Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Apoptosis Signal-regulating Kinase 138 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A01652 | 34667947 | JHEP Rep | New targets for NAFLD. | 2021 | Details |
| A01680 | 34656650 | J Hepatol | Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling. | 2021 | Details |
| A01846 | 34591986 | Hepatology | OTUB1 alleviates NASH through inhibition of the TRAF6-ASK1 signaling pathways. | 2021 | Details |
| A03067 | 34144391 | Redox Biol | Proteasome dysfunction under compromised redox metabolism dictates liver injury in NASH through ASK1/PPARγ binodal complementary modules. | 2021 | Details |
| A04207 | 33713358 | Hepatology | TNF-α-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1. | 2021 | Details |
| A07359 | 32526787 | Semin Liver Dis | Nonalcoholic Steatohepatitis Promoting Kinases. | 2020 | Details |
| A07397 | 32514497 | JHEP Rep | Combined alcoholic and non-alcoholic steatohepatitis. | 2020 | Details |
| A07905 | 32316235 | J Clin Med | The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis. | 2020 | Details |
| A07964 | 32297339 | Hepatology | Milk Fat Globule-Epidermal Growth Factor-Factor 8 Improves Hepatic Steatosis and Inflammation. | 2020 | Details |
| A08342 | 32147362 | J Hepatol | Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials. | 2020 | Details |
| A09534 | 31705800 | Hepatology | Interleukin-22 Ameliorates Neutrophil-Driven Nonalcoholic Steatohepatitis Through Multiple Targets. | 2020 | Details |
| A09830 | 31595673 | EMBO Mol Med | Liver ASK1 protects from non-alcoholic fatty liver disease and fibrosis. | 2019 | Details |
| A09967 | 31541591 | J Pineal Res | Melatonin safeguards against fatty liver by antagonizing TRAFs-mediated ASK1 deubiquitination and stabilization in a β-arrestin-1 dependent manner. | 2019 | Details |
| A11609 | 30820969 | Hepatology | Dual Specificity Phosphatase 12 Regulates Hepatic Lipid Metabolism Through Inhibition of the Lipogenesis and Apoptosis Signal-Regulating Kinase 1 Pathways. | 2019 | Details |
| A11866 | 30703849 | Hepatology | F-box/WD Repeat-Containing Protein 5 Mediates the Ubiquitination of Apoptosis Signal-Regulating Kinase 1 and Exacerbates Nonalcoholic Steatohepatitis in Mice. | 2019 | Details |
| A12898 | 30235807 | Diseases | Emerging Therapeutic Targets and Experimental Drugs for the Treatment of NAFLD. | 2018 | Details |
| A12967 | 30205811 | BMC Med | An exploratory study examining how nano-liquid chromatography-mass spectrometry and phosphoproteomics can differentiate patients with advanced fibrosis and higher percentage collagen in non-alcoholic fatty liver disease. | 2018 | Details |
| A13254 | 30063256 | Hepatology | Dual-Specificity Phosphatase 9 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through ASK1 Suppression. | 2018 | Details |
| A13843 | 29729191 | Hepatology | Caspase Recruitment Domain Protein 6 Protects Against Hepatic Steatosis and Insulin Resistance by Suppressing Apoptosis Signal-Regulating Kinase 1. | 2018 | Details |
| A14796 | 29227477 | Nat Med | The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis. | 2017 | Details |
| A15468 | 28892558 | Hepatology | The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial. | 2017 | Details |
| A15862 | 28677333 | Aliment Pharmacol Ther | Review article: new treatments in non-alcoholic fatty liver disease. | 2017 | Details |
| A16197 | 28508477 | Hepatology | The novel intracellular protein CREG inhibits hepatic steatosis, obesity, and insulin resistance. | 2017 | Details |
| A16515 | 28346237 | Curr Opin Gastroenterol | Current and future pharmacologic treatment of nonalcoholic steatohepatitis. | 2017 | Details |
| A18648 | 27016281 | J Hepatol | DKK3 expression in hepatocytes defines susceptibility to liver steatosis and obesity. | 2016 | Details |
| A23681 | 23567086 | J Hepatol | Decoding cell death signals in liver inflammation. | 2013 | Details |
| A29167 | 34482560 | Hepatology | Melanoma differentiation-Associated gene 5 protects against NASH in mice. | 2021 | Details |
| A30684 | 31996485 | JCI Insight | ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model. | 2020 | Details |
| A30889 | 31612792 | J Biomol Struct Dyn | Discovery of potent apoptosis signal-regulating kinase 1 inhibitors via integrated computational strategy and biological evaluation. | 2019 | Details |
| A31102 | 31222801 | Hepatology | Hepatocyte TNF Receptor-Associated Factor 6 Aggravates Hepatic Inflammation and Fibrosis by Promoting Lysine 6-Linked Polyubiquitination of Apoptosis Signal-Regulating Kinase 1. | 2019 | Details |
| A31241 | 30972180 | Am J Transl Res | Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype. | 2019 | Details |
| A31544 | 30315846 | Cancer Lett | Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells. | 2018 | Details |
| A31661 | 30084831 | J Lipid Res | Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice. | 2018 | Details |
| A43821 | 30791762 | Expert Rev Gastroenterol Hepatol | Apoptosis signal-regulating kinase-1 as a therapeutic target in nonalcoholic fatty liver disease. | 2019 | Details |
| A46957 | 32544093 | JCI Insight | Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPKα-dependent mechanisms. | 2020 | Details |
| A47764 | 32289582 | Eur J Med Chem | Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1). | 2020 | Details |
| A51251 | 35280676 | Int J Biol Sci | Hepatocyte-specific deletion of cellular repressor of E1A-stimulated genes 1 exacerbates alcohol-induced liver injury by activating stress kinases. | 2022 | Details |
| A51441 | 35352662 | Curr Top Med Chem | Probing the interaction of Selonsertib with human serum albumin: In silico and in vitro approaches. | 2022 | Details |