl-cysteine Exerts a Novel Protective Effect on Methionine and Choline Deficient Diet-Induced Fatty Liver via Akt/Nrf2/HO-1 Pathway. | 2016 | Details |
| A18193 | 27296438 | BMC Gastroenterol | Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine. | 2016 | Details |
| A18196 | 27291420 | Sci Rep | Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system. | 2016 | Details |
| A18212 | 27282405 | J Mol Cell Biol | Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis: a novel therapeutic target for fatty liver disease. | 2016 | Details |
| A18227 | 27273168 | Nat Rev Gastroenterol Hepatol | The role of the gut microbiota in NAFLD. | 2016 | Details |
| A18267 | 27254774 | Liver Int | ADAMTS5 deficiency protects against non-alcoholic steatohepatitis in obesity. | 2016 | Details |
| A18281 | 27245430 | J Hepatol | Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis. | 2016 | Details |
| A18297 | 27233293 | J Pharmacol Exp Ther | Biliary Elimination of Pemetrexed Is Dependent on Mrp2 in Rats: Potential Mechanism of Variable Response in Nonalcoholic Steatohepatitis. | 2016 | Details |
| A18302 | 27227672 | PLoS One | Contribution of Cyclooxygenase End Products and Oxidative Stress to Intrahepatic Endothelial Dysfunction in Early Non-Alcoholic Fatty Liver Disease. | 2016 | Details |
| A18366 | 27180087 | Toxicol Lett | Mainstream cigarette smoke accelerates the progression of nonalcoholic steatohepatitis by modulating Kupffer cell-mediated hepatocellular apoptosis in adolescent mice. | 2016 | Details |
| A18374 | 27174897 | Gen Physiol Biophys | Methionine-choline deprivation alters liver and brain acetylcholinesterase activity in C57BL6 mice. | 2016 | Details |
| A18382 | 27172901 | Oncotarget | IL-33 treatment attenuated diet-induced hepatic steatosis but aggravated hepatic fibrosis. | 2016 | Details |
| A18423 | 27145114 | Mol Nutr Food Res | Biochanin A improves hepatic steatosis and insulin resistance by regulating the hepatic lipid and glucose metabolic pathways in diet-induced obese mice. | 2016 | Details |
| A18436 | 27136390 | Mol Nutr Food Res | Nutritional depletion in n-3 PUFA in apoE knock-out mice: A new model of endothelial dysfunction associated with fatty liver disease. | 2016 | Details |
| A18461 | 27116542 | Int J Cancer | Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation. | 2016 | Details |
| A18478 | 27103143 | BMC Genomics | Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice. | 2016 | Details |
| A18498 | 27090939 | Biochim Biophys Acta | Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis. | 2016 | Details |
| A18509 | 27085070 | Biochim Biophys Acta | Unique microbial-derived volatile organic compounds in portal venous circulation in murine non-alcoholic fatty liver disease. | 2016 | Details |
| A18512 | 27081834 | Mol Med Rep | Artemisia capillaris formula inhibits hepatic steatosis via an miR‑122‑induced decrease in fatty acid synthase expression in vivo and in vitro. | 2016 | Details |
| A18521 | 27074921 | Dig Dis Sci | Treatment with Oxidized Phospholipids Directly Inhibits Nonalcoholic Steatohepatitis and Liver Fibrosis Without Affecting Steatosis. | 2016 | Details |
| A18527 | 27069868 | Mol Metab | Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis. | 2016 | Details |
| A18545 | 27063268 | Clin Liver Dis | Nonalcoholic Fatty Liver Disease and the Gut Microbiome. | 2015 | Details |
| A18580 | 27049024 | J Lipid Res | Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis. | 2016 | Details |
| A18585 | 27045862 | Sci Rep | Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies. | 2016 | Details |
| A18612 | 27035833 | PLoS One | Overexpression of Peroxiredoxin 4 Affects Intestinal Function in a Dietary Mouse Model of Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A18631 | 27023537 | Int J Mol Sci | Additive Effect of Non-Alcoholic Fatty Liver Disease on Metabolic Syndrome-Related Endothelial Dysfunction in Hypertensive Patients. | 2016 | Details |
| A18633 | 28868449 | GE Port J Gastroenterol | Microbiota Modulation With Synbiotic Decreases Liver Fibrosis in a High Fat Choline Deficient Diet Mice Model of Non-Alcoholic Steatohepatitis (NASH). | 2016 | Details |
| A18683 | 26999104 | Int J Mol Sci | Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics. | 2016 | Details |
| A18733 | 26979540 | Magn Reson Imaging | Gd-EOB-DTPA-enhanced-MR imaging in the inflammation stage of nonalcoholic steatohepatitis (NASH) in mice. | 2016 | Details |
| A18755 | 26970305 | Biochem Biophys Res Commun | Demethyleneberberine attenuates non-alcoholic fatty liver disease with activation of AMPK and inhibition of oxidative stress. | 2016 | Details |
| A18758 | 26968211 | Am J Physiol Gastrointest Liver Physiol | Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis. | 2016 | Details |
| A18792 | 26937139 | World J Gastroenterol | Glucagon-like peptide-1 analogue prevents nonalcoholic steatohepatitis in non-obese mice. | 2016 | Details |
| A18799 | 26934227 | Nature | NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. | 2016 | Details |
| A18810 | 26926384 | Hepatology | Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. | 2016 | Details |
| A18820 | 26921863 | J Affect Disord | Insulin receptor sensitizer, dicholine succinate, prevents both Toll-like receptor 4 (TLR4) upregulation and affective changes induced by a high-cholesterol diet in mice. | 2016 | Details |
| A18832 | 26912655 | J Biol Chem | Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells. | 2016 | Details |
| A18843 | 26907206 | Metabolism | Nonalcoholic fatty liver disease and hepatocellular carcinoma. | 2016 | Details |
| A18863 | 26895034 | PLoS One | Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis. | 2016 | Details |
| A18893 | 26881746 | PLoS One | Hepatoprotective Effect and Synergism of Bisdemethoycurcumin against MCD Diet-Induced Nonalcoholic Fatty Liver Disease in Mice. | 2016 | Details |
| A18895 | 26881239 | J Diabetes Res | Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe (-/-) Mice Fed with High-Fat Diet. | 2015 | Details |
| A18896 | 26881047 | Oxid Med Cell Longev | In Situ Evaluation of Oxidative Stress in Rat Fatty Liver Induced by a Methionine- and Choline-Deficient Diet. | 2016 | Details |
| A18900 | 26880573 | J Hepatobiliary Pancreat Sci | Enhancing hepatic fibrosis in spontaneously hypertensive rats fed a choline-deficient diet: a follow-up report on long-term effects of oxidative stress in non-alcoholic fatty liver disease. | 2016 | Details |
| A18901 | 26878785 | J Nutr Biochem | MicroRNA changes, activation of progenitor cells and severity of liver injury in mice induced by choline and folate deficiency. | 2015 | Details |