Repositioning Candidate Details
| Candidate ID: | R1033 |
| Source ID: | DB06506 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Repinotan |
| Synonyms: | Repinotan |
| Molecular Formula: | C21H24N2O4S |
| SMILES: | O=C1N(CCCCNC[C@H]2CCC3=CC=CC=C3O2)S(=O)(=O)C2=CC=CC=C12 |
| Structure: |
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| DrugBank Description: | Repinotan is a high-affinity, selective, full agonist of the 5HT1A-receptor subtype with neuroprotective properties. |
| CAS Number: | 144980-29-0 |
| Molecular Weight: | 400.49 |
| DrugBank Indication: | Investigated for use/treatment in strokes, cerebral ischemia, and depression. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | Repinotan is a 5-HT1A receptor agonist which inhibits glutamate induced depolarization. The effect of repinotan in neuronal cells has been reported to be mediated by a variety of mechanisms/signaling pathways, including activation of the anti-apoptotic phosphatidylinositol 3-kinase (PI-3K) pathway, inhibition of glutamate release (probably via opening of K+ channels leading to membrane hyperpolarization), extracellular-regulated kinase (Erk)-stimulated Bcl-2 expression or inhibition of caspase-3 activity, and increased release of the neurite extension factor S-100 beta. |
| Targets: | 5-hydroxytryptamine receptor 1A |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I16 | 6713 | Cerebrovascular disease | An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain. http://en.wikipedia.org/wiki/Cerebrovascular_disease, http://www.ncbi.nlm.nih.gov/books/NBK378/ | disease of anatomical entity/ cardiovascular system disease/ vascular disease/cerebrovascular disease | Details |
| I17 | 1596 | Mental depression | Mental depression | disease of mental health/ cognitive disorder/ mood disorder | Details |