Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Nicotinamide170 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00006 | 35256934 | Acta Pharm Sin B | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma. | 2021 | Details |
| A00091 | 35222903 | Ther Adv Chronic Dis | Nicotinamide supplementation in diabetic nonalcoholic fatty liver disease patients: randomized controlled trial. | 2022 | Details |
| A00251 | 35164657 | Bioengineered | Liraglutide inhibits receptor for advanced glycation end products (RAGE)/reduced form of nicotinamide-adenine dinucleotide phosphate (NAPDH) signaling to ameliorate non-alcoholic fatty liver disease (NAFLD) in vivo and vitro. | 2022 | Details |
| A01391 | 34762911 | J Biol Chem | Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes. | 2021 | Details |
| A01524 | 34708231 | Sheng Li Xue Bao | [The role of SIRT6 in nonalcoholic steatohepatitis]. | 2021 | Details |
| A01587 | 34684533 | Nutrients | Supplementation with a Specific Combination of Metabolic Cofactors Ameliorates Non-Alcoholic Fatty Liver Disease, Hepatic Fibrosis, and Insulin Resistance in Mice. | 2021 | Details |
| A01608 | 34680557 | Biomedicines | Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a High-Fat Diet. | 2021 | Details |
| A03278 | 34063865 | Metabolites | The Role of AKR1B10 in Physiology and Pathophysiology. | 2021 | Details |
| A03609 | 33932956 | J Physiol | NAD+ and NAFLD - caution, causality and careful optimism. | 2021 | Details |
| A03768 | 33870623 | Mol Nutr Food Res | Nicotinamide Protects Against Diet-Induced Body Weight Gain, Increases Energy Expenditure, and Induces White Adipose Tissue Beiging. | 2021 | Details |
| A04109 | 33754067 | Theranostics | NAD+-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin. | 2021 | Details |
| A04522 | 33588049 | Free Radic Biol Med | Influence of cardiometabolic comorbidities on myocardial function, infarction, and cardioprotection: Role of cardiac redox signaling. | 2021 | Details |
| A04731 | 33524747 | Chemosphere | Thiamethoxam induces nonalcoholic fatty liver disease in mice via methionine metabolism disturb via nicotinamide N-methyltransferase overexpression. | 2021 | Details |
| A05022 | 33408299 | J Toxicol Sci | Reduction of fatty liver in rats by nicotinamide via the regeneration of the methionine cycle and the inhibition of aldehyde oxidase. | 2021 | Details |
| A05131 | 33362385 | World J Gastroenterol | Untargeted metabolomics characteristics of nonobese nonalcoholic fatty liver disease induced by high-temperature-processed feed in Sprague-Dawley rats. | 2020 | Details |
| A05268 | 33318872 | J Adv Res | Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential. | 2020 | Details |
| A05645 | 33177546 | Sci Rep | PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat. | 2020 | Details |
| A05828 | 33105604 | Int J Mol Sci | Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor. | 2020 | Details |
| A06028 | 33035588 | Life Sci | Nicotinamide and ascorbic acid nanoparticles against the hepatic insult induced in rats by high fat high fructose diet: A comparative study. | 2020 | Details |
| A06119 | 32998280 | Metabolites | Neuronal Lipoprotein Lipase Deficiency Alters Neuronal Function and Hepatic Metabolism. | 2020 | Details |
| A06259 | 32951289 | Physiol Rep | Targeted and untargeted metabolomics provide insight into the consequences of glycine-N-methyltransferase deficiency including the novel finding of defective immune function. | 2020 | Details |
| A06472 | 32866186 | PLoS One | Differences among patients with and without nonalcoholic fatty liver disease having elevated alanine aminotransferase levels at various stages of metabolic syndrome. | 2020 | Details |
| A06691 | 32779442 | Cell J | Nicotinamide Phosphoribosyltransferase Knockdown Leads to Lipid Accumulation in HepG2 Cells through The SIRT1-AMPK Pathway. | 2020 | Details |
| A06880 | 32712045 | Asian J Surg | Sleeve gastrectomy ameliorated high-fat diet (HFD)-induced non-alcoholic fatty liver disease and upregulated the nicotinamide adenine dinucleotide +/ Sirtuin-1 pathway in mice. | 2020 | Details |
| A07521 | 32460191 | Biomed Pharmacother | Sodium acetate-mediated inhibition of histone deacetylase alleviates hepatic lipid dysregulation and its accompanied injury in streptozotocin-nicotinamide-induced diabetic rats. | 2020 | Details |
| A07643 | 32410680 | Lipids Health Dis | Hepatic steatosis induced in C57BL/6 mice by a non-ß oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD+/NADH ratio. | 2020 | Details |
| A07840 | 32337855 | Mol Syst Biol | The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease. | 2020 | Details |
| A07935 | 32305562 | Cell Mol Gastroenterol Hepatol | SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells. | 2020 | Details |
| A08286 | 32169417 | Biochem Pharmacol | Modulation of aryl hydrocarbon receptor (AHR) and the NAD+-consuming enzyme CD38: Searches of therapeutic options for nonalcoholic fatty liver disease (NAFLD). | 2020 | Details |
| A08401 | 32124686 | Curr Med Chem | The Effect of CB1 Antagonism on Hepatic Oxidative/Nitrosative Stress and Inflammation in Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A08424 | 32116659 | Front Pharmacol | Five Constituents in Psoralea corylifolia L. Attenuate Palmitic Acid-Induced Hepatocyte Injury via Inhibiting the Protein Kinase C-α/Nicotinamide-Adenine Dinucleotide Phosphate Oxidase Pathway. | 2020 | Details |
| A08741 | 32004929 | J Nutr Biochem | Advanced liver steatosis accompanies an increase in hepatic inflammation, colonic, secondary bile acids and Lactobacillaceae/Lachnospiraceae bacteria in C57BL/6 mice fed a high-fat diet. | 2020 | Details |
| A08763 | 31993314 | Acta Pharm Sin B | Impact of obese levels on the hepatic expression of nuclear receptors and drug-metabolizing enzymes in adult and offspring mice. | 2019 | Details |
| A08893 | 31950520 | Hepatology | Nonphagocytic Activation of NOX2 Is Implicated in Progressive Nonalcoholic Steatohepatitis During Aging. | 2020 | Details |
| A09214 | 31834057 | Eur J Gastroenterol Hepatol | Serum visfatin level as a noninvasive marker for nonalcoholic fatty liver disease in children and adolescents with obesity: relation to transient elastography with controlled attenuation parameter. | 2020 | Details |
| A09681 | 31650383 | Mol Biol Rep | High fructose-containing drinking water-induced steatohepatitis in rats is prevented by the nicotinamide-mediated modulation of redox homeostasis and NADPH-producing enzymes. | 2019 | Details |
| A10015 | 31523515 | PeerJ | Nicotinamide riboside exerts protective effect against aging-induced NAFLD-like hepatic dysfunction in mice. | 2019 | Details |
| A10055 | 31510030 | Metabolites | Nicotinamide and NAFLD: Is There Nothing New Under the Sun? | 2019 | Details |
| A10090 | 31491949 | Int J Mol Sci | Combined Treatment with L-Carnitine and Nicotinamide Riboside Improves Hepatic Metabolism and Attenuates Obesity and Liver Steatosis. | 2019 | Details |
| A10155 | 31465774 | Biochem Pharmacol | Functions of aryl hydrocarbon receptor (AHR) and CD38 in NAD metabolism and nonalcoholic steatohepatitis (NASH). | 2019 | Details |
| A10166 | 31462971 | Comput Struct Biotechnol J | Hallmarks of Aging in the Liver. | 2019 | Details |
| A10293 | 31396538 | J Diabetes Res | Visfatin Induces Inflammation and Insulin Resistance via the NF-κB and STAT3 Signaling Pathways in Hepatocytes. | 2019 | Details |
| A10435 | 31336926 | Nutrients | The Potential Use of Metabolic Cofactors in Treatment of NAFLD. | 2019 | Details |
| A10785 | 31195117 | Biochim Biophys Acta Mol Basis Dis | Nicotinamide riboside, an NAD+ precursor, attenuates the development of liver fibrosis in a diet-induced mouse model of liver fibrosis. | 2019 | Details |
| A10901 | 31132798 | Horm Metab Res | Association Between Visfatin and Hepatic Steatosis in the General Population During Long-Term Follow-Up. | 2019 | Details |
| A11672 | 30794635 | PLoS One | NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice. | 2019 | Details |
| A12267 | 30541001 | Ann Nutr Metab | Association of Circulating Adipsin, Visfatin, and Adiponectin with Nonalcoholic Fatty Liver Disease in Adults: A Case-Control Study. | 2018 | Details |
| A12460 | 30446221 | Biochem Biophys Res Commun | Alleviation of fatty liver in a rat model by enhancing N1-methylnicotinamide bioavailability through aldehyde oxidase inhibition. | 2018 | Details |
| A12637 | 30356218 | Nature | De novo NAD+ synthesis enhances mitochondrial function and improves health. | 2018 | Details |
| A12889 | 30240470 | J Gastrointestin Liver Dis | Genetic Variants in nicotinamide-N-methyltransferase (NNMT) gene are related to the stage of non-alcoholic fatty liver disease diagnosed by controlled attenuation parameter (CAP)-fibroscan. | 2018 | Details |
| A13056 | 30158971 | Gastroenterol Res Pract | Establishment and Comparison of Juvenile Female Mouse Models of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis. | 2018 | Details |
| A13346 | 30019598 | Antioxid Redox Signal | Does Nox2 Overactivate in Children with Nonalcoholic Fatty Liver Disease? | 2018 | Details |
| A13577 | 29898626 | Adipocyte | Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance. | 2018 | Details |
| A13578 | 29898429 | Biomed Pharmacother | Cyanidin-3-O-β-glucoside regulates the activation and the secretion of adipokines from brown adipose tissue and alleviates diet induced fatty liver. | 2018 | Details |
| A13777 | 29761652 | Pediatr Obes | Vitamin D status and associated genetic polymorphisms in a cohort of UK children with non-alcoholic fatty liver disease. | 2018 | Details |
| A13780 | 29761170 | Hepatol Commun | Nicotinamide adenine dinucleotide phosphate (reduced) oxidase 2 modulates inflammatory vigor during nonalcoholic fatty liver disease progression in mice. | 2018 | Details |
| A13963 | 29669855 | Sci Transl Med | Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target. | 2018 | Details |
| A14053 | 29608898 | Eur J Pharmacol | Canagliflozin protects against non-alcoholic steatohepatitis in type-2 diabetic rats through zinc alpha-2 glycoprotein up-regulation. | 2018 | Details |
| A14097 | 29589386 | Endocrinol Metab (Seoul) | Association of Adipokines with Development and Progression of Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A14104 | 29581157 | J Lipid Res | Regulation of mitochondrial trifunctional protein modulates nonalcoholic fatty liver disease in mice. | 2018 | Details |
| A14123 | 29574225 | Pharmacol Res | Dioscin alleviates non-alcoholic fatty liver disease through adjusting lipid metabolism via SIRT1/AMPK signaling pathway. | 2018 | Details |
| A14436 | 29408602 | Mol Cell Endocrinol | Hepatic NAD+ levels and NAMPT abundance are unaffected during prolonged high-fat diet consumption in C57BL/6JBomTac mice. | 2018 | Details |
| A14601 | 29329924 | Nutr Metab Cardiovasc Dis | Effects of dark chocolate on endothelial function in patients with non-alcoholic steatohepatitis. | 2017 | Details |
| A14733 | 29266812 | Mol Nutr Food Res | Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice. | 2018 | Details |
| A14761 | 29249967 | Front Pharmacol | Psoralea corylifolia L. Attenuates Nonalcoholic Steatohepatitis in Juvenile Mouse. | 2017 | Details |
| A15157 | 29069580 | Eur J Pharmacol | Nicotinamide prevents sweet beverage-induced hepatic steatosis in rats by regulating the G6PD, NADPH/NADP+ and GSH/GSSG ratios and reducing oxidative and inflammatory stress. | 2017 | Details |
| A15302 | 28973994 | Nutrients | Silibinin Restores NAD⁺ Levels and Induces the SIRT1/AMPK Pathway in Non-Alcoholic Fatty Liver. | 2017 | Details |
| A15369 | 28942246 | Free Radic Biol Med | Inhibition of hepatocyte nuclear factor 1b induces hepatic steatosis through DPP4/NOX1-mediated regulation of superoxide. | 2017 | Details |
| A15417 | 28923496 | Gastroenterology | Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice. | 2017 | Details |
| A15714 | 28748119 | J Adv Res | Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review. | 2016 | Details |
| A16139 | 28544208 | Liver Int | Ultra-high-field magnetic resonance spectroscopy in non-alcoholic fatty liver disease: Novel mechanistic and diagnostic insights of energy metabolism in non-alcoholic steatohepatitis and advanced fibrosis. | 2017 | Details |
| A16274 | 28473059 | Nutr Res | Nicotinamide protects hepatocytes against palmitate-induced lipotoxicity via SIRT1-dependent autophagy induction. | 2017 | Details |
| A16337 | 28449683 | Lipids Health Dis | Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway. | 2017 | Details |
| A16362 | 28437863 | Hepatology | Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity. | 2017 | Details |
| A16917 | 28092906 | Med Princ Pract | Association between Nicotinamide Phosphoribosyltransferase and de novo Lipogenesis in Nonalcoholic Fatty Liver Disease. | 2017 | Details |
| A16961 | 28073422 | Zhonghua Gan Zang Bing Za Zhi | [Research advances in the association between deacetylase Sirtuin3 and liver diseases]. | 2016 | Details |
| A17050 | 28028356 | World J Gastroenterol | Sirtuins and nonalcoholic fatty liver disease. | 2016 | Details |
| A17118 | 27982256 | Acta Cir Bras | Effect of curcumin on visfatin and zinc-α2-glycoprotein in a rat model of non-alcoholic fatty liver disease. | 2016 | Details |
| A17680 | 27663419 | J Hepatol | Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease. | 2016 | Details |
| A18108 | 27348013 | Biomolecules | Role of Transcription Factors in Steatohepatitis and Hypertension after Ethanol: The Epicenter of Metabolism. | 2016 | Details |
| A18246 | 27265388 | Aliment Pharmacol Ther | Effects of dark chocolate on NOX-2-generated oxidative stress in patients with non-alcoholic steatohepatitis. | 2016 | Details |
| A18259 | 27260465 | J Nutr Biochem | A conjugated fatty acid present at high levels in bitter melon seed favorably affects lipid metabolism in hepatocytes by increasing NAD(+)/NADH ratio and activating PPARα, AMPK and SIRT1 signaling pathway. | 2016 | Details |
| A18375 | 27174364 | Br J Pharmacol | Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. | 2016 | Details |
| A18927 | 26867120 | Folia Med Cracov | Visfatin and TGF-Β1 in primary biliary cirrhosis and two other common liver diseases. | 2015 | Details |
| A19388 | 26594248 | Diabetol Metab Syndr | Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus. | 2015 | Details |
| A19400 | 26591766 | Wei Sheng Yan Jiu | [Interaction of polymorphisms of monocyte chemoattractant protein-1 receptor CCR2 gene 190A/G, nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox gene C242T and cigarette smoking increases the risk of nonalcoholic fatty liver disease]. | 2015 | Details |
| A19702 | 26404765 | Hepatology | Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. | 2015 | Details |
| A20000 | 26215259 | Nat Rev Endocrinol | Physiological and pathophysiological roles of NAMPT and NAD metabolism. | 2015 | Details |
| A20100 | 26155043 | J Clin Exp Hepatol | The Riddle of Nonalcoholic Fatty Liver Disease: Progression From Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis. | 2015 | Details |
| A20315 | 26033245 | Mol Cell Endocrinol | Hepatic NAD salvage pathway is enhanced in mice on a high-fat diet. | 2015 | Details |
| A20481 | 25934505 | Genes Dev | Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. | 2015 | Details |
| A20754 | 25755546 | J Clin Exp Hepatol | Metadoxine Versus Placebo for the Treatment of Non-alcoholic Steatohepatitis: A Randomized Controlled Trial. | 2014 | Details |
| A20786 | 25736100 | Cancer Sci | Suppression of silent information regulator 1 activity in noncancerous tissues of hepatocellular carcinoma: Possible association with non-B non-C hepatitis pathogenesis. | 2015 | Details |
| A21337 | 25394651 | Pol Arch Med Wewn | A composite model including visfatin, tissue polypeptide-specific antigen, hyaluronic acid, and hematological variables for the diagnosis of moderate-to-severe fibrosis in nonalcoholic fatty liver disease: a preliminary study. | 2014 | Details |
| A21502 | 25270373 | Acta Radiol | High resolution in vivo 31P-MRS of the liver: potential advantages in the assessment of non-alcoholic fatty liver disease. | 2014 | Details |
| A21506 | 25267960 | J Gastrointestin Liver Dis | A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators. | 2014 | Details |
| A21815 | 25026599 | Biochem Pharmacol | Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice. | 2014 | Details |
| A21909 | 24968200 | Br J Nutr | Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats. | 2014 | Details |
| A23017 | 24115079 | Hepatology | IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice. | 2014 | Details |
| A23068 | 24067262 | Ann Hepatol | Adipocytokines and cytokeratin-18 in patients with nonalcoholic fatty liver disease: Introduction of CHA index. | 2014 | Details |