Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
stats1
stats2
stats3
stats4
Search for:
Choline1715 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A18910 | 26873633 | Biochim Biophys Acta | iPLA2β deficiency attenuates obesity and hepatic steatosis in ob/ob mice through hepatic fatty-acyl phospholipid remodeling. | 2016 | Details |
| A18915 | 26871756 | Can J Physiol Pharmacol | The ergogenic supplement β-hydroxy-β-methylbutyrate (HMB) attenuates insulin resistance through suppressing GLUT-2 in rat liver. | 2015 | Details |
| A18940 | 26858440 | Proc Natl Acad Sci U S A | Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease. | 2016 | Details |
| A18943 | 26857750 | Sci Rep | Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress. | 2016 | Details |
| A18963 | 26846427 | Lipids Health Dis | Tetradecylthiopropionic acid induces hepatic mitochondrial dysfunction and steatosis, accompanied by increased plasma homocysteine in mice. | 2016 | Details |
| A18984 | 26832170 | Amino Acids | Creatine supplementation as a possible new therapeutic approach for fatty liver disease: early findings. | 2016 | Details |
| A19008 | 26821176 | J Med Ultrason (2001) | Relationship between liver tissue stiffness and histopathological findings analyzed by shear wave elastography and compression testing in rats with non-alcoholic steatohepatitis. | 2016 | Details |
| A19014 | 26818807 | Sci Rep | Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice. | 2016 | Details |
| A19017 | 26817937 | Nutr Metab Cardiovasc Dis | Serum palmitoleate acts as a lipokine in subjects at high cardiometabolic risk. | 2015 | Details |
| A19031 | 26811286 | Int Rev Cell Mol Biol | Phosphatidylethanolamine Metabolism in Health and Disease. | 2015 | Details |
| A19055 | 26797396 | Am J Physiol Gastrointest Liver Physiol | Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice. | 2016 | Details |
| A19089 | 26773011 | Adv Nutr | Choline, Its Potential Role in Nonalcoholic Fatty Liver Disease, and the Case for Human and Bacterial Genes. | 2016 | Details |
| A19103 | 26764184 | Gastroenterology | Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes. | 2016 | Details |
| A19125 | 26743949 | Sci Rep | Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults. | 2016 | Details |
| A19139 | 26732252 | Sci Rep | Aliskiren Reduces Hepatic steatosis and Epididymal Fat Mass and Increases Skeletal Muscle Insulin Sensitivity in High-Fat Diet-Fed Mice. | 2016 | Details |
| A19158 | 26723251 | Biochem Biophys Res Commun | Suppressing cyclooxygenase-2 prevents nonalcoholic and inhibits apoptosis of hepatocytes that are involved in the Akt/p53 signal pathway. | 2015 | Details |
| A19190 | 28332698 | Mol Med | Induction of steatohepatitis (NASH) with insulin resistance in wildtype B6 mice by a western-type diet containing soybean oil and cholesterol. | 2017 | Details |
| A19223 | 26695085 | J Gastroenterol Hepatol | Treatment with geraniol ameliorates methionine-choline-deficient diet-induced non-alcoholic steatohepatitis in rats. | 2016 | Details |
| A19233 | 26682925 | Biochem Biophys Res Commun | DSS colitis promotes tumorigenesis and fibrogenesis in a choline-deficient high-fat diet-induced NASH mouse model. | 2015 | Details |
| A19249 | 26674248 | BBA Clin | Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy. | 2015 | Details |
| A19275 | 26663004 | Hepatobiliary Pancreat Dis Int | Gut microbiota and non-alcoholic fatty liver disease. | 2015 | Details |
| A19322 | 26629827 | PLoS One | Hyperreactivity of Blood Leukocytes in Patients with NAFLD to Ex Vivo Lipopolysaccharide Treatment Is Modulated by Metformin and Phosphatidylcholine but Not by Alpha Ketoglutarate. | 2015 | Details |
| A19327 | 26628841 | J Clin Exp Hepatol | Animal Models Correlating Immune Cells for the Development of NAFLD/NASH. | 2015 | Details |
| A19375 | 26600128 | PLoS One | Vitamin E Attenuates the Progression of Non-Alcoholic Fatty Liver Disease Caused by Partial Hepatectomy in Mice. | 2015 | Details |
| A19391 | 26593434 | Eur J Pharmacol | Protective role of autophagy in methionine-choline deficient diet-induced advanced nonalcoholic steatohepatitis in mice. | 2015 | Details |
| A19398 | 26592314 | Proc Nutr Soc | Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms. | 2015 | Details |
| A19456 | 26558403 | Clin Sci (Lond) | The balance between IL-17 and IL-22 produced by liver-infiltrating T-helper cells critically controls NASH development in mice. | 2015 | Details |
| A19460 | 26556989 | World J Gastroenterol | Gut microbiota and host metabolism in liver cirrhosis. | 2015 | Details |
| A19464 | 26555271 | J Hepatol | Liver Bid suppression for treatment of fibrosis associated with non-alcoholic steatohepatitis. | 2015 | Details |
| A19475 | 26537990 | Sci Rep | MiR-146a-5p suppresses activation and proliferation of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis through directly targeting Wnt1 and Wnt5a. | 2015 | Details |
| A19483 | 26529285 | Biochim Biophys Acta | Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis. | 2015 | Details |
| A19533 | 26506376 | Nutrients | The Ethanol Extract from Lonicera japonica Thunb. Regresses Nonalcoholic Steatohepatitis in a Methionine- and Choline-Deficient Diet-Fed Animal Model. | 2015 | Details |
| A19543 | 26498332 | Lipids Health Dis | Resveratrol ameliorates hepatic steatosis and inflammation in methionine/choline-deficient diet-induced steatohepatitis through regulating autophagy. | 2015 | Details |
| A19550 | 26494227 | Carcinogenesis | Connexin 32 and luteolin play protective roles in non-alcoholic steatohepatitis development and its related hepatocarcinogenesis in rats. | 2015 | Details |
| A19551 | 26494024 | Nutr Res Rev | Murine models provide insight to the development of non-alcoholic fatty liver disease. | 2015 | Details |
| A19584 | 26473344 | Comp Med | Evaluation of Nonalcoholic Fatty Liver Disease in C57BL/6J Mice by Using MRI and Histopathologic Analyses. | 2015 | Details |
| A19695 | 26406121 | Hepatology | Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes. | 2015 | Details |
| A19700 | 26405687 | Cell Mol Gastroenterol Hepatol | Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability. | 2015 | Details |
| A19705 | 26403427 | Dig Dis Sci | Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model. | 2015 | Details |
| A19715 | 26397391 | Mol Med Rep | Treatment of experimental non-alcoholic steatohepatitis by targeting α7 nicotinic acetylcholine receptor-mediated inflammatory responses in mice. | 2015 | Details |
| A19726 | 26394162 | J Hepatol | CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy. | 2015 | Details |
| A19807 | 26338827 | Gut | Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression. | 2015 | Details |
| A19814 | 26330688 | Trans Am Clin Climatol Assoc | A Lipidomic Readout of Disease Progression in A Diet-Induced Mouse Model of Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A19827 | 26322888 | PLoS One | Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A19830 | 26319415 | Biochim Biophys Acta | TRC8 downregulation contributes to the development of non-alcoholic steatohepatitis by exacerbating hepatic endoplasmic reticulum stress. | 2015 | Details |
| A19855 | 26303223 | Prim Care Diabetes | Analysis of the Japanese Diabetes Risk Score and fatty liver markers for incident diabetes in a Japanese cohort. | 2015 | Details |
| A19877 | 26289793 | Sci Rep | Characterization of hepatic lipid profiles in a mouse model with nonalcoholic steatohepatitis and subsequent fibrosis. | 2015 | Details |
| A19915 | 26270240 | J Gastroenterol Hepatol | Acetylcholine induces fibrogenic effects via M2/M3 acetylcholine receptors in non-alcoholic steatohepatitis and in primary human hepatic stellate cells. | 2016 | Details |
| A19924 | 26263022 | Sci Rep | Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis. | 2015 | Details |
| A19939 | 26253086 | Clin Sci (Lond) | CX3CR1-expressing inflammatory dendritic cells contribute to the progression of steatohepatitis. | 2015 | Details |
| A19943 | 26251667 | Nutr Metab (Lond) | Exercise training improves liver steatosis in mice. | 2015 | Details |
| A20004 | 26214582 | Lab Invest | Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression. | 2015 | Details |
| A20025 | 26201023 | Clin Sci (Lond) | Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis. | 2015 | Details |
| A20051 | 26190501 | J Gastroenterol | Beneficial effects of combined ursodeoxycholic acid and angiotensin-II type 1 receptor blocker on hepatic fibrogenesis in a rat model of nonalcoholic steatohepatitis. | 2015 | Details |
| A20069 | 26178698 | Hepatology | CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis. | 2015 | Details |
| A20078 | 26170532 | Mediators Inflamm | LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis. | 2015 | Details |
| A20124 | 26139990 | World J Gastroenterol | Altered distribution of regulatory lymphocytes by oral administration of soy-extracts exerts a hepatoprotective effect alleviating immune mediated liver injury, non-alcoholic steatohepatitis and insulin resistance. | 2015 | Details |
| A20131 | 26137185 | Oxid Med Cell Longev | Choline and Cystine Deficient Diets in Animal Models with Hepatocellular Injury: Evaluation of Oxidative Stress and Expression of RAGE, TNF-α, and IL-1β. | 2015 | Details |
| A20134 | 26134756 | Pharm Biol | Protective effect of ursodeoxycholic acid, resveratrol, and N-acetylcysteine on nonalcoholic fatty liver disease in rats. | 2015 | Details |
| A20136 | 26133820 | Zhonghua Gan Zang Bing Za Zhi | [Effects of telmisartan on resistin expression in a rat model of nonalcoholic steatohepatitis and insulin resistance]. | 2015 | Details |
| A20163 | 26116119 | EJNMMI Res | Potential of (99m)Tc-MIBI SPECT imaging for evaluating non-alcoholic steatohepatitis induced by methionine-choline-deficient diet in mice. | 2014 | Details |
| A20173 | 26112094 | Exp Mol Pathol | Fat-laden macrophages modulate lobular inflammation in nonalcoholic steatohepatitis (NASH). | 2015 | Details |
| A20175 | 26108973 | Eur J Clin Invest | Ursodeoxycholyl Lysophosphatidylethanolamide modifies aberrant lipid profiles in NAFLD. | 2015 | Details |
| A20176 | 26108664 | Am J Physiol Cell Physiol | Amelioration of nonalcoholic fatty liver disease by hepatic stimulator substance via preservation of carnitine palmitoyl transferase-1 activity. | 2015 | Details |
| A20180 | 26103964 | BMC Gastroenterol | Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis. | 2015 | Details |
| A20194 | 26090468 | Biomed Res Int | Gut Microbiota: Association with NAFLD and Metabolic Disturbances. | 2015 | Details |
| A20245 | 26064924 | Biomed Res Int | Nonalcoholic Steatohepatitis: A Search for Factual Animal Models. | 2015 | Details |
| A20260 | 26058518 | Antioxid Redox Signal | Myeloperoxidase-Hepatocyte-Stellate Cell Cross Talk Promotes Hepatocyte Injury and Fibrosis in Experimental Nonalcoholic Steatohepatitis. | 2015 | Details |
| A20273 | 26051274 | Biochem Biophys Res Commun | Succinate causes α-SMA production through GPR91 activation in hepatic stellate cells. | 2015 | Details |
| A20358 | 26017539 | PLoS One | Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease. | 2015 | Details |
| A20362 | 26016715 | Diabetes | Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis. | 2015 | Details |
| A20385 | 25999428 | Am J Physiol Gastrointest Liver Physiol | The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model. | 2015 | Details |
| A20407 | 25987847 | Nutr Metab Insights | Choline and Fructooligosaccharide: Non-alcoholic Fatty Liver Disease, Cardiac Fat Deposition, and Oxidative Stress Markers. | 2015 | Details |
| A20436 | 25967348 | Eur J Pharmacol | Epigallocatechin gallate attenuated non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet. | 2015 | Details |
| A20472 | 25940288 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | [Emodin worsens methionine-choline-deficient diet-induced non-alcoholic fatty liver disease in mice]. | 2015 | Details |
| A20482 | 25934180 | Diagn Interv Imaging | MRI versus histological methods for time course monitoring of steatosis amount in a murine model of NAFLD. | 2015 | Details |
| A20560 | 25886887 | BMC Gastroenterol | Fluvastatin attenuates hepatic steatosis-induced fibrogenesis in rats through inhibiting paracrine effect of hepatocyte on hepatic stellate cells. | 2015 | Details |
| A20584 | 25873078 | Exp Biol Med (Maywood) | Nonalcoholic fatty liver disease: update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine. | 2015 | Details |
| A20591 | 25868633 | Dig Dis Sci | Raloxifene Ameliorates Liver Fibrosis of Nonalcoholic Steatohepatitis Induced by Choline-Deficient High-Fat Diet in Ovariectomized Mice. | 2015 | Details |
| A20619 | 25849376 | PLoS One | Proteomic analysis of mice fed methionine and choline deficient diet reveals marker proteins associated with steatohepatitis. | 2015 | Details |
| A20635 | 25843661 | Nutr Metab Cardiovasc Dis | A role of 1,25(OH)2D3 supplementation in rats with nonalcoholic steatohepatitis induced by choline-deficient diet. | 2015 | Details |
| A20700 | 25790822 | Exp Biol Med (Maywood) | Sex hormone affects the severity of non-alcoholic steatohepatitis through the MyD88-dependent IL-6 signaling pathway. | 2015 | Details |
| A20718 | 25777368 | Genes Cells | Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis. | 2015 | Details |
| A20761 | 25751390 | Zhonghua Gan Zang Bing Za Zhi | [Effects and mechanisms of the inflammatory reaction related to NASH and induced by activation of the cholinergic anti-inflammatory pathway]. | 2015 | Details |
| A20784 | 25736301 | Biochim Biophys Acta | Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet. | 2015 | Details |
| A20788 | 25733650 | Am J Clin Nutr | High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice. | 2015 | Details |
| A20808 | 25721504 | Science | Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats. | 2015 | Details |
| A20816 | 25714891 | Braz J Med Biol Res | Sorafenib prevents liver fibrosis in a non-alcoholic steatohepatitis (NASH) rodent model. | 2015 | Details |
| A20822 | 25712622 | Mol Nutr Food Res | Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease. | 2015 | Details |
| A20839 | 25701721 | Eur J Pharmacol | Ipragliflozin, an SGLT2 inhibitor, exhibits a prophylactic effect on hepatic steatosis and fibrosis induced by choline-deficient l-amino acid-defined diet in rats. | 2015 | Details |
| A20871 | 25672270 | Int J Mol Med | MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis. | 2015 | Details |
| A20884 | 25665792 | Am J Pathol | Cytoglobin deficiency promotes liver cancer development from hepatosteatosis through activation of the oxidative stress pathway. | 2015 | Details |
| A20894 | 25658238 | Nutrients | 6-gingerol protects against nutritional steatohepatitis by regulating key genes related to inflammation and lipid metabolism. | 2015 | Details |
| A20917 | 25646700 | Liver Int | Beneficial effects of mineralocorticoid receptor blockade in experimental non-alcoholic steatohepatitis. | 2015 | Details |
| A20963 | 25617046 | Expert Rev Gastroenterol Hepatol | Effects of Mediterranean diet supplemented with silybin-vitamin E-phospholipid complex in overweight patients with non-alcoholic fatty liver disease. | 2015 | Details |
| A20975 | 25607821 | Oncol Rep | Hepatic expression of the Sptlc3 subunit of serine palmitoyltransferase is associated with the development of hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis. | 2015 | Details |
| A20982 | 25603556 | Biochim Biophys Acta | Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis. | 2015 | Details |
| A21013 | 25576488 | Mol Pharmacol | Repression of the nuclear receptor small heterodimer partner by steatotic drugs and in advanced nonalcoholic fatty liver disease. | 2015 | Details |
| A21078 | 25548482 | World J Gastroenterol | Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis. | 2014 | Details |
| A21162 | 25512370 | J Pharmacol Exp Ther | Mechanistic basis of altered morphine disposition in nonalcoholic steatohepatitis. | 2014 | Details |