Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Heme Oxygenase124 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00472 | 35068798 | J Clin Exp Hepatol | Diagnosis and Management of Cirrhotic Cardiomyopathy. | 2021 | Details |
| A00882 | 34943103 | Antioxidants (Basel) | Association of Serum Bilirubin and Functional Variants of Heme Oxygenase 1 and Bilirubin UDP-Glucuronosyl Transferase Genes in Czech Adult Patients with Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A02256 | 34445549 | Int J Mol Sci | Kaempferol and Kaempferide Attenuate Oleic Acid-Induced Lipid Accumulation and Oxidative Stress in HepG2 Cells. | 2021 | Details |
| A02455 | 34365685 | FASEB J | Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease. | 2021 | Details |
| A02594 | 34321089 | Stem Cell Res Ther | Addressing the liver progenitor cell response and hepatic oxidative stress in experimental non-alcoholic fatty liver disease/non-alcoholic steatohepatitis using amniotic epithelial cells. | 2021 | Details |
| A02787 | 34240649 | Int J Immunopathol Pharmacol | Allopurinol ameliorates liver injury in type 1 diabetic rats through activating Nrf2. | 2022 | Details |
| A03474 | 33990765 | Acta Pharmacol Sin | Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress. | 2021 | Details |
| A03643 | 33922045 | Molecules | Protective Effect of Cudrania tricuspidata Extract against High-Fat Diet Induced Nonalcoholic Fatty Liver Disease through Nrf-2/HO-1 Pathway. | 2021 | Details |
| A03702 | 33898958 | JHEP Rep | Weight-loss-independent benefits of exercise on liver steatosis and stiffness in Japanese men with NAFLD. | 2021 | Details |
| A03752 | 33878116 | PLoS One | Leaf powder supplementation of Senna alexandrina ameliorates oxidative stress, inflammation, and hepatic steatosis in high-fat diet-fed obese rats. | 2021 | Details |
| A03871 | 33838229 | J Nutr Biochem | Olive oil-derived nitro-fatty acids: protection of mitochondrial function in non-alcoholic fatty liver disease. | 2021 | Details |
| A03955 | 33808635 | Nutrients | Role of HO-1 against Saturated Fatty Acid-Induced Oxidative Stress in Hepatocytes. | 2021 | Details |
| A04518 | 33590347 | J Nat Med | Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis. | 2021 | Details |
| A04951 | 33439102 | Am J Physiol Gastrointest Liver Physiol | Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling. | 2021 | Details |
| A05012 | 33410857 | Food Funct | Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling. | 2021 | Details |
| A05060 | 33390979 | Front Pharmacol | Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate. | 2020 | Details |
| A05240 | 33327438 | Int J Mol Sci | Natural Product Heme Oxygenase Inducers as Treatment for Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A05268 | 33318872 | J Adv Res | Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential. | 2020 | Details |
| A05462 | 33248947 | Arch Biochem Biophys | The pivotal role of heme Oxygenase-1 in reversing the pathophysiology and systemic complications of NAFLD. | 2020 | Details |
| A06050 | 33027743 | Biomed Pharmacother | Sagittaria sagittifolia polysaccharide interferes with arachidonic acid metabolism in non-alcoholic fatty liver disease mice via Nrf2/HO-1 signaling pathway. | 2020 | Details |
| A06136 | 32992548 | Antioxidants (Basel) | Involvement of HO-1 and Autophagy in the Protective Effect of Magnolol in Hepatic Steatosis-Induced NLRP3 Inflammasome Activation In Vivo and In Vitro. | 2020 | Details |
| A06187 | 32976958 | Toxicology | Study on the attenuated effect of Ginkgolide B on ferroptosis in high fat diet induced nonalcoholic fatty liver disease. | 2020 | Details |
| A06248 | 32952590 | Evid Based Complement Alternat Med | Schisandra Fruit Vinegar Lowers Lipid Profile in High-Fat Diet Rats. | 2020 | Details |
| A07142 | 32604760 | Nutrients | Selenoneine Ameliorates Hepatocellular Injury and Hepatic Steatosis in a Mouse Model of NAFLD. | 2020 | Details |
| A07512 | 32461992 | Biomed Res Int | Heme Oxygenase-1 Suppresses Wnt Signaling Pathway in Nonalcoholic Steatohepatitis-Related Liver Fibrosis. | 2020 | Details |
| A07722 | 32376267 | Life Sci | Heme oxygenase-1 alleviated non-alcoholic fatty liver disease via suppressing ROS-dependent endoplasmic reticulum stress. | 2020 | Details |
| A07906 | 32315893 | Nutr Res | Siphonaxanthin, a carotenoid from green algae Codium cylindricum, protects Ob/Ob mice fed on a high-fat diet against lipotoxicity by ameliorating somatic stresses and restoring anti-oxidative capacity. | 2020 | Details |
| A08098 | 32245940 | Med Sci Monit | Ganoderma Lucidum Polysaccharides Ameliorates Hepatic Steatosis and Oxidative Stress in db/db Mice via Targeting Nuclear Factor E2 (Erythroid-Derived 2)-Related Factor-2/Heme Oxygenase-1 (HO-1) Pathway. | 2020 | Details |
| A08276 | 32171530 | Biochem Biophys Res Commun | Liraglutide ameliorates obesity-related nonalcoholic fatty liver disease by regulating Sestrin2-mediated Nrf2/HO-1 pathway. | 2020 | Details |
| A08499 | 32085637 | Nutrients | A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High-Cholesterol Diet. | 2020 | Details |
| A08555 | 32062620 | J Toxicol Sci | Taurine attenuates hepatic steatosis in a genetic model of fatty liver disease. | 2020 | Details |
| A08991 | 31913745 | Autophagy | SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. | 2020 | Details |
| A09072 | 31884405 | Phytomedicine | Protective effect of Hedansanqi Tiaozhi Tang against non-alcoholic fatty liver disease in vitro and in vivo through activating Nrf2/HO-1 antioxidant signaling pathway. | 2019 | Details |
| A09087 | 31881201 | Exp Mol Pathol | Alpha-syntrophin deficiency protects against non-alcoholic steatohepatitis associated increase of macrophages, CD8+ T-cells and galectin-3 in the liver. | 2019 | Details |
| A09097 | 31877680 | Int J Mol Sci | Mechanistic Insight of Na/K-ATPase Signaling and HO-1 into Models of Obesity and Nonalcoholic Steatohepatitis. | 2019 | Details |
| A10212 | 31430456 | Eur J Pharmacol | Pinolenic acid ameliorates oleic acid-induced lipogenesis and oxidative stress via AMPK/SIRT1 signaling pathway in HepG2 cells. | 2019 | Details |
| A10326 | 31387260 | Antioxidants (Basel) | Inhibition of Heme Oxygenase Antioxidant Activity Exacerbates Hepatic Steatosis and Fibrosis In Vitro. | 2019 | Details |
| A10337 | 31384535 | Acta Pharm Sin B | Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway. | 2019 | Details |
| A11012 | 31082341 | Zhonghua Gan Zang Bing Za Zhi | [Application of heme oxygenase 1 in the diagnosis of non-alcoholic fatty liver disease]. | 2019 | Details |
| A11098 | 31043271 | Biochem Biophys Res Commun | Hepatocellular iNOS protects liver from NASH through Nrf2-dependent activation of HO-1. | 2019 | Details |
| A11107 | 31039348 | Exp Cell Res | Epoxyeicosatrienoic intervention improves NAFLD in leptin receptor deficient mice by an increase in PGC1α-HO-1-PGC1α-mitochondrial signaling. | 2019 | Details |
| A11297 | 30950217 | J Cell Mol Med | Aucubin inhibited lipid accumulation and oxidative stress via Nrf2/HO-1 and AMPK signalling pathways. | 2019 | Details |
| A11385 | 30917489 | Int J Mol Sci | MicroRNA-29a Disrupts DNMT3b to Ameliorate Diet-Induced Non-Alcoholic Steatohepatitis in Mice. | 2019 | Details |
| A12108 | 30599260 | Free Radic Biol Med | Loss of RIP3 initiates annihilation of high-fat diet initialized nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4 and oxidative stress. | 2018 | Details |
| A12152 | 30580553 | Crit Rev Food Sci Nutr | n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review. | 2018 | Details |
| A13243 | 30067118 | J Med Food | Black Radish (Raphanus sativus L. var. niger) Extract Mediates Its Hepatoprotective Effect on Carbon Tetrachloride-Induced Hepatic Injury by Attenuating Oxidative Stress. | 2018 | Details |
| A13591 | 29890650 | Foods | Protection by the Total Flavonoids from Rosa laevigata Michx Fruit against Lipopolysaccharide-Induced Liver Injury in Mice via Modulation of FXR Signaling. | 2018 | Details |
| A13750 | 29775890 | Biomed Pharmacother | Triterpenic acids-enriched fraction from Cyclocarya paliurus attenuates non-alcoholic fatty liver disease via improving oxidative stress and mitochondrial dysfunction. | 2018 | Details |
| A13955 | 29672963 | Biofactors | Butein protects the nonalcoholic fatty liver through mitochondrial reactive oxygen species attenuation in rats. | 2018 | Details |
| A14172 | 29552625 | Cell Mol Gastroenterol Hepatol | Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2). | 2017 | Details |
| A14557 | 29355950 | J Pharm Pharmacol | Lansoprazole prevents the progression of liver fibrosis in non-alcoholic steatohepatitis model rats. | 2018 | Details |
| A15042 | 29121675 | PLoS One | Astaxanthin prevents ischemia-reperfusion injury of the steatotic liver in mice. | 2017 | Details |
| A15437 | 28906458 | Nutrients | Combination of Hypertension Along with a High Fat and Cholesterol Diet Induces Severe Hepatic Inflammation in Rats via a Signaling Network Comprising NF-κB, MAPK, and Nrf2 Pathways. | 2017 | Details |
| A16002 | 28618991 | Curr Med Chem | Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions. | 2018 | Details |
| A16085 | 28578014 | Free Radic Biol Med | Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway. | 2017 | Details |
| A16152 | 28536120 | FASEB J | Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressor. | 2017 | Details |
| A16743 | 28213091 | Toxicol Appl Pharmacol | Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity. | 2017 | Details |
| A16931 | 28088462 | Gastroenterology | Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones. | 2017 | Details |
| A17136 | 27973423 | Nutrients | Regressive Effect of Myricetin on Hepatic Steatosis in Mice Fed a High-Fat Diet. | 2016 | Details |
| A17170 | 27935258 | Mol Nutr Food Res | Polyphenols from Lonicera caerulea L. berry attenuate experimental nonalcoholic steatohepatitis by inhibiting proinflammatory cytokines productions and lipid peroxidation. | 2017 | Details |
| A17527 | 27738106 | J Biol Chem | Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α. | 2016 | Details |
| A17645 | 27692168 | Med Hypotheses | Does bilirubin prevent hepatic steatosis through activation of the PPARα nuclear receptor? | 2016 | Details |
| A17837 | 27547017 | World J Gastroenterol | Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review. | 2016 | Details |
| A18092 | 27354356 | Prostaglandins Other Lipid Mediat | EETs and HO-1 cross-talk. | 2016 | Details |
| A18158 | 27313828 | Oxid Med Cell Longev | S-Propargyl-cysteine Exerts a Novel Protective Effect on Methionine and Choline Deficient Diet-Induced Fatty Liver via Akt/Nrf2/HO-1 Pathway. | 2016 | Details |
| A18559 | 27057275 | Oxid Med Cell Longev | Synergistic Effects of Cilostazol and Probucol on ER Stress-Induced Hepatic Steatosis via Heme Oxygenase-1-Dependent Activation of Mitochondrial Biogenesis. | 2016 | Details |
| A18635 | 27021659 | Free Radic Res | Intermittent hypoxia upregulates hepatic heme oxygenase-1 and ferritin-1, thereby limiting hepatic pathogenesis in rats fed a high-fat diet. | 2016 | Details |
| A19084 | 26774456 | Biochem Pharmacol | Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer. | 2016 | Details |
| A19312 | 26634892 | Phytother Res | Gastrodin Ameliorates Oxidative Stress and Proinflammatory Response in Nonalcoholic Fatty Liver Disease through the AMPK/Nrf2 Pathway. | 2015 | Details |
| A19598 | 26463593 | Genes Nutr | Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice. | 2015 | Details |
| A19635 | 26445592 | Nutr Metab (Lond) | Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1. | 2015 | Details |
| A19899 | 26278387 | Curr Mol Pharmacol | Review: Precision Cut Liver Slices for the Evaluation of Fatty Liver and Fibrosis. | 2017 | Details |
| A20186 | 26098879 | PLoS One | Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose Diet. | 2015 | Details |
| A20305 | 26038701 | Pharmacol Res Perspect | Metformin protects primary rat hepatocytes against oxidative stress-induced apoptosis. | 2015 | Details |
| A20647 | 25835554 | Int J Obes (Lond) | Heme oxygenase-1 gene promoter polymorphism and the risk of pediatric nonalcoholic fatty liver disease. | 2015 | Details |
| A21023 | 25571645 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | [Effect of Nrf2 and related factors on the progression of nonalcoholic steatohepatitis]. | 2014 | Details |
| A21237 | 25462563 | Biochem Biophys Res Commun | The flavonoid monoHER promotes the adaption to oxidative stress during the onset of NAFLD. | 2014 | Details |
| A22108 | 24815820 | Food Chem Toxicol | Drug metabolism enzymes in a steatotic model of rat treated with a high fat diet and a low dose of streptozotocin. | 2014 | Details |
| A22876 | 24260182 | PLoS One | The heme oxygenase system rescues hepatic deterioration in the condition of obesity co-morbid with type-2 diabetes. | 2013 | Details |
| A22916 | 24214843 | Mol Nutr Food Res | Genistein alleviates the development of nonalcoholic steatohepatitis in ApoE(-/-) mice fed a high-fat diet. | 2013 | Details |
| A22939 | 24190226 | Int J Mol Med | Hypertension exacerbates liver injury and hepatic fibrosis induced by a choline-deficient L-amino acid-defined diet in rats. | 2013 | Details |
| A23012 | 24117897 | J Gastroenterol Hepatol | Effects of treatment with hydrogen sulfide on methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats. | 2014 | Details |
| A23083 | 24055888 | Biochim Biophys Acta | tert-Butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activation. | 2013 | Details |
| A23541 | 23697659 | Antioxid Redox Signal | A novel antihypoglycemic role of inducible nitric oxide synthase in liver inflammatory response induced by dietary cholesterol and endotoxemia. | 2013 | Details |
| A23780 | 23486573 | Bull Exp Biol Med | Characteristics of heme oxygenase-1 expression in rat hepatocytes during the development of nonalcoholic steatohepatitis. | 2013 | Details |
| A24396 | 22939811 | Eur J Intern Med | Reduced heme oxygenase-1 expression in steatotic livers infected with hepatitis C virus. | 2012 | Details |
| A24472 | 22863080 | Liver Int | α-lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats. | 2012 | Details |
| A24571 | 22739374 | J Nutr | Menhaden oil decreases high-fat diet-induced markers of hepatic damage, steatosis, inflammation, and fibrosis in obese Ldlr-/- mice. | 2012 | Details |
| A24614 | 22690236 | Hepat Mon | Heme oxygenase-1 mRNA expression in egyptian patients with chronic liver disease. | 2012 | Details |
| A24753 | 22535755 | J Nutr | Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats. | 2012 | Details |
| A25287 | 21994008 | Hepatology | Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation. | 2012 | Details |
| A26182 | 20943080 | Zhonghua Gan Zang Bing Za Zhi | [The role of heme oxygenase-1 in non-alcoholic steatohepatitis]. | 2010 | Details |
| A26360 | 20594230 | J Gastroenterol Hepatol | Oxidative stress and regulation of anti-oxidant enzymes in cytochrome P4502E1 transgenic mouse model of non-alcoholic fatty liver. | 2010 | Details |
| A26825 | 19702912 | J Gastroenterol Hepatol | Effect of dietary fat to produce non-alcoholic fatty liver in the rat. | 2009 | Details |
| A28293 | 15763346 | J Hepatol | Heme oxygenase-1 levels and oxidative stress-related parameters in non-alcoholic fatty liver disease patients. | 2005 | Details |
| A30027 | 33102487 | Front Cell Dev Biol | Distinct Factors Secreted by Adipose Stromal Cells Protect the Endothelium From Barrier Dysfunction and Apoptosis. | 2020 | Details |
| A30564 | 32205234 | Pharmacol Res | Obesity and NRF2-mediated cytoprotection: Where is the missing link? | 2020 | Details |
| A31279 | 30907226 | Autophagy | Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity. | 2019 | Details |
| A31673 | 30057822 | Int J Hepatol | Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress. | 2018 | Details |
| A33696 | 25385666 | Ir J Med Sci | Liver injury attenuation by curcumin in a rat NASH model: an Nrf2 activation-mediated effect? | 2014 | Details |