Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00095 | 35221291 | J Pharmacol Exp Ther | Resveratrol attenuates HFD-induced hepatic lipotoxicity by up-regulating Bmi-1 expression. | 2022 | Details |
| A00754 | 34979142 | Toxicol Appl Pharmacol | Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress. | 2021 | Details |
| A00879 | 34943221 | Biology (Basel) | Beta vulgaris L. (Beetroot) Methanolic Extract Prevents Hepatic Steatosis and Liver Damage in T2DM Rats by Hypoglycemic, Insulin-Sensitizing, Antioxidant Effects, and Upregulation of PPARα. | 2021 | Details |
| A01161 | 34848360 | J Ethnopharmacol | Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model. | 2021 | Details |
| A01185 | 34836315 | Nutrients | Network Pharmacology Exploration Reveals Anti-Apoptosis as a Common Therapeutic Mechanism for Non-Alcoholic Fatty Liver Disease Treated with Blueberry Leaf Polyphenols. | 2021 | Details |
| A01443 | 34743980 | Eur J Pharmacol | Preventive and therapeutic role of betaine in liver disease: A review on molecular mechanisms. | 2021 | Details |
| A01477 | 34733981 | Ann Transl Med | TLR2 inhibition ameliorates the amplification effect of LPS on lipid accumulation and lipotoxicity in hepatic cells. | 2021 | Details |
| A01679 | 34657040 | Cytogenet Genome Res | PinX1 Depletion Improves Liver Injury in a Mouse Model of Nonalcoholic Fatty Liver Disease via Increasing Telomerase Activity and Inhibiting Apoptosis. | 2021 | Details |
| A01787 | 34618611 | Immunopharmacol Immunotoxicol | Capillin protects against non-alcoholic steatohepatitis through suppressing NLRP3 inflammasome activation and oxidative stress. | 2021 | Details |
| A02243 | 34448436 | J Histochem Cytochem | Independent of Calorie Intake, Short-term Alternate-day Fasting Alleviates NASH, With Modulation of Markers of Lipogenesis, Autophagy, Apoptosis, and Inflammation in Rats. | 2021 | Details |
| A02388 | 34393793 | Front Pharmacol | Extracts of Vine Tea Improve Diet-Induced Non-Alcoholic Steatohepatitis Through AMPK-LXRα Signaling. | 2021 | Details |
| A02606 | 34311531 | Biomed Pharmacother | FTZ attenuates liver steatosis and fibrosis in the minipigs with type 2 diabetes by regulating the AMPK signaling pathway. | 2021 | Details |
| A02693 | 34280397 | Eur J Pharmacol | Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4. | 2021 | Details |
| A02777 | 34245170 | J Food Biochem | Ziziphus spina-christi (L.) fortified with Camellia sinensis mediates apoptosis, Notch-1 signaling, and mitigates obesity-induced non-alcoholic fatty liver. | 2021 | Details |
| A03926 | 33815655 | Oxid Med Cell Longev | Effect of Different Exercise Intensities on Hepatocyte Apoptosis in HFD-Induced NAFLD in Rats: The Possible Role of Endoplasmic Reticulum Stress through the Regulation of the IRE1/JNK and eIF2α/CHOP Signal Pathways. | 2021 | Details |
| A04289 | 33675775 | Biochem Pharmacol | Activation of FXR modulates SOCS3/Jak2/STAT3 signaling axis in a NASH-dependent hepatocellular carcinoma animal model. | 2021 | Details |
| A04764 | 33513383 | J Steroid Biochem Mol Biol | Long-term androgen excess induces insulin resistance and non-alcoholic fatty liver disease in PCOS-like rats. | 2021 | Details |
| A04822 | 33493657 | Pharmacol Res | Baicalin and the liver-gut system: Pharmacological bases explaining its therapeutic effects. | 2021 | Details |
| A05012 | 33410857 | Food Funct | Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling. | 2021 | Details |
| A05039 | 33397952 | Nat Commun | Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. | 2021 | Details |
| A05555 | 33207858 | Eur J Histochem | The selective blockade of metabotropic glutamate receptor-5 attenuates fat accumulation in an <em>in vitro</em> model of benign steatosis. | 2020 | Details |
| A05651 | 33172809 | Dig Liver Dis | Leptin induces NAFLD progression through infiltrated CD8+ T lymphocytes mediating pyroptotic-like cell death of hepatocytes and macrophages. | 2020 | Details |
| A06270 | 32945983 | Dig Dis Sci | FAM172A Deletion May Enhance Hepatic Steatosis by Promoting ER Stress. | 2020 | Details |
| A06832 | 32730863 | Toxicol In Vitro | Fructose-palmitate based high calorie induce steatosis in HepG2 cells via mitochondrial dysfunction: An in vitro approach. | 2020 | Details |
| A07510 | 32463484 | Hepatology | Protective and Detrimental Roles of p38α Mitogen-Activated Protein Kinase in Different Stages of Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A07539 | 32450865 | Lipids Health Dis | Long term N-acetylcysteine administration rescues liver steatosis via endoplasmic reticulum stress with unfolded protein response in mice. | 2020 | Details |
| A07631 | 32414691 | J Pharmacol Sci | Capsaicinoid nonivamide improves nonalcoholic fatty liver disease in rats fed a high-fat diet. | 2020 | Details |
| A07749 | 32365537 | Cells | EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats. | 2020 | Details |
| A08363 | 32143527 | Nutrients | The Effects of Endoplasmic-Reticulum-Resident Selenoproteins in a Nonalcoholic Fatty Liver Disease Pig Model Induced by a High-Fat Diet. | 2020 | Details |
| A08441 | 32110174 | Food Nutr Res | Purple sweet potato color protects against hepatocyte apoptosis through Sirt1 activation in high-fat-diet-treated mice. | 2020 | Details |
| A08635 | 32037512 | Br J Pharmacol | P7C3-A20 alleviates fatty liver by shaping gut microbiota and inducing FGF21/FGF1, via the AMP-activated protein kinase/CREB regulated transcription coactivator 2 pathway. | 2020 | Details |
| A08659 | 32029622 | Science | An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. | 2020 | Details |
| A08683 | 32023702 | Zhonghua Gan Zang Bing Za Zhi | [Effect of metformin on mitochondrial pathway of apoptosis and oxidative stress in cell model of nonalcoholic fatty liver disease]. | 2020 | Details |
| A08826 | 31975365 | Histol Histopathol | Cathepsin-B dependent autophagy ameliorates steatoheaptitis in chronic exercise rats. | 2020 | Details |
| A08940 | 31930271 | Food Funct | The preventive effect of phenolic-rich extracts from Chinese sumac fruits against nonalcoholic fatty liver disease in rats induced by a high-fat diet. | 2020 | Details |
| A09006 | 31907123 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | [Intervention of Catalpol on High-fat Diet Induced Nonalcoholic Fatty Liver Disease in Mice]. | 2019 | Details |
| A09337 | 31786336 | Biochim Biophys Acta Mol Basis Dis | Protective effect of metformin against palmitate-induced hepatic cell death. | 2019 | Details |
| A09488 | 31726115 | J Hepatol | A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis. | 2019 | Details |
| A09807 | 31602953 | Zhongguo Zhong Yao Za Zhi | [Mechanism of Calculus Bovis Sativus in inhibiting hepatocyte lipid deposition based on serum pharmacology]. | 2019 | Details |
| A10027 | 31520549 | Fundam Clin Pharmacol | Tanshinone IIA reduces palmitate-induced apoptosis via inhibition of endoplasmic reticulum stress in HepG2 liver cells. | 2019 | Details |
| A10696 | 31233751 | Eur J Pharmacol | Zoledronic acid prevents the hepatic changes associated with high fat diet in rats; the potential role of mevalonic acid pathway in nonalcoholic steatohepatitis. | 2019 | Details |
| A10871 | 31147590 | Sci Rep | Effects of açai on oxidative stress, ER stress, and inflammation-related parameters in mice with high fat diet-fed induced NAFLD. | 2019 | Details |
| A11132 | 31028903 | Pharmacol Res | Elafibranor restricts lipogenic and inflammatory responses in a human skin stem cell-derived model of NASH. | 2019 | Details |
| A11957 | 30668625 | Acta Biochim Biophys Sin (Shanghai) | Chronic intermittent hypoxia accelerates liver fibrosis in rats with combined hypoxia and nonalcoholic steatohepatitis via angiogenesis rather than endoplasmic reticulum stress. | 2019 | Details |
| A12761 | 30298839 | Nihon Yakurigaku Zasshi | [The involvement of NOX1/NADPH oxidase in the development of non-alcoholic steatohepatitis]. | 2018 | Details |
| A12827 | 30266038 | Br J Pharmacol | Diethyldithiocarbamate, an anti-abuse drug, alleviates steatohepatitis and fibrosis in rodents through modulating lipid metabolism and oxidative stress. | 2018 | Details |
| A12832 | 30262993 | Int J Biol Sci | Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice. | 2018 | Details |
| A13103 | 30137403 | J Clin Endocrinol Metab | Ghrelin Reduces TNF-α-Induced Human Hepatocyte Apoptosis, Autophagy, and Pyroptosis: Role in Obesity-Associated NAFLD. | 2019 | Details |
| A13156 | 30112044 | Exp Ther Med | Melatonin alleviates liver steatosis induced by prenatal dexamethasone exposure and postnatal high-fat diet. | 2018 | Details |
| A13335 | 30026676 | Food Nutr Res | Bitter melon extract ameliorates palmitate-induced apoptosis via inhibition of endoplasmic reticulum stress in HepG2 cells and high-fat/high-fructose-diet-induced fatty liver. | 2018 | Details |
| A13658 | 29852394 | Biomed Pharmacother | Naringin attenuates liver damage in streptozotocin-induced diabetic rats. | 2018 | Details |
| A13914 | 29696816 | J Dig Dis | Deletion of Smad4 reduces hepatic inflammation and fibrogenesis during nonalcoholic steatohepatitis progression. | 2018 | Details |
| A14053 | 29608898 | Eur J Pharmacol | Canagliflozin protects against non-alcoholic steatohepatitis in type-2 diabetic rats through zinc alpha-2 glycoprotein up-regulation. | 2018 | Details |
| A14156 | 29560693 | Acta Gastroenterol Belg | Apoptosis and Disease Severity is Associated with Insulin Resistance in Non-alcoholic Fatty Liver Disease. | 2018 | Details |
| A14543 | 29360762 | Mar Drugs | Protective Effect of Meretrix meretrix Oligopeptides on High-Fat-Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. | 2018 | Details |
| A14611 | 29324774 | PLoS One | Activated carbon N-acetylcysteine microcapsule protects against nonalcoholic fatty liver disease in young rats via activating telomerase and inhibiting apoptosis. | 2018 | Details |
| A14716 | 29274380 | Free Radic Biol Med | The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease. | 2017 | Details |
| A14956 | 29158052 | Life Sci | Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice. | 2017 | Details |
| A15137 | 29079763 | Sci Rep | Impact of intracellular glyceraldehyde-derived advanced glycation end-products on human hepatocyte cell death. | 2017 | Details |
| A15155 | 29071867 | Zhongguo Zhong Yao Za Zhi | [Effects of three Wenyang Jianpi Tang on cell proliferation and apoptosis of nonalcoholic fatty liver cells]. | 2017 | Details |
| A15367 | 28942443 | Cell Physiol Biochem | A Novel Role of SIRT1/ FGF-21 in Taurine Protection Against Cafeteria Diet-Induced Steatohepatitis in Rats. | 2017 | Details |
| A16047 | 28595079 | Int Immunopharmacol | Curcumin reduces the risk of chronic kidney damage in mice with nonalcoholic steatohepatitis by modulating endoplasmic reticulum stress and MAPK signaling. | 2017 | Details |
| A16114 | 28559541 | Int J Obes (Lond) | Adiponectin deficiency rescues high-fat diet-induced hepatic injury, apoptosis and autophagy loss despite persistent steatosis. | 2017 | Details |
| A16601 | 28288414 | Redox Biol | Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells. | 2017 | Details |
| A16617 | 28281516 | Ter Arkh | [Features of a necrotic and inflammatory process in different forms of nonalcoholic fatty liver disease]. | 2017 | Details |
| A16652 | 28264426 | Nutrients | The Combination of Blueberry Juice and Probiotics Ameliorate Non-Alcoholic Steatohepatitis (NASH) by Affecting SREBP-1c/PNPLA-3 Pathway via PPAR-α. | 2017 | Details |
| A16737 | 28216552 | Mar Drugs | Protective Effects and Mechanism of Meretrix meretrix Oligopeptides against Nonalcoholic Fatty Liver Disease. | 2017 | Details |
| A16804 | 28163820 | Oxid Med Cell Longev | Apolipoprotein CIII Overexpression-Induced Hypertriglyceridemia Increases Nonalcoholic Fatty Liver Disease in Association with Inflammation and Cell Death. | 2017 | Details |
| A17229 | 27899042 | Int J Food Sci Nutr | Hepatic rhythmicity of endoplasmic reticulum stress is disrupted in perinatal and adult mice models of high-fat diet-induced obesity. | 2016 | Details |
| A17286 | 27862769 | Cancer Sci | NS5ABP37 inhibits liver cancer by impeding lipogenesis and cholesterogenesis. | 2017 | Details |
| A17785 | 27594839 | Front Physiol | Roux-En Y Gastric Bypass Results in Long-Term Remission of Hepatocyte Apoptosis and Hepatic Histological Features of Non-alcoholic Steatohepatitis. | 2016 | Details |
| A17953 | 27456850 | BMC Complement Altern Med | Anti-lipoapoptotic effects of Alisma orientalis extract on non-esterified fatty acid-induced HepG2 cells. | 2016 | Details |
| A18096 | 30263346 | Food Sci Biotechnol | Kombucha tea prevents obese mice from developing hepatic steatosis and liver damage. | 2016 | Details |
| A18476 | 27104558 | Nutrients | Insulin Protects Hepatic Lipotoxicity by Regulating ER Stress through the PI3K/Akt/p53 Involved Pathway Independently of Autophagy Inhibition. | 2016 | Details |
| A19052 | 26799523 | J Food Sci | Effects of Long-Chain and Medium-Chain Fatty Acids on Apoptosis and Oxidative Stress in Human Liver Cells with Steatosis. | 2016 | Details |
| A19085 | 26773785 | Nutr Res | Adzuki bean ameliorates hepatic lipogenesis and proinflammatory mediator expression in mice fed a high-cholesterol and high-fat diet to induce nonalcoholic fatty liver disease. | 2015 | Details |
| A19214 | 26698665 | Free Radic Biol Med | Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development. | 2015 | Details |
| A19298 | 26640164 | Can J Physiol Pharmacol | Bicyclol attenuates tetracycline-induced fatty liver associated with inhibition of hepatic ER stress and apoptosis in mice. | 2015 | Details |
| A19473 | 26539645 | Oncotarget | Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis. | 2015 | Details |
| A19491 | 26524364 | Zhonghua Gan Zang Bing Za Zhi | [Effects of fenofibrate on hepatocyte apoptosis in nonalcoholic fatty liver]. | 2015 | Details |
| A19708 | 26401075 | World J Gastroenterol | Effects of salvianolic acid B on liver mitochondria of rats with nonalcoholic steatohepatitis. | 2015 | Details |
| A19811 | 26335364 | Biochem Cell Biol | Lactoferrin attenuates fatty acid-induced lipotoxicity via Akt signaling in hepatocarcinoma cells. | 2015 | Details |
| A19998 | 26215420 | Biomed Khim | [Intensity of apoptotic processes, aconitate hydratase activity and citrate level in patients with type 2 diabetes mellitus complicated steatohepatitis under application of epifamin at basic therapy]. | 2016 | Details |
| A20014 | 26203862 | Cell Death Dis | Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease. | 2015 | Details |
| A20902 | 25654291 | Zhonghua Gan Zang Bing Za Zhi | [Impact of JNK inhibitor XG-102 in a diet-induced rat model of non-alcoholic steatohepatitis]. | 2014 | Details |
| A21160 | 25512910 | Biomed Res Int | Uncoupling protein 2 regulates palmitic acid-induced hepatoma cell autophagy. | 2014 | Details |
| A21259 | 25450719 | J Hepatol | Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine. | 2014 | Details |
| A21318 | 25410681 | BMC Gastroenterol | High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma. | 2014 | Details |
| A21330 | 25400762 | Int J Clin Exp Pathol | Mechanism of the promotion of steatotic HepG2 cell apoptosis by cholesterol. | 2014 | Details |
| A21515 | 25261569 | Dis Model Mech | High-fat diet decreases activity of the oxidative phosphorylation complexes and causes nonalcoholic steatohepatitis in mice. | 2014 | Details |
| A21761 | 25064435 | J Hepatol | Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent. | 2014 | Details |
| A21799 | 25036839 | Biosci Biotechnol Biochem | Attenuation by a Vigna nakashimae extract of nonalcoholic fatty liver disease in high-fat diet-fed mice. | 2014 | Details |
| A22101 | 24821109 | Biochem Pharmacol | Cyanidin-3-O-β-glucoside protects primary mouse hepatocytes against high glucose-induced apoptosis by modulating mitochondrial dysfunction and the PI3K/Akt pathway. | 2014 | Details |
| A22202 | 24750664 | Liver Int | The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis. | 2014 | Details |
| A22620 | 24402912 | J Cell Biochem | HIF-1α expression as a protective strategy of HepG2 cells against fatty acid-induced toxicity. | 2014 | Details |
| A22760 | 24325816 | BMB Rep | The expression and secretion of vimentin in the progression of non-alcoholic steatohepatitis. | 2014 | Details |
| A22919 | 24211274 | Toxicol Appl Pharmacol | CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis. | 2013 | Details |
| A22990 | 24132507 | Dig Dis Sci | Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3β activation in human liver cells. | 2013 | Details |
| A23336 | 23861709 | Evid Based Complement Alternat Med | Garlic-Derived S-Allylmercaptocysteine Ameliorates Nonalcoholic Fatty Liver Disease in a Rat Model through Inhibition of Apoptosis and Enhancing Autophagy. | 2013 | Details |
| A23381 | 23831119 | J Hepatol | Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells. | 2013 | Details |