Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Article ID | PMID | Source | Title | Publish Year | |
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A00040 | 35247631 | Cell Mol Gastroenterol Hepatol | The critical and diverse roles of CD4-CD8- double negative T cells in nonalcoholic fatty liver disease. | 2022 | Details |
A00051 | 35242578 | Mol Genet Metab Rep | Expression signature of the Leigh syndrome French-Canadian type. | 2022 | Details |
A00095 | 35221291 | J Pharmacol Exp Ther | Resveratrol attenuates HFD-induced hepatic lipotoxicity by up-regulating Bmi-1 expression. | 2022 | Details |
A00117 | 35215517 | Nutrients | Potential Roles and Key Mechanisms of Hawthorn Extract against Various Liver Diseases. | 2022 | Details |
A00122 | 35213001 | Methods Mol Biol | In Vivo Analysis of Necrosis and Ferroptosis in Nonalcoholic Steatohepatitis (NASH). | 2022 | Details |
A00124 | 35212999 | Methods Mol Biol | Assessment of Lipotoxic Endoplasmic Reticulum (ER) Stress in Nonalcoholic Steatohepatitis (NASH). | 2022 | Details |
A00151 | 35208205 | Metabolites | A Potential Role for Bile Acid Signaling in Celiac Disease-Associated Fatty Liver. | 2022 | Details |
A00160 | 35204232 | Antioxidants (Basel) | Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway. | 2022 | Details |
A00248 | 35166723 | Clin Transl Gastroenterol | Relationship between hepatic gene expression, intestinal microbiota and inferred functional metagenomic analysis in NAFLD. | 2022 | Details |
A00251 | 35164657 | Bioengineered | Liraglutide inhibits receptor for advanced glycation end products (RAGE)/reduced form of nicotinamide-adenine dinucleotide phosphate (NAPDH) signaling to ameliorate non-alcoholic fatty liver disease (NAFLD) in vivo and vitro. | 2022 | Details |
A00287 | 35152446 | Hepatology | FGF4 protects the liver from nonalcoholic fatty liver disease by activating the AMP-activated protein kinase-Caspase 6 signal axis. | 2022 | Details |
A00342 | 35127372 | Acta Pharm Sin B | The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy. | 2021 | Details |
A00358 | 35122118 | Semin Immunopathol | TNF in the liver: targeting a central player in inflammation. | 2022 | Details |
A00370 | 35115498 | Cell Death Discov | Bdh1 overexpression ameliorates hepatic injury by activation of Nrf2 in a MAFLD mouse model. | 2022 | Details |
A00474 | 35068796 | J Clin Exp Hepatol | A Current Understanding of Bile Acids in Chronic Liver Disease. | 2021 | Details |
A00519 | 35054478 | Life (Basel) | Deep Sea Water-Dissolved Organic Matter Intake Improves Hyperlipidemia and Inhibits Thrombus Formation and Vascular Inflammation in High-Fat Diet Hamsters. | 2022 | Details |
A00550 | 35050176 | Metabolites | Lentinan Protects against Nonalcoholic Fatty Liver Disease by Reducing Oxidative Stress and Apoptosis via the PPARα Pathway. | 2022 | Details |
A00665 | 35010950 | Nutrients | Sulforaphane Attenuates Nonalcoholic Fatty Liver Disease by Inhibiting Hepatic Steatosis and Apoptosis. | 2021 | Details |
A00687 | 35003513 | Oxid Med Cell Longev | TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization. | 2021 | Details |
A00695 | 35000120 | Clin J Gastroenterol | The impact of emricasan on chronic liver diseases: current data. | 2022 | Details |
A00728 | 34986838 | Cancer Cell Int | STK25 enhances hepatocellular carcinoma progression through the STRN/AMPK/ACC1 pathway. | 2022 | Details |
A00746 | 34981443 | Clin J Gastroenterol | Hepatocellular carcinoma diagnosis using a novel electrochemiluminescence immunoassay targeting serum IgM-free AIM. | 2022 | Details |
A00754 | 34979142 | Toxicol Appl Pharmacol | Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress. | 2021 | Details |
A00763 | 34977130 | Front Nutr | Sirt1 Promotes the Restoration of Hepatic Progenitor Cell (HPC)-Mediated Liver Fatty Injury in NAFLD Through Activating the Wnt/β-Catenin Signal Pathway. | 2021 | Details |
A00824 | 34956386 | Evid Based Complement Alternat Med | Procyanidin B2 Alleviates Palmitic Acid-Induced Injury in HepG2 Cells via Endoplasmic Reticulum Stress Pathway. | 2021 | Details |
A00834 | 34954022 | Free Radic Biol Med | Mitochondriotropic antioxidant based on caffeic acid AntiOxCIN4 activates Nrf2-dependent antioxidant defenses and quality control mechanisms to antagonize oxidative stress-induced cell damage. | 2021 | Details |
A00859 | 34944732 | Biomedicines | Therapeutic Opportunities of IL-22 in Non-Alcoholic Fatty Liver Disease: From Molecular Mechanisms to Clinical Applications. | 2021 | Details |
A00895 | 34938205 | Front Physiol | Ectodysplasin A/Ectodysplasin A Receptor System and Their Roles in Multiple Diseases. | 2021 | Details |
A00926 | 34927282 | Drug Dev Res | Schisandrin B ameliorates non-alcoholic liver disease through anti-inflammation activation in diabetic mice. | 2021 | Details |
A01000 | 34906049 | Biochemistry (Mosc) | AMPK/PGC-1α/GLUT4-Mediated Effect of Icariin on Hyperlipidemia-Induced Non-Alcoholic Fatty Liver Disease and Lipid Metabolism Disorder in Mice. | 2021 | Details |
A01185 | 34836315 | Nutrients | Network Pharmacology Exploration Reveals Anti-Apoptosis as a Common Therapeutic Mechanism for Non-Alcoholic Fatty Liver Disease Treated with Blueberry Leaf Polyphenols. | 2021 | Details |
A01204 | 34829876 | Biomedicines | Estimating Drug Efficacy with a Diet-Induced NASH Model in Chimeric Mice with Humanized Livers. | 2021 | Details |
A01262 | 34810376 | Saudi J Gastroenterol | Nonalcoholic fatty liver disease: The role of quercetin and its therapeutic implications. | 2022 | Details |
A01265 | 34808701 | Phytother Res | Esculetin: A review of its pharmacology and pharmacokinetics. | 2021 | Details |
A01269 | 34808388 | Bioorg Med Chem Lett | Design, synthesis and activity evaluation of prodrug form JBP485 and Vitamin E for alleviation of NASH. | 2021 | Details |
A01283 | 34803490 | Int J Biol Sci | SOCS2 Suppresses Inflammation and Apoptosis during NASH Progression through Limiting NF-κB Activation in Macrophages. | 2021 | Details |
A01344 | 34780785 | Exp Cell Res | MicroRNA-22 inhibition promotes the development of atherosclerosis via targeting interferon regulator factor 5. | 2021 | Details |
A01368 | 34773257 | Hepatology | A GLP-1/GLP-2 receptor dual agonist to treat NASH: Targeting the gut-liver axis and microbiome. | 2021 | Details |
A01385 | 34765085 | Oxid Med Cell Longev | Target Sestrin2 to Rescue the Damaged Organ: Mechanistic Insight into Its Function. | 2021 | Details |
A01415 | 34756030 | ACS Appl Mater Interfaces | Fluorescent Egg White-Based Carbon Dots as a High-Sensitivity Iron Chelator for the Therapy of Nonalcoholic Fatty Liver Disease by Iron Overload in Zebrafish. | 2021 | Details |
A01437 | 34746195 | Front Med (Lausanne) | Liver Fibrosis and MAFLD: From Molecular Aspects to Novel Pharmacological Strategies. | 2021 | Details |
A01444 | 34743657 | Adipocyte | Association of cell death mechanisms and fibrosis in visceral white adipose tissue with pathological alterations in the liver of morbidly obese patients with NAFLD. | 2021 | Details |
A01477 | 34733981 | Ann Transl Med | TLR2 inhibition ameliorates the amplification effect of LPS on lipid accumulation and lipotoxicity in hepatic cells. | 2021 | Details |
A01554 | 34695558 | J Nutr Biochem | Nobiletin mitigates hepatocytes death, liver inflammation, and fibrosis in a murine model of NASH through modulating hepatic oxidative stress and mitochondrial dysfunction. | 2021 | Details |
A01572 | 34689159 | Cell Death Discov | HES5-mediated repression of LIGHT transcription may contribute to apoptosis in hepatocytes. | 2021 | Details |
A01577 | 34687092 | Biofactors | Perspectives in liver redox imbalance: Toxicological and pharmacological aspects underlying iron overloading, nonalcoholic fatty liver disease, and thyroid hormone action. | 2021 | Details |
A01585 | 34684653 | Nutrients | Coffeeberry Activates the CaMKII/CREB/BDNF Pathway, Normalizes Autophagy and Apoptosis Signaling in Nonalcoholic Fatty Liver Rodent Model. | 2021 | Details |
A01602 | 34681600 | Int J Mol Sci | Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling. | 2021 | Details |
A01609 | 34680522 | Biomedicines | Lipid Disorders in NAFLD and Chronic Kidney Disease. | 2021 | Details |
A01622 | 34678374 | Toxicol Appl Pharmacol | Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3. | 2021 | Details |
A01652 | 34667947 | JHEP Rep | New targets for NAFLD. | 2021 | Details |
A01679 | 34657040 | Cytogenet Genome Res | PinX1 Depletion Improves Liver Injury in a Mouse Model of Nonalcoholic Fatty Liver Disease via Increasing Telomerase Activity and Inhibiting Apoptosis. | 2021 | Details |
A01680 | 34656650 | J Hepatol | Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling. | 2021 | Details |
A01715 | 34646017 | Nature | Convergent somatic mutations in metabolism genes in chronic liver disease. | 2021 | Details |
A01787 | 34618611 | Immunopharmacol Immunotoxicol | Capillin protects against non-alcoholic steatohepatitis through suppressing NLRP3 inflammasome activation and oxidative stress. | 2021 | Details |
A01794 | 34614409 | Cell Metab | DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing. | 2021 | Details |
A01802 | 34609305 | Turk J Gastroenterol | Histological Characteristics of Non-alcoholic Steatohepatitis in NAFLD Patients With Low Degree of Hepatocyte Apoptosis. | 2021 | Details |
A01846 | 34591986 | Hepatology | OTUB1 alleviates NASH through inhibition of the TRAF6-ASK1 signaling pathways. | 2021 | Details |
A01847 | 34591699 | J Med Food | Artichoke Extract Directly Suppresses Inflammation and Apoptosis in Hepatocytes During the Development of Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
A01901 | 34566670 | Front Physiol | Gardenoside Hinders Caspase-1-Mediated Hepatocyte Pyroptosis Through the CTCF/DPP4 Signaling Pathway. | 2021 | Details |
A01917 | 34563665 | J Nutr Biochem | Cholic acid supplementation accelerates the progression of nonalcoholic fatty liver disease to the procarcinogenic state in mice fed a high-fat and high-cholesterol diet. | 2021 | Details |
A01931 | 34558856 | Hepatol Commun | Role of Cholesterol-Associated Steatohepatitis in the Development of NASH. | 2021 | Details |
A01969 | 34548598 | Sci Rep | Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis. | 2021 | Details |
A01977 | 34543756 | Clin Res Hepatol Gastroenterol | Adipose tissue dysfunction and MAFLD in obesity on the scene of COVID-19. | 2021 | Details |
A01998 | 34534913 | Redox Biol | Hepatic Regulator of G Protein Signaling 6 (RGS6) drives non-alcoholic fatty liver disease by promoting oxidative stress and ATM-dependent cell death. | 2021 | Details |
A02043 | 34521905 | Sci Rep | Development of a highly sensitive chemiluminescent enzyme immunoassay for fragmented cytokeratin 18 using new antibodies. | 2021 | Details |
A02080 | 34511460 | Georgian Med News | [METABOLIC FEATURES OF ADIPOSE TISSUE AND CLINICAL SIGNIFICANCE OF ADIPOKINS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE (REVIEW)]. | 2021 | Details |
A02083 | 34511037 | Bioengineered | Long non-coding RNA AC012668 suppresses non-alcoholic fatty liver disease by competing for microRNA miR-380-5p with lipoprotein-related protein LRP2. | 2021 | Details |
A02107 | 34505423 | Endocrinol Diabetes Metab | Oxy210, a novel inhibitor of hedgehog and TGF-β signalling, ameliorates hepatic fibrosis and hypercholesterolemia in mice. | 2021 | Details |
A02128 | 34496884 | Lipids Health Dis | Metformin ameliorates maternal high-fat diet-induced maternal dysbiosis and fetal liver apoptosis. | 2021 | Details |
A02166 | 34478580 | FASEB J | CELSR2 deficiency suppresses lipid accumulation in hepatocyte by impairing the UPR and elevating ROS level. | 2021 | Details |
A02172 | 34475098 | Diabetes | Hepatocytic Activating Transcription Factor 3 Protects Against Steatohepatitis via Hepatocyte Nuclear Factor 4α. | 2021 | Details |
A02225 | 34453940 | Life Sci | Pancreastatin induces hepatic steatosis in type 2 diabetes by impeding mitochondrial functioning. | 2021 | Details |
A02233 | 34450307 | Pharmacol Res | Traditional Chinese medicine in the treatment of nonalcoholic steatohepatitis. | 2021 | Details |
A02235 | 34450119 | Exp Cell Res | miR-23b Ameliorates nonalcoholic steatohepatitis by targeting Acyl-CoA thioesterases 4. | 2021 | Details |
A02243 | 34448436 | J Histochem Cytochem | Independent of Calorie Intake, Short-term Alternate-day Fasting Alleviates NASH, With Modulation of Markers of Lipogenesis, Autophagy, Apoptosis, and Inflammation in Rats. | 2021 | Details |
A02254 | 34445644 | Int J Mol Sci | Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome. | 2021 | Details |
A02280 | 34439474 | Antioxidants (Basel) | Garcinia cambogia Ameliorates Non-Alcoholic Fatty Liver Disease by Inhibiting Oxidative Stress-Mediated Steatosis and Apoptosis through NRF2-ARE Activation. | 2021 | Details |
A02285 | 34437407 | Toxins (Basel) | Microcystin Toxicokinetics, Molecular Toxicology, and Pathophysiology in Preclinical Rodent Models and Humans. | 2021 | Details |
A02291 | 34434195 | Front Immunol | Caveolin-1 Deficiency Protects Mice Against Carbon Tetrachloride-Induced Acute Liver Injury Through Regulating Polarization of Hepatic Macrophages. | 2021 | Details |
A02306 | 34426744 | Evid Based Complement Alternat Med | Targeting miRNA by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty Liver. | 2021 | Details |
A02317 | 34422075 | Evid Based Complement Alternat Med | Antifibrotic Effects of Kangxian Ruangan Capsule on Rats with Nonalcoholic Fatty Liver Fibrosis and Hepatic Stellate Cells through Regulation of TGF-β and TLR4 Signaling Pathways. | 2021 | Details |
A02329 | 34416350 | Toxicology | Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent. | 2021 | Details |
A02342 | 34410623 | Hum Cell | Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression. | 2021 | Details |
A02365 | 34401690 | JHEP Rep | Comprehensive lipidomics reveals phenotypic differences in hepatic lipid turnover in ALD and NAFLD during alcohol intoxication. | 2021 | Details |
A02380 | 34396890 | Arch Physiol Biochem | Hepatoprotection of capsaicin in alcoholic and non-alcoholic fatty liver diseases. | 2021 | Details |
A02388 | 34393793 | Front Pharmacol | Extracts of Vine Tea Improve Diet-Induced Non-Alcoholic Steatohepatitis Through AMPK-LXRα Signaling. | 2021 | Details |
A02397 | 34387896 | Hepatology | Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice. | 2021 | Details |
A02411 | 34383111 | Calcif Tissue Int | Neuregulin 4 Attenuates Osteoarthritis Progression by Inhibiting Inflammation and Apoptosis of Chondrocytes in Mice. | 2021 | Details |
A02423 | 34375691 | Pharmacol Ther | Xyloketal B: A marine compound with medicinal potential. | 2021 | Details |
A02428 | 34374253 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | [Effects of GPR81 agonist on insulin resistance in rats with nonalcoholic fatty liver disease]. | 2021 | Details |
A02518 | 34343274 | Endocrinology | SGLT2 Inhibition for Cardiovascular Diseases, Chronic Kidney Disease, and NAFLD. | 2021 | Details |
A02531 | 34339914 | Biomed Pharmacother | Molecular mechanisms and therapeutic implications of dihydromyricetin in liver disease. | 2021 | Details |
A02568 | 34326886 | Evid Based Complement Alternat Med | Pharmacological Mechanisms Underlying the Hepatoprotective Effects of Ecliptae herba on Hepatocellular Carcinoma. | 2021 | Details |
A02594 | 34321089 | Stem Cell Res Ther | Addressing the liver progenitor cell response and hepatic oxidative stress in experimental non-alcoholic fatty liver disease/non-alcoholic steatohepatitis using amniotic epithelial cells. | 2021 | Details |
A02601 | 34314787 | Adv Drug Deliv Rev | Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis. | 2021 | Details |
A02606 | 34311531 | Biomed Pharmacother | FTZ attenuates liver steatosis and fibrosis in the minipigs with type 2 diabetes by regulating the AMPK signaling pathway. | 2021 | Details |
A02659 | 34294714 | Nat Commun | CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells. | 2021 | Details |
A02689 | 34281337 | J Agric Food Chem | γ-Linolenic Acid Prevents Lipid Metabolism Disorder in Palmitic Acid-Treated Alpha Mouse Liver-12 Cells by Balancing Autophagy and Apoptosis via the LKB1-AMPK-mTOR Pathway. | 2021 | Details |
A02692 | 34280515 | Adv Drug Deliv Rev | Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis. | 2021 | Details |