Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Rapamycin222 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00006 | 35256934 | Acta Pharm Sin B | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma. | 2021 | Details |
| A00056 | 35240344 | Cell Mol Gastroenterol Hepatol | Activation of Liver mTORC1 Protects Against NASH via Dual Regulation of VLDL-TAG Secretion and De Novo Lipogenesis. | 2022 | Details |
| A00093 | 35222075 | Front Physiol | MicroRNA-122-5p Inhibition Improves Inflammation and Oxidative Stress Damage in Dietary-Induced Non-alcoholic Fatty Liver Disease Through Targeting FOXO3. | 2022 | Details |
| A00101 | 35219732 | Eur J Pharmacol | mTOR as an eligible molecular target for possible pharmacological treatment of nonalcoholic steatohepatitis. | 2022 | Details |
| A00324 | 35134508 | J Nutr Biochem | Mechanisms of autophagic responses to altered nutritional status. | 2022 | Details |
| A00342 | 35127372 | Acta Pharm Sin B | The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy. | 2021 | Details |
| A00343 | 35127371 | Acta Pharm Sin B | Therapeutic regulation of autophagy in hepatic metabolism. | 2021 | Details |
| A00413 | 35093393 | Biochem Pharmacol | Targeting lipophagy as a potential therapeutic strategy for nonalcoholic fatty liver disease. | 2022 | Details |
| A01179 | 34838715 | Mol Metab | A novel role of CRTC2 in promoting nonalcoholic fatty liver disease. | 2021 | Details |
| A01279 | 34803916 | Front Endocrinol (Lausanne) | Sestrin2 as a Potential Target for Regulating Metabolic-Related Diseases. | 2021 | Details |
| A01393 | 34762761 | FASEB J | Intracellular C3 prevents hepatic steatosis by promoting autophagy and very-low-density lipoprotein secretion. | 2021 | Details |
| A01406 | 34758326 | Cell Rep | m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity. | 2021 | Details |
| A01479 | 34732369 | Pharmacol Res | Ajugol enhances TFEB-mediated lysosome biogenesis and lipophagy to alleviate non-alcoholic fatty liver disease. | 2021 | Details |
| A01585 | 34684653 | Nutrients | Coffeeberry Activates the CaMKII/CREB/BDNF Pathway, Normalizes Autophagy and Apoptosis Signaling in Nonalcoholic Fatty Liver Rodent Model. | 2021 | Details |
| A01932 | 34558854 | Hepatol Commun | RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes. | 2021 | Details |
| A02352 | 34406209 | Braz J Med Biol Res | α,β-Amyrin prevents steatosis and insulin resistance in a high-fat diet-induced mouse model of NAFLD via the AMPK-mTORC1-SREBP1 signaling mechanism. | 2021 | Details |
| A02413 | 34382907 | Autophagy | Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy. | 2021 | Details |
| A02415 | 34381984 | JHEP Rep | The role of cGAS-STING signalling in liver diseases. | 2021 | Details |
| A02520 | 34342231 | J Agric Food Chem | Phloridzin Ameliorates Lipid Deposition in High-Fat-Diet-Fed Mice with Nonalcoholic Fatty Liver Disease via Inhibiting the mTORC1/SREBP-1c Pathway. | 2021 | Details |
| A02603 | 34312684 | J Mol Med (Berl) | Lipid metabolism, inflammation, and foam cell formation in health and metabolic disorders: targeting mTORC1. | 2021 | Details |
| A02814 | 34233024 | Hepatology | A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis. | 2021 | Details |
| A02818 | 34231324 | Physiol Rep | Crosstalk between beta-adrenergic and insulin signaling mediates mechanistic target of rapamycin hyperactivation in liver of high-fat diet-fed male mice. | 2021 | Details |
| A02838 | 34224699 | Eur J Pharmacol | Dapagliflozin attenuates steatosis in livers of high-fat diet-induced mice and oleic acid-treated L02 cells via regulating AMPK/mTOR pathway. | 2021 | Details |
| A03019 | 34161185 | Autophagy | Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective. | 2021 | Details |
| A03159 | 34107584 | Zhonghua Gan Zang Bing Za Zhi | [Liraglutide alleviates lipotoxic liver cell damage and promotes autophagy to improve non-alcoholic fatty liver]. | 2021 | Details |
| A03417 | 34007325 | Exp Ther Med | Maternal obesity accelerated non-alcoholic fatty liver disease in offspring mice by reducing autophagy. | 2021 | Details |
| A03532 | 33966599 | Autophagy | Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death. | 2021 | Details |
| A03544 | 33961941 | J Hepatol | Glutaminolysis-induced mTORC1 activation drives non-alcoholic steatohepatitis progression. | 2021 | Details |
| A03786 | 33864571 | Mol Cell Biochem | Upregulated SOCC and IP3R calcium channels and subsequent elevated cytoplasmic calcium signaling promote nonalcoholic fatty liver disease by inhibiting autophagy. | 2021 | Details |
| A04000 | 33794741 | Autophagy | The ménage à trois of autophagy, lipid droplets and liver disease. | 2021 | Details |
| A04129 | 33746450 | J Clin Exp Hepatol | Long-term Management of the Adult Liver Transplantation Recipients. | 2020 | Details |
| A04440 | 33615993 | Gut Microbes | Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response. | 2022 | Details |
| A04690 | 33541129 | Exp Biol Med (Maywood) | Effect of vitamin D3 supplementation on hepatic lipid dysregulation associated with autophagy regulatory AMPK/Akt-mTOR signaling in type 2 diabetic mice. | 2021 | Details |
| A05061 | 33390956 | Front Pharmacol | Hydrogen Sulfide Attenuates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Inhibiting Apoptosis and Promoting Autophagy via Reactive Oxygen Species/Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin Signaling Pathway. | 2020 | Details |
| A05268 | 33318872 | J Adv Res | Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential. | 2020 | Details |
| A05351 | 33290156 | Can J Physiol Pharmacol | Theobromine ameliorates nonalcoholic fatty liver disease by regulating hepatic lipid metabolism via mTOR signaling pathway in vivo and in vitro. | 2020 | Details |
| A05421 | 33264665 | J Nutr Biochem | Hepatic metabolic adaptation and adipose tissue expansion are altered in mice with steatohepatitis induced by high-fat high sucrose diet. | 2020 | Details |
| A05445 | 33254688 | Environ Pollut | Autophagy mediates perfluorooctanoic acid-induced lipid metabolism disorder and NLRP3 inflammasome activation in hepatocytes. | 2020 | Details |
| A05608 | 33190588 | Autophagy | TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation. | 2020 | Details |
| A05676 | 33163950 | JHEP Rep | NAFLD and liver transplantation: Disease burden, current management and future challenges. | 2020 | Details |
| A05873 | 33093014 | Diabetes | ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway. | 2020 | Details |
| A05876 | 33092030 | Int J Mol Sci | Accumulation of 8-hydroxydeoxyguanosine, L-arginine and Glucose Metabolites by Liver Tumor Cells Are the Important Characteristic Features of Metabolic Syndrome and Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis. | 2020 | Details |
| A05910 | 33078654 | Autophagy | Mir214-3p and Hnf4a/Hnf4α reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis. | 2020 | Details |
| A05983 | 33052067 | Am J Physiol Cell Physiol | Inositol-requiring enzyme 1α links palmitate-induced mTOR activation and lipotoxicity in hepatocytes. | 2020 | Details |
| A06053 | 33027655 | Cell Rep | The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development. | 2020 | Details |
| A06102 | 33007418 | Pharmacol Res | Endoplasmic reticulum stress and protein degradation in chronic liver disease. | 2020 | Details |
| A06117 | 32998777 | Lipids Health Dis | Signaling and other functions of lipids in autophagy: a review. | 2020 | Details |
| A06448 | 32878529 | Pharm Biol | Cyclocarya paliurus extract attenuates hepatic lipid deposition in HepG2 cells by the lipophagy pathway. | 2020 | Details |
| A06717 | 32771373 | Peptides | Liraglutide ameliorates lipotoxicity-induced inflammation through the mTORC1 signalling pathway. | 2020 | Details |
| A06843 | 32726654 | Eur J Pharmacol | Neuregulin 4 alleviates hepatic steatosis via activating AMPK/mTOR-mediated autophagy in aged mice fed a high fat diet. | 2020 | Details |
| A07294 | 32553647 | Ann Hepatol | Hepatic autophagy fluctuates during the development of non-alcoholic fatty liver disease. | 2020 | Details |
| A07303 | 32548088 | Front Chem | Rapamycin-Loaded mPEG-PLGA Nanoparticles Ameliorate Hepatic Steatosis and Liver Injury in Non-alcoholic Fatty Liver Disease. | 2020 | Details |
| A07454 | 32489856 | Integr Med Res | Herbal formulation MIT ameliorates high-fat diet-induced non-alcoholic fatty liver disease. | 2020 | Details |
| A07496 | 32473093 | Mol Cell | Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation. | 2020 | Details |
| A07771 | 32360132 | Dig Liver Dis | Mitochondrial DNA from hepatocytes induces upregulation of interleukin-33 expression of macrophages in nonalcoholic steatohepatitis. | 2020 | Details |
| A07939 | 32304762 | Life Sci | ApoE deficiency promotes non-alcoholic fatty liver disease in mice via impeding AMPK/mTOR mediated autophagy. | 2020 | Details |
| A07973 | 32293113 | J Cell Mol Med | Geniposide alleviates non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways. | 2020 | Details |
| A08001 | 32283200 | Food Chem Toxicol | Impaired ferritinophagy flux induced by high fat diet mediates hepatic insulin resistance via endoplasmic reticulum stress. | 2020 | Details |
| A08123 | 32239376 | Dig Dis Sci | Exercise Attenuates Ribosomal Protein Six Phosphorylation in Fatty Liver Disease. | 2020 | Details |
| A08272 | 32175386 | Ann Transl Med | Scientometric analysis of mTOR signaling pathway in liver disease. | 2020 | Details |
| A08460 | 32103588 | Mol Nutr Food Res | Regulation of Adipocyte and Macrophage Functions by mTORC1 and 2 in Metabolic Diseases. | 2020 | Details |
| A08500 | 32084429 | Metabolism | mTORC1-dependent protein synthesis and autophagy uncouple in the regulation of Apolipoprotein A-I expression. | 2020 | Details |
| A08568 | 32058217 | Biomed Pharmacother | Iridoids of Valeriana fauriei contribute to alleviating hepatic steatosis in obese mice by lipophagy. | 2020 | Details |
| A08991 | 31913745 | Autophagy | SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. | 2020 | Details |
| A09209 | 31835352 | Cells | The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases. | 2019 | Details |
| A09223 | 31831718 | Aging (Albany NY) | Bone morphogenetic protein 4 (BMP4) alleviates hepatic steatosis by increasing hepatic lipid turnover and inhibiting the mTORC1 signaling axis in hepatocytes. | 2019 | Details |
| A09253 | 31817227 | Nutrients | Fermented Korean Red Ginseng Extract Enriched in Rd and Rg3 Protects against Non-Alcoholic Fatty Liver Disease through Regulation of mTORC1. | 2019 | Details |
| A09275 | 31809000 | J Cell Mol Med | Long non-coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes. | 2019 | Details |
| A09350 | 31782176 | Hepatology | Lipotoxic Hepatocyte-Derived Exosomal MicroRNA 192-5p Activates Macrophages Through Rictor/Akt/Forkhead Box Transcription Factor O1 Signaling in Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A09403 | 31759065 | Food Chem Toxicol | Baicalein attenuates impairment of hepatic lysosomal acidification induced by high fat diet via maintaining V-ATPase assembly. | 2019 | Details |
| A09801 | 31604805 | J Lipid Res | Angiotensinogen in hepatocytes contributes to Western diet-induced liver steatosis. | 2019 | Details |
| A10166 | 31462971 | Comput Struct Biotechnol J | Hallmarks of Aging in the Liver. | 2019 | Details |
| A10254 | 31409773 | Cell Death Dis | mTOR direct crosstalk with STAT5 promotes de novo lipid synthesis and induces hepatocellular carcinoma. | 2019 | Details |
| A10417 | 31344750 | Hepatology | Mitochondrial General Control of Amino Acid Synthesis 5 Like 1 Regulates Glutaminolysis, Mammalian Target of Rapamycin Complex 1 Activity, and Murine Liver Regeneration. | 2019 | Details |
| A10736 | 31215672 | Hepatology | Sestrin 3 Protects Against Diet-Induced Nonalcoholic Steatohepatitis in Mice Through Suppression of Transforming Growth Factor β Signal Transduction. | 2019 | Details |
| A10807 | 31180545 | Mol Med Rep | LRG ameliorates steatohepatitis by activating the AMPK/mTOR/SREBP1 signaling pathway in C57BL/6J mice fed a high‑fat diet. | 2019 | Details |
| A10946 | 31109939 | Diabetes | The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism. | 2019 | Details |
| A11140 | 31024446 | Front Endocrinol (Lausanne) | ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and Disease. | 2019 | Details |
| A11436 | 30896868 | Mol Med Rep | Hepatic miR‑215 target Rictor and modulation of hepatic insulin signalling in rats. | 2019 | Details |
| A11556 | 30841536 | Int J Mol Sci | mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars. | 2019 | Details |
| A11777 | 30753863 | Eur J Pharmacol | Acetaminophen aggravates fat accumulation in NAFLD by inhibiting autophagy via the AMPK/mTOR pathway. | 2019 | Details |
| A11834 | 30715741 | Hepatology | Glial Cell Line-Derived Neurotrophic Factor Enhances Autophagic Flux in Mouse and Rat Hepatocytes and Protects Against Palmitate Lipotoxicity. | 2019 | Details |
| A11865 | 30704899 | Mol Cell | Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism. | 2019 | Details |
| A11897 | 30689995 | Eur J Pharmacol | Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease. | 2019 | Details |
| A12182 | 30572788 | Biosci Biotechnol Biochem | A review of the studies on food-derived factors which regulate energy metabolism via the modulation of lipid-sensing nuclear receptors. | 2018 | Details |
| A12206 | 30562559 | Biochim Biophys Acta Mol Basis Dis | Hepatic mTOR-AKT2-Insig2 signaling pathway contributes to the improvement of hepatic steatosis after Roux-en-Y Gastric Bypass in mice. | 2018 | Details |
| A12271 | 30539788 | Cell Mol Gastroenterol Hepatol | Macrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis. | 2018 | Details |
| A12405 | 30469030 | Redox Biol | Selenium-binding protein 1 (SELENBP1) is a marker of mature adipocytes. | 2018 | Details |
| A12524 | 30411173 | Sleep Breath | Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice. | 2018 | Details |
| A12765 | 30298052 | Front Endocrinol (Lausanne) | The Antidiabetic Drug Lobeglitazone Protects Mice From Lipogenesis-Induced Liver Injury via Mechanistic Target of Rapamycin Complex 1 Inhibition. | 2018 | Details |
| A13277 | 30054905 | FEBS Lett | Upstream stimulating factor 1 suppresses autophagy and hepatic lipid droplet catabolism by activating mTOR. | 2018 | Details |
| A13295 | 30044707 | Autophagy | Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply. | 2018 | Details |
| A13580 | 29897151 | Chembiochem | Quinoline-Glycomimetic Conjugates Reducing Lipogenesis and Lipid Accumulation in Hepatocytes. | 2018 | Details |
| A13813 | 29743930 | Nutr Metab (Lond) | LXRɑ participates in the mTOR/S6K1/SREBP-1c signaling pathway during sodium palmitate-induced lipogenesis in HepG2 cells. | 2018 | Details |
| A13963 | 29669855 | Sci Transl Med | Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target. | 2018 | Details |
| A14045 | 29615085 | Diagn Pathol | Expression patterns of STAT3, ERK and estrogen-receptor α are associated with development and histologic severity of hepatic steatosis: a retrospective study. | 2018 | Details |
| A14049 | 29609842 | J Pharmacol Sci | Akebia saponin D alleviates hepatic steatosis through BNip3 induced mitophagy. | 2017 | Details |
| A14227 | 29515134 | Sci Rep | Celecoxib alleviates nonalcoholic fatty liver disease by restoring autophagic flux. | 2018 | Details |
| A14243 | 29507903 | Hepatol Commun | Insulin signaling as a potential natural killer cell checkpoint in fatty liver disease. | 2018 | Details |
| A14519 | 29371918 | Oncotarget | Long-term administration of tacrolimus and everolimus prevents high cholesterol-high fructose-induced steatosis in C57BL/6J mice by inhibiting de-novo lipogenesis. | 2017 | Details |