Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
stats1
stats2
stats3
stats4
Search for:
apoptosis1710 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A17961 | 27449657 | Physiol Genomics | Early steatohepatitis in hyperlipidemic mice with endothelial-specific gain of TRPC3 function precedes changes in aortic atherosclerosis. | 2016 | Details |
| A17963 | 27447538 | Ann N Y Acad Sci | Deferoxamine ameliorates hepatosteatosis via several mechanisms in ob/ob mice. | 2016 | Details |
| A18013 | 27415158 | Food Nutr Res | Lipolysis stimulating peptides of potato protein hydrolysate effectively suppresses high-fat-diet-induced hepatocyte apoptosis and fibrosis in aging rats. | 2016 | Details |
| A18035 | 27393639 | Mech Ageing Dev | Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis. | 2016 | Details |
| A18062 | 27377869 | Clin Exp Immunol | MicroRNA-26a-interleukin (IL)-6-IL-17 axis regulates the development of non-alcoholic fatty liver disease in a murine model. | 2016 | Details |
| A18070 | 27371158 | Exp Cell Res | Role of antigen presenting cell invariant chain in the development of hepatic steatosis in mouse model. | 2016 | Details |
| A18096 | 30263346 | Food Sci Biotechnol | Kombucha tea prevents obese mice from developing hepatic steatosis and liver damage. | 2016 | Details |
| A18146 | 27321932 | Biochim Biophys Acta | Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice. | 2016 | Details |
| A18168 | 27310371 | PLoS One | Macrophage Activation in Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) Correlates with Hepatic Progenitor Cell Response via Wnt3a Pathway. | 2016 | Details |
| A18179 | 27308467 | Mol Cell Oncol | Tricking an ancient immune function to eradicate hepatocellular carcinoma. | 2015 | Details |
| A18246 | 27265388 | Aliment Pharmacol Ther | Effects of dark chocolate on NOX-2-generated oxidative stress in patients with non-alcoholic steatohepatitis. | 2016 | Details |
| A18247 | 27265384 | Life Sci | Dihydromyricetin ameliorates oleic acid-induced lipid accumulation in L02 and HepG2 cells by inhibiting lipogenesis and oxidative stress. | 2016 | Details |
| A18288 | 27239734 | Lab Invest | C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis. | 2016 | Details |
| A18311 | 27220460 | Int J Mol Med | Protective role of magnesium isoglycyrrhizinate in non-alcoholic fatty liver disease and the associated molecular mechanisms. | 2016 | Details |
| A18333 | 27199746 | Front Pharmacol | Triggering of Parkin Mitochondrial Translocation in Mitophagy: Implications for Liver Diseases. | 2016 | Details |
| A18366 | 27180087 | Toxicol Lett | Mainstream cigarette smoke accelerates the progression of nonalcoholic steatohepatitis by modulating Kupffer cell-mediated hepatocellular apoptosis in adolescent mice. | 2016 | Details |
| A18459 | 27121253 | Int J Obes (Lond) | Reduced circulating levels of sTWEAK are associated with NAFLD and may affect hepatocyte triglyceride accumulation. | 2016 | Details |
| A18462 | 27113292 | Nutr Metab Cardiovasc Dis | The innovative "Bio-Oil Spread" prevents metabolic disorders and mediates preconditioning-like cardioprotection in rats. | 2016 | Details |
| A18467 | 27109475 | Biochem Biophys Res Commun | AMPKα1 overexpression alleviates the hepatocyte model of nonalcoholic fatty liver disease via inactivating p38MAPK pathway. | 2016 | Details |
| A18479 | 27102725 | Liver Int | The macrophage activation marker sCD163 is associated with morphological disease stages in patients with non-alcoholic fatty liver disease. | 2016 | Details |
| A18523 | 27073470 | Exp Ther Med | Low simvastatin concentrations reduce oleic acid-induced steatosis in HepG2 cells: An in vitro model of non-alcoholic fatty liver disease. | 2016 | Details |
| A18580 | 27049024 | J Lipid Res | Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis. | 2016 | Details |
| A18630 | 27023590 | Int J Environ Res Public Health | Pathway Analysis Revealed Potential Diverse Health Impacts of Flavonoids that Bind Estrogen Receptors. | 2016 | Details |
| A18643 | 27018279 | Geriatr Gerontol Int | Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease. | 2016 | Details |
| A18648 | 27016281 | J Hepatol | DKK3 expression in hepatocytes defines susceptibility to liver steatosis and obesity. | 2016 | Details |
| A18682 | 26999105 | Int J Mol Sci | Mitochondrial Molecular Pathophysiology of Nonalcoholic Fatty Liver Disease: A Proteomics Approach. | 2016 | Details |
| A18690 | 26997538 | Metabolism | Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease. | 2016 | Details |
| A18705 | 26989875 | Mol Nutr Food Res | Punicalagin attenuates palmitate-induced lipotoxicity in HepG2 cells by activating the Keap1-Nrf2 antioxidant defense system. | 2016 | Details |
| A18710 | 26985892 | Int J Mol Sci | Extracellular Vesicles: A New Frontier in Biomarker Discovery for Non-Alcoholic Fatty Liver Disease. | 2016 | Details |
| A18731 | 26980020 | Hum Pathol | Acidophil bodies in nonalcoholic steatohepatitis. | 2016 | Details |
| A18744 | 26975539 | Metabolism | Plasma osteoprotegerin levels are inversely associated with nonalcoholic fatty liver disease in patients with type 2 diabetes: A case-control study in China. | 2015 | Details |
| A18748 | 26972222 | Metabolism | Noninvasive diagnosis of nonalcoholic fatty liver disease: Are we there yet? | 2016 | Details |
| A18773 | 26952573 | Exp Gerontol | β2-Adrenergic receptor ablation modulates hepatic lipid accumulation and glucose tolerance in aging mice. | 2016 | Details |
| A18789 | 26938481 | Hepatol Res | Lipotoxicity pathways intersect in hepatocytes: Endoplasmic reticulum stress, c-Jun N-terminal kinase-1, and death receptors. | 2016 | Details |
| A18804 | 26932533 | Int J Food Sci Nutr | Medium-chain fatty acid reduces lipid accumulation by regulating expression of lipid-sensing genes in human liver cells with steatosis. | 2016 | Details |
| A18848 | 26905378 | Appl Physiol Nutr Metab | Exercise mitigates mitochondrial permeability transition pore and quality control mechanisms alterations in nonalcoholic steatohepatitis. | 2015 | Details |
| A18865 | 26894897 | Cell Mol Life Sci | Pathogenesis of nonalcoholic steatohepatitis. | 2016 | Details |
| A18875 | 26890135 | Cell Death Dis | Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease. | 2016 | Details |
| A18889 | 26883167 | Sci Rep | Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis. | 2016 | Details |
| A18910 | 26873633 | Biochim Biophys Acta | iPLA2β deficiency attenuates obesity and hepatic steatosis in ob/ob mice through hepatic fatty-acyl phospholipid remodeling. | 2016 | Details |
| A18929 | 26866272 | Cell Death Dis | Loss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis. | 2016 | Details |
| A18978 | 26835904 | J Pediatr Gastroenterol Nutr | Plasma Cytokeratin-18 Level As a Novel Biomarker for Liver Fibrosis in Children With Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A19033 | 26810228 | J Immunol | Subclinical-Dose Endotoxin Sustains Low-Grade Inflammation and Exacerbates Steatohepatitis in High-Fat Diet-Fed Mice. | 2016 | Details |
| A19052 | 26799523 | J Food Sci | Effects of Long-Chain and Medium-Chain Fatty Acids on Apoptosis and Oxidative Stress in Human Liver Cells with Steatosis. | 2016 | Details |
| A19088 | 26773297 | Hepatology | Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. | 2016 | Details |
| A19103 | 26764184 | Gastroenterology | Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes. | 2016 | Details |
| A19117 | 26753695 | Naunyn Schmiedebergs Arch Pharmacol | Thymoquinone alleviates nonalcoholic fatty liver disease in rats via suppression of oxidative stress, inflammation, apoptosis. | 2016 | Details |
| A19147 | 26728181 | J Neuroinflammation | Non-alcoholic fatty liver disease induces signs of Alzheimer's disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model. | 2016 | Details |
| A19152 | 26726030 | J Vet Sci | Aristolochia manshuriensis Kom ethyl acetate extract protects against high-fat diet-induced non-alcoholic steatohepatitis by regulating kinase phosphorylation in mouse. | 2016 | Details |
| A19158 | 26723251 | Biochem Biophys Res Commun | Suppressing cyclooxygenase-2 prevents nonalcoholic and inhibits apoptosis of hepatocytes that are involved in the Akt/p53 signal pathway. | 2015 | Details |
| A19190 | 28332698 | Mol Med | Induction of steatohepatitis (NASH) with insulin resistance in wildtype B6 mice by a western-type diet containing soybean oil and cholesterol. | 2017 | Details |
| A19192 | 26717317 | PLoS One | HIF3A DNA Methylation Is Associated with Childhood Obesity and ALT. | 2015 | Details |
| A19213 | 26698881 | J Biol Chem | The Hepatitis C Virus-induced NLRP3 Inflammasome Activates the Sterol Regulatory Element-binding Protein (SREBP) and Regulates Lipid Metabolism. | 2015 | Details |
| A19214 | 26698665 | Free Radic Biol Med | Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development. | 2015 | Details |
| A19223 | 26695085 | J Gastroenterol Hepatol | Treatment with geraniol ameliorates methionine-choline-deficient diet-induced non-alcoholic steatohepatitis in rats. | 2016 | Details |
| A19235 | 26681923 | Int J Biol Sci | A20 Attenuates FFAs-induced Lipid Accumulation in Nonalcoholic Steatohepatitis. | 2015 | Details |
| A19247 | 26674289 | Physiol Res | The effect of D-galactosamine on lean and steatotic rat hepatocytes in primary culture. | 2015 | Details |
| A19248 | 26674288 | Physiol Res | The effect of oleic and palmitic acid on induction of steatosis and cytotoxicity on rat hepatocytes in primary culture. | 2015 | Details |
| A19272 | 26663034 | Acta Physiol (Oxf) | Gastric bypass surgery is protective from high-fat diet-induced non-alcoholic fatty liver disease and hepatic endoplasmic reticulum stress. | 2015 | Details |
| A19274 | 26663010 | Hepatobiliary Pancreat Dis Int | Ankaflavin ameliorates steatotic liver ischemia-reperfusion injury in mice. | 2015 | Details |
| A19282 | 26655953 | J Biol Chem | Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice. | 2015 | Details |
| A19298 | 26640164 | Can J Physiol Pharmacol | Bicyclol attenuates tetracycline-induced fatty liver associated with inhibition of hepatic ER stress and apoptosis in mice. | 2015 | Details |
| A19339 | 26621219 | Sci Rep | Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis. | 2015 | Details |
| A19344 | 26619117 | J Clin Invest | E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis. | 2015 | Details |
| A19346 | 26617882 | Int J Clin Exp Pathol | Curcumin prevents the non-alcoholic fatty hepatitis via mitochondria protection and apoptosis reduction. | 2015 | Details |
| A19356 | 26609894 | Expert Opin Ther Targets | Pathophysiological mechanisms and therapeutic potentials of macrophages in non-alcoholic steatohepatitis. | 2016 | Details |
| A19447 | 26565986 | PLoS One | Performance of Serum microRNAs -122, -192 and -21 as Biomarkers in Patients with Non-Alcoholic Steatohepatitis. | 2015 | Details |
| A19464 | 26555271 | J Hepatol | Liver Bid suppression for treatment of fibrosis associated with non-alcoholic steatohepatitis. | 2015 | Details |
| A19473 | 26539645 | Oncotarget | Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis. | 2015 | Details |
| A19491 | 26524364 | Zhonghua Gan Zang Bing Za Zhi | [Effects of fenofibrate on hepatocyte apoptosis in nonalcoholic fatty liver]. | 2015 | Details |
| A19573 | 28962484 | Toxicol Rep | Effects of 4-nonylphenol on oxidant/antioxidant balance system inducing hepatic steatosis in male rat. | 2015 | Details |
| A19587 | 26472223 | Am J Physiol Gastrointest Liver Physiol | Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet. | 2015 | Details |
| A19595 | 26464382 | J Mol Endocrinol | Glucose fluctuation increased hepatocyte apoptosis under lipotoxicity and the involvement of mitochondrial permeability transition opening. | 2015 | Details |
| A19602 | 26462489 | Dig Dis Sci | Poor Inter-test Reliability Between CK18 Kits as a Biomarker of NASH. | 2015 | Details |
| A19606 | 26461297 | Free Radic Biol Med | Oxysterols induce mitochondrial impairment and hepatocellular toxicity in non-alcoholic fatty liver disease. | 2014 | Details |
| A19662 | 26429665 | Nutrition | ω-3 Fatty acids reverse lipotoxity through induction of autophagy in nonalcoholic fatty liver disease. | 2015 | Details |
| A19675 | 26419929 | Mol Cell Endocrinol | C1q/TNF-Related Protein 9 (CTRP9) attenuates hepatic steatosis via the autophagy-mediated inhibition of endoplasmic reticulum stress. | 2015 | Details |
| A19705 | 26403427 | Dig Dis Sci | Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model. | 2015 | Details |
| A19708 | 26401075 | World J Gastroenterol | Effects of salvianolic acid B on liver mitochondria of rats with nonalcoholic steatohepatitis. | 2015 | Details |
| A19717 | 26397061 | Mol Med Rep | Therapeutic effects of the dipeptidyl peptidase-IV inhibitor, sitagliptin, on non-alcoholic steatohepatitis in FLS-ob/ob male mice. | 2015 | Details |
| A19737 | 26383163 | Cancer Res | Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma. | 2015 | Details |
| A19811 | 26335364 | Biochem Cell Biol | Lactoferrin attenuates fatty acid-induced lipotoxicity via Akt signaling in hepatocarcinoma cells. | 2015 | Details |
| A19824 | 26325428 | Biochem Biophys Res Commun | Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced lipotoxicity. | 2015 | Details |
| A19830 | 26319415 | Biochim Biophys Acta | TRC8 downregulation contributes to the development of non-alcoholic steatohepatitis by exacerbating hepatic endoplasmic reticulum stress. | 2015 | Details |
| A19865 | 26298775 | Sleep Med | Evaluation of circulating markers of hepatic apoptosis and inflammation in obese children with and without obstructive sleep apnea. | 2015 | Details |
| A19988 | 26223319 | Free Radic Res | Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease. | 2015 | Details |
| A19998 | 26215420 | Biomed Khim | [Intensity of apoptotic processes, aconitate hydratase activity and citrate level in patients with type 2 diabetes mellitus complicated steatohepatitis under application of epifamin at basic therapy]. | 2016 | Details |
| A20000 | 26215259 | Nat Rev Endocrinol | Physiological and pathophysiological roles of NAMPT and NAD metabolism. | 2015 | Details |
| A20005 | 26214517 | PLoS One | PDIA3 Knockdown Exacerbates Free Fatty Acid-Induced Hepatocyte Steatosis and Apoptosis. | 2015 | Details |
| A20014 | 26203862 | Cell Death Dis | Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease. | 2015 | Details |
| A20053 | 26190035 | Hepatol Res | Amelioration of free fatty acid-induced fatty liver by quercetin-3-O-β-D-glucuronide through modulation of peroxisome proliferator-activated receptor-alpha/sterol regulatory element-binding protein-1c signaling. | 2015 | Details |
| A20058 | 26187450 | Toxicol Sci | Low-Dose Cadmium Causes Metabolic and Genetic Dysregulation Associated With Fatty Liver Disease in Mice. | 2015 | Details |
| A20078 | 26170532 | Mediators Inflamm | LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis. | 2015 | Details |
| A20099 | 26155623 | Ter Arkh | [Evaluation of endothelial function and estimation of the degree of apoptosis in patients with metabolic syndrome and non-alcoholic fatty liver disease]. | 2015 | Details |
| A20113 | 26147696 | Hepatol Res | Glucagon-like peptide-1 preserves non-alcoholic fatty liver disease through inhibition of the endoplasmic reticulum stress-associated pathway. | 2015 | Details |
| A20182 | 26102086 | PLoS One | Elongation Factor 1A-1 Is a Mediator of Hepatocyte Lipotoxicity Partly through Its Canonical Function in Protein Synthesis. | 2015 | Details |
| A20190 | 26094890 | Cell Metab | Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling. | 2015 | Details |
| A20237 | 26070860 | Expert Rev Gastroenterol Hepatol | Physiology and pathophysiology of liver lipid metabolism. | 2015 | Details |
| A20240 | 26069285 | Thorax | Altered gut-liver axis and hepatic adiponectin expression in OSAS: novel mediators of liver injury in paediatric non-alcoholic fatty liver. | 2015 | Details |
| A20260 | 26058518 | Antioxid Redox Signal | Myeloperoxidase-Hepatocyte-Stellate Cell Cross Talk Promotes Hepatocyte Injury and Fibrosis in Experimental Nonalcoholic Steatohepatitis. | 2015 | Details |