Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Choline1715 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00040 | 35247631 | Cell Mol Gastroenterol Hepatol | The critical and diverse roles of CD4-CD8- double negative T cells in nonalcoholic fatty liver disease. | 2022 | Details |
| A00049 | 35243280 | JHEP Rep | Cellular origins of regenerating liver and hepatocellular carcinoma. | 2021 | Details |
| A00056 | 35240344 | Cell Mol Gastroenterol Hepatol | Activation of Liver mTORC1 Protects Against NASH via Dual Regulation of VLDL-TAG Secretion and De Novo Lipogenesis. | 2022 | Details |
| A00069 | 35232986 | Sci Rep | Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation. | 2022 | Details |
| A00100 | 35220131 | Phytomedicine | 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside ameliorates NAFLD via attenuating hepatic steatosis through inhibiting mitochondrial dysfunction dependent on SIRT5. | 2022 | Details |
| A00122 | 35213001 | Methods Mol Biol | In Vivo Analysis of Necrosis and Ferroptosis in Nonalcoholic Steatohepatitis (NASH). | 2022 | Details |
| A00141 | 35212227 | J Agric Food Chem | Targeted Lipidomics Reveal the Effects of Different Phospholipids on the Phospholipid Profiles of Hepatic Mitochondria and Endoplasmic Reticulum in High-Fat/High-Fructose-Diet-Induced Nonalcoholic Fatty Liver Disease Mice. | 2022 | Details |
| A00142 | 35212074 | J Magn Reson Imaging | Water Specific MRI T1 Mapping for Evaluating Liver Inflammation Activity Grades in Rats With Methionine-Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A00158 | 35204522 | Diagnostics (Basel) | A Comparative Study of the Triglycerides/HDL Ratio and Pseudocholinesterase Levels in Patients with Bladder Cancer. | 2022 | Details |
| A00209 | 35185113 | J Pediatr Gastroenterol Nutr | Comparison of the Lipidomic Signature of Fatty Liver in Children and Adults: A Cross-Sectional Study. | 2022 | Details |
| A00221 | 35178496 | APL Bioeng | Development of resveratrol with thiolated alginate as a supplement to prevent nonalcoholic fatty liver disease (NAFLD). | 2022 | Details |
| A00229 | 35174500 | J Sci Food Agric | Identification of a novel probiotic and its protective effects on NAFLD via modulating gut microbial community. | 2022 | Details |
| A00253 | 35164140 | Molecules | A Comparison of the Gene Expression Profiles of Non-Alcoholic Fatty Liver Disease between Animal Models of a High-Fat Diet and Methionine-Choline-Deficient Diet. | 2022 | Details |
| A00257 | 35163821 | Int J Mol Sci | Proglumide Reverses Nonalcoholic Steatohepatitis by Interaction with the Farnesoid X Receptor and Altering the Microbiome. | 2022 | Details |
| A00294 | 35148334 | PLoS One | Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression. | 2022 | Details |
| A00395 | 35102146 | Nat Commun | Formyl peptide receptor 2 determines sex-specific differences in the progression of nonalcoholic fatty liver disease and steatohepatitis. | 2022 | Details |
| A00414 | 35093339 | Life Sci | Endothelial group IVA phospholipase A2 promotes hepatic fibrosis with sinusoidal capillarization in the early stage of non-alcoholic steatohepatitis in mice. | 2022 | Details |
| A00456 | 35075477 | Lab Med | Serum Metabolomics in Patients with Coexisting NAFLD and T2DM Using Liquid Chromatography-Mass Spectrometry. | 2022 | Details |
| A00457 | 35075185 | Sci Rep | MAFLD progression contributes to altered thalamus metabolism and brain structure. | 2022 | Details |
| A00485 | 35065166 | Life Sci | Hepatocellular BChE as a therapeutic target to ameliorate hypercholesterolemia through PRMT5 selective degradation to restore LDL receptor transcription. | 2022 | Details |
| A00490 | 35063810 | Nutrition | Satellite cell content and muscle regeneration in a mouse model of NAFLD. | 2021 | Details |
| A00504 | 35058782 | Front Pharmacol | TMEM88 Modulates Lipid Synthesis and Metabolism Cytokine by Regulating Wnt/β-Catenin Signaling Pathway in Non-Alcoholic Fatty Liver Disease. | 2022 | Details |
| A00526 | 35053205 | Biomolecules | Understanding the Role of the Gut Microbiome and Microbial Metabolites in Non-Alcoholic Fatty Liver Disease: Current Evidence and Perspectives. | 2021 | Details |
| A00562 | 35046474 | Sci Rep | Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model. | 2022 | Details |
| A00583 | 35040254 | Chem Biol Drug Des | SU5, a new Auraptene analog with improved metabolic stability, ameliorates nonalcoholic fatty liver disease in methionine- and choline-deficient diet-fed db/db mice. | 2022 | Details |
| A00592 | 35036886 | JHEP Rep | Vasoconstrictor antagonism improves functional and structural vascular alterations and liver damage in rats with early NAFLD. | 2021 | Details |
| A00597 | 35035378 | Front Endocrinol (Lausanne) | Bifidobacterium adolescentis Alleviates Liver Steatosis and Steatohepatitis by Increasing Fibroblast Growth Factor 21 Sensitivity. | 2021 | Details |
| A00622 | 35024313 | Acta Pharm Sin B | Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity. | 2021 | Details |
| A00647 | 35015019 | Food Funct | Preventive effects of black soybean polyphenols on non-alcoholic fatty liver disease in three different mouse models. | 2022 | Details |
| A00687 | 35003513 | Oxid Med Cell Longev | TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization. | 2021 | Details |
| A00775 | 34971904 | Biochem Biophys Res Commun | Hepatoprotective effects of gemigliptin and empagliflozin in a murine model of diet-induced non-alcoholic fatty liver disease. | 2021 | Details |
| A00832 | 34954499 | Redox Biol | Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation. | 2021 | Details |
| A00854 | 34945677 | Foods | Lactobacillus plantarum MA2 Ameliorates Methionine and Choline-Deficient Diet Induced Non-Alcoholic Fatty Liver Disease in Rats by Improving the Intestinal Microecology and Mucosal Barrier. | 2021 | Details |
| A00871 | 34944021 | Cells | IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism. | 2021 | Details |
| A00891 | 34939051 | J Mass Spectrom Adv Clin Lab | A pilot study optimizing metabolomic and lipidomic acquisition in serum for biomarker discovery in nonalcoholic fatty liver disease. | 2021 | Details |
| A00908 | 34933425 | Zhonghua Gan Zang Bing Za Zhi | [Intestinal flora polymorphisms with different lesional stages in an animal model of MAFLD]. | 2021 | Details |
| A00971 | 34915054 | J Hepatol | A structurally engineered fatty acid, icosabutate, suppresses liver inflammation and fibrosis in NASH. | 2021 | Details |
| A00999 | 34906552 | Chem Phys Lipids | Study of lipid proton difference evaluation via 9.4T MRI analysis of fatty liver induced by exposure to methionine and choline-deficient (MCD) diet and high-fat diet (HFD) in an animal model. | 2021 | Details |
| A01050 | 34887931 | Evid Based Complement Alternat Med | Pharmacodynamic Evaluation of the Gexia Zhuyu Decoction in the Treatment of NAFLD and the Molecular Mechanism Underlying the TRPM4 Pathway Regulation. | 2021 | Details |
| A01100 | 34869532 | Front Nutr | Clinical Relevance of Vitamins and Carotenoids With Liver Steatosis and Fibrosis Detected by Transient Elastography in Adults. | 2021 | Details |
| A01136 | 34859106 | J Immunol Res | Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD. | 2021 | Details |
| A01180 | 34838052 | J Nanobiotechnology | Hepatic small extracellular vesicles promote microvascular endothelial hyperpermeability during NAFLD via novel-miRNA-7. | 2021 | Details |
| A01204 | 34829876 | Biomedicines | Estimating Drug Efficacy with a Diet-Induced NASH Model in Chimeric Mice with Humanized Livers. | 2021 | Details |
| A01214 | 34827721 | Biomolecules | The Effect of Mycotoxins and Silymarin on Liver Lipidome of Mice with Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A01288 | 34801522 | Biochem Pharmacol | Models of nonalcoholic steatohepatitis potentiated by chemical inducers leading to hepatocellular carcinoma. | 2021 | Details |
| A01336 | 34785385 | Clin Res Hepatol Gastroenterol | Trans-anethole attenuates diet-induced nonalcoholic steatohepatitis through suppressing TGF-β-mediated fibrosis. | 2021 | Details |
| A01342 | 34783017 | Br J Pharmacol | A novel HSF1 activator ameliorates non-alcoholic steatohepatitis by stimulating mitochondrial adaptive oxidation. | 2022 | Details |
| A01368 | 34773257 | Hepatology | A GLP-1/GLP-2 receptor dual agonist to treat NASH: Targeting the gut-liver axis and microbiome. | 2021 | Details |
| A01391 | 34762911 | J Biol Chem | Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes. | 2021 | Details |
| A01404 | 34758848 | Chin Med | Honokiol attenuates lipotoxicity in hepatocytes via activating SIRT3-AMPK mediated lipophagy. | 2021 | Details |
| A01413 | 34757046 | Mol Metab | Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis. | 2021 | Details |
| A01488 | 34727379 | Biomed Chromatogr | Lipidomic-based investigation into the therapeutic effects of polyene phosphatidylcholine and Babao Dan on rats with non-alcoholic fatty liver disease. | 2021 | Details |
| A01502 | 34721326 | Front Microbiol | Disentangling the Progression of Non-alcoholic Fatty Liver Disease in the Human Gut Microbiota. | 2021 | Details |
| A01509 | 34717002 | Hepatology | Breviscapine alleviates NASH by inhibiting TGF-β-activated kinase 1-dependent signaling. | 2021 | Details |
| A01517 | 34711912 | Sci Rep | Loss of hepatic Flcn protects against fibrosis and inflammation by activating autophagy pathways. | 2021 | Details |
| A01521 | 34710382 | Am J Pathol | A Novel Mouse Model of Nonalcoholic Steatohepatitis Suggests that Liver Fibrosis Initiates around Lipid-Laden Macrophages. | 2021 | Details |
| A01528 | 34707622 | Front Immunol | Oral Pathobiont-Induced Changes in Gut Microbiota Aggravate the Pathology of Nonalcoholic Fatty Liver Disease in Mice. | 2021 | Details |
| A01554 | 34695558 | J Nutr Biochem | Nobiletin mitigates hepatocytes death, liver inflammation, and fibrosis in a murine model of NASH through modulating hepatic oxidative stress and mitochondrial dysfunction. | 2021 | Details |
| A01557 | 34694029 | FASEB J | BTT-105 ameliorates hepatic fibrosis in non-alcoholic fatty liver animal model. | 2021 | Details |
| A01581 | 34685636 | Cells | Oxysterol 7-α Hydroxylase (CYP7B1) Attenuates Metabolic-Associated Fatty Liver Disease in Mice at Thermoneutrality. | 2021 | Details |
| A01590 | 34684455 | Nutrients | Zonarol Protected Liver from Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease in a Mouse Model. | 2021 | Details |
| A01601 | 34681695 | Int J Mol Sci | Astaxanthin Prevents Diet-Induced NASH Progression by Shaping Intrahepatic Immunity. | 2021 | Details |
| A01640 | 34671210 | Int J Biol Sci | Lrp6 Genotype affects Individual Susceptibility to Nonalcoholic Fatty Liver Disease and Silibinin Therapeutic Response via Wnt/β-catenin-Cyp2e1 Signaling. | 2021 | Details |
| A01646 | 34669440 | Sci Transl Med | Peptide-based urinary monitoring of fibrotic nonalcoholic steatohepatitis by mass-barcoded activity-based sensors. | 2021 | Details |
| A01652 | 34667947 | JHEP Rep | New targets for NAFLD. | 2021 | Details |
| A01754 | 34629052 | Lipids Health Dis | Serum lipids are associated with nonalcoholic fatty liver disease: a pilot case-control study in Mexico. | 2021 | Details |
| A01803 | 34609304 | Turk J Gastroenterol | Safety and Effectiveness of Essential Phospholipids Paste in Patients with Non-alcoholic Fatty Liver Disease or Viral Hepatitis. | 2021 | Details |
| A01820 | 34604283 | Front Nutr | Combined Transcriptomic and Lipidomic Analysis Reveals Dysregulated Genes Expression and Lipid Metabolism Profiles in the Early Stage of Fatty Liver Disease in Rats. | 2021 | Details |
| A01844 | 34592488 | Phytomedicine | Activation of AMPK by triptolide alleviates nonalcoholic fatty liver disease by improving hepatic lipid metabolism, inflammation and fibrosis. | 2021 | Details |
| A01895 | 34570568 | Bratisl Lek Listy | Serum butyrylcholinesterase activities in patients with non-alcoholic fatty liver disease. Comparison with liver proteosynthetic function and liver fibrosis. | 2021 | Details |
| A01918 | 34563519 | J Lipid Res | Inhibition of chylomicron assembly leads to dissociation of hepatic steatosis from inflammation and fibrosis. | 2021 | Details |
| A01923 | 34560694 | Eur J Gastroenterol Hepatol | Healthcare practitioners' diagnostic and treatment practice patterns of nonalcoholic fatty liver disease in Poland: a cross-sectional survey. | 2022 | Details |
| A01972 | 34547171 | Liver Int | The role of hepatic lipid composition in obesity-related metabolic disease. | 2021 | Details |
| A01992 | 34536498 | Life Sci | Intermittent hypoxia aggravates non-alcoholic fatty liver disease via RIPK3-dependent necroptosis-modulated Nrf2/NFκB signaling pathway. | 2021 | Details |
| A02001 | 34533882 | Cancer Sci | Gut-liver axis-mediated mechanism of liver cancer: A special focus on the role of gut microbiota. | 2021 | Details |
| A02039 | 34523053 | Inflammation | Hepatic Macrophages Express Melanoma Differentiation-Associated Gene 5 in Nonalcoholic Steatohepatitis. | 2021 | Details |
| A02064 | 34513923 | Front Mol Biosci | The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis. | 2021 | Details |
| A02106 | 34505434 | Se Pu | [Identification of LAMTOR1-regulated metabolites using ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry in malignant transformation of liver inflammation]. | 2021 | Details |
| A02112 | 34503151 | Cancers (Basel) | Host-Microbiota Interactions in Liver Inflammation and Cancer. | 2021 | Details |
| A02163 | 34479345 | Rev Med Chil | [The role of intestinal microbiota in the development of non-alcoholic fatty liver disease]. | 2021 | Details |
| A02258 | 34445195 | Int J Mol Sci | Immunonano-Lipocarrier-Mediated Liver Sinusoidal Endothelial Cell-Specific RUNX1 Inhibition Impedes Immune Cell Infiltration and Hepatic Inflammation in Murine Model of NASH. | 2021 | Details |
| A02317 | 34422075 | Evid Based Complement Alternat Med | Antifibrotic Effects of Kangxian Ruangan Capsule on Rats with Nonalcoholic Fatty Liver Fibrosis and Hepatic Stellate Cells through Regulation of TGF-β and TLR4 Signaling Pathways. | 2021 | Details |
| A02323 | 34419589 | Biochim Biophys Acta Mol Cell Biol Lipids | Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes. | 2021 | Details |
| A02365 | 34401690 | JHEP Rep | Comprehensive lipidomics reveals phenotypic differences in hepatic lipid turnover in ALD and NAFLD during alcohol intoxication. | 2021 | Details |
| A02388 | 34393793 | Front Pharmacol | Extracts of Vine Tea Improve Diet-Induced Non-Alcoholic Steatohepatitis Through AMPK-LXRα Signaling. | 2021 | Details |
| A02389 | 34392687 | J Agric Food Chem | Understanding Choline Bioavailability and Utilization: First Step Toward Personalizing Choline Nutrition. | 2021 | Details |
| A02397 | 34387896 | Hepatology | Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice. | 2021 | Details |
| A02445 | 34369032 | J Biochem Mol Toxicol | Shc inhibitor idebenone ameliorates liver injury and fibrosis in dietary NASH in mice. | 2021 | Details |
| A02462 | 34363921 | J Hepatol | Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis. | 2021 | Details |
| A02479 | 34359438 | Foods | Comparison of Egg Yolk and Soybean Phospholipids on Hepatic Fatty Acid Profile and Liver Protection in Rats Fed a High-Fructose Diet. | 2021 | Details |
| A02530 | 34339944 | Phytomedicine | Network pharmacology-based identification of significant pathway for protection of Yinhuang granule in a mice model of metabolic-associated fatty liver disease. | 2021 | Details |
| A02570 | 34326695 | Int J Biol Sci | Aberrant FGFR4 signaling worsens nonalcoholic steatohepatitis in FGF21KO mice. | 2021 | Details |
| A02583 | 34322898 | Hepatology | Guanine Nucleotide-Binding Protein G(i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1-Related Inflammation and Lipophagy. | 2021 | Details |
| A02597 | 34320238 | Hepatology | SIMPLE Is an Endosomal Regulator That Protects Against NAFLD by Targeting the Lysosomal Degradation of EGFR. | 2021 | Details |
| A02616 | 34308853 | Nan Fang Yi Ke Da Xue Xue Bao | [Parathyroid hormone-related protein aggravates nonalcoholic fatty liver disease induced by methionine choline-deficient diet in mice]. | 2021 | Details |
| A02724 | 34273192 | J Gastroenterol Hepatol | Insulin-like growth factor binding protein 1 ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease. | 2021 | Details |
| A02733 | 34267042 | Curr Opin Infect Dis | The impact of alteration in gut microbiome in the pathogenesis of nonalcoholic fatty liver disease. | 2021 | Details |
| A02739 | 34264552 | Vopr Pitan | [Pathogenetic mechanisms for the development of hematological disorders in induced fatty liver disease in Wistar rats and assessment of the regulatory effects of carnosine and α-lipoic acid]. | 2021 | Details |
| A02760 | 34256994 | Hepatobiliary Pancreat Dis Int | LC-MS-based lipidomic analysis in distinguishing patients with nonalcoholic steatohepatitis from nonalcoholic fatty liver. | 2021 | Details |
| A02779 | 34243681 | Pharm Biol | Esculin protects against methionine choline-deficient diet-induced non-alcoholic steatohepatitis by regulating the Sirt1/NF-κB p65 pathway. | 2021 | Details |