Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A47138 | 25278688 | World J Gastroenterol | New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases. | 2014 | Details |
| A47140 | 25132354 | Hepatology | Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice. | 2014 | Details |
| A47145 | 24950483 | J Hepatol | How predictive quantitative modelling of tissue organisation can inform liver disease pathogenesis. | 2014 | Details |
| A47167 | 24417906 | Gastroenterol Hepatol | [Comparison of the M and XL FibroScan(®) probes to estimate liver stiffness by transient elastography]. | 2014 | Details |
| A47172 | 24262277 | Gastroenterology | Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver. | 2013 | Details |
| A47179 | 24086266 | PLoS One | Hepatocyte expression of the senescence marker p21 is linked to fibrosis and an adverse liver-related outcome in alcohol-related liver disease. | 2013 | Details |
| A47190 | 23697887 | Zebrafish | Defining hepatic dysfunction parameters in two models of fatty liver disease in zebrafish larvae. | 2013 | Details |
| A47207 | 22902304 | Gene | Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population. | 2012 | Details |
| A47210 | 22841474 | Am J Pathol | Epigenetic regulation of miR-34a expression in alcoholic liver injury. | 2012 | Details |
| A47213 | 22676331 | Alcohol Clin Exp Res | Thromboxane inhibitors attenuate inflammatory and fibrotic changes in rat liver despite continued ethanol administrations. | 2012 | Details |
| A47218 | 22504185 | Gastroenterology | MicroRNAs in liver disease. | 2012 | Details |
| A47221 | 22425478 | Presse Med | [Current trends in liver biopsy indications in chronic liver diseases]. | 2012 | Details |
| A47222 | 22413959 | Alcohol Clin Exp Res | Carvedilol attenuates the progression of alcohol fatty liver disease in rats. | 2012 | Details |
| A47225 | 22320921 | J Gastroenterol Hepatol | Retinoic acids and hepatic stellate cells in liver disease. | 2012 | Details |
| A47226 | 22273278 | Alcohol Clin Exp Res | Inhibition of apoptosis protects mice from ethanol-mediated acceleration of early markers of CCl4 -induced fibrosis but not steatosis or inflammation. | 2012 | Details |
| A47234 | 21913943 | Alcohol Clin Exp Res | Housekeeping gene variability in the liver of alcoholic patients. | 2011 | Details |
| A47237 | 21826088 | Nat Rev Gastroenterol Hepatol | Alcoholic liver disease: pathogenesis and new targets for therapy. | 2011 | Details |
| A47244 | 21645218 | Liver Int | Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts. | 2011 | Details |
| A47245 | 21633659 | World J Gastroenterol | Hepatic stellate cells and innate immunity in alcoholic liver disease. | 2011 | Details |
| A47246 | 21535024 | Alcohol Clin Exp Res | Chronic ethanol consumption in mice alters hepatocyte lipid droplet properties. | 2011 | Details |
| A47248 | 21457226 | Br J Pharmacol | The endocannabinoid system as a key mediator during liver diseases: new insights and therapeutic openings. | 2011 | Details |
| A47249 | 21423135 | Lab Invest | Fructose-induced steatosis in mice: role of plasminogen activator inhibitor-1, microsomal triglyceride transfer protein and NKT cells. | 2011 | Details |
| A47251 | 21401100 | J Agric Food Chem | Effects of Antrodia camphorata on alcohol clearance and antifibrosis in livers of rats continuously fed alcohol. | 2011 | Details |
| A47252 | 21386907 | PLoS One | Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury. | 2011 | Details |
| A47253 | 21334404 | J Hepatol | Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease. | 2011 | Details |
| A47261 | 20399524 | J Hepatol | Harmful effect of adipose tissue on liver lesions in patients with alcoholic liver disease. | 2010 | Details |
| A47263 | 20180235 | World J Gastroenterol | Increased liver stiffness in alcoholic liver disease: differentiating fibrosis from steatohepatitis. | 2010 | Details |
| A47275 | 19608736 | Am J Physiol Gastrointest Liver Physiol | Pathological roles of bone marrow-derived stellate cells in a mouse model of alcohol-induced fatty liver. | 2009 | Details |
| A47280 | 19285261 | Best Pract Res Clin Endocrinol Metab | The role of the endocannabinoid system in liver diseases. | 2009 | Details |
| A47282 | 19221436 | J Clin Invest | Adenosine signaling contributes to ethanol-induced fatty liver in mice. | 2009 | Details |
| A47286 | 19109846 | Liver Transpl | Impact of donor graft steatosis on overall outcome and viral recurrence after liver transplantation for hepatitis C virus cirrhosis. | 2009 | Details |
| A47289 | 19011575 | Eur J Gastroenterol Hepatol | The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption. | 2009 | Details |
| A47303 | 18369908 | Methods Mol Biol | A voluntary oral-feeding rat model for pathological alcoholic liver injury. | 2008 | Details |
| A47304 | 18341647 | Alcohol Clin Exp Res | A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury. | 2008 | Details |
| A47305 | 18339590 | Dig Liver Dis | Inhibitory effect of osthole on alcohol-induced fatty liver in mice. | 2008 | Details |
| A47306 | 18337117 | Cytokine | Evaluation of the transforming growth factor beta1 codon 25 (Arg-->Pro) polymorphism in alcoholic liver disease. | 2008 | Details |
| A47313 | 17544978 | Clin Liver Dis | Steatosis as a cofactor in other liver diseases: hepatitis C virus, alcohol, hemochromatosis, and others. | 2007 | Details |
| A47314 | 17453353 | Cell Biol Toxicol | Fenugreek seed (Trigonella foenum graecum) polyphenols inhibit ethanol-induced collagen and lipid accumulation in rat liver. | 2007 | Details |
| A47317 | 17307722 | Am J Physiol Gastrointest Liver Physiol | Proteomic analysis of hepatic iron overload in mice suggests dysregulation of urea cycle, impairment of fatty acid oxidation, and changes in the methylation cycle. | 2007 | Details |
| A47318 | 17255218 | Gut | Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease. | 2007 | Details |
| A47327 | 16958658 | J Gastroenterol Hepatol | Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation. | 2006 | Details |
| A47328 | 16696916 | Zhong Xi Yi Jie He Xue Bao | [Establishment of a rat model of alcoholic liver fibrosis induced by complex factors]. | 2006 | Details |
| A47334 | 16344062 | Gastroenterology | Steatosis is a cofactor in liver injury in hemochromatosis. | 2005 | Details |
| A47339 | 15885730 | Toxicol Appl Pharmacol | Role of osteopontin in hepatic neutrophil infiltration during alcoholic steatohepatitis. | 2005 | Details |
| A47340 | 15826726 | J Hepatol | Hepatic phospholipids in alcoholic liver disease assessed by proton-decoupled 31P magnetic resonance spectroscopy. | 2005 | Details |
| A47341 | 15674092 | Eur J Gastroenterol Hepatol | Correlation of alcohol consumption with liver histological features in non-cirrhotic patients. | 2005 | Details |
| A47344 | 15371166 | Int J Toxicol | Early-phase alcoholic liver disease: an update on animal models, pathology, and pathogenesis. | 2005 | Details |
| A47349 | 14976881 | Zhongguo Zhong Xi Yi Jie He Za Zhi | [Clinical study on treatment of alcoholic liver disease by qinggan huoxue recipe]. | 2004 | Details |
| A47360 | 12601343 | Hepatology | Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. | 2003 | Details |
| A47361 | 12540792 | Hepatology | Genetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease. | 2003 | Details |
| A47365 | 12198368 | Alcohol Clin Exp Res | Assessment of a difference in ALDH2 heterozygotes and alcoholic liver injury. | 2002 | Details |
| A47370 | 11343243 | Hepatology | Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease. | 2001 | Details |
| A47373 | 11268819 | Am J Addict | Liver diseases by alcohol and hepatitis C: early detection and new insights in pathogenesis lead to improved treatment. | 2001 | Details |
| A47374 | 10898311 | J Hepatol | Serum YKL-40 is increased in patients with hepatic fibrosis. | 2000 | Details |
| A47376 | 10703221 | Orv Hetil | [Pathology of alcoholic liver disease]. | 2000 | Details |
| A47380 | 10397283 | Alcohol Clin Exp Res | Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review. | 1999 | Details |
| A47386 | 9685833 | Acta Radiol | MR and magnetisation transfer imaging in cirrhotic and fatty livers. | 1998 | Details |
| A47393 | 9514306 | Alcohol Clin Exp Res | Increased circulating products of lipid peroxidation in patients with alcoholic liver disease. | 1998 | Details |
| A47395 | 9438537 | Alcohol Clin Exp Res | Clinical significance of hepatitis GB virus C infection in alcoholic liver disease. | 1997 | Details |
| A47397 | 9397995 | Hepatology | Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the rat. | 1997 | Details |
| A47401 | 9200292 | Scand J Gastroenterol | Plasma YKL-40: a new potential marker of fibrosis in patients with alcoholic cirrhosis? | 1997 | Details |
| A47405 | 9113278 | Alcohol Clin Exp Res | Polyenylphosphatidylcholine decreases alcohol-induced oxidative stress in the baboon. | 1997 | Details |
| A47407 | 8978360 | Gastroenterology | Thromboxane inhibitors attenuate pathological changes in alcoholic liver disease in the rat. | 1997 | Details |
| A47408 | 8938169 | Hepatology | Serum hyaluronate reflects hepatic fibrogenesis in alcoholic liver disease and is useful as a marker of fibrosis. | 1996 | Details |
| A47409 | 8938545 | J Hepatol | Hepatic stellate cell activation occurs in the absence of hepatitis in alcoholic liver disease and correlates with the severity of steatosis. | 1996 | Details |
| A47413 | 8871873 | J Viral Hepat | Hepatitis C virus infection in patients with clinically diagnosed alcoholic liver diseases. | 1996 | Details |
| A47414 | 8666324 | Hepatology | Alcoholism in hereditary hemochromatosis revisited: prevalence and clinical consequences among homozygous siblings. | 1996 | Details |
| A47418 | 8550047 | Hepatology | Quantification of apolipoprotein A-I and B messenger RNA in heavy drinkers according to liver disease. | 1996 | Details |
| A47419 | 8583149 | J Hepatol | Ethanol-related liver injury in the rat: a model of steatosis, inflammation and pericentral fibrosis. | 1995 | Details |
| A47420 | 7475591 | Lancet | Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver. | 1995 | Details |
| A47424 | 7584688 | Clin Exp Allergy | Increased serum IgE in alcohol abusers. | 1995 | Details |
| A47426 | 7644783 | Rev Clin Esp | [Hepatitis C virus antibodies in alcoholic patients]. | 1995 | Details |
| A47436 | 8188171 | Hepatology | Tissue inhibitor of metalloproteinase is increased in the serum of precirrhotic and cirrhotic alcoholic patients and can serve as a marker of fibrosis. | 1994 | Details |
| A47437 | 8176892 | Lab Invest | Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation. | 1994 | Details |
| A47438 | 7908498 | Am J Gastroenterol | Association between restriction fragment length polymorphism of the human cytochrome P450IIE1 gene and susceptibility to alcoholic liver cirrhosis. | 1994 | Details |
| A47439 | 8119681 | Hepatology | "Inapparent" hepatitis B virus infection and hepatitis C virus replication in alcoholic subjects with and without liver disease. | 1994 | Details |
| A47442 | 8105167 | Lancet | Comparison of serum procollagen III peptide concentrations and PGA index for assessment of hepatic fibrosis. | 1993 | Details |
| A47444 | 8279675 | Alcohol Clin Exp Res | Alcohol consumption and alcoholic liver disease: evidence of a threshold level of effects of ethanol. | 1993 | Details |
| A47447 | 8403799 | Clin Sci (Lond) | Plasma membrane form of phosphatidate phosphohydrolase: a possible role in signal transduction during liver fibrogenesis. | 1993 | Details |
| A47450 | 7689516 | Gastroenterol Jpn | Influence of HCV infection and its subtypes on clinical course of alcoholic liver disease. | 1993 | Details |
| A47457 | 7511380 | Alcohol Alcohol Suppl | Serum vitronectin receptor in alcoholic liver disease: correlation with fibronectin receptor and morphological features. | 1993 | Details |
| A47460 | 1408055 | Orv Hetil | [Diagnostic value of the determination of serum alpha2-HS-glycoprotein]. | 1992 | Details |
| A47466 | 1311967 | J Gastroenterol Hepatol | High prevalence of antibody to hepatitis C virus in heavy drinkers with chronic liver diseases in Japan. | 1992 | Details |
| A47467 | 1770192 | J Am Coll Nutr | Alcohol, liver, and nutrition. | 1991 | Details |
| A47469 | 2029987 | Hepatology | Hepatic fibrosis and cirrhosis after chronic administration of alcohol and "low-dose" carbon tetrachloride vapor in the rat. | 1991 | Details |
| A47475 | 2258155 | Hepatology | Attenuation of alcohol-induced hepatic fibrosis by polyunsaturated lecithin. | 1990 | Details |
| A47483 | 2295475 | Hepatology | The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. | 1990 | Details |
| A47486 | 2511135 | Hepatology | High levels of acetaldehyde in nonalcoholic liver injury after threonine or ethanol administration. | 1989 | Details |
| A47488 | 2806468 | Exp Mol Pathol | Relationship between fatty liver and subsequent development of necrosis, inflammation and fibrosis in experimental alcoholic liver disease. | 1989 | Details |
| A47491 | 2668943 | Mod Pathol | Morphometry of liver parenchyma in needle biopsy specimens from patients with alcoholic liver disease: preliminary variables for the diagnosis and prognosis of cirrhosis. | 1989 | Details |
| A47494 | 2650922 | Clin Biochem | Biochemical basis for alcohol-induced liver injury. | 1989 | Details |
| A47503 | 3417223 | Hepatology | Lipocytes and transitional cells in alcoholic liver disease: a morphometric study. | 1988 | Details |
| A47504 | 3183356 | J Hepatol | Is alcohol hepatotoxic in the baboon? | 1988 | Details |
| A47505 | 3288454 | Dig Dis Sci | Differences of liver membrane antibody frequency in alcoholic liver disease. Detection of IgG and IgA classes using radioimmunoassay. | 1988 | Details |
| A47508 | 3341254 | Am J Clin Nutr | Overweight as a risk factor or a predictive sign of histological liver damage in alcoholics. | 1988 | Details |
| A47512 | 3314562 | Alcohol Clin Exp Res | Carbohydrate-deficient transferrin in serum in patients with liver diseases. | 1987 | Details |
| A47515 | 3307495 | Alcohol Clin Exp Res | Serum procollagen type III N-terminal peptides and laminin P1 peptide in alcoholic liver disease. | 1987 | Details |
| A47522 | 3794550 | J Lipid Res | Pathogenesis of the hypertriglyceridemia at early stages of alcoholic liver injury in the baboon. | 1986 | Details |
| A47523 | 3023474 | J Clin Gastroenterol | Alcoholic liver disease in Japan. | 1986 | Details |
| A47527 | 3080046 | Br Med J (Clin Res Ed) | Ultrasound scanning in the detection of hepatic fibrosis and steatosis. | 1986 | Details |