Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00004 | 35258780 | Chin J Integr Med | Protective Roles of Shilajit in Modulating Resistin, Adiponectin, and Cytokines in Rats with Non-alcoholic Fatty Liver Disease. | 2022 | Details |
| A00203 | 35187967 | Exp Biol Med (Maywood) | Iron-accumulating splenocytes may exacerbate non-alcoholic steatohepatitis through the production of proinflammatory cytokines and reactive oxygen species. | 2022 | Details |
| A00213 | 35182670 | J Ethnopharmacol | Gryllus bimaculatus De Geer hydrolysates alleviate lipid accumulation, inflammation, and endoplasmic reticulum stress in palmitic acid-treated human hepatoma G2 cells. | 2022 | Details |
| A00251 | 35164657 | Bioengineered | Liraglutide inhibits receptor for advanced glycation end products (RAGE)/reduced form of nicotinamide-adenine dinucleotide phosphate (NAPDH) signaling to ameliorate non-alcoholic fatty liver disease (NAFLD) in vivo and vitro. | 2022 | Details |
| A00342 | 35127372 | Acta Pharm Sin B | The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy. | 2021 | Details |
| A00390 | 35104757 | Phytomedicine | Seed oil of Rosa roxburghii Tratt against non-alcoholic fatty liver disease in vivo and in vitro through PPARα/PGC-1α-mediated mitochondrial oxidative metabolism. | 2022 | Details |
| A00430 | 35087037 | Cell Death Dis | Long-term oral administration of an HNF4α agonist prevents weight gain and hepatic steatosis by promoting increased mitochondrial mass and function. | 2022 | Details |
| A00469 | 35069993 | World J Hepatol | Liver-side of inflammatory bowel diseases: Hepatobiliary and drug-induced disorders. | 2021 | Details |
| A00490 | 35063810 | Nutrition | Satellite cell content and muscle regeneration in a mouse model of NAFLD. | 2021 | Details |
| A00583 | 35040254 | Chem Biol Drug Des | SU5, a new Auraptene analog with improved metabolic stability, ameliorates nonalcoholic fatty liver disease in methionine- and choline-deficient diet-fed db/db mice. | 2022 | Details |
| A00658 | 35013040 | J Oleo Sci | Pink Lotus Essential Oil and Alleviates on Free Fatty Acid Induced Steatosis in HepG2 Cells via PI3K/Akt and NF-κB Pathways. | 2022 | Details |
| A00666 | 35010924 | Nutrients | Lactoferrin Prevents Hepatic Injury and Fibrosis via the Inhibition of NF-κB Signaling in a Rat Non-Alcoholic Steatohepatitis Model. | 2021 | Details |
| A00687 | 35003513 | Oxid Med Cell Longev | TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization. | 2021 | Details |
| A00775 | 34971904 | Biochem Biophys Res Commun | Hepatoprotective effects of gemigliptin and empagliflozin in a murine model of diet-induced non-alcoholic fatty liver disease. | 2021 | Details |
| A00869 | 34944525 | Biomolecules | A System-Level Mechanism of Anmyungambi Decoction for Obesity: A Network Pharmacological Approach. | 2021 | Details |
| A00871 | 34944021 | Cells | IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism. | 2021 | Details |
| A00895 | 34938205 | Front Physiol | Ectodysplasin A/Ectodysplasin A Receptor System and Their Roles in Multiple Diseases. | 2021 | Details |
| A00908 | 34933425 | Zhonghua Gan Zang Bing Za Zhi | [Intestinal flora polymorphisms with different lesional stages in an animal model of MAFLD]. | 2021 | Details |
| A00946 | 34922604 | Trials | Omega-3 mechanism of action in inflammation and endoplasmic reticulum stress in mononuclear cells from overweight non-alcoholic fatty liver disease participants: study protocol for the "Brazilian Omega Study" (BROS)-a randomized controlled trial. | 2021 | Details |
| A00950 | 34921696 | Biofactors | High-fat-induced nonalcoholic fatty liver potentiates vulnerability to and the severity of viral hepatitis in a C3H/HeN mouse model. | 2021 | Details |
| A01074 | 34877910 | Expert Rev Gastroenterol Hepatol | Effects of probiotics on nonalcoholic fatty liver disease: a systematic review and meta-analysis. | 2021 | Details |
| A01096 | 34870139 | Metabol Open | Protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on intestine and liver. | 2021 | Details |
| A01098 | 34869957 | JACC Basic Transl Sci | Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction. | 2021 | Details |
| A01167 | 34847213 | Food Funct | Curcumin supplementation improves biomarkers of oxidative stress and inflammation in conditions of obesity, type 2 diabetes and NAFLD: updating the status of clinical evidence. | 2021 | Details |
| A01212 | 34828420 | Genes (Basel) | Circulatory Endothelin 1-Regulating RNAs Panel: Promising Biomarkers for Non-Invasive NAFLD/NASH Diagnosis and Stratification: Clinical and Molecular Pilot Study. | 2021 | Details |
| A01218 | 34825156 | JHEP Rep | Bile acids contribute to the development of non-alcoholic steatohepatitis in mice. | 2021 | Details |
| A01230 | 34821093 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | [Effects of curcumol on liver function and fibrosis in rats of nonalcoholic fatty liver disease and its mechanism]. | 2021 | Details |
| A01299 | 34797530 | Rheumatol Ther | Psoriatic Arthritis: The Influence of Co-morbidities on Drug Choice. | 2021 | Details |
| A01343 | 34781143 | Biomed Pharmacother | Carminic acid mitigates fructose-triggered hepatic steatosis by inhibition of oxidative stress and inflammatory reaction. | 2021 | Details |
| A01379 | 34768813 | Int J Mol Sci | The Ameliorative Effects of Saikosaponin in Thioacetamide-Induced Liver Injury and Non-Alcoholic Fatty Liver Disease in Mice. | 2021 | Details |
| A01405 | 34758532 | Zhonghua Yi Xue Za Zhi | [Analysis of hub genes and molecular mechanisms in non-alcoholic steatohepatitis based on the gene expression omnibus database]. | 2021 | Details |
| A01465 | 34737604 | J Inflamm Res | Curcumae Ameliorates Diethylnitrosamine-Induced Hepatocellular Carcinoma via Alteration of Oxidative Stress, Inflammation and Gut Microbiota. | 2021 | Details |
| A01533 | 34707201 | Sci Rep | Characterization of a murine model of endothelial dysfunction induced by chronic intraperitoneal administration of angiotensin II. | 2021 | Details |
| A01649 | 34668765 | J Med Food | Ameliorative Effect of Myricetin on Nonalcoholic Fatty Liver Disease in ob/ob Mice. | 2021 | Details |
| A01698 | 34651285 | J Physiol Biochem | Astaxanthin attenuates hepatic steatosis in high-fat diet-fed rats by suppressing microRNA-21 via transactivation of nuclear factor erythroid 2-related factor 2. | 2021 | Details |
| A01704 | 34649337 | Biomed Pharmacother | Jiangzhi Granule attenuates non-alcoholic steatohepatitis by suppressing TNF/NFκB signaling pathway-a study based on network pharmacology. | 2021 | Details |
| A01723 | 34638941 | Int J Mol Sci | MERTK+/hi M2c Macrophages Induced by Baicalin Alleviate Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A01843 | 34593018 | BMC Pharmacol Toxicol | Saroglitazar improved hepatic steatosis and fibrosis by modulating inflammatory cytokines and adiponectin in an animal model of non-alcoholic steatohepatitis. | 2021 | Details |
| A01846 | 34591986 | Hepatology | OTUB1 alleviates NASH through inhibition of the TRAF6-ASK1 signaling pathways. | 2021 | Details |
| A01875 | 34576229 | Int J Mol Sci | Methyl Brevifolincarboxylate Attenuates Free Fatty Acid-Induced Lipid Metabolism and Inflammation in Hepatocytes through AMPK/NF-κB Signaling Pathway. | 2021 | Details |
| A01882 | 34574082 | Foods | AGL9: A Novel Hepatoprotective Peptide from the Larvae of Edible Insects Alleviates Obesity-Induced Hepatic Inflammation by Regulating AMPK/Nrf2 Signaling. | 2021 | Details |
| A01991 | 34536973 | FEBS Lett | Transcription factor SOX2 contributes to nonalcoholic fatty liver disease development by regulating the expression of the fatty acid transporter CD36. | 2021 | Details |
| A01993 | 34536264 | Anat Rec (Hoboken) | Network pharmacology-based investigation to explore the effect and mechanism of Erchen decoction against the nonalcoholic fatty liver disease. | 2021 | Details |
| A02161 | 34479550 | BMC Complement Med Ther | Administration of hydro-alcoholic extract of spinach improves oxidative stress and inflammation in high-fat diet-induced NAFLD rats. | 2021 | Details |
| A02212 | 34459004 | J Food Biochem | Chlorella vulgaris is an effective supplement in counteracting non-alcoholic fatty liver disease-related complications through modulation of dyslipidemia, insulin resistance, and inflammatory pathways. | 2021 | Details |
| A02244 | 34447968 | J Anim Sci Technol | Effect of ciglitazone on adipogenic transdifferentiation of bovine skeletal muscle satellite cells. | 2021 | Details |
| A02272 | 34440652 | Cells | Long Non-Coding RNAs Involved in Progression of Non-Alcoholic Fatty Liver Disease to Steatohepatitis. | 2021 | Details |
| A02291 | 34434195 | Front Immunol | Caveolin-1 Deficiency Protects Mice Against Carbon Tetrachloride-Induced Acute Liver Injury Through Regulating Polarization of Hepatic Macrophages. | 2021 | Details |
| A02305 | 34427662 | Clin Sci (Lond) | Exposure to cigarette smoke precipitates simple hepatosteatosis to NASH in high-fat diet fed mice by inducing oxidative stress. | 2021 | Details |
| A02348 | 34407548 | Exp Clin Endocrinol Diabetes | Hepatic Meteorin-like and Krüppel-like Factor 3 are Associated with Weight Loss and Liver Injury. | 2021 | Details |
| A02426 | 34374658 | J Physiol Pharmacol | Hesperidin, a novel candidate for the successful treatment of high fat diet plus ethanol-induced fatty liver disease in mice. | 2021 | Details |
| A02444 | 34370215 | World J Pediatr | Increased asprosin is associated with non-alcoholic fatty liver disease in children with obesity. | 2021 | Details |
| A02662 | 34294375 | J Pharmacol Sci | Ferulic acid attenuates non-alcoholic steatohepatitis by reducing oxidative stress and inflammation through inhibition of the ROCK/NF-κB signaling pathways. | 2021 | Details |
| A02676 | 34289181 | J Gastroenterol Hepatol | Circulating tumor necrosis factor-α levels in non-alcoholic fatty liver disease: A systematic review and a meta-analysis. | 2021 | Details |
| A02709 | 34276380 | Front Pharmacol | Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1. | 2021 | Details |
| A02757 | 34257694 | Evid Based Complement Alternat Med | Alleviative Effect of Ruellia tuberosa L. on Insulin Resistance and Abnormal Lipid Accumulation in TNF-α-Treated FL83B Mouse Hepatocytes. | 2021 | Details |
| A02777 | 34245170 | J Food Biochem | Ziziphus spina-christi (L.) fortified with Camellia sinensis mediates apoptosis, Notch-1 signaling, and mitigates obesity-induced non-alcoholic fatty liver. | 2021 | Details |
| A02784 | 34242656 | Am J Pathol | Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Is Associated with Increased Intestinal Inflammation. | 2021 | Details |
| A02790 | 34239622 | Dis Markers | Jiangzhi Ligan Decoction Inhibits GSDMD-Mediated Canonical/Noncanonical Pyroptosis Pathways and Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A02794 | 34238176 | Curr Mol Pharmacol | The Protective Role of Etoricoxib Against Diethylnitrosamine/2-acetylaminofluorene- Induced Hepatocarcinogenesis in Wistar Rats: The Impact of NF-κB/COX-2/PGE2 Signaling. | 2022 | Details |
| A02846 | 34221262 | Gastroenterol Hepatol Bed Bench | Is melatonin associated with pro-inflammatory cytokine activity and liver fibrosis in non-alcoholic fatty liver disease (NAFLD) patients? | 2021 | Details |
| A02898 | 34203178 | Int J Mol Sci | Intestinal Permeability Is a Mechanical Rheostat in the Pathogenesis of Liver Cirrhosis. | 2021 | Details |
| A02970 | 34179049 | Front Med (Lausanne) | Exploring the Protective Effects and Mechanism of Crocetin From Saffron Against NAFLD by Network Pharmacology and Experimental Validation. | 2021 | Details |
| A02980 | 34175381 | Toxicology | Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms. | 2021 | Details |
| A03016 | 34162924 | Sci Rep | Validation of an adipose-liver human-on-a-chip model of NAFLD for preclinical therapeutic efficacy evaluation. | 2021 | Details |
| A03087 | 34136174 | Food Sci Nutr | Synergistic effects of black ginseng and aged garlic extracts for the amelioration of nonalcoholic fatty liver disease (NAFLD) in mice. | 2021 | Details |
| A03106 | 34129252 | J Gastroenterol Hepatol | The effects of dapagliflozin on hepatic and visceral fat in type 2 diabetes patients with non-alcoholic fatty liver disease. | 2021 | Details |
| A03127 | 34119629 | J Nutr Biochem | Sugar kelp (Saccharina latissima) inhibits hepatic inflammation and fibrosis in a mouse model of diet-induced nonalcoholic steatohepatitis. | 2021 | Details |
| A03188 | 34095305 | Biomed Res Int | A Combination of Geniposide and Chlorogenic Acid Combination Ameliorates Nonalcoholic Steatohepatitis in Mice by Inhibiting Kupffer Cell Activation. | 2021 | Details |
| A03318 | 34047129 | Zhongguo Zhong Yao Za Zhi | [Effect of total saponins from Panax japonicus on non-alcoholic steatohepatitis by regulating autophagy]. | 2021 | Details |
| A03377 | 34025131 | J Ginseng Res | Effect of Korean Red Ginseng on metabolic syndrome. | 2020 | Details |
| A03378 | 34025071 | World J Gastroenterol | Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis. | 2021 | Details |
| A03424 | 34004342 | J Nutr Biochem | Saskatoon berry powder reduces hepatic steatosis and insulin resistance in high fat-high sucrose diet-induced obese mice. | 2021 | Details |
| A03479 | 33989346 | PLoS One | Is there a role for neuregulin 4 in human nonalcoholic fatty liver disease? | 2021 | Details |
| A03507 | 33977953 | Food Funct | Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD. | 2021 | Details |
| A03726 | 33889834 | Metabol Open | Non-alcoholic fatty liver disease is a risk factor for occurrence of hepatocellular carcinoma after sustained virologic response in chronic hepatitis C patients: A prospective four-years follow-up study. | 2021 | Details |
| A03747 | 33879188 | Lipids Health Dis | TWIST2 and the PPAR signaling pathway are important in the progression of nonalcoholic steatohepatitis. | 2021 | Details |
| A03869 | 33838673 | Nutr J | Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-controlled, clinical trial. | 2021 | Details |
| A03927 | 33815606 | Exp Ther Med | Cytokines, paraoxonase-1, periostin and non-invasive liver fibrosis scores in patients with non-alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study. | 2021 | Details |
| A03945 | 33810882 | Clin Investig Arterioscler | Alleviation of non-alcoholic fatty liver disease by Huazhi Fugan Granules is associated with suppression of TLR4/NF-κB signaling pathway. | 2021 | Details |
| A03952 | 33809593 | Nutrients | Fortifying Butterfat with Soybean Oil Attenuates the Onset of Diet-Induced Non-Alcoholic Steatohepatitis and Glucose Intolerance. | 2021 | Details |
| A04044 | 33777700 | Toxicol Rep | Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis. | 2021 | Details |
| A04045 | 33777674 | Acta Pharm Sin B | S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling. | 2020 | Details |
| A04063 | 33772456 | Indian J Gastroenterol | Efficacy of combining pentoxiphylline and vitamin E versus vitamin E alone in non-alcoholic steatohepatitis- A randomized pilot study. | 2021 | Details |
| A04072 | 33769703 | Physiol Rep | ω-Imidazolyl-alkyl derivatives as new preclinical drug candidates for treating non-alcoholic steatohepatitis. | 2021 | Details |
| A04077 | 33768585 | Hepatology | Tumor Necrosis Factor α-Induced Protein 8-Like 2 Alleviates Nonalcoholic Fatty Liver Disease Through Suppressing Transforming Growth Factor Beta-Activated Kinase 1 Activation. | 2021 | Details |
| A04091 | 33763027 | Front Endocrinol (Lausanne) | Association and Interaction Between Serum Interleukin-6 Levels and Metabolic Dysfunction-Associated Fatty Liver Disease in Patients With Severe Coronavirus Disease 2019. | 2021 | Details |
| A04094 | 33762733 | Nature | NASH limits anti-tumour surveillance in immunotherapy-treated HCC. | 2021 | Details |
| A04098 | 33761609 | Biomed Pharmacother | Ethyl pyruvate supplemented in drinking water ameliorates experimental nonalcoholic steatohepatitis. | 2021 | Details |
| A04160 | 33733575 | Biofactors | Quercetin prevents cadmium chloride-induced hepatic steatosis and fibrosis by downregulating the transcription of miR-21. | 2021 | Details |
| A04169 | 33730435 | Hepatology | In Utero Exposure to Mercury Is Associated With Increased Susceptibility to Liver Injury and Inflammation in Childhood. | 2021 | Details |
| A04173 | 33728708 | Phytother Res | Effect of Nigella sativa in the treatment of nonalcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials. | 2021 | Details |
| A04192 | 33721354 | Clin Exp Pharmacol Physiol | Sodium butyrate ameliorates non-alcoholic fatty liver disease by upregulating miR-150 to suppress CXCR4 expression. | 2021 | Details |
| A04356 | 33648923 | Eur Cytokine Netw | Absence of increased liver-related inflammatory markers in type 1 diabetes with metabolic syndrome: a nested case-control study from Brazil. | 2020 | Details |
| A04370 | 33643422 | Evid Based Complement Alternat Med | Gegen Qinlian Decoction Ameliorates Nonalcoholic Fatty Liver Disease in Rats via Oxidative Stress, Inflammation, and the NLRP3 Signal Axis. | 2021 | Details |
| A04375 | 33642741 | J Indian Soc Periodontol | Association between nonalcoholic fatty liver disease and inflammatory periodontal disease: A case‑control study. | 2020 | Details |
| A04376 | 33642551 | Biol Pharm Bull | Deletion of TRPC3 or TRPC6 Fails to Attenuate the Formation of Inflammation and Fibrosis in Non-alcoholic Steatohepatitis. | 2021 | Details |
| A04387 | 33639080 | Int J Med Mushrooms | In Vitro Antioxidation, Antihepatic Steatosis, and Anti-Inflammatory Effects of Ethyl Acetate Fraction from Auricularia nigricans (Agaricomycetes). | 2021 | Details |
| A04534 | 33585009 | Gastroenterol Hepatol Bed Bench | Showing NAFLD, as a key connector disease between Alzheimer's disease and diabetes via analysis of systems biology. | 2020 | Details |
| A04618 | 33561256 | J Nutr | Dietary Fruit and Vegetable Supplementation Suppresses Diet-Induced Atherosclerosis in LDL Receptor Knockout Mice. | 2021 | Details |