Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Phosphatidylcholine289 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00056 | 35240344 | Cell Mol Gastroenterol Hepatol | Activation of Liver mTORC1 Protects Against NASH via Dual Regulation of VLDL-TAG Secretion and De Novo Lipogenesis. | 2022 | Details |
| A00141 | 35212227 | J Agric Food Chem | Targeted Lipidomics Reveal the Effects of Different Phospholipids on the Phospholipid Profiles of Hepatic Mitochondria and Endoplasmic Reticulum in High-Fat/High-Fructose-Diet-Induced Nonalcoholic Fatty Liver Disease Mice. | 2022 | Details |
| A00209 | 35185113 | J Pediatr Gastroenterol Nutr | Comparison of the Lipidomic Signature of Fatty Liver in Children and Adults: A Cross-Sectional Study. | 2022 | Details |
| A00832 | 34954499 | Redox Biol | Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation. | 2021 | Details |
| A00891 | 34939051 | J Mass Spectrom Adv Clin Lab | A pilot study optimizing metabolomic and lipidomic acquisition in serum for biomarker discovery in nonalcoholic fatty liver disease. | 2021 | Details |
| A01488 | 34727379 | Biomed Chromatogr | Lipidomic-based investigation into the therapeutic effects of polyene phosphatidylcholine and Babao Dan on rats with non-alcoholic fatty liver disease. | 2021 | Details |
| A01521 | 34710382 | Am J Pathol | A Novel Mouse Model of Nonalcoholic Steatohepatitis Suggests that Liver Fibrosis Initiates around Lipid-Laden Macrophages. | 2021 | Details |
| A01754 | 34629052 | Lipids Health Dis | Serum lipids are associated with nonalcoholic fatty liver disease: a pilot case-control study in Mexico. | 2021 | Details |
| A01803 | 34609304 | Turk J Gastroenterol | Safety and Effectiveness of Essential Phospholipids Paste in Patients with Non-alcoholic Fatty Liver Disease or Viral Hepatitis. | 2021 | Details |
| A01972 | 34547171 | Liver Int | The role of hepatic lipid composition in obesity-related metabolic disease. | 2021 | Details |
| A02323 | 34419589 | Biochim Biophys Acta Mol Cell Biol Lipids | Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes. | 2021 | Details |
| A02365 | 34401690 | JHEP Rep | Comprehensive lipidomics reveals phenotypic differences in hepatic lipid turnover in ALD and NAFLD during alcohol intoxication. | 2021 | Details |
| A02583 | 34322898 | Hepatology | Guanine Nucleotide-Binding Protein G(i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1-Related Inflammation and Lipophagy. | 2021 | Details |
| A02760 | 34256994 | Hepatobiliary Pancreat Dis Int | LC-MS-based lipidomic analysis in distinguishing patients with nonalcoholic steatohepatitis from nonalcoholic fatty liver. | 2021 | Details |
| A02799 | 34235481 | Curr Res Struct Biol | A two-stage computational approach to predict novel ligands for a chemosensory receptor. | 2020 | Details |
| A02909 | 34200685 | Metabolites | Metabolomic Study of High-Fat Diet-Induced Obese (DIO) and DIO Plus CCl4-Induced NASH Mice and the Effect of Obeticholic Acid. | 2021 | Details |
| A03082 | 34137937 | Metabolomics | Plasma and stool metabolomics to identify microbiota derived-biomarkers of metabolic dysfunction-associated fatty liver disease: effect of PNPLA3 genotype. | 2021 | Details |
| A03338 | 34036256 | JHEP Rep | A human liver chimeric mouse model for non-alcoholic fatty liver disease. | 2021 | Details |
| A03508 | 33977946 | Food Funct | DHA-enriched phosphatidylserine ameliorates non-alcoholic fatty liver disease and intestinal dysbacteriosis in mice induced by a high-fat diet. | 2021 | Details |
| A03860 | 33841814 | Food Sci Nutr | Functional beverages improve insulin resistance and hepatic steatosis modulating lysophospholipids in diet-induced obese rats. | 2021 | Details |
| A03950 | 33809964 | Metabolites | Stable Isotopic Tracer Phospholipidomics Reveals Contributions of Key Phospholipid Biosynthetic Pathways to Low Hepatocyte Phosphatidylcholine to Phosphatidylethanolamine Ratio Induced by Free Fatty Acids. | 2021 | Details |
| A04410 | 33629536 | Mol Nutr Food Res | Effect of Mastiha supplementation on NAFLD: The MAST4HEALTH Randomised, Controlled Trial. | 2021 | Details |
| A04419 | 33626003 | Turk J Gastroenterol | Berberine inhibits liver damage in rats with non-alcoholic fatty liver disease by regulating TLR4/MyD88/NF-κB pathway. | 2020 | Details |
| A04470 | 33603909 | Maedica (Bucur) | Red Blood Cell Dysfunction in Non-Alcoholic Fatty Liver Disease: Marker and Mediator of Molecular Mechanisms. | 2020 | Details |
| A04747 | 33515803 | Ann Hepatol | Effects of chronic HBV infection on lipid metabolism in non-alcoholic fatty liver disease: A lipidomic analysis. | 2021 | Details |
| A05004 | 33417276 | Mol Syst Biol | Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis. | 2021 | Details |
| A05337 | 33298075 | Lipids Health Dis | Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease. | 2020 | Details |
| A05523 | 33219609 | Liver Int | Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids. | 2020 | Details |
| A05552 | 33208407 | Gut | Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis. | 2020 | Details |
| A05955 | 33062150 | Oxid Med Cell Longev | Prevention of Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement of Adiponectin-Induced Inhibition of Hepatic SREBP-1c. | 2020 | Details |
| A06141 | 32991778 | Mol Nutr Food Res | Methionine- and Choline-Deficient Diet Enhances Adipose Lipolysis and Leptin Release in aP2-Cre Fatp4-Knockout Mice. | 2020 | Details |
| A06266 | 32947564 | J Pediatr Gastroenterol Nutr | Lipidomics in Nonalcoholic Fatty Liver Disease: Exploring Serum Lipids as Biomarkers for Pediatric Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A06812 | 32738061 | Hepatology | Prenatal Exposure to Perfluoroalkyl Substances Associated With Increased Susceptibility to Liver Injury in Children. | 2020 | Details |
| A06855 | 32720691 | Hum Mol Genet | Insights into genetic variants associated with NASH-fibrosis from metabolite profiling. | 2020 | Details |
| A07524 | 32455496 | Hepatol Res | Metabolomic/lipidomic-based analysis of plasma to diagnose hepatocellular ballooning in patients with non-alcoholic fatty liver disease: A multicenter study. | 2020 | Details |
| A07600 | 32429478 | Cells | Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH. | 2020 | Details |
| A07793 | 32353385 | Toxicol Appl Pharmacol | Metabolomic-based assessment reveals dysregulation of lipid profiles in human liver cells exposed to environmental obesogens. | 2020 | Details |
| A07822 | 32344934 | J Clin Med | Lipidomics Reveals Reduced Inflammatory Lipid Species and Storage Lipids after Switching from EFV/FTC/TDF to RPV/FTC/TDF: A Randomized Open-Label Trial. | 2020 | Details |
| A07844 | 32337059 | BMJ Open Gastroenterol | Effectiveness of phosphatidylcholine as adjunctive therapy in improving liver function tests in patients with non-alcoholic fatty liver disease and metabolic comorbidities: real-life observational study from Russia. | 2020 | Details |
| A07921 | 32309295 | Kidney Dis (Basel) | Plasma Metabolomics Profiling in Maintenance Hemodialysis Patients Based on Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry. | 2020 | Details |
| A08075 | 32257815 | Mol Genet Metab Rep | Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice. | 2020 | Details |
| A08081 | 32255515 | Lipids | Lipid Profiles of Five Essential Phospholipid Preparations for the Treatment of Nonalcoholic Fatty Liver Disease: A Comparative Study. | 2020 | Details |
| A08417 | 32119738 | J Nutr | One-Carbon Metabolism in Fatty Liver Disease and Fibrosis: One-Carbon to Rule Them All. | 2020 | Details |
| A08477 | 32095253 | BMJ Open Gastroenterol | Effectiveness of phosphatidylcholine in alleviating steatosis in patients with non-alcoholic fatty liver disease and cardiometabolic comorbidities (MANPOWER study). | 2020 | Details |
| A08501 | 32084378 | Cell Metab | Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly. | 2020 | Details |
| A08657 | 32030821 | J Gastroenterol Hepatol | Aging exacerbates high-fat diet-induced steatohepatitis through alteration in hepatic lipid metabolism in mice. | 2020 | Details |
| A09480 | 31728041 | Sci Rep | Multi-technique comparison of atherogenic and MCD NASH models highlights changes in sphingolipid metabolism. | 2019 | Details |
| A09498 | 31718984 | J Pharm Biomed Anal | Metabolic impact of partial hepatectomy in the non-alcoholic steatohepatitis animal model of methionine-choline deficient diet. | 2019 | Details |
| A09526 | 31709254 | Front Cell Dev Biol | Fatty Liver Due to Increased de novo Lipogenesis: Alterations in the Hepatic Peroxisomal Proteome. | 2019 | Details |
| A09546 | 31699440 | Environ Int | Hepatotoxic effects of inhalation exposure to polycyclic aromatic hydrocarbons on lipid metabolism of C57BL/6 mice. | 2019 | Details |
| A09558 | 31695245 | J Clin Exp Hepatol | Whole-Exome Sequencing Identifies a Variant in Phosphatidylethanolamine N-Methyltransferase Gene to be Associated With Lean-Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A09693 | 31645659 | Acta Pharmacol Sin | WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice. | 2019 | Details |
| A09888 | 31574193 | Mol Nutr Food Res | Green Tea Extract Treatment in Obese Mice with Nonalcoholic Steatohepatitis Restores the Hepatic Metabolome in Association with Limiting Endotoxemia-TLR4-NFκB-Mediated Inflammation. | 2019 | Details |
| A09934 | 31554528 | Br J Nutr | Randomised trial of chronic supplementation with a nutraceutical mixture in subjects with non-alcoholic fatty liver disease. | 2020 | Details |
| A10018 | 31523440 | BMJ Open Gastroenterol | Real-world comorbidities and treatment patterns among patients with non-alcoholic fatty liver disease receiving phosphatidylcholine as adjunctive therapy in Russia. | 2019 | Details |
| A10023 | 31521175 | Lipids Health Dis | Variations in hepatic lipid species of age-matched male mice fed a methionine-choline-deficient diet and housed in different animal facilities. | 2019 | Details |
| A10068 | 31503515 | Am J Physiol Endocrinol Metab | HDL flux is higher in patients with nonalcoholic fatty liver disease. | 2019 | Details |
| A10205 | 31433301 | J Hepatol | Integrin β1-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH. | 2019 | Details |
| A10570 | 31284753 | FASEB J | Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance. | 2019 | Details |
| A10678 | 31239664 | Int J Nanomedicine | Mixed micelles loaded with the 5-benzylidenethiazolidine-2,4-dione derivative SKLB023 for efficient treatment of non-alcoholic steatohepatitis. | 2019 | Details |
| A10774 | 31199045 | Liver Int | Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression. | 2019 | Details |
| A10960 | 31101783 | Georgian Med News | RESULTS OF CORRECTION OF THE HEPATIC STEATOSIS ON THE BACKGROUND OF HYPERTENSION AND OVERWEIGHT WITH HELP OF ESSENTIAL PHOSPHOLIPID COMPLEX. | 2019 | Details |
| A11670 | 30796508 | Eur J Nutr | Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial. | 2019 | Details |
| A11769 | 30758417 | Rev Assoc Med Bras (1992) | The efficacy of saxagliptin in T2DM patients with non-alcoholic fatty liver disease: preliminary data. | 2019 | Details |
| A11799 | 30735855 | Biochim Biophys Acta Mol Cell Biol Lipids | Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling. | 2019 | Details |
| A11800 | 30735854 | Biochim Biophys Acta Mol Cell Biol Lipids | iPla2β deficiency in mice fed with MCD diet does not correct the defect of phospholipid remodeling but attenuates hepatocellular injury via an inhibition of lipid uptake genes. | 2019 | Details |
| A12053 | 30621707 | Lipids Health Dis | Plasma lipidomic signatures of spontaneous obese rhesus monkeys. | 2019 | Details |
| A12182 | 30572788 | Biosci Biotechnol Biochem | A review of the studies on food-derived factors which regulate energy metabolism via the modulation of lipid-sensing nuclear receptors. | 2018 | Details |
| A12341 | 30500173 | Anal Chem | LipidMS: An R Package for Lipid Annotation in Untargeted Liquid Chromatography-Data Independent Acquisition-Mass Spectrometry Lipidomics. | 2018 | Details |
| A12679 | 30333136 | J Cell Sci | Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress. | 2018 | Details |
| A12754 | 30300671 | Biochim Biophys Acta Mol Basis Dis | Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice. | 2018 | Details |
| A12798 | 30283798 | World J Clin Cases | PNPLA3 rs139051 is associated with phospholipid metabolite profile and hepatic inflammation in nonalcoholic fatty liver disease. | 2018 | Details |
| A12823 | 30266576 | Diabetes Metab | Clinical and metabolic characterization of obese subjects without non-alcoholic fatty liver: A targeted metabolomics approach. | 2018 | Details |
| A13052 | 30160786 | J Gastroenterol Hepatol | Caspase-independent hepatocyte death: A result of the decrease of lysophosphatidylcholine acyltransferase 3 in non-alcoholic steatohepatitis. | 2018 | Details |
| A13301 | 30042157 | J Lipid Res | Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression. | 2018 | Details |
| A13500 | 29947103 | Eur J Clin Invest | Plasma lecithin:cholesterol acyltransferase and phospholipid transfer protein activity independently associate with nonalcoholic fatty liver disease. | 2018 | Details |
| A13604 | 29883377 | Nutrients | Circulating Phospholipid Patterns in NAFLD Patients Associated with a Combination of Metabolic Risk Factors. | 2018 | Details |
| A13686 | 29805971 | Int J Chronic Dis | Reduction of Liver Span and Parameters of Inflammation in Nonalcoholic Fatty Liver Disease Patients Treated with Lycosome Formulation of Phosphatidylcholine: A Preliminary Report. | 2018 | Details |
| A14103 | 29583004 | J Agric Food Chem | Effects of Stigmasterol and β-Sitosterol on Nonalcoholic Fatty Liver Disease in a Mouse Model: A Lipidomic Analysis. | 2018 | Details |
| A14260 | 29498345 | Br J Nutr | 20-Week follow-up of hepatic steatosis installation and liver mitochondrial structure and activity and their interrelation in rats fed a high-fat-high-fructose diet. | 2018 | Details |
| A14275 | 29488482 | Ter Arkh | [Optimization of therapy for hepatobiliary disorders in psoriatic patients]. | 2019 | Details |
| A14417 | 29416063 | Nat Commun | AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle. | 2018 | Details |
| A14473 | 29397594 | Zhonghua Nei Ke Za Zhi | [Efficacy of probiotics on the treatment of non-alcoholic fatty liver disease]. | 2018 | Details |
| A14902 | 29182572 | Int J Mol Sci | Aberrant Lipid Metabolism in Hepatocellular Carcinoma Revealed by Liver Lipidomics. | 2017 | Details |
| A14963 | 29154964 | J Hepatol | Lipotoxicity and the gut-liver axis in NASH pathogenesis. | 2017 | Details |
| A15103 | 29093267 | JCI Insight | Loss of miR-141/200c ameliorates hepatic steatosis and inflammation by reprogramming multiple signaling pathways in NASH. | 2017 | Details |
| A15335 | 28962213 | Exp Ther Med | Effects of telmisartan on improving leptin resistance and inhibiting hepatic fibrosis in rats with non-alcoholic fatty liver disease. | 2017 | Details |
| A15475 | 28887301 | J Biol Chem | The phospholipase PNPLA7 functions as a lysophosphatidylcholine hydrolase and interacts with lipid droplets through its catalytic domain. | 2017 | Details |
| A15558 | 28844958 | Biochim Biophys Acta Mol Basis Dis | Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet. | 2017 | Details |
| A15696 | 28754826 | J Lipid Res | Osteopontin regulates the cross-talk between phosphatidylcholine and cholesterol metabolism in mouse liver. | 2017 | Details |
| A15742 | 28733574 | Sci Rep | Metabolomic characteristics of cholesterol-induced non-obese nonalcoholic fatty liver disease in mice. | 2017 | Details |
| A15783 | 28711489 | Life Sci | Time-course microarrays reveal early activation of the immune transcriptome in a choline-deficient mouse model of liver injury. | 2017 | Details |
| A15921 | 28652427 | In Vivo | A Long-term Treatment with Silybin in Patients with Non-alcoholic Steatohepatitis Stimulates Catalase Activity in Human Endothelial Cells. | 2018 | Details |
| A15931 | 28646856 | BMC Immunol | The imbalance of Th17/Treg cells is involved in the progression of nonalcoholic fatty liver disease in mice. | 2017 | Details |
| A16412 | 28411170 | Biochim Biophys Acta Biomembr | The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease. | 2017 | Details |
| A16582 | 28297799 | Zhonghua Gan Zang Bing Za Zhi | [A serum lipidomic study of patients with non-alcoholic fatty liver disease]. | 2017 | Details |
| A16654 | 28262979 | J Cell Biochem | Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism During Hepatocyte Lipotoxicity. | 2017 | Details |
| A16700 | 28235613 | J Hepatol | Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD. | 2017 | Details |
| A16811 | 28159867 | J Lipid Res | Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase. | 2017 | Details |
| A16862 | 28123936 | Mol Metab | Metabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose metabolism. | 2016 | Details |