Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Acetaminophen88 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00271 | 35159219 | Cells | S-Adenosylmethionine: From the Discovery of Its Inhibition of Tumorigenesis to Its Use as a Therapeutic Agent. | 2022 | Details |
| A01583 | 34685496 | Cells | Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD Progression. | 2021 | Details |
| A02279 | 34439491 | Antioxidants (Basel) | TRPM2 Non-Selective Cation Channels in Liver Injury Mediated by Reactive Oxygen Species. | 2021 | Details |
| A02364 | 34401974 | Cell Biol Toxicol | Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury. | 2021 | Details |
| A02623 | 34305621 | Front Pharmacol | Caveolin-1 Alleviates Acetaminophen-Induced Fat Accumulation in Non-Alcoholic Fatty Liver Disease by Enhancing Hepatic Antioxidant Ability via Activating AMPK Pathway. | 2021 | Details |
| A04090 | 33763324 | Cureus | Glycogen Hepatopathy: A Reversible yet Relapsing Cause of Hepatitis in Type 1 Diabetics. | 2021 | Details |
| A04767 | 33511336 | JHEP Rep | Sex disparities in waitlisting and liver transplant for acute liver failure. | 2020 | Details |
| A04794 | 33504774 | Nat Commun | Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA. | 2021 | Details |
| A05034 | 33400402 | J Cell Mol Med | Val-Val-Tyr-Pro protects against non-alcoholic steatohepatitis in mice by modulating the gut microbiota and gut-liver axis activation. | 2021 | Details |
| A05151 | 33353156 | Int J Mol Sci | Cell Death in Liver Diseases: A Review. | 2020 | Details |
| A05555 | 33207858 | Eur J Histochem | The selective blockade of metabotropic glutamate receptor-5 attenuates fat accumulation in an <em>in vitro</em> model of benign steatosis. | 2020 | Details |
| A05834 | 33103092 | JHEP Rep | Purinergic signalling in liver diseases: Pathological functions and therapeutic opportunities. | 2020 | Details |
| A05880 | 33090351 | Obes Surg | First Case Report of Fulminant Hepatitis After Laparoscopic Sleeve Gastrectomy Associated with Concomitant Maximal Therapeutic Dose of Acetaminophen Use, Protein Calorie Malnutrition, and Vitamins A and D, Selenium, and Glutathione Deficiencies. | 2020 | Details |
| A06533 | 32836224 | Dig Dis | Opioid Use Is More Common in Nonalcoholic Fatty Liver Disease Patients with Cirrhosis, Higher BMI, and Psychiatric Disease. | 2020 | Details |
| A06927 | 32695965 | JHEP Rep | Imaging and immunometabolic phenotyping uncover changes in the hepatic immune response in the early phases of NAFLD. | 2020 | Details |
| A06969 | 32683859 | Anal Chem | High-Selectivity Fluorescent Reporter toward Peroxynitrite in a Coexisting Nonalcoholic Fatty Liver and Drug-Induced Liver Diseases Model. | 2020 | Details |
| A07306 | 32546444 | Dig Liver Dis | Increased risk of acute liver failure by pain killer drugs in NAFLD: Focus on nuclear receptors and their coactivators. | 2020 | Details |
| A07403 | 32514433 | JGH Open | Epidemiological differences of common liver conditions between Asia and the West. | 2019 | Details |
| A08002 | 32283070 | Chem Biol Interact | Role of epidermal growth factor receptor in liver injury and lipid metabolism: Emerging new roles for an old receptor. | 2020 | Details |
| A09192 | 31840883 | Phytother Res | Protective effects of glycycoumarin on liver diseases. | 2019 | Details |
| A09705 | 31638270 | Clin Pharmacol Ther | Acetaminophen-Induced Liver Damage in Hepatic Steatosis. | 2019 | Details |
| A10308 | 31391339 | JCI Insight | The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis. | 2019 | Details |
| A10514 | 31307592 | Adv Pharmacol | Drug-induced liver injury in obesity and nonalcoholic fatty liver disease. | 2019 | Details |
| A11032 | 31076404 | Gut | Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis. | 2019 | Details |
| A11777 | 30753863 | Eur J Pharmacol | Acetaminophen aggravates fat accumulation in NAFLD by inhibiting autophagy via the AMPK/mTOR pathway. | 2019 | Details |
| A12287 | 30529260 | Food Chem Toxicol | Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects. | 2018 | Details |
| A13191 | 30092856 | Gene Expr | Stress of Strains: Inbred Mice in Liver Research. | 2018 | Details |
| A13932 | 29682868 | Liver Int | Role and mechanisms of autophagy in acetaminophen-induced liver injury. | 2018 | Details |
| A14598 | 29331340 | J Hepatol | Hsp72 protects against liver injury via attenuation of hepatocellular death, oxidative stress, and JNK signaling. | 2018 | Details |
| A14906 | 29179698 | BMC Gastroenterol | Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice. | 2017 | Details |
| A15830 | 28691103 | J Clin Transl Res | Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity. | 2017 | Details |
| A16026 | 28603092 | Hepatobiliary Pancreat Dis Int | Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance. | 2017 | Details |
| A17365 | 27822971 | Expert Opin Drug Metab Toxicol | Drug-induced liver injury: Is chronic liver disease a risk factor and a clinical issue? | 2016 | Details |
| A19132 | 26739624 | Toxicol Appl Pharmacol | A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. | 2015 | Details |
| A19609 | 26460177 | Br J Clin Pharmacol | Can paracetamol (acetaminophen) be administered to patients with liver impairment? | 2015 | Details |
| A20157 | 26117210 | Vascul Pharmacol | Decreased plasma endogenous soluble RAGE, and enhanced adipokine secretion, oxidative stress and platelet/coagulative activation identify non-alcoholic fatty liver disease among patients with familial combined hyperlipidemia and/or metabolic syndrome. | 2015 | Details |
| A20267 | 26055245 | Nat Rev Gastroenterol Hepatol | Inflammasome activation and function in liver disease. | 2015 | Details |
| A20706 | 25788542 | Drug Metab Dispos | Altered regulation of hepatic efflux transporters disrupts acetaminophen disposition in pediatric nonalcoholic steatohepatitis. | 2015 | Details |
| A21780 | 25048953 | J Hepatol | Cyclophilin inhibition as potential therapy for liver diseases. | 2014 | Details |
| A22131 | 24797163 | Sci Rep | Lipid modulatory activities of Cichorium glandulosum Boiss et Huet are mediated by multiple components within hepatocytes. | 2014 | Details |
| A22441 | 24575957 | Liver Int | Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease. | 2014 | Details |
| A22643 | 24388027 | Mayo Clin Proc | Drug-induced liver injury. | 2014 | Details |
| A22841 | 24274872 | Clin Liver Dis | The impact of obesity and metabolic syndrome on chronic hepatitis B and drug-induced liver disease. | 2014 | Details |
| A23343 | 23856494 | Food Chem Toxicol | Glutathione defense mechanism in liver injury: insights from animal models. | 2013 | Details |
| A23648 | 23598120 | Talanta | Validated liquid chromatography-tandem mass spectrometry method for determination of totally nine probe metabolites of cytochrome P450 enzymes and UDP-glucuronosyltransferases. | 2012 | Details |
| A24110 | 23223517 | Drug Metab Dispos | Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease. | 2012 | Details |
| A24164 | 23130907 | Physiol Res | Steatotic rat hepatocytes in primary culture are more susceptible to the acute toxic effect of acetaminophen. | 2012 | Details |
| A24343 | 22982943 | Gastroenterology | Sterile inflammation in the liver. | 2012 | Details |
| A25611 | 21649732 | J Gastroenterol Hepatol | Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. | 2012 | Details |
| A25982 | 21240014 | J Pediatr Gastroenterol Nutr | Acetaminophen pharmacokinetics in children with nonalcoholic fatty liver disease. | 2011 | Details |
| A26158 | 20980222 | Orv Hetil | [Alterations in microRNA expression patterns in liver diseases]. | 2010 | Details |
| A27699 | 17640958 | Drug Metab Dispos | Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease. | 2007 | Details |
| A28338 | 15603755 | Mutat Res | Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. | 2005 | Details |
| A28348 | 15554233 | Drug Metab Rev | The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role. | 2004 | Details |
| A29270 | 34324818 | Biomacromolecules | Rationally Designed Galactose Dendrimer for Hepatocyte-Specific Targeting and Intracellular Drug Delivery for the Treatment of Liver Disorders. | 2021 | Details |
| A29308 | 34272737 | Med J Aust | Drug-induced liver injury in Australia, 2009-2020: the increasing proportion of non-paracetamol cases linked with herbal and dietary supplements. | 2021 | Details |
| A30167 | 32875282 | JHEP Rep | Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis. | 2020 | Details |
| A31425 | 30595544 | Nucl Med Biol | Validation of hepatobiliary transport PET imaging in liver function assessment: Evaluation of 3β-[18F]FCA in mouse models of liver disease. | 2018 | Details |
| A31546 | 30309020 | Int J Mol Sci | Danger-Associated Molecular Patterns (DAMPs): Molecular Triggers for Sterile Inflammation in the Liver. | 2018 | Details |
| A33269 | 26330343 | Am J Physiol Endocrinol Metab | Tracer-based assessments of hepatic anaplerotic and TCA cycle flux: practicality, stoichiometry, and hidden assumptions. | 2015 | Details |
| A33569 | 25687506 | Cell Mol Life Sci | Pathological implications of cadherin zonation in mouse liver. | 2015 | Details |
| A34310 | 23793039 | Food Chem Toxicol | Nuclear erythroid 2-related factor 2: a novel potential therapeutic target for liver fibrosis. | 2013 | Details |
| A35496 | 20539006 | Am J Physiol Gastrointest Liver Physiol | Diabetic KK-A(y) mice are highly susceptible to oxidative hepatocellular damage induced by acetaminophen. | 2010 | Details |
| A36302 | 18501395 | Toxicol Appl Pharmacol | Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARalpha with clofibrate. | 2008 | Details |
| A36718 | 17393512 | Hepatology | Chronic intermittent hypoxia predisposes to liver injury. | 2007 | Details |
| A38236 | 11812920 | Toxicol Sci | Mechanisms of hepatotoxicity. | 2002 | Details |
| A40742 | 6729821 | Toxicol Appl Pharmacol | The toxicity and biotransformation of single doses of acetaminophen in dogs and cats. | 1984 | Details |
| A42403 | 34630116 | Front Pharmacol | An Integrative Pharmacology Based Analysis of Refined Liuweiwuling Against Liver Injury: A Novel Component Combination and Hepaprotective Mechanism. | 2021 | Details |
| A42750 | 33584986 | World J Hepatol | Autophagy in liver diseases. | 2021 | Details |
| A43098 | 32571750 | Clin Res Hepatol Gastroenterol | Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis. | 2020 | Details |
| A45469 | 24397281 | Liver Int | Panaxatriol saponin ameliorated liver injury by acetaminophen via restoring thioredoxin-1 and pro-caspase-12. | 2014 | Details |
| A45806 | 22647274 | J Pharmacol Exp Ther | Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice. | 2012 | Details |
| A45946 | 21908766 | Toxicol Sci | 3,5,5-trimethyl-hexanoyl-ferrocene diet protects mice from moderate transient acetaminophen-induced hepatotoxicity. | 2011 | Details |
| A45953 | 21886053 | South Med J | A paradigm shift in the outpatient approach to liver function tests. | 2011 | Details |
| A46419 | 18821593 | Hepatology | Hepatitis C is a predictor of acute liver injury among hospitalizations for acetaminophen overdose in the United States: a nationwide analysis. | 2008 | Details |
| A46471 | 18408456 | Curr Opin Gastroenterol | Drug-induced liver injury in 2007. | 2008 | Details |
| A47007 | 30248395 | Alcohol | Pharmacokinetic changes of tramadol in rats with hepatotoxicity induced by ethanol and acetaminophen in perfused rat liver model. | 2018 | Details |
| A47333 | 16439473 | Am J Physiol Gastrointest Liver Physiol | Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity. | 2006 | Details |
| A47380 | 10397283 | Alcohol Clin Exp Res | Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review. | 1999 | Details |
| A47526 | 3518564 | Ann Intern Med | Drug-induced hepatotoxicity. | 1986 | Details |
| A47806 | 31545919 | Am J Physiol Gastrointest Liver Physiol | Emerging role of extracellular vesicles in liver diseases. | 2019 | Details |
| A48256 | 18335886 | Rev Med Suisse | [Highlights in hepatology]. | 2008 | Details |
| A48772 | 29246445 | Biochim Biophys Acta Mol Basis Dis | Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease. | 2017 | Details |
| A48828 | 27439970 | Clin Sci (Lond) | NLRP3 inflammasome as a target of berberine in experimental murine liver injury: interference with P2X7 signalling. | 2016 | Details |
| A48852 | 26609559 | Redox Biol | Curcumin inhibits activation of TRPM2 channels in rat hepatocytes. | 2015 | Details |
| A49181 | 15180496 | Curr Drug Metab | Cytochrome P450 and liver diseases. | 2004 | Details |
| A50742 | 35282052 | Ann Transl Med | Regulatory mechanism of HIF-1α and its role in liver diseases: a narrative review. | 2022 | Details |
| A51972 | 32719086 | Drug Metab Dispos | Multiomics Profiling Reveals Protective Function of Schisandra Lignans against Acetaminophen-Induced Hepatotoxicity. | 2020 | Details |