Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Toll-like receptor 4290 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00450 | 35077907 | Environ Toxicol Pharmacol | Enterobacter cloacae aggravates metabolic disease by inducing inflammation and lipid accumulation. | 2022 | Details |
| A00598 | 35035359 | Front Physiol | Exercise Alleviates the Apolipoprotein A5-Toll-Like Receptor 4 Axis Impairment in Mice With High-Fat Diet-Induced Non-alcoholic Steatohepatitis. | 2021 | Details |
| A00875 | 34943814 | Cells | Exercise-Induced Irisin Decreases Inflammation and Improves NAFLD by Competitive Binding with MD2. | 2021 | Details |
| A00969 | 34915801 | Pharm Biol | Jiang Zhi Granule protects immunological barrier of intestinal mucosa in rats with non-alcoholic steatohepatitis. | 2021 | Details |
| A01443 | 34743980 | Eur J Pharmacol | Preventive and therapeutic role of betaine in liver disease: A review on molecular mechanisms. | 2021 | Details |
| A01446 | 34742934 | Arch Biochem Biophys | The probiotic effects of AB23A on high-fat-diet-induced non-alcoholic fatty liver disease in mice may be associated with suppressing the serum levels of lipopolysaccharides and branched-chain amino acids. | 2021 | Details |
| A01652 | 34667947 | JHEP Rep | New targets for NAFLD. | 2021 | Details |
| A01696 | 34651580 | J Clin Invest | Sparcl1 promotes nonalcoholic steatohepatitis progression in mice through upregulation of CCL2. | 2021 | Details |
| A01969 | 34548598 | Sci Rep | Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis. | 2021 | Details |
| A01980 | 34543583 | Arch Physiol Biochem | Dipeptedyl peptidase-4 (DPP-4) inhibitor downregulates HMGB1/TLR4/NF-κB signaling pathway in a diabetic rat model of non-alcoholic fatty liver disease. | 2021 | Details |
| A02165 | 34478730 | Arch Biochem Biophys | Luteolin alleviates non-alcoholic fatty liver disease in rats via restoration of intestinal mucosal barrier damage and microbiota imbalance involving in gut-liver axis. | 2021 | Details |
| A02254 | 34445644 | Int J Mol Sci | Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome. | 2021 | Details |
| A02307 | 34426178 | J Integr Med | Hepatic protective effects of Shenling Baizhu powder, a herbal compound, against inflammatory damage via TLR4/NLRP3 signalling pathway in rats with nonalcoholic fatty liver disease. | 2021 | Details |
| A02462 | 34363921 | J Hepatol | Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis. | 2021 | Details |
| A02583 | 34322898 | Hepatology | Guanine Nucleotide-Binding Protein G(i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1-Related Inflammation and Lipophagy. | 2021 | Details |
| A02898 | 34203178 | Int J Mol Sci | Intestinal Permeability Is a Mechanical Rheostat in the Pathogenesis of Liver Cirrhosis. | 2021 | Details |
| A03017 | 34162749 | Sci Transl Med | Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis. | 2021 | Details |
| A03252 | 34070893 | Mar Drugs | Attenuating Effects of Dieckol on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Decreasing the NLRP3 Inflammasome and Pyroptosis. | 2021 | Details |
| A03665 | 33915261 | J Nutr Biochem | Consumption of soybean or olive oil at recommended concentrations increased the intestinal microbiota diversity and insulin sensitivity and prevented fatty liver compared to the effects of coconut oil. | 2021 | Details |
| A03945 | 33810882 | Clin Investig Arterioscler | Alleviation of non-alcoholic fatty liver disease by Huazhi Fugan Granules is associated with suppression of TLR4/NF-κB signaling pathway. | 2021 | Details |
| A04419 | 33626003 | Turk J Gastroenterol | Berberine inhibits liver damage in rats with non-alcoholic fatty liver disease by regulating TLR4/MyD88/NF-κB pathway. | 2020 | Details |
| A04654 | 33550112 | Redox Biol | Citrulline supplementation attenuates the development of non-alcoholic steatohepatitis in female mice through mechanisms involving intestinal arginase. | 2021 | Details |
| A04874 | 33471632 | Am J Physiol Gastrointest Liver Physiol | Bacterial and eukaryotic extracellular vesicles and nonalcoholic fatty liver disease: new players in the gut-liver axis? | 2021 | Details |
| A05062 | 33390939 | Front Pharmacol | Inulin Exerts Beneficial Effects on Non-Alcoholic Fatty Liver Disease via Modulating gut Microbiome and Suppressing the Lipopolysaccharide-Toll-Like Receptor 4-Mψ-Nuclear Factor-κB-Nod-Like Receptor Protein 3 Pathway via gut-Liver Axis in Mice. | 2020 | Details |
| A05342 | 33294831 | JHEP Rep | Macrophage-derived thrombospondin 1 promotes obesity-associated non-alcoholic fatty liver disease. | 2020 | Details |
| A05457 | 33249742 | Mol Nutr Food Res | Catechin-Rich Green Tea Extract and the Loss-of-TLR4 Signaling Differentially Alter the Hepatic Metabolome in Mice with Nonalcoholic Steatohepatitis. | 2020 | Details |
| A05631 | 33182043 | Int Immunopharmacol | Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice. | 2020 | Details |
| A05780 | 33121337 | Cell Cycle | Gypenosides improves nonalcoholic fatty liver disease induced by high-fat diet induced through regulating LPS/TLR4 signaling pathway. | 2020 | Details |
| A05788 | 33116732 | Diabetes Metab Syndr Obes | Serum LPS and CD163 Biomarkers Confirming the Role of Gut Dysbiosis in Overweight Patients with NASH. | 2020 | Details |
| A06030 | 33034193 | J Agric Food Chem | High-Fat Proteins Drive Dynamic Changes in Gut Microbiota, Hepatic Metabolome, and Endotoxemia-TLR-4-NFκB-Mediated Inflammation in Mice. | 2020 | Details |
| A06309 | 32933722 | Tissue Cell | Liraglutide in combination with human umbilical cord mesenchymal stem cell could improve liver lesions by modulating TLR4/NF-kB inflammatory pathway and oxidative stress in T2DM/NAFLD rats. | 2020 | Details |
| A06322 | 32929325 | Theranostics | Lack of FGF21 promotes NASH-HCC transition via hepatocyte-TLR4-IL-17A signaling. | 2020 | Details |
| A06327 | 32927776 | Nutrients | New Insights into the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Gut-Derived Lipopolysaccharides and Oxidative Stress. | 2020 | Details |
| A06478 | 32863955 | Theranostics | Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid metabolism disorder. | 2020 | Details |
| A06628 | 32801031 | J Nutr Biochem | Anti-inflammatory activities of green tea catechins along the gut-liver axis in nonalcoholic fatty liver disease: lessons learned from preclinical and human studies. | 2020 | Details |
| A06752 | 32759852 | Int J Mol Sci | Effective Combination Therapy of Angiotensin-II Receptor Blocker and Rifaximin for Hepatic Fibrosis in Rat Model of Nonalcoholic Steatohepatitis. | 2020 | Details |
| A06756 | 32758573 | Eur J Pharmacol | Gut microbiota modulation as a promising therapy with metformin in rats with non-alcoholic steatohepatitis: Role of LPS/TLR4 and autophagy pathways. | 2020 | Details |
| A06809 | 32738301 | Biochim Biophys Acta Mol Cell Biol Lipids | Palmitoleic acid reduces high fat diet-induced liver inflammation by promoting PPAR-γ-independent M2a polarization of myeloid cells. | 2020 | Details |
| A06927 | 32695965 | JHEP Rep | Imaging and immunometabolic phenotyping uncover changes in the hepatic immune response in the early phases of NAFLD. | 2020 | Details |
| A07100 | 32622362 | J Neuroinflammation | Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis. | 2020 | Details |
| A07309 | 32545403 | Int J Mol Sci | Relationship between IL-8 Circulating Levels and TLR2 Hepatic Expression in Women with Morbid Obesity and Nonalcoholic Steatohepatitis. | 2020 | Details |
| A07311 | 32544504 | Eur J Pharmacol | Vitexin ameliorates chronic stress plub high fat diet-induced nonalcoholic fatty liver disease by inhibiting inflammation. | 2020 | Details |
| A07320 | 32540565 | Environ Pollut | Bisphenol A exposure induces gut microbiota dysbiosis and consequent activation of gut-liver axis leading to hepatic steatosis in CD-1 mice. | 2020 | Details |
| A07436 | 32497536 | Metabolism | Fortifying diet with rapeseed oil instead of butterfat attenuates the progression of diet-induced non-alcoholic fatty liver disease (NAFLD) and impairment of glucose tolerance. | 2020 | Details |
| A07577 | 32437795 | Life Sci | TLR4 knockout upregulates the expression of Mfn2 and PGC-1α in a high-fat diet and ischemia-reperfusion mice model of liver injury. | 2020 | Details |
| A07647 | 32410294 | J Cell Mol Med | Magnesium isoglycyrrhizinate prevents the nonalcoholic hepatic steatosis via regulating energy homeostasis. | 2020 | Details |
| A07814 | 32348835 | Life Sci | Exenatide ameliorates experimental non-alcoholic fatty liver in rats via suppression of toll-like receptor 4/NFκB signaling: Comparison to metformin. | 2020 | Details |
| A07816 | 32347583 | FASEB J | Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll-like 4 receptor signaling. | 2020 | Details |
| A07865 | 32330379 | Cell Physiol Biochem | Genistein and 17β-Estradiol Protect Hepatocytes from Fatty Degeneration by Mechanisms Involving Mitochondria, Inflammasome and Kinases Activation. | 2020 | Details |
| A08006 | 32281563 | J Oleo Sci | Epigallocatechin Gallate Suppresses Inflammatory Responses by Inhibiting Toll-like Receptor 4 Signaling and Alleviates Insulin Resistance in the Livers of High-fat-diet Rats. | 2020 | Details |
| A08133 | 32235497 | Nutrients | Oral Supplementation of Sodium Butyrate Attenuates the Progression of Non-Alcoholic Steatohepatitis. | 2020 | Details |
| A08283 | 32169759 | Biomed Pharmacother | Gegen Qinlian Decoction abates nonalcoholic steatohepatitis associated liver injuries via anti-oxidative stress and anti-inflammatory response involved inhibition of toll-like receptor 4 signaling pathways. | 2020 | Details |
| A08393 | 32128893 | J Gastroenterol Hepatol | Regulation of lipid-induced macrophage polarization through modulating peroxisome proliferator-activated receptor-gamma activity affects hepatic lipid metabolism via a Toll-like receptor 4/NF-κB signaling pathway. | 2020 | Details |
| A08672 | 32026851 | Med Sci Monit | The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid. | 2020 | Details |
| A08681 | 32024509 | BMC Complement Med Ther | Structural modulation of gut microbiota during alleviation of non-alcoholic fatty liver disease with Gynostemma pentaphyllum in rats. | 2020 | Details |
| A08696 | 32019793 | mBio | Endotoxin Producers Overgrowing in Human Gut Microbiota as the Causative Agents for Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A08873 | 31955065 | Int Immunopharmacol | Baicalin and its nanoliposomes ameliorates nonalcoholic fatty liver disease via suppression of TLR4 signaling cascade in mice. | 2020 | Details |
| A09109 | 31870746 | Ann Hepatol | Peroxisomal footprint in the pathogenesis of nonalcoholic steatohepatitis. | 2019 | Details |
| A09276 | 31808577 | Hepatology | Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD. | 2020 | Details |
| A09338 | 31786271 | Physiol Behav | Modulation of hippocampal TLR4/BDNF signal pathway using probiotics is a step closer towards treating cognitive impairment in NASH model. | 2019 | Details |
| A09888 | 31574193 | Mol Nutr Food Res | Green Tea Extract Treatment in Obese Mice with Nonalcoholic Steatohepatitis Restores the Hepatic Metabolome in Association with Limiting Endotoxemia-TLR4-NFκB-Mediated Inflammation. | 2019 | Details |
| A09892 | 31572482 | Arch Med Sci | Effect of Lactobacillus paracasei N1115 and fructooligosaccharides in nonalcoholic fatty liver disease. | 2019 | Details |
| A10071 | 31503268 | Food Funct | Green tea extract inhibits early oncogenic responses in mice with nonalcoholic steatohepatitis. | 2019 | Details |
| A10226 | 31421545 | Int Immunopharmacol | Scoparone alleviates inflammation, apoptosis and fibrosis of non-alcoholic steatohepatitis by suppressing the TLR4/NF-κB signaling pathway in mice. | 2019 | Details |
| A10316 | 31388695 | Diabetologia | Genetic inactivation of the LIGHT (TNFSF14) cytokine in mice restores glucose homeostasis and diminishes hepatic steatosis. | 2019 | Details |
| A10737 | 31215394 | Mol Med | FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic fatty liver disease. | 2019 | Details |
| A10840 | 31163617 | Int J Mol Sci | Exogenous Administration of Low-Dose Lipopolysaccharide Potentiates Liver Fibrosis in a Choline-Deficient l-Amino-Acid-Defined Diet-Induced Murine Steatohepatitis Model. | 2019 | Details |
| A10940 | 31113580 | Ann Hepatol | miR-182-5p Attenuates High-Fat -Diet-Induced Nonalcoholic Steatohepatitis in Mice. | 2020 | Details |
| A10963 | 31101239 | Arch Med Res | Intestinal Trefoil Factor 3 Alleviates the Intestinal Barrier Function Through Reducing the Expression of TLR4 in Rats with Nonalcoholic Steatohepatitis. | 2019 | Details |
| A11032 | 31076404 | Gut | Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis. | 2019 | Details |
| A11105 | 31040374 | Sci Rep | Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine. | 2019 | Details |
| A11195 | 31004566 | Biochem Pharmacol | Telmisartan and/or chlorogenic acid attenuates fructose-induced non-alcoholic fatty liver disease in rats: Implications of cross-talk between angiotensin, the sphingosine kinase/sphingoine-1-phosphate pathway, and TLR4 receptors. | 2019 | Details |
| A11796 | 30737662 | Inflammation | Saroglitazar Deactivates the Hepatic LPS/TLR4 Signaling Pathway and Ameliorates Adipocyte Dysfunction in Rats with High-Fat Emulsion/LPS Model-Induced Non-alcoholic Steatohepatitis. | 2019 | Details |
| A11937 | 30673851 | Med Mol Morphol | The therapeutic effects of resveratrol on hepatic steatosis in high-fat diet-induced obese mice by improving oxidative stress, inflammation and lipid-related gene transcriptional expression. | 2019 | Details |
| A12024 | 30639268 | Chem Biol Interact | Chronic intake of moderate fat-enriched diet induces fatty liver and low-grade inflammation without obesity in rabbits. | 2019 | Details |
| A12092 | 30605883 | Redox Biol | Consumption of decaffeinated coffee protects against the development of early non-alcoholic steatohepatitis: Role of intestinal barrier function. | 2018 | Details |
| A12108 | 30599260 | Free Radic Biol Med | Loss of RIP3 initiates annihilation of high-fat diet initialized nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4 and oxidative stress. | 2018 | Details |
| A12262 | 30525304 | Mol Nutr Food Res | SIRT3 Deficiency Promotes High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Correlation with Impaired Intestinal Permeability through Gut Microbial Dysbiosis. | 2018 | Details |
| A12291 | 30527903 | Hepatobiliary Pancreat Dis Int | Gut microbial dysbiosis associates hepatocellular carcinoma via the gut-liver axis. | 2018 | Details |
| A12580 | 30379980 | Acta Biochim Biophys Sin (Shanghai) | Chronic intermittent hypoxia promotes the development of experimental non-alcoholic steatohepatitis by modulating Treg/Th17 differentiation. | 2018 | Details |
| A12898 | 30235807 | Diseases | Emerging Therapeutic Targets and Experimental Drugs for the Treatment of NAFLD. | 2018 | Details |
| A12929 | 30221732 | Mol Med Rep | Inhibition of CCL19 benefits non‑alcoholic fatty liver disease by inhibiting TLR4/NF‑κB‑p65 signaling. | 2018 | Details |
| A12987 | 30194936 | Eur J Pharmacol | Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent. | 2018 | Details |
| A13186 | 30096092 | Eur J Gastroenterol Hepatol | Rifaximin in nonalcoholic fatty liver disease: hit multiple targets with a single shot. | 2018 | Details |
| A13278 | 30054551 | Sci Rep | Palmitate-induced lipotoxicity is crucial for the pathogenesis of nonalcoholic fatty liver disease in cooperation with gut-derived endotoxin. | 2018 | Details |
| A13318 | 30034633 | Oncotarget | Toll-like receptor 4: a target for chemoprevention of hepatocellular carcinoma in obesity and steatohepatitis. | 2018 | Details |
| A13363 | 30015859 | Int J Mol Med | Effect of celastrol on toll‑like receptor 4‑mediated inflammatory response in free fatty acid‑induced HepG2 cells. | 2018 | Details |
| A13479 | 29956204 | Adv Exp Med Biol | Pathogenesis of NASH: How Metabolic Complications of Overnutrition Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease. | 2018 | Details |
| A13902 | 29701903 | Mol Nutr Food Res | Impact of miR-140 Deficiency on Non-Alcoholic Fatty Liver Disease. | 2018 | Details |
| A13954 | 29673059 | J Cell Mol Med | The TLR4-IRE1α pathway activation contributes to palmitate-elicited lipotoxicity in hepatocytes. | 2018 | Details |
| A13966 | 29666152 | J Endocrinol | Phenylmethimazole abrogates diet-induced inflammation, glucose intolerance and NAFLD. | 2018 | Details |
| A14591 | 29335857 | Chin J Integr Med | Effect of Soothing Gan (Liver) and Invigorating Pi (Spleen) Recipes on TLR4-p38 MAPK Pathway in Kupffer Cells of Non-alcoholic Steatohepatitis Rats. | 2018 | Details |
| A14622 | 29319180 | J Cell Physiol | WISP1 promotes non-alcoholic fatty liver disease and skeletal muscle insulin resistance via TLR4/JNK signaling. | 2018 | Details |
| A14727 | 29269727 | Nat Commun | Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4-MD2 complex. | 2017 | Details |
| A14746 | 29259643 | Evid Based Complement Alternat Med | Dahuang Zexie Decoction Protects against High-Fat Diet-Induced NAFLD by Modulating Gut Microbiota-Mediated Toll-Like Receptor 4 Signaling Activation and Loss of Intestinal Barrier. | 2017 | Details |
| A14793 | 29229391 | Biochem Biophys Res Commun | Hepatocyte-specific clusterin overexpression attenuates diet-induced nonalcoholic steatohepatitis. | 2017 | Details |
| A14887 | 29190550 | J Nutr Biochem | Green tea extract protects against hepatic NFκB activation along the gut-liver axis in diet-induced obese mice with nonalcoholic steatohepatitis by reducing endotoxin and TLR4/MyD88 signaling. | 2017 | Details |
| A14957 | 29156529 | Biomed Pharmacother | Alpinetin improved high fat diet-induced non-alcoholic fatty liver disease (NAFLD) through improving oxidative stress, inflammatory response and lipid metabolism. | 2017 | Details |
| A15064 | 29113135 | Nutrients | Nonalcoholic Fatty Liver Disease Is Exacerbated in High-Fat Diet-Fed Gnotobiotic Mice by Colonization with the Gut Microbiota from Patients with Nonalcoholic Steatohepatitis. | 2017 | Details |
| A15103 | 29093267 | JCI Insight | Loss of miR-141/200c ameliorates hepatic steatosis and inflammation by reprogramming multiple signaling pathways in NASH. | 2017 | Details |