Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A20285 | 26045704 | Hepat Mon | Clinical values of elevated serum cytokeratin-18 levels in hepatitis: a meta-analysis. | 2015 | Details |
| A20286 | 26045616 | Am J Physiol Gastrointest Liver Physiol | Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation. | 2015 | Details |
| A20305 | 26038701 | Pharmacol Res Perspect | Metformin protects primary rat hepatocytes against oxidative stress-induced apoptosis. | 2015 | Details |
| A20315 | 26033245 | Mol Cell Endocrinol | Hepatic NAD salvage pathway is enhanced in mice on a high-fat diet. | 2015 | Details |
| A20327 | 26027904 | Biochim Biophys Acta | Recent insights on the role of cholesterol in non-alcoholic fatty liver disease. | 2015 | Details |
| A20358 | 26017539 | PLoS One | Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease. | 2015 | Details |
| A20381 | 26001595 | Transl Res | High-throughput sequencing reveals altered expression of hepatic microRNAs in nonalcoholic fatty liver disease-related fibrosis. | 2015 | Details |
| A20385 | 25999428 | Am J Physiol Gastrointest Liver Physiol | The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model. | 2015 | Details |
| A20397 | 25993337 | PLoS One | Ceramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosis. | 2015 | Details |
| A20455 | 25951129 | Nutrients | Can skin exposure to sunlight prevent liver inflammation? | 2015 | Details |
| A20463 | 25945652 | Cell Cycle | Modulation of insulin degrading enzyme activity and liver cell proliferation. | 2015 | Details |
| A20508 | 25916635 | Biochim Biophys Acta | Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway. | 2015 | Details |
| A20542 | 25904325 | Mol Biol Cell | CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis. | 2015 | Details |
| A20545 | 25896720 | Pharmacology | Fenofibrate treatment attenuated chronic endoplasmic reticulum stress in the liver of nonalcoholic fatty liver disease mice. | 2015 | Details |
| A20550 | 25892963 | Int J Biol Sci | ER stress and autophagy dysfunction contribute to fatty liver in diabetic mice. | 2015 | Details |
| A20596 | 25865685 | Hepatobiliary Pancreat Dis Int | Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease. | 2015 | Details |
| A20628 | 25846498 | Food Chem Toxicol | Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection. | 2015 | Details |
| A20635 | 25843661 | Nutr Metab Cardiovasc Dis | A role of 1,25(OH)2D3 supplementation in rats with nonalcoholic steatohepatitis induced by choline-deficient diet. | 2015 | Details |
| A20637 | 25841776 | Free Radic Biol Med | Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes. | 2015 | Details |
| A20661 | 27308418 | Mol Cell Oncol | KEAP the balance between life and death. | 2014 | Details |
| A20666 | 25819147 | Orv Hetil | [Non-invasive assessment of fatty liver]. | 2015 | Details |
| A20672 | 25815106 | Oxid Med Cell Longev | P2X7 receptor as a key player in oxidative stress-driven cell fate in nonalcoholic steatohepatitis. | 2015 | Details |
| A20742 | 25764498 | Dig Dis Sci | Circulating Soluble Fas and Fas Ligand Levels Are Elevated in Children with Nonalcoholic Steatohepatitis. | 2015 | Details |
| A20748 | 25757271 | Yao Xue Xue Bao | [Recent advances in curcumin and its derivatives for treatment of liver diseases]. | 2014 | Details |
| A20795 | 25729762 | Cell Mol Gastroenterol Hepatol | Death Receptor-Mediated Cell Death and Proinflammatory Signaling in Nonalcoholic Steatohepatitis. | 2015 | Details |
| A20799 | 25729475 | World J Hepatol | Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease. | 2015 | Details |
| A20883 | 25666017 | J Hepatol | Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. | 2015 | Details |
| A20896 | 25655997 | J Ethnopharmacol | Total aralosides of aralia elata (Miq) seem (TASAES) ameliorate nonalcoholic steatohepatitis by modulating IRE1α-mediated JNK and NF-κB pathways in ApoE-/- mice. | 2015 | Details |
| A20902 | 25654291 | Zhonghua Gan Zang Bing Za Zhi | [Impact of JNK inhibitor XG-102 in a diet-induced rat model of non-alcoholic steatohepatitis]. | 2014 | Details |
| A20927 | 25636888 | Phytomedicine | Two cinnamoyloctopamine antioxidants from garlic skin attenuates oxidative stress and liver pathology in rats with non-alcoholic steatohepatitis. | 2014 | Details |
| A20957 | 25617860 | Atherosclerosis | A concise review of non-alcoholic fatty liver disease. | 2015 | Details |
| A20982 | 25603556 | Biochim Biophys Acta | Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis. | 2015 | Details |
| A20995 | 25597144 | J Egypt Soc Parasitol | Pharmacological and antioxidant actions of garlic and.or onion in non-alcoholic fatty liver disease (NAFLD) in rats. | 2014 | Details |
| A21016 | 25575598 | J Biol Chem | Adiponectin reduces hepatic stellate cell migration by promoting tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion. | 2015 | Details |
| A21067 | 27214981 | Eksp Klin Gastroenterol | [EFFICIENCY OF URSODEOXYCHOLIC ACID APPLICATION IN NONALCOCHOLIC STEATOHEPATITIS]. | 2015 | Details |
| A21160 | 25512910 | Biomed Res Int | Uncoupling protein 2 regulates palmitic acid-induced hepatoma cell autophagy. | 2014 | Details |
| A21163 | 25512222 | BMC Gastroenterol | Expression of NALPs in adipose and the fibrotic progression of non-alcoholic fatty liver disease in obese subjects. | 2014 | Details |
| A21171 | 25502558 | PLoS One | A model of metabolic syndrome and related diseases with intestinal endotoxemia in rats fed a high fat and high sucrose diet. | 2014 | Details |
| A21214 | 25476828 | Life Sci | Chronic intermittent hypobaric hypoxia ameliorates endoplasmic reticulum stress mediated liver damage induced by fructose in rats. | 2014 | Details |
| A21221 | 25470242 | PLoS One | Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-κB and JNK in hepatocytes. | 2014 | Details |
| A21269 | 25445398 | J Hepatol | TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess. | 2014 | Details |
| A21318 | 25410681 | BMC Gastroenterol | High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma. | 2014 | Details |
| A21322 | 25406833 | J Transl Med | Hepatoprotective and antioxidant activities of extracts from Salvia-Nelumbinis naturalis against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet in mice. | 2014 | Details |
| A21330 | 25400762 | Int J Clin Exp Pathol | Mechanism of the promotion of steatotic HepG2 cell apoptosis by cholesterol. | 2014 | Details |
| A21339 | 25392542 | J Am Heart Assoc | Mitochondrial aldehyde dehydrogenase activation by Alda-1 inhibits atherosclerosis and attenuates hepatic steatosis in apolipoprotein E-knockout mice. | 2014 | Details |
| A21396 | 25350950 | J Diabetes | Circulating dipeptidyl peptidase-4 activity correlates with measures of hepatocyte apoptosis and fibrosis in non-alcoholic fatty liver disease in type 2 diabetes mellitus and obesity: A dual cohort cross-sectional study. | 2014 | Details |
| A21412 | 25339829 | World J Gastroenterol | FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation. | 2014 | Details |
| A21414 | 25339807 | World J Gastroenterol | Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease. | 2014 | Details |
| A21416 | 25339805 | World J Gastroenterol | Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome. | 2014 | Details |
| A21424 | 25330059 | Cell Transplant | Preoperative hepatocyte transplantation improves the survival of rats with nonalcoholic steatohepatitis-related cirrhosis after partial hepatectomy. | 2014 | Details |
| A21442 | 25314137 | PLoS One | Mmu-miR-615-3p regulates lipoapoptosis by inhibiting C/EBP homologous protein. | 2014 | Details |
| A21447 | 25311610 | Nutr Res | Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease. | 2014 | Details |
| A21465 | 25302503 | PLoS One | Circulating AIM as an indicator of liver damage and hepatocellular carcinoma in humans. | 2014 | Details |
| A21485 | 25284781 | Cell Rep | Circulating AIM prevents hepatocellular carcinoma through complement activation. | 2014 | Details |
| A21506 | 25267960 | J Gastrointestin Liver Dis | A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators. | 2014 | Details |
| A21522 | 25256142 | J Cell Mol Med | ASPP2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non-alcoholic fatty liver disease. | 2014 | Details |
| A21627 | 25171027 | Eur J Gastroenterol Hepatol | A Bayesian approach to an integrated multimodal noninvasive diagnosis of definitive nonalcoholic steatohepatitis in the spectrum of nonalcoholic fatty liver disease. | 2014 | Details |
| A21652 | 25152587 | World J Gastroenterol | Noninvasive biomarkers in non-alcoholic fatty liver disease: current status and a glimpse of the future. | 2014 | Details |
| A21738 | 25083077 | World J Gastroenterol | Translational approaches: from fatty liver to non-alcoholic steatohepatitis. | 2014 | Details |
| A21754 | 25071314 | World J Gastroenterol | Could metabolic syndrome lead to hepatocarcinoma via non-alcoholic fatty liver disease? | 2014 | Details |
| A21761 | 25064435 | J Hepatol | Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent. | 2014 | Details |
| A21766 | 25061559 | Mol Metab | ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload. | 2014 | Details |
| A21774 | 25053716 | Gut | Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis. | 2014 | Details |
| A21799 | 25036839 | Biosci Biotechnol Biochem | Attenuation by a Vigna nakashimae extract of nonalcoholic fatty liver disease in high-fat diet-fed mice. | 2014 | Details |
| A21800 | 25035929 | Biochem Biophys Res Commun | PKCδ regulates hepatic triglyceride accumulation and insulin signaling in Lepr(db/db) mice. | 2014 | Details |
| A21828 | 25019654 | Gen Comp Endocrinol | The effect of recombinant adeno-associated virus-adiponectin (rAAV2/1-Acrp30) on glycolipid dysmetabolism and liver morphology in diabetic rats. | 2014 | Details |
| A21842 | 25008241 | Mol Cell Endocrinol | Role of aquaglyceroporins and caveolins in energy and metabolic homeostasis. | 2014 | Details |
| A21854 | 24998389 | Sci Rep | Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model. | 2014 | Details |
| A21906 | 24968846 | Nan Fang Yi Ke Da Xue Xue Bao | [Therapeutic effect of saxagliptin in rat models of nonalcoholic fatty liver and type 2 diabetes]. | 2014 | Details |
| A21907 | 24968841 | Nan Fang Yi Ke Da Xue Xue Bao | [Establishment of a L-02 cell model of hepatic steatosis]. | 2014 | Details |
| A21923 | 24963148 | EMBO Mol Med | A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis. | 2014 | Details |
| A21947 | 24946279 | J Hepatol | ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. | 2014 | Details |
| A21954 | 24938610 | Genet Mol Res | Roles of Fas/Fasl, Bcl-2/Bax, and Caspase-8 in rat nonalcoholic fatty liver disease pathogenesis. | 2014 | Details |
| A21956 | 24937020 | Eur J Pharmacol | Treatment with baicalein attenuates methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats. | 2014 | Details |
| A21993 | 24904743 | Cell Biosci | Autophagy protects against palmitate-induced apoptosis in hepatocytes. | 2014 | Details |
| A22030 | 24866317 | Rev Med Inst Mex Seguro Soc | [Nonalcoholic fatty liver disease in children]. | 2014 | Details |
| A22031 | 24865256 | Dig Dis Sci | Tauroursodeoxycholic acid attenuates progression of steatohepatitis in mice fed a methionine-choline-deficient diet. | 2014 | Details |
| A22061 | 24845607 | J Hepatol | Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic steatohepatitis in mice. | 2014 | Details |
| A22081 | 24830635 | Horm Metab Res | Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. | 2014 | Details |
| A22083 | 24830559 | Int J Mol Sci | Evolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation. | 2014 | Details |
| A22101 | 24821109 | Biochem Pharmacol | Cyanidin-3-O-β-glucoside protects primary mouse hepatocytes against high glucose-induced apoptosis by modulating mitochondrial dysfunction and the PI3K/Akt pathway. | 2014 | Details |
| A22114 | 24811405 | Appl Microbiol Biotechnol | Preventing non-alcoholic fatty liver disease through Lactobacillus johnsonii BS15 by attenuating inflammation and mitochondrial injury and improving gut environment in obese mice. | 2014 | Details |
| A22138 | 24795036 | Dig Dis Sci | Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model. | 2014 | Details |
| A22154 | 24784707 | Mol Cell Endocrinol | Resolvin D1 reduces ER stress-induced apoptosis and triglyceride accumulation through JNK pathway in HepG2 cells. | 2014 | Details |
| A22175 | 24766485 | Clin Sci (Lond) | Endoplasmic reticulum stress does not contribute to steatohepatitis in obese and insulin-resistant high-fat-diet-fed foz/foz mice. | 2014 | Details |
| A22198 | 24753158 | Hepatology | Saturated free fatty acids induce cholangiocyte lipoapoptosis. | 2014 | Details |
| A22201 | 24750688 | Liver Int | (Cleaved) CK18 serum and tissue expression levels differentiate acute HCV reinfection from acute rejection in liver allografts. | 2014 | Details |
| A22202 | 24750664 | Liver Int | The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis. | 2014 | Details |
| A22206 | 24749698 | Expert Opin Investig Drugs | Modulation of autophagy for the treatment of liver diseases. | 2014 | Details |
| A22216 | 24743734 | Cell Death Dis | Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. | 2014 | Details |
| A22256 | 24716162 | J Tradit Complement Med | Recent advances in the herbal treatment of non-alcoholic Fatty liver disease. | 2013 | Details |
| A22271 | 24702768 | FEBS J | Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease. | 2014 | Details |
| A22318 | 24667697 | Clin Chim Acta | The cytokeratin-18 fragment level as a biomarker of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. | 2014 | Details |
| A22378 | 24630506 | Arab J Gastroenterol | Apoptotic and anti-apoptotic seromarkers for assessment of disease severity of non-alcoholic steatohepatitis. | 2014 | Details |
| A22392 | 24622832 | J Physiol Pharmacol | Effects of treatment with melatonin and tryptophan on liver enzymes, parameters of fat metabolism and plasma levels of cytokines in patients with non-alcoholic fatty liver disease--14 months follow up. | 2014 | Details |
| A22404 | 24608675 | Acta Pharmacol Sin | Palmitic acid induces autophagy in hepatocytes via JNK2 activation. | 2014 | Details |
| A22424 | 24587658 | World J Gastroenterol | Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver. | 2014 | Details |
| A22425 | 24587654 | World J Gastroenterol | Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease. | 2014 | Details |
| A22463 | 24549004 | J Proteomics | A combination of metallomics and metabolomics studies to evaluate the effects of metal interactions in mammals. Application to Mus musculus mice under arsenic/cadmium exposure. | 2014 | Details |
| A22482 | 24523491 | J Nutr | Bitter gourd inhibits the development of obesity-associated fatty liver in C57BL/6 mice fed a high-fat diet. | 2014 | Details |