Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Fatty acid synthase594 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00006 | 35256934 | Acta Pharm Sin B | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma. | 2021 | Details |
| A00205 | 35187676 | J Food Biochem | Chitosan oligosaccharide attenuates hepatic steatosis in HepG2 cells via the activation of AMP-activated protein kinase. | 2022 | Details |
| A00213 | 35182670 | J Ethnopharmacol | Gryllus bimaculatus De Geer hydrolysates alleviate lipid accumulation, inflammation, and endoplasmic reticulum stress in palmitic acid-treated human hepatoma G2 cells. | 2022 | Details |
| A00538 | 35052685 | Biomedicines | Fatty Acid Synthase Inhibitor Platensimycin Intervenes the Development of Nonalcoholic Fatty Liver Disease in a Mouse Model. | 2021 | Details |
| A00539 | 35052640 | Antioxidants (Basel) | Phytochemicals from the Cocoa Shell Modulate Mitochondrial Function, Lipid and Glucose Metabolism in Hepatocytes via Activation of FGF21/ERK, AKT, and mTOR Pathways. | 2022 | Details |
| A00540 | 35052597 | Antioxidants (Basel) | Gallic Acid Improves Diabetic Steatosis by Downregulating MicroRNA-34a-5p through Targeting NFE2L2 Expression in High-Fat Diet-Fed db/db Mice. | 2021 | Details |
| A00658 | 35013040 | J Oleo Sci | Pink Lotus Essential Oil and Alleviates on Free Fatty Acid Induced Steatosis in HepG2 Cells via PI3K/Akt and NF-κB Pathways. | 2022 | Details |
| A00748 | 34981123 | Biosci Rep | Tandem mass tag-based proteomics analysis of type 2 diabetes mellitus with non-alcoholic fatty liver disease in mice treated with acupuncture. | 2022 | Details |
| A01056 | 34884968 | Int J Mol Sci | Neochlorogenic Acid Attenuates Hepatic Lipid Accumulation and Inflammation via Regulating miR-34a In Vitro. | 2021 | Details |
| A01219 | 34825068 | Biochem Biophys Rep | Metformin treatment reverses high fat diet- induced non-alcoholic fatty liver diseases and dyslipidemia by stimulating multiple antioxidant and anti-inflammatory pathways. | 2021 | Details |
| A01357 | 34776827 | Food Nutr Res | Weissella cibaria MG5285 and Lactobacillus reuteri MG5149 attenuated fat accumulation in adipose and hepatic steatosis in high-fat diet-induced C57BL/6J obese mice. | 2021 | Details |
| A01411 | 34757160 | Toxicology | The combined impact of decabromodiphenyl ether and high fat exposure on non-alcoholic fatty liver disease in vivo and in vitro. | 2021 | Details |
| A01542 | 34704008 | Metabol Open | Deficiency of SREBP1c modulates autophagy mediated lipid droplet catabolism during oleic acid induced steatosis. | 2021 | Details |
| A01652 | 34667947 | JHEP Rep | New targets for NAFLD. | 2021 | Details |
| A01693 | 34652536 | Mol Cell Biochem | Acetylation of H3K27 activated lncRNA NEAT1 and promoted hepatic lipid accumulation in non-alcoholic fatty liver disease via regulating miR-212-5p/GRIA3. | 2021 | Details |
| A01698 | 34651285 | J Physiol Biochem | Astaxanthin attenuates hepatic steatosis in high-fat diet-fed rats by suppressing microRNA-21 via transactivation of nuclear factor erythroid 2-related factor 2. | 2021 | Details |
| A01775 | 34621326 | Evid Based Complement Alternat Med | A Novel Identified Peptide Hormone "Metabolitin" Attenuates Lipid Absorption in the Small Intestine of Diabetic Mice with Nonalcoholic Fatty Liver Disease by Regulating Neurotensin and AMPK Signaling Pathway. | 2021 | Details |
| A01777 | 34621168 | Front Pharmacol | Study on the Hepatoprotection of Schisandra chinensis Caulis Polysaccharides in Nonalcoholic Fatty Liver Disease in Rats Based on Metabolomics. | 2021 | Details |
| A01861 | 34585409 | J Food Biochem | Crataegus aronia prevents high-fat diet-induced hepatic steatosis in rats by activating AMPK-induced suppression of SREBP1 and activation of PPARα. | 2021 | Details |
| A01875 | 34576229 | Int J Mol Sci | Methyl Brevifolincarboxylate Attenuates Free Fatty Acid-Induced Lipid Metabolism and Inflammation in Hepatocytes through AMPK/NF-κB Signaling Pathway. | 2021 | Details |
| A01882 | 34574082 | Foods | AGL9: A Novel Hepatoprotective Peptide from the Larvae of Edible Insects Alleviates Obesity-Induced Hepatic Inflammation by Regulating AMPK/Nrf2 Signaling. | 2021 | Details |
| A02182 | 34470993 | J Toxicol Sci | Resveratrol reverses the programmed high-susceptibility to non-alcoholic fatty liver disease by targeting the hepatic SIRT1-SREBP1c pathway in prenatal ethanol-exposed rat offspring. | 2021 | Details |
| A02244 | 34447968 | J Anim Sci Technol | Effect of ciglitazone on adipogenic transdifferentiation of bovine skeletal muscle satellite cells. | 2021 | Details |
| A02256 | 34445549 | Int J Mol Sci | Kaempferol and Kaempferide Attenuate Oleic Acid-Induced Lipid Accumulation and Oxidative Stress in HepG2 Cells. | 2021 | Details |
| A02426 | 34374658 | J Physiol Pharmacol | Hesperidin, a novel candidate for the successful treatment of high fat diet plus ethanol-induced fatty liver disease in mice. | 2021 | Details |
| A02610 | 34310978 | Gastroenterology | TVB-2640 (FASN Inhibitor) for the Treatment of Nonalcoholic Steatohepatitis: FASCINATE-1, a Randomized, Placebo-Controlled Phase 2a Trial. | 2021 | Details |
| A02819 | 34231239 | Hepatology | Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD. | 2021 | Details |
| A03114 | 34125646 | Gut Microbes | Desulfovibrio vulgaris, a potent acetic acid-producing bacterium, attenuates nonalcoholic fatty liver disease in mice. | 2021 | Details |
| A03118 | 34122607 | Evid Based Complement Alternat Med | Dendrobium officinale Regulates Fatty Acid Metabolism to Ameliorate Liver Lipid Accumulation in NAFLD Mice. | 2021 | Details |
| A03200 | 34092291 | Chin J Nat Med | Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptor α. | 2021 | Details |
| A03245 | 34073834 | Int J Mol Sci | P2Y2R Deficiency Ameliorates Hepatic Steatosis by Reducing Lipogenesis and Enhancing Fatty Acid β-Oxidation through AMPK and PGC-1α Induction in High-Fat Diet-Fed Mice. | 2021 | Details |
| A03267 | 34065270 | Nutrients | Comparison of the Improvement Effect of Deep Ocean Water with Different Mineral Composition on the High Fat Diet-Induced Blood Lipid and Nonalcoholic Fatty Liver Disease in a Mouse Model. | 2021 | Details |
| A03377 | 34025131 | J Ginseng Res | Effect of Korean Red Ginseng on metabolic syndrome. | 2020 | Details |
| A03474 | 33990765 | Acta Pharmacol Sin | Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress. | 2021 | Details |
| A03558 | 33955510 | Mol Med Rep | Parthenolide plays a protective role in the liver of mice with metabolic dysfunction‑associated fatty liver disease through the activation of the HIPPO pathway. | 2021 | Details |
| A03689 | 33901636 | Comp Biochem Physiol C Toxicol Pharmacol | Ameliorative role of ellagic acid against acute liver steatosis in adult zebrafish experimental model. | 2021 | Details |
| A03693 | 33900847 | Am J Physiol Endocrinol Metab | High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling. | 2021 | Details |
| A03753 | 33877366 | Diabetologia | Liver-targeting drugs and their effect on blood glucose and hepatic lipids. | 2021 | Details |
| A03925 | 33815675 | World J Hepatol | Papaya improves non-alcoholic fatty liver disease in obese rats by attenuating oxidative stress, inflammation and lipogenic gene expression. | 2021 | Details |
| A04044 | 33777700 | Toxicol Rep | Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis. | 2021 | Details |
| A04100 | 33760189 | Mol Med Rep | Silibinin improves nonalcoholic fatty liver by regulating the expression of miR‑122: An in vitro and in vivo study. | 2021 | Details |
| A04366 | 33647280 | Gastroenterology | Squalene Epoxidase Induces Nonalcoholic Steatohepatitis Via Binding to Carbonic Anhydrase III and is a Therapeutic Target. | 2021 | Details |
| A04441 | 33615637 | Anim Sci J | Complement C3 participates in the development of goose fatty liver potentially by regulating the expression of FASN and ETNK1. | 2021 | Details |
| A04618 | 33561256 | J Nutr | Dietary Fruit and Vegetable Supplementation Suppresses Diet-Induced Atherosclerosis in LDL Receptor Knockout Mice. | 2021 | Details |
| A04660 | 33548473 | J Nutr Biochem | Tomatidine ameliorates obesity-induced nonalcoholic fatty liver disease in mice. | 2021 | Details |
| A04731 | 33524747 | Chemosphere | Thiamethoxam induces nonalcoholic fatty liver disease in mice via methionine metabolism disturb via nicotinamide N-methyltransferase overexpression. | 2021 | Details |
| A04967 | 33435558 | Molecules | Protective Effects of Polyphenol Enriched Complex Plants Extract on Metabolic Dysfunctions Associated with Obesity and Related Nonalcoholic Fatty Liver Diseases in High Fat Diet-Induced C57BL/6 Mice. | 2021 | Details |
| A04984 | 33425805 | Can J Gastroenterol Hepatol | Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A04987 | 33424396 | Saudi J Biol Sci | Regulatory effect of diosgenin on lipogenic genes expression in high-fat diet-induced obesity in mice. | 2020 | Details |
| A05011 | 33411880 | Food Funct | Berbamine induced activation of the SIRT1/LKB1/AMPK signaling axis attenuates the development of hepatic steatosis in high-fat diet-induced NAFLD rats. | 2021 | Details |
| A05030 | 33401717 | Int J Mol Sci | Risperidone Exacerbates Glucose Intolerance, Nonalcoholic Fatty Liver Disease, and Renal Impairment in Obese Mice. | 2021 | Details |
| A05187 | 33343352 | Front Pharmacol | Hepatoprotective Effect and Molecular Mechanisms of Hengshun Aromatic Vinegar on Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A05244 | 33326684 | IUBMB Life | Combination of metformin and chlorogenic acid attenuates hepatic steatosis and inflammation in high-fat diet fed mice. | 2020 | Details |
| A05268 | 33318872 | J Adv Res | Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential. | 2020 | Details |
| A05323 | 33302736 | Exp Biol Med (Maywood) | Characterizing disease progression of nonalcoholic steatohepatitis in Leptin-deficient rats by integrated transcriptome analysis. | 2020 | Details |
| A05352 | 33289350 | Diabetes Obes Metab | Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: Results from two early-phase randomized trials. | 2020 | Details |
| A05366 | 33281535 | Food Nutr Res | Bile salt hydrolase-overexpressing Lactobacillus strains can improve hepatic lipid accumulation in vitro in an NAFLD cell model. | 2020 | Details |
| A05505 | 33227217 | J Med Food | Whole Red Raspberry (Rubus idaeus)-Enriched Diet Is Hepatoprotective in the Obese Zucker Rat, a Model of the Metabolic Syndrome. | 2020 | Details |
| A05595 | 33195520 | Front Vet Sci | Lipid Accumulation and Injury in Primary Calf Hepatocytes Challenged With Different Long-Chain Fatty Acids. | 2020 | Details |
| A05608 | 33190588 | Autophagy | TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation. | 2020 | Details |
| A05744 | 33134908 | JHEP Rep | Hepatic miR-192-3p reactivation alleviates steatosis by targeting glucocorticoid receptor. | 2020 | Details |
| A05748 | 33133572 | Food Sci Nutr | Alleviative effect of Ruellia tuberosa L. on NAFLD and hepatic lipid accumulation via modulating hepatic de novo lipogenesis in high-fat diet plus streptozotocin-induced diabetic rats. | 2020 | Details |
| A05936 | 33071788 | Front Pharmacol | Veratrilla baillonii Franch Could Alleviate Lipid Accumulation in LO2 Cells by Regulating Oxidative, Inflammatory, and Lipid Metabolic Signaling Pathways. | 2020 | Details |
| A05955 | 33062150 | Oxid Med Cell Longev | Prevention of Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement of Adiponectin-Induced Inhibition of Hepatic SREBP-1c. | 2020 | Details |
| A06004 | 33040080 | Cell Death Dis | USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638. | 2020 | Details |
| A06019 | 33037652 | J Food Sci | Coniferaldehyde ameliorates the lipid and glucose metabolism in palmitic acid-induced HepG2 cells via the LKB1/AMPK signaling pathway. | 2020 | Details |
| A06045 | 33029298 | Anim Cells Syst (Seoul) | Capsaicin suppresses liver fat accumulation in high-fat diet-induced NAFLD mice. | 2020 | Details |
| A06078 | 33014333 | Cell Biosci | Phloretin ameliorates hepatic steatosis through regulation of lipogenesis and Sirt1/AMPK signaling in obese mice. | 2020 | Details |
| A06136 | 32992548 | Antioxidants (Basel) | Involvement of HO-1 and Autophagy in the Protective Effect of Magnolol in Hepatic Steatosis-Induced NLRP3 Inflammasome Activation In Vivo and In Vitro. | 2020 | Details |
| A06225 | 32962167 | Mar Drugs | Diphlorethohydroxycarmalol Attenuates Palmitate-Induced Hepatic Lipogenesis and Inflammation. | 2020 | Details |
| A06277 | 32944984 | J Food Biochem | trans-Chalcone inhibits high-fat diet-induced disturbances in FXR/SREBP-1c/FAS and FXR/Smad-3 pathways in the kidney of rats. | 2020 | Details |
| A06559 | 32825154 | Nutrients | The Protective Effect of Myristica fragrans Houtt. Extracts Against Obesity and Inflammation by Regulating Free Fatty Acids Metabolism in Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A06597 | 32812944 | Metabol Open | Regulation of hepatic genes related to lipid metabolism and antioxidant enzymes by sodium butyrate supplementation. | 2020 | Details |
| A06668 | 32786869 | J Agric Food Chem | Combined Effect of Quercetin and Fish Oil on Oxidative Stress in the Liver of Mice Fed a Western-Style Diet. | 2020 | Details |
| A06691 | 32779442 | Cell J | Nicotinamide Phosphoribosyltransferase Knockdown Leads to Lipid Accumulation in HepG2 Cells through The SIRT1-AMPK Pathway. | 2020 | Details |
| A06696 | 32777136 | FASEB J | Betulinic acid improves nonalcoholic fatty liver disease through YY1/FAS signaling pathway. | 2020 | Details |
| A06729 | 32767404 | Cell Biochem Funct | Apoptosis-inducing factor deficient mice fail to develop hepatic steatosis under high fat high fructose diet or bile duct ligation. | 2020 | Details |
| A06753 | 32759548 | Biol Pharm Bull | Amelioration of the Lipogenesis, Oxidative Stress and Apoptosis of Hepatocytes by a Novel Proteoglycan from Ganoderma lucidum. | 2020 | Details |
| A06873 | 32715385 | Arch Pharm Res | Ganoderic acid A attenuates high-fat-diet-induced liver injury in rats by regulating the lipid oxidation and liver inflammation. | 2020 | Details |
| A06900 | 32705195 | Mol Med Rep | Trimetazidine improves hepatic lipogenesis and steatosis in non‑alcoholic fatty liver disease via AMPK‑ChREBP pathway. | 2020 | Details |
| A06917 | 32698101 | Growth Horm IGF Res | Growth hormone ameliorates high glucose-induced steatosis on in vitro cultured human HepG2 hepatocytes by inhibiting de novo lipogenesis via ChREBP and FAS suppression. | 2020 | Details |
| A06996 | 32666969 | Food Funct | Ameliorative effects and molecular mechanisms of vine tea on western diet-induced NAFLD. | 2020 | Details |
| A07015 | 32657010 | Obesity (Silver Spring) | Hepatocyte Notch Signaling Deregulation Related to Lipid Metabolism in Women with Obesity and Nonalcoholic Fatty Liver. | 2020 | Details |
| A07059 | 32638492 | Aging Cell | Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease. | 2020 | Details |
| A07078 | 32630596 | Int J Mol Sci | SGL 121 Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism Through AMPK Signaling Pathway. | 2020 | Details |
| A07190 | 32588069 | Naunyn Schmiedebergs Arch Pharmacol | In vitro targeted screening and molecular docking of stilbene, quinones, and flavonoid on 3T3-L1 pre-adipocytes for anti-adipogenic actions. | 2020 | Details |
| A07214 | 32579753 | J Food Sci | Psoralea corylifolia L. extract ameliorates nonalcoholic fatty liver disease in free-fatty-acid-incubated HEPG2 cells and in high-fat diet-fed mice. | 2020 | Details |
| A07362 | 32526241 | Eur J Pharmacol | Berbamine induced AMPK activation regulates mTOR/SREBP-1c axis and Nrf2/ARE pathway to allay lipid accumulation and oxidative stress in steatotic HepG2 cells. | 2020 | Details |
| A07520 | 32460375 | J Food Sci | Effects of polar compounds in fried palm oil on liver lipid metabolism in C57 mice. | 2020 | Details |
| A07613 | 32420361 | Biomed Res Int | Catalpol Attenuates Hepatic Steatosis by Regulating Lipid Metabolism via AMP-Activated Protein Kinase Activation. | 2020 | Details |
| A07751 | 32365055 | J Clin Invest | Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes. | 2020 | Details |
| A07752 | 32364539 | J Clin Invest | Insulin-stimulated lipogenesis gets an epigenetic makeover. | 2020 | Details |
| A08038 | 32272865 | Adipocyte | MiR-455 targeting SOCS3 improve liver lipid disorders in diabetic mice. | 2020 | Details |
| A08076 | 32256659 | Evid Based Complement Alternat Med | Protective Effect of a Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract against Hepatic Steatosis in High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mice. | 2020 | Details |
| A08145 | 32229588 | J Lipid Res | The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice. | 2020 | Details |
| A08149 | 32228319 | Am J Physiol Endocrinol Metab | Downregulated microRNA-130b-5p prevents lipid accumulation and insulin resistance in a murine model of nonalcoholic fatty liver disease. | 2020 | Details |
| A08192 | 32212193 | Cell Biochem Funct | Knockdown of long non-coding RNA Gm10804 suppresses disorders of hepatic glucose and lipid metabolism in diabetes with non-alcoholic fatty liver disease. | 2020 | Details |
| A08330 | 32150756 | Hepatology | N6 -Methyladenosine Reader Protein YT521-B Homology Domain-Containing 2 Suppresses Liver Steatosis by Regulation of mRNA Stability of Lipogenic Genes. | 2020 | Details |
| A08338 | 32148418 | J Ginseng Res | Ameliorative effects of black ginseng on nonalcoholic fatty liver disease in free fatty acid-induced HepG2 cells and high-fat/high-fructose diet-fed mice. | 2019 | Details |
| A08376 | 32138593 | Prion | The role of cellular prion protein in lipid metabolism in the liver. | 2020 | Details |