Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Ketohexokinase22 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A02345 | 34409309 | STAR Protoc | A luminescence-based protocol for assessing fructose metabolism via quantification of ketohexokinase enzymatic activity in mouse or human hepatocytes. | 2021 | Details |
| A02927 | 34195217 | Front Nutr | Grape Polyphenols Attenuate Diet-Induced Obesity and Hepatic Steatosis in Mice in Association With Reduced Butyrate and Increased Markers of Intestinal Carbohydrate Oxidation. | 2021 | Details |
| A04317 | 33667726 | Mol Metab | Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction. | 2021 | Details |
| A04831 | 33490936 | JHEP Rep | Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis. | 2020 | Details |
| A05527 | 33218081 | Biology (Basel) | Organismal Fructose Metabolism in Health and Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A05972 | 33057854 | Curr Diab Rep | Tissue-Specific Fructose Metabolism in Obesity and Diabetes. | 2020 | Details |
| A06369 | 32910646 | J Med Chem | Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose. | 2020 | Details |
| A06932 | 32694791 | Nat Metab | The small intestine shields the liver from fructose-induced steatosis. | 2020 | Details |
| A07203 | 32583961 | Clin Transl Sci | Evolving Role for Pharmacotherapy in NAFLD/NASH. | 2020 | Details |
| A07966 | 32296880 | J Mol Med (Berl) | HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD. | 2020 | Details |
| A08928 | 31935149 | Crit Rev Clin Lab Sci | Fructose and hepatic insulin resistance. | 2020 | Details |
| A09516 | 31713637 | Cell Mol Life Sci | Recent advances in the pathogenesis of hereditary fructose intolerance: implications for its treatment and the understanding of fructose-induced non-alcoholic fatty liver disease. | 2019 | Details |
| A11662 | 30798914 | Med Hypotheses | Fructose-associated hepatotoxicity indexed by the lactate dehydrogenase isoenzyme LDH-5. | 2019 | Details |
| A15307 | 28972537 | J Clin Invest | Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. | 2017 | Details |
| A17041 | 28034722 | Brain Res | Specific regions of the brain are capable of fructose metabolism. | 2016 | Details |
| A19922 | 26264689 | Proc Nutr Soc | Dietary carbohydrate and control of hepatic gene expression: mechanistic links from ATP and phosphate ester homeostasis to the carbohydrate-response element-binding protein. | 2015 | Details |
| A25056 | 33907358 | J Proteomics Bioinform | High Fat Diet-Induced Changes in Hepatic Protein Abundance in Mice. | 2012 | Details |
| A49355 | 35779864 | Drug Metab Dispos | Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, A First-in-class Ketohexokinase Inhibitor for Metabolic Disorders and Non-alcoholic Fatty Liver Disease. | 2022 | Details |
| A49931 | 35590219 | Med (N Y) | Inhibition of ketohexokinase in adults with NAFLD reduces liver fat and inflammatory markers: A randomized phase 2 trial. | 2021 | Details |
| A51762 | 34302121 | Int J Obes (Lond) | Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae. | 2021 | Details |
| A52079 | 31577934 | Cell Metab | Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins. | 2019 | Details |
| A52261 | 29533924 | J Clin Invest | Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice. | 2018 | Details |