Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00395 | 35102146 | Nat Commun | Formyl peptide receptor 2 determines sex-specific differences in the progression of nonalcoholic fatty liver disease and steatohepatitis. | 2022 | Details |
| A00556 | 35047580 | Front Cardiovasc Med | Alterations of Gut Microbiome and Serum Metabolome in Coronary Artery Disease Patients Complicated With Non-alcoholic Fatty Liver Disease Are Associated With Adverse Cardiovascular Outcomes. | 2022 | Details |
| A01047 | 34890043 | Eur J Clin Invest | The advantages of physical exercise as a preventive strategy against NAFLD in postmenopausal women. | 2022 | Details |
| A01718 | 34641807 | BMC Geriatr | A low follicle-stimulating hormone level is a protective factor for non-alcoholic fatty liver disease in older men aged over 80. | 2021 | Details |
| A02250 | 34446275 | Maturitas | The interplay between metabolic dysregulations and non-alcoholic fatty liver disease in women after menopause. | 2021 | Details |
| A03138 | 34116975 | Dig Liver Dis | Association of sex hormones with hepatic steatosis in men with chronic hepatitis B. | 2021 | Details |
| A05916 | 33076582 | Life (Basel) | Quercitrin Ameliorates Hyperlipidemia and Hepatic Steatosis in Ovariectomized Mice. | 2020 | Details |
| A06140 | 32991990 | J Steroid Biochem Mol Biol | Involvement of endogenous testosterone in hepatic steatosis in women with polycystic ovarian syndrome. | 2020 | Details |
| A06486 | 32860311 | Liver Int | The association of sex steroid hormone concentrations with non-alcoholic fatty liver disease and liver enzymes in US men. | 2021 | Details |
| A06527 | 32840311 | J Clin Endocrinol Metab | Sex Hormone Relations to Histologic Severity of Pediatric Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A06693 | 32777485 | Phytomedicine | Cajanolactone A, a stilbenoid from cajanus cajan, prevents ovariectomy-induced obesity and liver steatosis in mice fed a regular diet. | 2020 | Details |
| A06736 | 32765626 | Evid Based Complement Alternat Med | Improvement in Menopause-Associated Hepatic Lipid Metabolic Disorders by Herbal Formula HPC03 on Ovariectomized Rats. | 2020 | Details |
| A07498 | 32472585 | J Pathol | Sex-opposed inflammatory effects of 27-hydroxycholesterol are mediated via differences in estrogen signaling. | 2020 | Details |
| A07753 | 32363890 | Am J Physiol Gastrointest Liver Physiol | Immune modulating effects of additional supplementation of estradiol combined with testosterone in murine testosterone-deficient NAFLD model. | 2020 | Details |
| A07865 | 32330379 | Cell Physiol Biochem | Genistein and 17β-Estradiol Protect Hepatocytes from Fatty Degeneration by Mechanisms Involving Mitochondria, Inflammasome and Kinases Activation. | 2020 | Details |
| A08450 | 32105829 | Free Radic Biol Med | 17β-estradiol ameliorates lipotoxicity-induced hepatic mitochondrial oxidative stress and insulin resistance. | 2020 | Details |
| A09182 | 31846369 | Am J Physiol Endocrinol Metab | Pgc1a is responsible for the sex differences in hepatic Cidec/Fsp27β mRNA expression in hepatic steatosis of mice fed a Western diet. | 2019 | Details |
| A09475 | 31730885 | Toxicol Lett | In vitro and in vivo approaches for identifying the role of aryl hydrocarbon receptor in the development of nonalcoholic fatty liver disease. | 2019 | Details |
| A09765 | 31619023 | Cells | Potential Therapeutic Application of Estrogen in Gender Disparity of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis. | 2019 | Details |
| A10521 | 31304450 | Hepatol Commun | Selective Liver Estrogen Receptor α Modulation Prevents Steatosis, Diabetes, and Obesity Through the Anorectic Growth Differentiation Factor 15 Hepatokine in Mice. | 2019 | Details |
| A10604 | 31274482 | Asian J Androl | Histologically proven hepatic steatosis associates with lower testosterone levels in men with obesity. | 2021 | Details |
| A10761 | 31206703 | J Physiol | Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance. | 2019 | Details |
| A10832 | 31168625 | Carcinogenesis | Sex hormone-binding globulin suppresses NAFLD-triggered hepatocarcinogenesis after menopause. | 2019 | Details |
| A11061 | 31062612 | Artif Cells Nanomed Biotechnol | Long non-coding RNA NEAT1 promotes steatosis via enhancement of estrogen receptor alpha-mediated AQP7 expression in HepG2 cells. | 2019 | Details |
| A12339 | 30500887 | Endocr Rev | Reproductive Endocrinology of Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A13405 | 29992886 | Curr Vasc Pharmacol | Menopause and Non-Alcoholic Fatty Liver Disease: A Review Focusing on Therapeutic Perspectives. | 2019 | Details |
| A13797 | 29751074 | Food Chem Toxicol | Effects of high fructose intake on liver injury progression in high fat diet induced fatty liver disease in ovariectomized female mice. | 2018 | Details |
| A14480 | 29391432 | Sci Rep | Systems Analysis of the Liver Transcriptome in Adult Male Zebrafish Exposed to the Plasticizer (2-Ethylhexyl) Phthalate (DEHP). | 2018 | Details |
| A14580 | 29342107 | Molecules | Honokiol Improves Liver Steatosis in Ovariectomized Mice. | 2018 | Details |
| A14804 | 29224108 | Adv Exp Med Biol | Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men. | 2017 | Details |
| A14805 | 29224098 | Adv Exp Med Biol | Role of Estrogens in the Regulation of Liver Lipid Metabolism. | 2017 | Details |
| A15236 | 29030588 | Sci Rep | Impaired branched-chain amino acid metabolism may underlie the nonalcoholic fatty liver disease-like pathology of neonatal testosterone-treated female rats. | 2017 | Details |
| A15635 | 28797077 | PLoS One | Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1. | 2017 | Details |
| A17266 | 27879963 | Minerva Endocrinol | Hypogonadism and non-alcoholic fatty liver disease. | 2016 | Details |
| A18346 | 27189962 | J Pharmacol Exp Ther | Nuclear Factor Erythroid 2-Related Factor 2 Deficiency Results in Amplification of the Liver Fat-Lowering Effect of Estrogen. | 2016 | Details |
| A18372 | 27176782 | Mol Med Rep | Treatment with estrogen protects against ovariectomy-induced hepatic steatosis by increasing AQP7 expression. | 2016 | Details |
| A18377 | 27174168 | Life Sci | Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes. | 2016 | Details |
| A18502 | 27087367 | Sci Rep | Sexually Dimorphic Expression of eGFP Transgene in the Akr1A1 Locus of Mouse Liver Regulated by Sex Hormone-Related Epigenetic Remodeling. | 2016 | Details |
| A19240 | 26678239 | J Gastroenterol Hepatol | Follicle-stimulating hormone is associated with non-alcoholic fatty liver disease in Chinese women over 55 years old. | 2016 | Details |
| A20064 | 26183212 | Dis Model Mech | Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis. | 2015 | Details |
| A20253 | 26062079 | Eur J Gastroenterol Hepatol | Nonalcoholic fatty liver disease and alteration in semen quality and reproductive hormones. | 2015 | Details |
| A20615 | 25850006 | Cardiovasc Diabetol | Serum fibroblast growth factor 21 levels is associated with lower extremity atherosclerotic disease in Chinese female diabetic patients. | 2015 | Details |
| A20700 | 25790822 | Exp Biol Med (Maywood) | Sex hormone affects the severity of non-alcoholic steatohepatitis through the MyD88-dependent IL-6 signaling pathway. | 2015 | Details |
| A20998 | 25592661 | Clin Gastroenterol Hepatol | Association Between Endogenous Sex Hormones and Liver Fat in a Multiethnic Study of Atherosclerosis. | 2015 | Details |
| A21953 | 24939737 | Am J Physiol Endocrinol Metab | Bazedoxifene and conjugated estrogen prevent diet-induced obesity, hepatic steatosis, and type 2 diabetes in mice without impacting the reproductive tract. | 2014 | Details |
| A22368 | 24634829 | Mol Metab | Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice. | 2014 | Details |
| A23183 | 23980352 | Zhongguo Zhong Xi Yi Jie He Za Zhi | [Effects of resolving method of Chinese medicine on the lipid metabolism in polycystic ovary syndrome accompanied with non-alcoholic fatty liver disease]. | 2013 | Details |
| A23291 | 23895155 | Am J Chin Med | Ligusticum chuanxiong prevents ovariectomy-induced liver and vascular damage in rats. | 2013 | Details |
| A24152 | 23175777 | J Lipid Res | Differential effects of estrogen/androgen on the prevention of nonalcoholic fatty liver disease in the male rat. | 2012 | Details |
| A24565 | 24121382 | Hormones (Athens) | Sex steroids and sex hormone-binding globulin in postmenopausal women with nonalcoholic fatty liver disease. | 2014 | Details |
| A25024 | 22239319 | Obes Rev | Oestradiol is a protective factor for non-alcoholic fatty liver disease in healthy men. | 2012 | Details |
| A25256 | 22037452 | Biochem Biophys Res Commun | 17β-Estradiol attenuates saturated fatty acid diet-induced liver injury in ovariectomized mice by up-regulating hepatic senescence marker protein-30. | 2011 | Details |
| A25405 | 21885686 | Am J Physiol Gastrointest Liver Physiol | Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet. | 2011 | Details |
| A25426 | 21862168 | Diabetes Res Clin Pract | Serum sex hormone-binding globulin levels are independently associated with nonalcoholic fatty liver disease in people with type 2 diabetes. | 2011 | Details |
| A25566 | 21705395 | J Endocrinol | A selective estrogen receptor α agonist ameliorates hepatic steatosis in the male aromatase knockout mouse. | 2011 | Details |
| A26124 | 21057159 | Ann Hepatol | Prevalence of non alcoholic fatty liver disease in premenopausal, posmenopausal and polycystic ovary syndrome women. The role of estrogens. | 2011 | Details |
| A27668 | 17708600 | World J Gastroenterol | Female hepatology: favorable role of estrogen in chronic liver disease with hepatitis B virus infection. | 2007 | Details |
| A27804 | 17397511 | Hepatol Res | Protection of estrogens against the progression of chronic liver disease. | 2007 | Details |
| A27977 | 16817817 | Clin Endocrinol (Oxf) | Effects of HRT on liver enzyme levels in women with type 2 diabetes: a randomized placebo-controlled trial. | 2006 | Details |
| A30407 | 32493884 | Exp Anim | Gender difference in development of steatohepatitis in p62/Sqstm1 and Nrf2 double-knockout mice. | 2020 | Details |
| A34509 | 23281043 | Hepatology | Brahma-related gene 1 bridges epigenetic regulation of proinflammatory cytokine production to steatohepatitis in mice. | 2013 | Details |
| A37113 | 16446999 | Arch Environ Contam Toxicol | Mercury concentrations in gonad, liver, and muscle of white sturgeon Acipenser transmontanus in the lower Columbia River. | 2006 | Details |
| A37886 | 12857433 | Gynecol Endocrinol | Estradiol/progesterone-releasing vaginal rings for hormone replacement therapy in postmenopausal women. | 2003 | Details |
| A38044 | 12413986 | Fertil Steril | Vaginal rings delivering progesterone and estradiol may be a new method of hormone replacement therapy. | 2002 | Details |
| A38323 | 11560246 | Toxicol Pathol | The roles of estrogen and progestin in producing deciduosarcoma and other lesions in the rabbit. | 2002 | Details |
| A38674 | 10601920 | Am J Obstet Gynecol | Estradiol-delivering vaginal rings for hormone replacement therapy. | 1999 | Details |
| A39098 | 9032744 | Maturitas | Estradiol delivery by vaginal rings: potential for hormone replacement therapy. | 1997 | Details |
| A39951 | 1900200 | Biochim Biophys Acta | Enzymic synthesis of steroid sulphates. XVII. On the structure of bovine estrogen sulphotransferase. | 1991 | Details |
| A42455 | 34496266 | J Ethnopharmacol | Xiaoyao San attenuates hepatic steatosis through estrogen receptor α pathway in ovariectomized ApoE-/- mice. | 2021 | Details |
| A43986 | 30217819 | J Biol Chem | Impact of 17β-estradiol on complex I kinetics and H2O2 production in liver and skeletal muscle mitochondria. | 2018 | Details |
| A44598 | 28043364 | Theriogenology | Inhibition of peripubertal sheep mammary gland development by cysteamine through reducing progesterone and growth factor production. | 2016 | Details |
| A44681 | 27746822 | Evid Based Complement Alternat Med | Effects of Hot Water Extracts from Polygonum multiflorum on Ovariectomy Induced Osteopenia in Mice. | 2016 | Details |
| A45727 | 23047983 | Am J Physiol Endocrinol Metab | Maternal androgen excess reduces placental and fetal weights, increases placental steroidogenesis, and leads to long-term health effects in their female offspring. | 2012 | Details |
| A46566 | 17547681 | Clin Endocrinol (Oxf) | A novel compound heterozygous mutation of the aromatase gene in an adult man: reinforced evidence on the relationship between congenital oestrogen deficiency, adiposity and the metabolic syndrome. | 2007 | Details |
| A46797 | 15345470 | Am J Physiol Gastrointest Liver Physiol | Reduced hepatic extraction of palmitate in steatosis correlated to lower level of liver fatty acid binding protein. | 2004 | Details |
| A47459 | 1461852 | Postgrad Med J | Severity of alcoholic liver disease and markers of thyroid and steroid status. | 1992 | Details |
| A48414 | 12058881 | Intern Med | Tamoxifen-induced nonalcoholic steatohepatitis in breast cancer patients treated with adjuvant tamoxifen. | 2002 | Details |
| A48490 | 6873594 | Gastroenterol Jpn | "Nonalcoholic steatohepatitis" induced by massive doses of synthetic estrogen. | 1983 | Details |
| A49048 | 20064513 | Gastroenterology | Gender dimorphic formation of mouse Mallory-Denk bodies and the role of xenobiotic metabolism and oxidative stress. | 2010 | Details |
| A49475 | 35741728 | Genes (Basel) | Associations of Sex Steroids and Sex Hormone-Binding Globulin with Non-Alcoholic Fatty Liver Disease: A Population-Based Study and Meta-Analysis. | 2022 | Details |
| A49493 | 35738176 | Biomed Pharmacother | Sex hormone binding globulin as a potential drug candidate for liver-related metabolic disorders treatment. | 2022 | Details |
| A49828 | 35625920 | Biomedicines | Premenopausal Syndrome and NAFLD: A New Approach Based on Gender Medicine. | 2022 | Details |
| A49889 | 35606076 | Atherosclerosis | Non-genetic influences on lipoprotein(a) concentrations. | 2022 | Details |
| A50628 | 35321990 | Endocr J | Associations between sex hormones and metabolic-associated fatty liver disease in a middle-aged and elderly community. | 2022 | Details |
| A51641 | 35364299 | Mol Metab | Hepatic adropin is regulated by estrogen and contributes to adverse metabolic phenotypes in ovariectomized mice. | 2022 | Details |
| A52191 | 30282988 | Sci Rep | Maternal high-fat diet consumption induces sex-dependent alterations of the endocannabinoid system and redox homeostasis in liver of adult rat offspring. | 2018 | Details |
| A52257 | 29641977 | Toxicol Appl Pharmacol | Chronic low-dose exposure of nonylphenol alters energy homeostasis in the reproductive system of female rats. | 2018 | Details |
| A52404 | 27552247 | Endocrinology | Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice. | 2016 | Details |
| A52480 | 26491440 | Int J Endocrinol | Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis. | 2015 | Details |
| A52504 | 26265751 | Physiol Rep | Ovariectomy results in differential shifts in gut microbiota in low versus high aerobic capacity rats. | 2015 | Details |
| A52699 | 23341867 | PLoS One | Angiotensin AT(2) receptor contributes towards gender bias in weight gain. | 2013 | Details |
| A52805 | 21536228 | Gend Med | Relations of adiponectin to levels of metabolic parameters and sexual hormones in elderly type 2 diabetic patients. | 2011 | Details |
| A53159 | 9243107 | Diabetologia | Short-term oestrogen replacement therapy improves insulin resistance, lipids and fibrinolysis in postmenopausal women with NIDDM. | 1997 | Details |