Repositioning Candidate Details
| Candidate ID: | R1083 |
| Source ID: | DB06696 |
| Source Type: | experimental; investigational |
| Compound Type: | small molecule |
| Compound Name: | Arbekacin |
| Synonyms: | ABK; Arbekacin; Haberacin |
| Molecular Formula: | C22H44N6O10 |
| SMILES: | NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)CC[C@H]2N)[C@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](N)[C@H]1O |
| Structure: |
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| DrugBank Description: | An semisynthetic aminoglycoside antibiotic. Often used for treatment of multi-resistant bacterial infection such as methicillin-resistant _Staphylococcus aureus_ (MRSA). |
| CAS Number: | 51025-85-5 |
| Molecular Weight: | 552.619 |
| DrugBank Indication: | Arbekacin is used for the short term treatment of multi-resistant bacterial infections, such as methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). |
| DrugBank Pharmacology: | Arbekacin is an aminoglycoside. Aminoglycosides function by binding to bacterial 30S ribosomal subunits, causing t-RNA misreads, and preventing the production of proteins. Anaerobes are less susceptible to aminoglycosides because they do not spend as much energy as aerobes on taking up chemicals like aminoglycosides. Aminoglycosides are useful primarily in infections involving aerobic, gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. |
| DrugBank MoA: | Arbekacin irreversibly binds bacterial 30S and 16S ribosomal subunits inhibiting protein synthesis. Arbekacin binds to 4 nucleotides of the 16S subunit and 1 amino acid of protein S12 to interfere with the decoding site around nucleotide 1400 in the 16S subunit. Interference with the decoding site interferes with its interaction with the wobble base of tRNA. This hindered interaction causes mRNA to be misread and the incorrect amino acids are inserted into protein. These error filled proteins are not able to function or may even be toxic. |
| Targets: | 30S ribosomal protein S12 inhibitor |
| Inclusion Criteria: | Indication associated |
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