Repositioning Candidate Details
| Candidate ID: | R1024 |
| Source ID: | DB06470 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Clomethiazole |
| Synonyms: | Clomethiazole |
| Molecular Formula: | C6H8ClNS |
| SMILES: | CC1=C(CCCl)SC=N1 |
| Structure: |
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| DrugBank Description: | Clomethiazole is a well-established γ-aminobutyric acid (GABAA)-mimetic drug. It is a sedative and hypnotic that is widely used in treating and preventing symptoms of acute alcohol withdrawal. It is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant. It is also used for the management of agitation, restlessness, short-term insomnia and Parkinson's disease in the elderly. |
| CAS Number: | 533-45-9 |
| Molecular Weight: | 161.65 |
| DrugBank Indication: | Investigated for use/treatment in strokes. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | clomethiazole interacts with the GABAA receptor complex. It inhibits the binding of butyl-bicyclophosphorothionate (TBPS), an effect indicative of GABAA receptor-channel activation, by increasing the rate of TBPS dissociation and decreasing the binding affinity. Gamma-aminobutyric acid (GABA), acting at GABAA receptors, is the main fast inhibitory neurotransmitter in mammalian central nervous system |
| Targets: | Gamma-aminobutyric acid receptor subunit alpha-1 |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I16 | 6713 | Cerebrovascular disease | An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain. http://en.wikipedia.org/wiki/Cerebrovascular_disease, http://www.ncbi.nlm.nih.gov/books/NBK378/ | disease of anatomical entity/ cardiovascular system disease/ vascular disease/cerebrovascular disease | Details |