Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Caspase-1136 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00123 | 35213000 | Methods Mol Biol | Ex Vivo Dual-Hit Method for Inflammasome Activation in Liver. | 2022 | Details |
| A00319 | 35138995 | Pharm Biol | Jinlida granules ameliorate the high-fat-diet induced liver injury in mice by antagonising hepatocytes pyroptosis. | 2022 | Details |
| A00949 | 34922061 | Clin Res Hepatol Gastroenterol | Upregulated NLRP3 inflammasome activation is attenuated by anthocyanins in patients with nonalcoholic fatty liver disease: A case-control and an intervention study. | 2021 | Details |
| A01136 | 34859106 | J Immunol Res | Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD. | 2021 | Details |
| A01428 | 34752711 | Annu Rev Pathol | Role of the Inflammasome in Liver Disease. | 2021 | Details |
| A01787 | 34618611 | Immunopharmacol Immunotoxicol | Capillin protects against non-alcoholic steatohepatitis through suppressing NLRP3 inflammasome activation and oxidative stress. | 2021 | Details |
| A01901 | 34566670 | Front Physiol | Gardenoside Hinders Caspase-1-Mediated Hepatocyte Pyroptosis Through the CTCF/DPP4 Signaling Pathway. | 2021 | Details |
| A02064 | 34513923 | Front Mol Biosci | The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis. | 2021 | Details |
| A02136 | 34492534 | Int Immunopharmacol | Antcin A alleviates pyroptosis and inflammatory response in Kupffercells of non-alcoholic fatty liver disease by targeting NLRP3. | 2021 | Details |
| A02373 | 34399601 | Int J Immunopathol Pharmacol | Melatonin ameliorates hepatic steatosis by inhibiting NLRP3 inflammasome in db/db mice. | 2022 | Details |
| A02428 | 34374253 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | [Effects of GPR81 agonist on insulin resistance in rats with nonalcoholic fatty liver disease]. | 2021 | Details |
| A02790 | 34239622 | Dis Markers | Jiangzhi Ligan Decoction Inhibits GSDMD-Mediated Canonical/Noncanonical Pyroptosis Pathways and Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A02860 | 34213784 | Phytother Res | Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride by regulating TGF-β1/Smad2, NF-κB, and AMPK signaling pathways. | 2021 | Details |
| A03252 | 34070893 | Mar Drugs | Attenuating Effects of Dieckol on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Decreasing the NLRP3 Inflammasome and Pyroptosis. | 2021 | Details |
| A03374 | 34026086 | Food Sci Nutr | Alpha-lipoic acid alleviates NAFLD and triglyceride accumulation in liver via modulating hepatic NLRP3 inflammasome activation pathway in type 2 diabetic rats. | 2021 | Details |
| A03493 | 33984334 | Metabolism | A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage. | 2021 | Details |
| A03585 | 33941551 | BMJ Open Diabetes Res Care | Insulin resistance and liver histopathology in metabolically unhealthy subjects do not correlate with the hepatic abundance of NLRP3 inflammasome nor circulating IL-1β levels. | 2021 | Details |
| A03615 | 33930586 | Clin Res Hepatol Gastroenterol | Pathogenetic mechanisms of nonalcoholic fatty liver disease and inhibition of the inflammasome as a new therapeutic target. | 2021 | Details |
| A03656 | 33918059 | J Pers Med | Animal Evidence for Synergistic Induction of Hepatic Injury by Dietary Fat and Alcohol Consumption and Its Potential Mechanisms. | 2021 | Details |
| A03714 | 33894425 | Cell Mol Gastroenterol Hepatol | Caspase-11-Mediated Hepatocytic Pyroptosis Promotes the Progression of Nonalcoholic Steatohepatitis. | 2021 | Details |
| A03788 | 33862553 | Int Immunopharmacol | Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis. | 2021 | Details |
| A04243 | 33692776 | Front Immunol | TGR5 Regulates Macrophage Inflammation in Nonalcoholic Steatohepatitis by Modulating NLRP3 Inflammasome Activation. | 2021 | Details |
| A04370 | 33643422 | Evid Based Complement Alternat Med | Gegen Qinlian Decoction Ameliorates Nonalcoholic Fatty Liver Disease in Rats via Oxidative Stress, Inflammation, and the NLRP3 Signal Axis. | 2021 | Details |
| A05062 | 33390939 | Front Pharmacol | Inulin Exerts Beneficial Effects on Non-Alcoholic Fatty Liver Disease via Modulating gut Microbiome and Suppressing the Lipopolysaccharide-Toll-Like Receptor 4-Mψ-Nuclear Factor-κB-Nod-Like Receptor Protein 3 Pathway via gut-Liver Axis in Mice. | 2020 | Details |
| A05155 | 33352229 | Pharmacol Res | Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome-mediated diseases. | 2020 | Details |
| A05246 | 33325949 | Food Funct | Taxifolin ameliorate high-fat-diet feeding plus acute ethanol binge-induced steatohepatitis through inhibiting inflammatory caspase-1-dependent pyroptosis. | 2020 | Details |
| A05252 | 33323025 | AIDS Res Hum Retroviruses | Pro-Inflammatory Interleukin-18 is Associated with Hepatic Steatosis and Elevated Liver Enzymes in People with HIV Monoinfection. | 2021 | Details |
| A05411 | 33268842 | Lab Invest | Exercise suppresses NLRP3 inflammasome activation in mice with diet-induced NASH: a plausible role of adropin. | 2020 | Details |
| A05651 | 33172809 | Dig Liver Dis | Leptin induces NAFLD progression through infiltrated CD8+ T lymphocytes mediating pyroptotic-like cell death of hepatocytes and macrophages. | 2020 | Details |
| A05801 | 33114221 | Antioxidants (Basel) | Auranofin Attenuates Non-Alcoholic Fatty Liver Disease by Suppressing Lipid Accumulation and NLRP3 Inflammasome-Mediated Hepatic Inflammation In Vivo and In Vitro. | 2020 | Details |
| A05819 | 33106416 | Proc Natl Acad Sci U S A | Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-κB/NLRP3 inflammasome circuit. | 2020 | Details |
| A06397 | 32893589 | Zhongguo Zhong Yao Za Zhi | [Effect and mechanism of Bidens pilosa decoction on non-alcoholic fatty liver induced by high fat and high glucose in mice]. | 2020 | Details |
| A06742 | 32763266 | J Hepatol | Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis. | 2020 | Details |
| A07282 | 32556446 | Eur J Nutr | S-allylmercaptocysteine improves nonalcoholic steatohepatitis by enhancing AHR/NRF2-mediated drug metabolising enzymes and reducing NF-κB/IκBα and NLRP3/6-mediated inflammation. | 2020 | Details |
| A07904 | 32316419 | Int J Mol Sci | Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome. | 2020 | Details |
| A07937 | 32304992 | Int Immunopharmacol | Role of pyroptosis in liver diseases. | 2020 | Details |
| A08114 | 32242391 | J Tradit Chin Med | Sini powder ameliorates the inflammatory response in rats with stress-induced non-alcoholic fatty liver disease by inhibiting the nuclear factor kappa-B / pyrin domain-containing protein 3 pathway. | 2020 | Details |
| A08193 | 32211410 | Front Cell Dev Biol | Involvement of Nucleotide-Binding Oligomerization Domain-Like Receptor Family Pyrin Domain Containing 3 Inflammasome in the Pathogenesis of Liver Diseases. | 2020 | Details |
| A08222 | 32194416 | Front Pharmacol | Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis. | 2020 | Details |
| A08223 | 32194141 | Immunol Lett | MiR-149 attenuates endoplasmic reticulum stress-induced inflammation and apoptosis in nonalcoholic fatty liver disease by negatively targeting ATF6 pathway. | 2020 | Details |
| A08396 | 32126269 | Biochim Biophys Acta Mol Basis Dis | Chemical hypoxia induces pro-inflammatory signals in fat-laden hepatocytes and contributes to cellular crosstalk with Kupffer cells through extracellular vesicles. | 2020 | Details |
| A08747 | 32002713 | Inflammation | Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD. | 2020 | Details |
| A08760 | 31998283 | Front Immunol | Absence of the Caspases 1/11 Modulates Liver Global Lipid Profile and Gut Microbiota in High-Fat-Diet-Induced Obese Mice. | 2020 | Details |
| A09213 | 31834465 | Naunyn Schmiedebergs Arch Pharmacol | NLRP3 inhibitor glibenclamide attenuates high-fat diet and streptozotocin-induced non-alcoholic fatty liver disease in rat: studies on oxidative stress, inflammation, DNA damage and insulin signalling pathway. | 2019 | Details |
| A09817 | 31599445 | Eur Rev Med Pharmacol Sci | Cardiolipin inhibitor ameliorates the non-alcoholic steatohepatitis through suppressing NLRP3 inflammasome activation. | 2019 | Details |
| A09835 | 31595205 | Aging Dis | Pyroptosis in Liver Disease: New Insights into Disease Mechanisms. | 2019 | Details |
| A11730 | 30773868 | Zhen Ci Yan Jiu | [Progress of researches on acupuncture treatment of diseases by regulating endoplasmic reticulum stress]. | 2019 | Details |
| A11877 | 30700851 | Lab Invest | Impaired mitophagy triggers NLRP3 inflammasome activation during the progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis. | 2019 | Details |
| A11957 | 30668625 | Acta Biochim Biophys Sin (Shanghai) | Chronic intermittent hypoxia accelerates liver fibrosis in rats with combined hypoxia and nonalcoholic steatohepatitis via angiogenesis rather than endoplasmic reticulum stress. | 2019 | Details |
| A12328 | 30514673 | Nan Fang Yi Ke Da Xue Xue Bao | [Effects of sera of rats fed with Huganqingzhi tablets on endoplasmic reticulum stress in a HepG2 cell model of nonalcoholic fatty liver disease]. | 2018 | Details |
| A12819 | 30269815 | Biochem Biophys Res Commun | Liraglutide protects non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in a mouse model induced by high-fat diet. | 2018 | Details |
| A13055 | 30160281 | Food Funct | Freshwater clam extract reduces liver injury by lowering cholesterol accumulation, improving dysregulated cholesterol synthesis and alleviating inflammation in high-fat, high-cholesterol and cholic acid diet-induced steatohepatitis in mice. | 2018 | Details |
| A13096 | 30140364 | Oxid Med Cell Longev | NLRP3 Inflammasome Formation and Activation in Nonalcoholic Steatohepatitis: Therapeutic Target for Antimetabolic Syndrome Remedy FTZ. | 2018 | Details |
| A13103 | 30137403 | J Clin Endocrinol Metab | Ghrelin Reduces TNF-α-Induced Human Hepatocyte Apoptosis, Autophagy, and Pyroptosis: Role in Obesity-Associated NAFLD. | 2019 | Details |
| A13145 | 30116360 | Exp Ther Med | 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside attenuates methionine and choline-deficient diet-induced non-alcoholic fatty liver disease. | 2018 | Details |
| A13165 | 30105078 | Evid Based Complement Alternat Med | Chaihu-Shugan-San Decoction Modulates Intestinal Microbe Dysbiosis and Alleviates Chronic Metabolic Inflammation in NAFLD Rats via the NLRP3 Inflammasome Pathway. | 2018 | Details |
| A13168 | 30103942 | Cell Immunol | Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release. | 2018 | Details |
| A13348 | 30019185 | J Physiol Biochem | Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation. | 2018 | Details |
| A13544 | 29921379 | J Biol Regul Homeost Agents | The involvement and mechanism of febuxostat in non-alcoholic fatty liver disease cells. | 2018 | Details |
| A13829 | 29735977 | Cell Mol Immunol | Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice. | 2018 | Details |
| A13967 | 29665983 | Trends Mol Med | IL-1 Family Cytokine Pathways Underlying NAFLD: Towards New Treatment Strategies. | 2018 | Details |
| A14339 | 29457838 | Hepatology | Bax inhibitor-1 protects from nonalcoholic steatohepatitis by limiting inositol-requiring enzyme 1 alpha signaling in mice. | 2018 | Details |
| A14467 | 29399273 | World J Hepatol | Role of inflammatory response in liver diseases: Therapeutic strategies. | 2018 | Details |
| A14561 | 29353414 | Probiotics Antimicrob Proteins | Oral Administration of Compound Probiotics Ameliorates HFD-Induced Gut Microbe Dysbiosis and Chronic Metabolic Inflammation via the G Protein-Coupled Receptor 43 in Non-alcoholic Fatty Liver Disease Rats. | 2019 | Details |
| A15315 | 28970254 | FASEB J | Silybin inhibits NLRP3 inflammasome assembly through the NAD+/SIRT2 pathway in mice with nonalcoholic fatty liver disease. | 2018 | Details |
| A15749 | 28730512 | Inflammation | NLRP3 Deletion Inhibits the Non-alcoholic Steatohepatitis Development and Inflammation in Kupffer Cells Induced by Palmitic Acid. | 2017 | Details |
| A15860 | 28677866 | J Appl Toxicol | Increased incidence of non-alcoholic fatty liver disease in male rat offspring exposed to fluoxetine during fetal and neonatal life involves the NLRP3 inflammasome and augmented de novo hepatic lipogenesis. | 2017 | Details |
| A16047 | 28595079 | Int Immunopharmacol | Curcumin reduces the risk of chronic kidney damage in mice with nonalcoholic steatohepatitis by modulating endoplasmic reticulum stress and MAPK signaling. | 2017 | Details |
| A16683 | 28249038 | PLoS One | Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis. | 2017 | Details |
| A16684 | 28245087 | Hepatol Res | Hepatic nucleotide binding oligomerization domain-like receptors pyrin domain-containing 3 inflammasomes are associated with the histologic severity of non-alcoholic fatty liver disease. | 2017 | Details |
| A16798 | 28167322 | J Hepatol | NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. | 2017 | Details |
| A16804 | 28163820 | Oxid Med Cell Longev | Apolipoprotein CIII Overexpression-Induced Hypertriglyceridemia Increases Nonalcoholic Fatty Liver Disease in Association with Inflammation and Cell Death. | 2017 | Details |
| A18004 | 27423696 | Am J Pathol | High-Fat Diet-Induced IL-17A Exacerbates Psoriasiform Dermatitis in a Mouse Model of Steatohepatitis. | 2016 | Details |
| A18257 | 27261776 | Mol Med | Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance. | 2016 | Details |
| A18458 | 27121255 | Int J Obes (Lond) | Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR-/-.Leiden mice. | 2016 | Details |
| A18519 | 27075683 | Sci Rep | A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet. | 2016 | Details |
| A18758 | 26968211 | Am J Physiol Gastrointest Liver Physiol | Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis. | 2016 | Details |
| A18791 | 26937141 | World J Gastroenterol | Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation. | 2016 | Details |
| A18902 | 26878782 | J Nutr Biochem | A nutritional nonalcoholic steatohepatitis minipig model. | 2015 | Details |
| A19198 | 26709799 | Front Biosci (Landmark Ed) | Inflammasomes in non-alcoholic fatty liver disease. | 2016 | Details |
| A19213 | 26698881 | J Biol Chem | The Hepatitis C Virus-induced NLRP3 Inflammasome Activates the Sterol Regulatory Element-binding Protein (SREBP) and Regulates Lipid Metabolism. | 2015 | Details |
| A19260 | 26668503 | World J Gastroenterol | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease. | 2015 | Details |
| A19998 | 26215420 | Biomed Khim | [Intensity of apoptotic processes, aconitate hydratase activity and citrate level in patients with type 2 diabetes mellitus complicated steatohepatitis under application of epifamin at basic therapy]. | 2016 | Details |
| A20267 | 26055245 | Nat Rev Gastroenterol Hepatol | Inflammasome activation and function in liver disease. | 2015 | Details |
| A20985 | 25602171 | Antioxid Redox Signal | Reactive oxygen species-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation. | 2015 | Details |
| A21163 | 25512222 | BMC Gastroenterol | Expression of NALPs in adipose and the fibrotic progression of non-alcoholic fatty liver disease in obese subjects. | 2014 | Details |
| A21214 | 25476828 | Life Sci | Chronic intermittent hypobaric hypoxia ameliorates endoplasmic reticulum stress mediated liver damage induced by fructose in rats. | 2014 | Details |
| A21805 | 25034283 | Dig Dis | The inflammasome in liver injury and non-alcoholic fatty liver disease. | 2014 | Details |
| A21817 | 25024607 | World J Gastroenterol | High fat diet feeding results in gender specific steatohepatitis and inflammasome activation. | 2014 | Details |
| A22343 | 24650018 | Liver Int | Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis. | 2014 | Details |
| A23040 | 24084392 | J Chin Med Assoc | The involvement of NLRX1 and NLRP3 in the development of nonalcoholic steatohepatitis in mice. | 2013 | Details |
| A23510 | 25755488 | J Clin Exp Hepatol | Gut-liver axis: role of inflammasomes. | 2013 | Details |
| A23596 | 23647015 | Br J Pharmacol | Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats. | 2013 | Details |
| A24337 | 22987396 | Hepatology | Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. | 2013 | Details |
| A24343 | 22982943 | Gastroenterology | Sterile inflammation in the liver. | 2012 | Details |
| A24830 | 22455888 | Zhonghua Bing Li Xue Za Zhi | [Mechanism of hepatocyte apoptosis in rats with liver fibrosis induced by lipogenic methionine-choline-deficient diet]. | 2012 | Details |
| A25745 | 21488066 | Hepatology | Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. | 2011 | Details |
| A25947 | 21280192 | Liver Transpl | Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts. | 2011 | Details |
| A27148 | 19084941 | World J Gastroenterol | Inhibition of hepatic interleukin-18 production by rosiglitazone in a rat model of nonalcoholic fatty liver disease. | 2008 | Details |
| A28644 | 35194060 | Sci Rep | Pemafibrate suppresses NLRP3 inflammasome activation in the liver and heart in a novel mouse model of steatohepatitis-related cardiomyopathy. | 2022 | Details |